’Tis late; the astronomer in his lonely height
Exploring all the dark, descries from far
Orbs that like distant isles of splendor are,
And mornings whitening in the infinite.…
He summons one disheveled, wandering star,—
Return ten centuries hence on such a night.
That star will come. It dare not by one hour
Cheat science, or falsify her calculation;
Men will have passed, but watchful in the tower
Man shall remain in sleepless contemplation;
And should all men have perished there in turn,
Truth in their stead would watch that star’s return.

“These changes in the body,” he wrote in the review paper he sent to the American Journal of Physiology late in 1913, “are, each one of them, directly serviceable in making the organism more efficient in the struggle which fear or rage or pain may involve; for fear and rage are organic preparations for action, and pain is the most powerful known stimulus to supreme exertion. The organism which with the aid of increased adrenal secretion can best muster its energies, can best call forth sugar to supply the labouring muscles, can best lessen fatigue, and can best send blood to the parts essential in the run or the fight for life, is most likely to survive. Such, according to the view here propounded, is the function of the adrenal medulla at times of great emergency.”

[Brook's Law:] Adding manpower to a late software project makes it later.

[1665-08-16] ...Hence to the Exchange, which I have not been a great while. But Lord, how sad a sight it is to see the streets empty of people, and very few upon the Change - jealous of every door that one sees shut up, lest it should be the plague - and about us, two shops in three, if not more, generally shut up. ... It was dark before I could get home; and so land at church-yard stairs, where to my great trouble I met a dead Corps, of the plague, in the narrow ally, just bringing down a little pair of stairs - but I thank God I was not much disturbed at it. However, I shall beware of being late abroad again.

[1665-08-31] Up, and after putting several things in order to my removal to Woolwich, the plague having a great increase this week beyond all expectation, of almost 2000 - making the general Bill 7000, odd 100 and the plague above 6000 .... Thus this month ends, with great sadness upon the public through the greateness of the plague, everywhere through the Kingdom almost. Every day sadder and sadder news of its increase. In the City died this week 7496; and all of them, 6102 of the plague. But it is feared that the true number of the dead this week is near 10000 - partly from the poor that cannot be taken notice of through the greatness of the number, and partly from the Quakers and others that will not have any bell ring for them. As to myself, I am very well; only, in fear of the plague, and as much of an Ague, by being forced to go early and late to Woolwich, and my family to lie there continually.

[At my secondary school] if you were very bright, you did classics; if you were pretty thick, you did woodwork; and if you were neither of those poles, you did science. The number of kids in my school who did science because they were excited by the notion of science was pretty small. You were allocated to those things, you weren’t asked. This was in the late 1930s/early 1940s … Science was seen as something more remote and less to do with everyday life.

[I]magine you want to know the sex of your unborn child. There are several approaches. You could, for example, do what the late film star ... Cary Grant did before he was an actor: In a carnival or fair or consulting room, you suspend a watch or a plumb bob above the abdomen of the expectant mother; if it swings left-right it's a boy, and if it swings forward-back it's a girl. The method works one time in two. Of course he was out of there before the baby was born, so he never heard from customers who complained he got it wrong. ... But if you really want to know, then you go to amniocentesis, or to sonograms; and there your chance of being right is 99 out of 100. ... If you really want to know, you go to science.

[Penguins] are extraordinarily like children, these little people of the Antarctic world, either like children, or like old men, full of their own importance and late for dinner, in their black tail-coats and white shirt-fronts — and rather portly withal.

[To] explain the phenomena of the mineral kingdom ... systems are usually reduced to two classes, according as they refer to the origin of terrestrial bodies to FIRE or to WATER; and ... their followers have of late been distinguished by the fanciful names of Vulcanists and Neptunists. To the former of these Dr HUTTON belongs much more than to the latter; though, as he employs the agency both of fire and water in his system, he cannot, in strict propriety, be arranged with either.

Ac astronomye is an hard thyng,
And yvel for to knowe;
Geometrie and geomesie,
So gynful of speche,
Who so thynketh werche with tho two
Thryveth ful late,
For sorcerie is the sovereyn book
That to tho sciences bilongeth.
Now, astronomy is a difficult discipline, and the devil to learn;
And geometry and geomancy have confusing terminology:
If you wish to work in these two, you will not succeed quickly.
For sorcery is the chief study that these sciences entail.

A hot topic of late, expressed most notably in Bernie Siegel’s best-selling books, has emphasized the role of positive attitude in combating such serious diseases as cancer. From the depths of my skeptical and rationalist soul, I ask the Lord to protect me from California touchie-feeliedom.

A physician is someone who knows everything and does nothing.
A surgeon is someone who does everything and knows nothing.
A psychiatrist is someone who knows nothing and does nothing.
A pathologist is someone who knows everything and does everything too late.

After all, we scientific workers … like women, are the victims of fashion: at one time we wear dissociated ions, at another electrons; and we are always loth to don rational clothing; some fixed belief we must have manufactured for us: we are high or low church, of this or that degree of nonconformity, according to the school in which we are brought up—but the agnostic is always rare of us and of late years the critic has been taboo.

Although few expressions are more commonly used in writing about science than “science revolution,” there is a continuing debate as to the propriety of applying the concept and term “revolution” to scientific change. There is, furthermore, a wide difference of opinion as to what may constitute a revolution. And although almost all historians would agree that a genuine alteration of an exceptionally radical nature (the Scientific Revolution) occurred in the sciences at some time between the late fifteenth (or early sixteenth) century and the end of the seventeenth century, the question of exactly when this revolution occurred arouses as much scholarly disagreement as the cognate question of precisely what it was.

As an exercise of the reasoning faculty, pure mathematics is an admirable exercise, because it consists of reasoning alone, and does not encumber the student with an exercise of judgment: and it is well to begin with learning one thing at a time, and to defer a combination of mental exercises to a later period.

