...after my first feeling of revulsion had passed, I spent three of the most entertaining and instructive weeks of my life studying the fascinating molds which appeared one by one on the slowly disintegrating mass of horse-dung. Microscopic molds are both very beautiful and absorbingly interesting. The rapid growth of their spores, the way they live on each other, the manner in which the different forms come and go, is so amazing and varied that I believe a man could spend his life and not exhaust the forms or problems contained in one plate of manure.

...it would be a simple way of solving the goiter problem. And in addition to that it would be the biggest thing in a medical proposition to be carried out in the state of Michigan, and Michigan is a large place. And as I thought of the thing the more convinced I became that this oughtn't to be a personal thing, This ought to be something done by the Michigan State Medical Society as a body.
Recommending the addition of a trace of iodine to table salt.

...Outer space, once a region of spirited international competition, is also a region of international cooperation. I realized this as early as 1959, when I attended an international conference on cosmic radiation in Moscow. At this conference, there were many differing views and differing methods of attack, but the problems were common ones to all of us and a unity of basic purpose was everywhere evident. Many of the papers presented there depended in an essential way upon others which had appeared originally in as many as three or four different languages. Surely science is one of the universal human activities.

Les mathématiciens parviennent à la solution d’un problême par le simple arrangement des données, & en réduisant le raisonnement à des opérations si simples, à des jugemens si courts, qu’ils ne perdent jamais de vue l’évidence qui leur sert de guide.
Mathematicians come to the solution of a problem by the simple arrangement of the data, and reducing the reasoning to such simple operations, to judgments so brief, that they never lose sight of the evidence that serves as their guide.

Neumann, to a physicist seeking help with a difficult problem: Simple. This can be solved by using the method of characteristics.
Physicist: I'm afraid I don’t understand the method of characteristics.
Neumann: In mathematics you don't understand things. You just get used to them.

Quand les physiciens nous demandent la solution d'un problème, ce n'est pas une corvée qu'ils nous impsent, c'est nous au contraire qui leur doivent des remercîments.
When the physicists ask us for the solution of a problem, it is not drudgery that they impose on us, on the contrary, it is us who owe them thanks.

Quod est, Nullum non problema solvere.
There is no problem that cannot be solved.

Sir Robert Chiltern: You think science cannot grapple with the problem of women?
Mrs. Cheveley: Science can never grapple with the irrational. That is why it has no future before it in this world.

Une même expression, dont les géomètres avaient considéré les propriétés abstraites, … représente'aussi le mouvement de la lumière dans l’atmosphère, quelle détermine les lois de la diffusion de la chaleur dans la matière solide, et quelle entre dans toutes les questions principales de la théorie des probabilités.
The same expression whose abstract properties geometers had considered … represents as well the motion of light in the atmosphere, as it determines the laws of diffusion of heat in solid matter, and enters into all the chief problems of the theory of probability.

A central lesson of science is that to understand complex issues (or even simple ones), we must try to free our minds of dogma and to guarantee the freedom to publish, to contradict, and to experiment. Arguments from authority are unacceptable.

A chess problem is genuine mathematics, but it is in some way “trivial” mathematics. However, ingenious and intricate, however original and surprising the moves, there is something essential