At quite uncertain times and places,
The atoms left their heavenly path,
And by fortuitous embraces,
Engendered all that being hath.
And though they seem to cling together,
And form 'associations' here,
Yet, soon or late, they burst their tether,
And through the depths of space career.

Be not sick too late, nor well too soon.

Because basic learning takes place so early—as…the classic musical South Pacific reminds us, “You've got to be taught before it’s too late, before you are six or seven or eight; you’ve got to be carefully taught,”—we must strengthen our pre-school program, especially Headstart, Kindergarten and Day Care.

Bread has been made (indifferent) from potatoes;
And galvanism has set some corpses grinning,
But has not answer'd like the apparatus
Of the Humane Society's beginning,
By which men are unsuffocated gratis:
What wondrous new machines have late been spinning.

But does Man have any “right” to spread through the universe? Man is what he is, a wild animal with the will to survive, and (so far) the ability, against all competition. Unless one accepts that, anything one says about morals, war, politics, you name it, is nonsense. Correct morals arise from knowing what man is, not what do-gooders and well-meaning old Aunt Nellies would like him to be. The Universe will let us know—later—whether or not Man has any “right” to expand through it.

Come, my friends,
’Tis not too late to seek a newer world.
Push off, and sitting well in order smite
The sounding furrows; for my purpose holds
To sail beyond the sunset, and the baths
Of all the western stars, until I die.

Common sense always speaks too late. Common sense is the guy who tells you you ought to have had your brakes relined last week before you smashed a front end this week. Common sense is the Monday morning quarterback who could have won the ball game if he had been on the team. But he never is. He’s high up in the stands with a flask on his hip. Common sense is the little man in a grey suit who never makes a mistake in addition. But it’s always somebody else’s money he’s adding up.

Death seems to have been a rather late invention in evolution. One can go a long way in evolution before encountering an authentic corpse.

Early Greek astronomers, derived their first knowledge from the Egyptians, and these from the Chaldeans, among whom the science was studied, at a very early period. Their knowledge of astronomy, which gave their learned men the name of Magi, wise men, afterwards degenerated into astrology, or the art of consulting the position of the stars to foretel events—and hence sprung the silly occupation of sooth saying, for which the Chaldeans were noted to a proverb, in later ages.

Experimenters don’t come in late—they never went home.

For Linnaeus, Homo sapiens was both special and not special ... Special and not special have come to mean nonbiological and biological, or nurture and nature. These later polarizations are nonsensical. Humans are animals and everything we do lies within our biological potential ... the statement that humans are animals does not imply that our specific patterns of behavior and social arrangements are in any way directly determined by our genes. Potentiality and determination are different concepts.

For more than ten years, my theory was in limbo. Then, finally, in the late 1980s, physicists at Princeton said, “There’s nothing wrong with this theory. It’s the only one that works, and we have to open out minds to hyperspace.” We weren’t destined to discover this theory for another 100 years because it’s so bizarre, so different from everything we’d been doing. We didn’t use the normal sequence of discoveries to get to it.
Describing reaction to his superstring theory of hyperspace which mathematically relates the universe’s basic forces.

For the sake of our children and our future, we must do more to combat climate change. Now, it’s true that no single event makes a trend. But the fact is the 12 hottest years on record have all come in the last 15. Heat waves, droughts, wildfires, floods—all are now more frequent and more intense. We can choose to believe that Superstorm Sandy, and the most severe drought in decades, and the worst wildfires some states have ever seen were all just a freak coincidence. Or we can choose to believe in the overwhelming judgment of science—and act before it’s too late.

From my father I learned to build things, to take them apart, and to fix mechanical and electrical equipment in general. I spent vast hours in a woodworking shop he maintained in the basement of our house, building gadgets, working both with my father and alone, often late into the night. … This play with building, fixing, and designing was my favorite activity throughout my childhood, and was a wonderful preparation for my later career as an experimentalist working on the frontiers of chemistry and physics.

How did I discover saccharin? Well, it was partly by accident and partly by study. I had worked a long time on the compound radicals and substitution products of coal tar... One evening I was so interested in my laboratory that I forgot about my supper till quite late, and then rushed off for a meal without stopping to wash my hands. I sat down, broke a piece of bread, and put it to my lips. It tasted unspeakably sweet. I did not ask why it was so, probably because I thought it was some cake or sweetmeat. I rinsed my mouth with water, and dried my moustache with my napkin, when, to my surprise the napkin tasted sweeter than the bread. Then I was puzzled. I again raised my goblet, and, as fortune would have it, applied my mouth where my fingers had touched it before. The water seemed syrup. It flashed on me that I was the cause of the singular universal sweetness, and I accordingly tasted the end of my thumb, and found it surpassed any confectionery I had ever eaten. I saw the whole thing at once. I had discovered some coal tar substance which out-sugared sugar. I dropped my dinner, and ran back to the laboratory. There, in my excitement, I tasted the contents of every beaker and evaporating dish on the table.

Hyper-selectionism has been with us for a long time in various guises; for it represents the late nineteenth century’s scientific version of the myth of natural harmony–all is for the best in the best of all possible worlds (all structures well designed for a definite purpose in this case). It is, indeed, the vision of foolish Dr. Pangloss, so vividly satirized by Voltaire in Candide–the world is not necessarily good, but it is the best we could possibly have.

I always tried to live up to Leo Szilard's commandment, “don't lie if you don't have to.” I had to. I filled up pages with words and plans I knew I would not follow. When I go home from my laboratory in the late afternoon, I often do not know what I am going to do the next day. I expect to think that up during the night. How could I tell them what I would do a year hence?

I built the solenoid and with great expectations late one evening I pressed the switch which sent a current of 40 amperes through the coil. The result was spectacular—a deafening explosion, the apparatus disappeared, all windows were blown in or out, a wall caved in, and thus ended my pioneering experiment on liquid hydrogen cooled coils! [Recalling the result of his experiment, on 31 Mar 1930, to maximize the magnetic field by cooling the coils of an electromagnet in liquid hydrogen to reduce their resistance.]

I can see him [Sylvester] now, with his white beard and few locks of gray hair, his forehead wrinkled o’er with thoughts, writing rapidly his figures and formulae on the board, sometimes explaining as he wrote, while we, his listeners, caught the reflected sounds from the board. But stop, something is not right, he pauses, his hand goes to his forehead to help his thought, he goes over the work again, emphasizes the leading points, and finally discovers his difficulty. Perhaps it is some error in his figures, perhaps an oversight in the reasoning. Sometimes, however, the difficulty is not elucidated, and then there is not much to the rest of the lecture. But at the next lecture we would hear of some new discovery that was the outcome of that difficulty, and of some article for the Journal, which he had begun. If a text-book had been taken up at the beginning, with the intention of following it, that text-book was most likely doomed to oblivion for the rest of the term, or until the class had been made listeners to every new thought and principle that had sprung from the laboratory of his mind, in consequence of that first difficulty. Other difficulties would soon appear, so that no text-book could last more than half of the term. In this way his class listened to almost all of the work that subsequently appeared in the Journal. It seemed to be the quality of his mind that he must adhere to one subject. He would think about it, talk about it to his class, and finally write about it for the Journal. The merest accident might start him, but once started, every moment, every thought was given to it, and, as much as possible, he read what others had done in the same direction; but this last seemed to be his real point; he could not read without finding difficulties in the way of understanding the author. Thus, often his own work reproduced what had been done by others, and he did not find it out until too late.
A notable example of this is in his theory of cyclotomic functions, which he had reproduced in several foreign journals, only to find that he had been greatly anticipated by foreign authors. It was manifest, one of the critics said, that the learned professor had not read Rummer’s elementary results in the theory of ideal primes. Yet Professor Smith’s report on the theory of numbers, which contained a full synopsis of Kummer’s theory, was Professor Sylvester’s constant companion.
This weakness of Professor Sylvester, in not being able to read what others had done, is perhaps a concomitant of his peculiar genius. Other minds could pass over little difficulties and not be troubled by them, and so go on to a final understanding of the results of the author. But not so with him. A difficulty, however small, worried him, and he was sure to have difficulties until the subject had been worked over in his own way, to correspond with his own mode of thought. To read the work of others, meant therefore to him an almost independent development of it. Like the man whose pleasure in life is to pioneer the way for society into the forests, his rugged mind could derive satisfaction only in hewing out its own paths; and only when his efforts brought him into the uncleared fields of mathematics did he find his place in the Universe.

I do not see any reason to assume that the heuristic significance of the principle of general relativity is restricted to gravitation and that the rest of physics can be dealt with separately on the basis of special relativity, with the hope that later on the whole may be fitted consistently into a general relativistic scheme. I do not think that such an attitude, although historically understandable, can be objectively justified. The comparative smallness of what we know today as gravitational effects is not a conclusive reason for ignoring the principle of general relativity in theoretical investigations of a fundamental character. In other words, I do not believe that it is justifiable to ask: What would physics look like without gravitation?

I had begun it, it will now be unnecessary for me to finish it.[At a late age, expressing his enthusiasm for mathematics had gone, as when informed of some other mathematician's current work.]

I have been branded with folly and madness for attempting what the world calls impossibilities, and even from the great engineer, the late James Watt, who said ... that I deserved hanging for bringing into use the high-pressure engine. This has so far been my reward from the public; but should this be all, I shall be satisfied by the great secret pleasure and laudable pride that I feel in my own breast from having been the instrument of bringing forward new principles and new arrangements of boundless value to my country, and however much I may be straitened in pecuniary circumstances, the great honour of being a useful subject can never be taken from me, which far exceeds riches.

I have been so electrically occupied of late that I feel as if hungry for a little chemistry: but then the conviction crosses my mind that these things hang together under one law & that the more haste we make onwards each in his own path the sooner we shall arrive, and meet each other, at that state of knowledge of natural causes from which all varieties of effects may be understood & enjoyed.

I much condole with you on your late loss... pains and diseases of the mind are only cured by Forgetfulness;-—Reason but skins the wound, which is perpetually liable to fester again.

I remember discussions with Bohr which went through many hours till very late at night and ended almost in despair; and when at the end of the discussion I went alone for a walk in the neighboring park I repeated to myself again and again the question: Can nature possibly be as absurd as it seemed to us in these atomic experiments?

I used to say the evening that I developed the first x-ray photograph I took of insulin in 1935 was the most exciting moment of my life. But the Saturday afternoon in late July 1969, when we realized that the insulin electron density map was interpretable, runs that moment very close.

I, Galileo Galilei, son of the late Vincenzo Galilei, of Florence, aged seventy years, being brought personally to judgment, and kneeling before your Most Eminent and Most Reverend Lords Cardinals, General Inquisitors of the universal Christian republic against heretical depravity, having before my eyes the Holy Gospels, which I touch with my own hands, swear that I have always believed, and now believe, and with the help of God will in future believe, every article which the Holy Catholic and Apostolic Church of Rome holds, teaches, and preaches. But because I have been enjoined by this Holy Office altogether to abandon the false opinion which maintains that the sun is the centre and immovable, and forbidden to hold, defend, or teach the said false doctrine in any manner, and after it hath been signified to me that the said doctrine is repugnant with the Holy Scripture, I have written and printed a book, in which I treat of the same doctrine now condemned, and adduce reasons with great force in support of the same, without giving any solution, and therefore have been judged grievously suspected of heresy; that is to say, that I held and believed that the sun is the centre of the universe and is immovable, and that the earth is not the centre and is movable; willing, therefore, to remove from the minds of your Eminences, and of every Catholic Christian, this vehement suspicion rightfully entertained toward me, with a sincere heart and unfeigned faith, I abjure, curse, and detest the said errors and heresies, and generally every other error and sect contrary to Holy Church; and I swear that I will never more in future say or assert anything verbally, or in writing, which may give rise to a similar suspicion of me; but if I shall know any heretic, or anyone suspected of heresy, that I will denounce him to this Holy Office, or to the Inquisitor or Ordinary of the place where I may be; I swear, moreover, and promise, that I will fulfil and observe fully, all the penances which have been or shall be laid on me by this Holy Office. But if it shall happen that I violate any of my said promises, oaths, and protestations (which God avert!), I subject myself to all the pains and punishments which have been decreed and promulgated by the sacred canons, and other general and particular constitutions, against delinquents of this description. So may God help me, and his Holy Gospels which I touch with my own hands. I, the above-named Galileo Galilei, have abjured, sworn, promised, and bound myself as above, and in witness thereof with my own hand have subscribed this present writing of my abjuration, which I have recited word for word. At Rome, in the Convent of Minerva, June 22, 1633. I, Galileo Galilei, have abjured as above with my own hand.

In a certain sense I made a living for five or six years out of that one star [υ Sagittarii] and it is still a fascinating, not understood, star. It’s the first star in which you could clearly demonstrate an enormous difference in chemical composition from the sun. It had almost no hydrogen. It was made largely of helium, and had much too much nitrogen and neon. It’s still a mystery in many ways … But it was the first star ever analysed that had a different composition, and I started that area of spectroscopy in the late thirties.

In a world that is rightly so concerned about climate change and the atmosphere, to be so ignorant and neglectful of our oceans is deeply troubling. However, … having woken up to this living disaster and having realized that there are limits to how much abuse we can inflict, it’s not too late to turn things around.

In the twenties the late Dr. Glenn Frank, an eminent social scientist, developed a new statement of the scientific code, which has been referred to as the “Five Fingers of the Scientific Method.” It may be outlined as follows: find the facts; filter the facts; focus the facts; face the facts; follow the facts. The facts or truths are found by experimentation; the motivation is material. The facts are filtered by research into the literature; the motivation is material. The facts are focused by the publication of results; again the motivation is material. Thus the first three-fifths of the scientific method have a material motivation. It is about time scientists acknowledge that there is more to the scientific convention than the material aspect. Returning to the fourth and fifth fingers of Dr. Frank's conception of the scientific method, the facts should be faced by the proper interpretation of them for society. In other words, a scientist must assume social responsibility for his discoveries, which means that he must have a moral motivation. Finally, in the fifth definition of the scientific method, the facts are to be followed by their proper application to everyday life in society, which means moral motivation through responsibility to society.

In the Vienna of the late 1920s and 1930s there throve an internationally famous philosophical bunch called the logical positivists. … They said that a key ingredient of knowledge was “sense data,” and proclaimed emphatically, in the words of … J.S.L. Gilmour, that sense data are “objective and unalterable.” …Good guess, but no cigar!

In war, science has proven itself an evil genius; it has made war more terrible than it ever was before. Man used to be content to slaughter his fellowmen on a single plane—the earth’s surface. Science has taught him to go down into the water and shoot up from below and to go up into the clouds and shoot down from above, thus making the battlefield three times as bloody as it was before; but science does not teach brotherly love. Science has made war so hellish that civilization was about to commit suicide; and now we are told that newly discovered instruments of destruction will make the cruelties of the late war seem trivial in comparison with the cruelties of wars that may come in the future.

Investigating the conditions under which mutations occur … requires studies of mutation frequency under various methods of handling the organisms. As yet, extremely little has been done along this line. That is because, in the past, a mutation was considered a windfall, and the expression “mutation frequency” would have seemed a contradiction in terms. To attempt to study it would have seemed as absurd as to study the conditions affecting the distribution of dollar bills on the sidewalk. You were simply fortunate if you found one. … Of late, however, we may say that certain very exceptional banking houses have been found, in front of which the dollars fall more frequently—in other words, specially mutable genes have been discovered, that are beginning to yield abundant data at the hands of Nilsson-Ehle, Zeleny, Emerson, Anderson and others.

It is a misfortune for a science to be born too late when the means of observation have become too perfect. That is what is happening at this moment with respect to physical chemistry; the founders are hampered in their general grasp by third and fourth decimal places; happily they are men of robust faith.

It is curious to observe how differently these great men [Plato and Bacon] estimated the value of every kind of knowledge. Take Arithmetic for example. Plato, after speaking slightly of the convenience of being able to reckon and compute in the ordinary transactions of life, passes to what he considers as a far more important advantage. The study of the properties of numbers, he tells us, habituates the mind to the contemplation of pure truth, and raises us above the material universe. He would have his disciples apply themselves to this study, not that they may be able to buy or sell, not that they may qualify themselves to be shop-keepers or travelling merchants, but that they may learn to withdraw their minds from the ever-shifting spectacle of this visible and tangible world, and to fix them on the immutable essences of things.
Bacon, on the other hand, valued this branch of knowledge only on account of its uses with reference to that visible and tangible world which Plato so much despised. He speaks with scorn of the mystical arithmetic of the later Platonists, and laments the propensity of mankind to employ, on mere matters of curiosity, powers the whole exertion of which is required for purposes of solid advantage. He advises arithmeticians to leave these trifles, and employ themselves in framing convenient expressions which may be of use in physical researches.

It is never too late to be what you might have been.

It is notorious that the same discovery is frequently made simultaneously and quite independently, by different persons. Thus, to speak of only a few cases in late years, the discoveries of photography, of electric telegraphy, and of the planet Neptune through theoretical calculations, have all their rival claimants. It would seem, that discoveries are usually made when the time is ripe for them—that is to say, when the ideas from which they naturally flow are fermenting in the minds of many men.

It is rigid dogma that destroys truth; and, please notice, my emphasis is not on the dogma, but on the rigidity. When men say of any question, “This is all there is to be known or said of the subject; investigation ends here,” that is death. It may be that the mischief comes not from the thinker but for the use made of his thinking by late-comers. Aristotle, for example, gave us our scientific technique … yet his logical propositions, his instruction in sound reasoning which was bequeathed to Europe, are valid only within the limited framework of formal logic, and, as used in Europe, they stultified the minds of whole generations of mediaeval Schoolmen. Aristotle invented science, but destroyed philosophy.

It is said that the composing of the Lilavati was occasioned by the following circumstance. Lilavati was the name of the author’s daughter, concerning whom it appeared, from the qualities of the ascendant at her birth, that she was destined to pass her life unmarried, and to remain without children. The father ascertained a lucky hour for contracting her in marriage, that she might be firmly connected and have children. It is said that when that hour approached, he brought his daughter and his intended son near him. He left the hour cup on the vessel of water and kept in attendance a time-knowing astrologer, in order that when the cup should subside in the water, those two precious jewels should be united. But, as the intended arrangement was not according to destiny, it happened that the girl, from a curiosity natural to children, looked into the cup, to observe the water coming in at the hole, when by chance a pearl separated from her bridal dress, fell into the cup, and, rolling down to the hole, stopped the influx of water. So the astrologer waited in expectation of the promised hour. When the operation of the cup had thus been delayed beyond all moderate time, the father was in consternation, and examining, he found that a small pearl had stopped the course of the water, and that the long-expected hour was passed. In short, the father, thus disappointed, said to his unfortunate daughter, I will write a book of your name, which shall remain to the latest times—for a good name is a second life, and the ground-work of eternal existence.

It should be the function of medicine to have people die young as late as possible.

It’s a case of many oceans around the world being degraded by negligence. The ocean is the lifeblood of our world. If we were to lose our fish that we appreciate so much by overfishing; or if we were to lose some of our favorite beaches to overbuilding and pollution, then how would we feel? It’s become a case of not knowing what you’ve got until it’s gone. But by no means is it too late.

It’s never too late for a happy childhood.

Know then thyself, presume not God to scan;
The proper study of Mankind is Man.
Plac'd on this isthmus of a middle state,
A being darkly wise, and rudely great:
With too much knowledge for the Sceptic side,
With too much weakness for the Stoic's pride,
He hangs between; in doubt to act, or rest;
In doubt to deem himself a God, or Beast;
In doubt his Mind or Body to prefer,
Born but to die, and reas'ning but to err;
Alike in ignorance, his reason such,
Whether he thinks too little, or too much:
Chaos of Thought and Passion, all confus'd;
Still by himself abus'd, or disabus'd;
Created half to rise, and half to fall;
Great lord of all things, yet a prey to all;
Sole judge of Truth, in endless Error hurl'd:
The glory, jest, and riddle of the world!
... Superior beings, when of late they saw
A mortal Man unfold all Nature's law,
Admir'd such wisdom in an earthly shape,
And shew'd a NEWTON as we shew an Ape.

Late children, early orphans.

Later is usually too late.

Later, I realized that the mission had to end in a let-down because the real barrier wasn’t in the sky but in our knowledge and experience of supersonic flight.

Let us make education brave and preventive. Politics is an afterwork, a poor patching. We are always a little late… We shall one day learn to supercede politics by education… We must begin higher up, namely in Education.

Man is not only part of a field, but a part and member of his group. When people are together, as when they are at work, then the most unnatural behavior, which only appears in late stages or abnormal cases, would be to behave as separate Egos. Under normal circumstances they work in common, each a meaningfully functioning part of the whole.

Mankind will not remain on Earth forever, but in its quest for light and space will at first timidly penetrate beyond the confines of the atmosphere, and later will conquer for itself all the space near the Sun.

Most books, after all, are ephemeral; their specifics, several years later, inspire about as much interest as daily battle reports from the Hundred Years’ War.

Never regard study as a duty, but as the enviable opportunity to learn to know the liberating influence of beauty in the realm of the spirit for your own personal joy and to the profit of the community to which your later work belongs.

Next to the word 'Nature,' 'the Great Chain of Being' was the sacred phrase of the eighteenth century, playing a part somewhat analogous to that of the blessed word 'evolution' in the late nineteenth.

Now, it may be stretching an analogy to compare epidemics of cholera—caused by a known agent—with that epidemic of violent crime which is destroying our cities. It is unlikely that our social problems can be traced to a single, clearly defined cause in the sense that a bacterial disease is ‘caused’ by a microbe. But, I daresay, social science is about as advanced in the late twentieth century as bacteriological science was in the mid nineteenth century. Our forerunners knew something about cholera; they sensed that its spread was associated with misdirected sewage, filth, and the influx of alien poor into crowded, urban tenements. And we know something about street crime; nowhere has it been reported that a member of the New York Stock Exchange has robbed ... at the point of a gun. Indeed, I am naively confident that an enlightened social scientist of the next century will be able to point out that we had available to us at least some of the clues to the cause of urban crime.

Nowadays most people die of a sort of creeping common sense, and discover when it is too late that the only things one never regrets are one’s mistakes.

Ohm (a distinguished mathematician, be it noted) brought into order a host of puzzling facts connecting electromotive force and electric current in conductors, which all previous electricians had only succeeded in loosely binding together qualitatively under some rather vague statements. Even as late as 20 years ago, “quantity” and “tension” were much used by men who did not fully appreciate Ohm's law. (Is it not rather remarkable that some of Germany's best men of genius should have been, perhaps, unfairly treated? Ohm; Mayer; Reis; even von Helmholtz has mentioned the difficulty he had in getting recognised. But perhaps it is the same all the world over.)

One feature which will probably most impress the mathematician accustomed to the rapidity and directness secured by the generality of modern methods is the deliberation with which Archimedes approaches the solution of any one of his main problems. Yet this very characteristic, with its incidental effects, is calculated to excite the more admiration because the method suggests the tactics of some great strategist who foresees everything, eliminates everything not immediately conducive to the execution of his plan, masters every position in its order, and then suddenly (when the very elaboration of the scheme has almost obscured, in the mind of the spectator, its ultimate object) strikes the final blow. Thus we read in Archimedes proposition after proposition the bearing of which is not immediately obvious but which we find infallibly used later on; and we are led by such easy stages that the difficulties of the original problem, as presented at the outset, are scarcely appreciated. As Plutarch says: “It is not possible to find in geometry more difficult and troublesome questions, or more simple and lucid explanations.” But it is decidedly a rhetorical exaggeration when Plutarch goes on to say that we are deceived by the easiness of the successive steps into the belief that anyone could have discovered them for himself. On the contrary, the studied simplicity and the perfect finish of the treatises involve at the same time an element of mystery. Though each step depends on the preceding ones, we are left in the dark as to how they were suggested to Archimedes. There is, in fact, much truth in a remark by Wallis to the effect that he seems “as it were of set purpose to have covered up the traces of his investigation as if he had grudged posterity the secret of his method of inquiry while he wished to extort from them assent to his results.” Wallis adds with equal reason that not only Archimedes but nearly all the ancients so hid away from posterity their method of Analysis (though it is certain that they had one) that more modern mathematicians found it easier to invent a new Analysis than to seek out the old.

Our understanding of the causes of biological diversity is still crude. The science addressing it can be generously put at about the level of physics in the late nineteenth century.

Science is not about control. It is about cultivating a perpetual sense of wonder in the face of something that forever grows one step richer and subtler than our latest theory about it. It is about reverence, not mastery.

Science is really in the business of disproving current models or changing them to conform to new information. In essence, we are constantly proving our latest ideas wrong.

Sometimes I wonder whether there is any such thing as biology. The word was invented rather late—in 1809—and other words like botany, zoology, physiology, anatomy, have much longer histories and in general cover more coherent and unified subject matters. … I would like to see the words removed from dictionaries and college catalogues. I think they do more harm than good because they separate things that should not be separated…

Sooner or later in every talk, [David] Brower describes the creation of the world. He invites his listeners to consider the six days of Genesis as a figure of speech for what has in fact been 4 billion years. On this scale, one day equals something like six hundred and sixty-six million years, and thus, all day Monday and until Tuesday noon, creation was busy getting the world going. Life began Tuesday noon, and the beautiful organic wholeness of it developed over the next four days. At 4 p.m. Saturday, the big reptiles came on. At three minutes before midnight on the last day, man appeared. At one-fourth of a second before midnight Christ arrived. At one-fortieth of a second before midnight, the Industrial Revolution began. We are surrounded with people who think that what we have been doing for that one-fortieth of a second can go on indefinitely. They are considered normal, but they are stark. raving mad.

Speaking of libraries: A big open-stack academic or public library is no small pleasure to work in. You’re, say, trying to do a piece on something in Nevada, and you go down to C Floor, deep in the earth, and out to what a miner would call a remote working face. You find 10995.497S just where the card catalog and the online computer thought it would be, but that is only the initial nick. The book you knew about has led you to others you did not know about. To the ceiling the shelves are loaded with books about Nevada. You pull them down, one at a time, and sit on the floor and look them over until you are sitting on a pile five feet high, at which point you are late home for dinner and you get up and walk away. It’s an incomparable boon to research, all that; but it is also a reason why there are almost no large open-stack libraries left in the world.

Spending an evening on the World Wide Web is much like sitting down to a dinner of Cheetos, two hours later your fingers are yellow and you’re no longer hungry, but you haven’t been nourished.

Standing now in diffused light, with the wind at my back, I experience suddenly a feeling of completeness–not a feeling of having achieved something or of being stronger than everyone who was ever here before, not a feeling of having arrived at the ultimate point, not a feeling of supremacy. Just a breath of happiness deep inside my mind and my breast. The summit seemed suddenly to me to be a refuge, and I had not expected to find any refuge up here. Looking at the steep, sharp ridges below us, I have the impression that to have come later would have been too late. Everything we now say to one another, we only say out of embarrassment. I don’t think anymore. As I pull the tape recorder, trancelike, from my rucksack, and switch it on wanting to record a few appropriate phrases, tears again well into my eyes. “Now we are on the summit of Everest,” I begin, “it is so cold that we cannot take photographs…” I cannot go on, I am immediately shaken with sobs. I can neither talk nor think, feeling only how this momentous experience changes everything. To reach only a few meters below the summit would have required the same amount of effort, the same anxiety and burden of sorrow, but a feeling like this, an eruption of feeling, is only possible on the summit itself.

The argument of the ‘long view’ may be correct in some meaninglessly abstract sense, but it represents a fundamental mistake in categories and time scales. Our only legitimate long view extends to our children and our children’s children’s children–hundreds or a few thousands of years down the road. If we let the slaughter continue, they will share a bleak world with rats, dogs, cockroaches, pigeons, and mosquitoes. A potential recovery millions of years later has no meaning at our appropriate scale.

The Greeks in the first vigour of their pursuit of mathematical truth, at the time of Plato and soon after, had by no means confined themselves to those propositions which had a visible bearing on the phenomena of nature; but had followed out many beautiful trains of research concerning various kinds of figures, for the sake of their beauty alone; as for instance in their doctrine of Conic Sections, of which curves they had discovered all the principal properties. But it is curious to remark, that these investigations, thus pursued at first as mere matters of curiosity and intellectual gratification, were destined, two thousand years later, to play a very important part in establishing that system of celestial motions which succeeded the Platonic scheme of cycles and epicycles. If the properties of conic sections had not been demonstrated by the Greeks and thus rendered familiar to the mathematicians of succeeding ages, Kepler would probably not have been able to discover those laws respecting the orbits and motions of planets which were the occasion of the greatest revolution that ever happened in the history of science.

The history of aëronautic adventure affords a curious illustration of the same [dip of the horizon] principle. The late Mr. Sadler, the celebrated aeronaut, ascended on one occasion in a balloon from Dublin, and was wafted across the Irish Channel, when, on his approach to the Welsh coast, the balloon descended nearly to the surface of the sea. By this time the sun was set, and the shades of evening began to close in. He threw out nearly all his ballast, and suddenly sprang upwards to a great height, and by so doing brought his horizon to dip below the sun, producing the whole phenomenon of a western sunrise. Subsequently descending in Wales, he of course witnessed a second sunset on the same evening.

The landed classes neglected technical education, taking refuge in classical studies; as late as 1930, for example, long after Ernest Rutherford at Cambridge had discovered the atomic nucleus and begun transmuting elements, the physics laboratory at Oxford had not been wired for electricity. Intellectuals neglect technical education to this day.

The late Alan Gregg pointed out that human population growth within the ecosystem was closely analogous to the growth of malignant tumor cells within an organism: that man was acting like a cancer on the biosphere. The multiplication of human numbers certainly seems wild and uncontrolled… Four million a month—the equivalent of the population of Chicago… We seem to be doing all right at the moment; but if you could ask cancer cells, I suspect they would think they were doing fine. But when the organism dies, so do they; and for our own, selfish, practical, utilitarian reasons, I think we should be careful about how we influence the rest of the ecosystem.

The late James McNeil Whistler had a French poodle of which he was extravagantly fond. This poodle was seized with an affection of the throat, and Whistler had the audacity to send for the great throat specialist, Mackenzie. Sir Morell, when he saw that he had been called to treat a dog, didn't like it much, it was plain. But he said nothing. He prescribed, pocketed a big fee, and drove away.
The next day he sent posthaste for Whistler. And Whistler, thinking he was summoned on some matter connected with his beloved dog, dropped his work and rushed like the wind to Mackenzie's. On his arrival Sir Morell said, gravely: “How do you do, Mr. Whistler? I wanted to see you about having my front door painted.”

The late Mr. David Hume, in his posthumous works, places the powers of generation much above those of our boasted reason; and adds, that reason can only make a machine, as a clock or a ship, but the power of generation makes the maker of the machine; … he concludes, that the world itself might have been generated, rather than created; that is, it might have been gradually produced from very small beginnings, increasing by the activity of its inherent principles, rather than by a sudden evolution of the whole by the Almighty fiat.—What a magnificent idea of the infinite power of THE GREAT ARCHITECT! THE CAUSE OF CAUSES! PARENT OF PARENTS! ENS ENTIUM!
For if we may compare infinities, it would seem to require a greater infinity of power to cause the causes of effects, than to cause the effects themselves.

The latest refinements of science are linked with the cruelties of the Stone Age.

The manuscript looks chaotic, even by mathematics standards.
[About newly-found late work of Srinivasa Ramanujan.]

The moon is a very nice place. When we landed, we were 20 minutes behind. Because time on the Moon was so precious, what I remember most is trying to catch up.

The next care to be taken, in respect of the Senses, is a supplying of their infirmities with Instruments, and, as it were, the adding of artificial Organs to the natural; this in one of them has been of late years accomplisht with prodigious benefit to all sorts of useful knowledge, by the invention of Optical Glasses. By the means of Telescopes, there is nothing so far distant but may be represented to our view; and by the help of Microscopes, there is nothing so small, as to escape our inquiry; hence there is a new visible World discovered to the understanding. By this means the Heavens are open'd, and a vast number of new Stars, and new Motions, and new Productions appear in them, to which all the ancient Astronomers were utterly Strangers. By this the Earth it self, which lyes so neer us, under our feet, shews quite a new thing to us, and in every little particle of its matter, we now behold almost as great a variety of creatures as we were able before to reckon up on the whole Universe it self.

The number of travellers by gigs, the outside of coaches, and on horseback, have, since the introduction of railways, been prodigiously diminished; and as, in addition, the members of the medical faculty having lent their aid to run down the use of water-proof (apparently having found it decided enemy against their best friends colds and catarrhs), the use of the article [the Macintosh] in the form of cloaks, etc., has of late become comparatively extinct.

The opinion of Bacon on this subject [geometry] was diametrically opposed to that of the ancient philosophers. He valued geometry chiefly, if not solely, on account of those uses, which to Plato appeared so base. And it is remarkable that the longer Bacon lived the stronger this feeling became. When in 1605 he wrote the two books on the Advancement of Learning, he dwelt on the advantages which mankind derived from mixed mathematics; but he at the same time admitted that the beneficial effect produced by mathematical study on the intellect, though a collateral advantage, was “no less worthy than that which was principal and intended.” But it is evident that his views underwent a change. When near twenty years later, he published the De Augmentis, which is the Treatise on the Advancement of Learning, greatly expanded and carefully corrected, he made important alterations in the part which related to mathematics. He condemned with severity the pretensions of the mathematicians, “delidas et faslum mathematicorum.” Assuming the well-being of the human race to be the end of knowledge, he pronounced that mathematical science could claim no higher rank than that of an appendage or an auxiliary to other sciences. Mathematical science, he says, is the handmaid of natural philosophy; she ought to demean herself as such; and he declares that he cannot conceive by what ill chance it has happened that she presumes to claim precedence over her mistress.

The person most often late for a doctor's appointment is the doctor himself.

The power of man to do work—one man-power—is, in its purely physical sense, now an insignificant accomplishment, and could only again justify his existence if other sources of power failed. … Curious persons in cloisteral seclusion are experimenting with new sources of energy, which, if ever harnessed, would make coal and oil as useless as oars and sails. If they fail in their quest, or are too late, so that coal and oil, everywhere sought for, are no longer found, and the only hope of men lay in their time-honoured traps to catch the sunlight, who doubts that galley-slaves and helots would reappear in the world once more?

The reproaches against science for not having yet solved the problems of the universe are exaggerated in an unjust and malicious manner; it has truly not had time enough yet for these great achievements. Science is very young—a human activity which developed late.

The school of Plato has advanced the interests of the race as much through geometry as through philosophy. The modern engineer, the navigator, the astronomer, built on the truths which those early Greeks discovered in their purely speculative investigations. And if the poetry, statesmanship, oratory, and philosophy of our day owe much to Plato’s divine Dialogues, our commerce, our manufactures, and our science are equally indebted to his Conic Sections. Later instances may be abundantly quoted, to show that the labors of the mathematician have outlasted those of the statesman, and wrought mightier changes in the condition of the world. Not that we would rank the geometer above the patriot, but we claim that he is worthy of equal honor.

The scientific method cannot lead mankind because it is based upon experiment, and every experiment postpones the present moment until one knows the result. We always come to each other and even to ourselves too late so soon as we wish to know in advance what to do.

The transition from sea-floor spreading to plate tectonics is largely a change of emphasis. Sea-floor spreading is a view about the method of production of new oceans floor on the ridge axis. The magnetic lineations give the history of this production back into the late Mesozoic and illuminate the history of the new aseismic parts of the ocean floor. This naturally directed attention to the relation of the sea-floor to the continents. There are two approaches: in the first, one looks back in time to earlier arrangements of the continents; in the second, one considers the current problem of the disposal of the rapidly growing sea floor.

The truly awesome intellectuals in our history have not merely made discoveries; they have woven variegated, but firm, tapestries of comprehensive coverage. The tapestries have various fates: Most burn or unravel in the foot steps of time and the fires of later discovery. But their glory lies in their integrity as unified structures of great complexity and broad implication.

The world of mathematics and theoretical physics is hierarchical. That was my first exposure to it. There's a limit beyond which one cannot progress. The differences between the limiting abilities of those on successively higher steps of the pyramid are enormous. I have not seen described anywhere the shock a talented man experiences when he finds, late in his academic life, that there are others enormously more talented than he. I have personally seen more tears shed by grown men and women over this discovery than I would have believed possible. Most of those men and women shift to fields where they can compete on more equal terms

This is our fifth White House Science Fair. And every year, I walk out smarter than I walked in, because … these young scientists and engineers teach us something beyond the specific topics that they’re exploring. They teach us how to question assumptions; to wonder why something is the way it is, and how we can make it better. And they remind us that there’s always something more to learn, and to try, and to discover, and to imagine—and that it’s never too early, or too late to create or discover something new.

This is the question
Marry
Children—(if it Please God)—Constant companion (& friend in old age) who will feel interested in one—object to be beloved and played with—better than a dog anyhow. Home, & someone to take care of house—Charms of music and female chit-chat.—These things good for one’s health.—but terrible loss of time.—
My God, it is Intolerable to think of spending ones whole life, like a neuter bee, working, working—& nothing after all.—No, no, won’t do. Imagine living all one’s day solitary in smoky dirty London House.—Only picture to yourself a nice soft wife on a sofa with good fire, & books & music perhaps-—Compare this vision with the dingy reality of Grt. Marlbro’ Street.
Not Marry
Freedom to go where one liked—choice of Society and little of it. —Conversation of clever men at clubs—Not forced to visit relatives, & to bend in every trifle. —to have the expense and anxiety of children—perhaps quarreling—Loss of time. —cannot read in the Evenings—fatness & idleness—Anxiety & responsibility—less money for books &c—if many children forced to gain one’s bread. —(but then it is very bad for ones health to work too much)
Perhaps my wife won’t like London; then the sentence is banishment & degradation into indolent, idle fool.
Marry—Marry—Marry Q.E.D.
It being proved necessary to Marry When? Soon or late?

This leads us to ask for the reasons which call for this new theory of transmutation. The beginning of things must needs lie in obscurity, beyond the bounds of proof, though within those of conjecture or of analogical inference. Why not hold fast to the customary view, that all species were directly, instead of indirectly, created after their respective kinds, as we now behold them,--and that in a manner which, passing our comprehension, we intuitively refer to the supernatural? Why this continual striving after “the unattained and dim,”—these anxious endeavors, especially of late years, by naturalists and philosophers of various schools and different tendencies, to penetrate what one of them calls “the mystery of mysteries,” the origin of species? To this, in general, sufficient answer may be found in the activity of the human intellect, “the delirious yet divine desire to know,” stimulated as it has been by its own success in unveiling the laws and processes of inorganic Nature,—in the fact that the principal triumphs of our age in physical science have consisted in tracing connections where none were known before, in reducing heterogeneous phenomena to a common cause or origin, in a manner quite analogous to that of the reduction of supposed independently originated species to a common ultimate origin,—thus, and in various other ways, largely and legitimately extending the domain of secondary causes. Surely the scientific mind of an age which contemplates the solar system as evolved from a common, revolving, fluid mass,— which, through experimental research, has come to regard light, heat, electricity, magnetism, chemical affinity, and mechanical power as varieties or derivative and convertible forms of one force, instead of independent species,—which has brought the so-called elementary kinds of matter, such as the metals, into kindred groups, and raised the question, whether the members of each group may not be mere varieties of one species,—and which speculates steadily in the direction of the ultimate unity of matter, of a sort of prototype or simple element which may be to the ordinary species of matter what the protozoa or component cells of an organism are to the higher sorts of animals and plants,—the mind of such an age cannot be expected to let the old belief about species pass unquestioned.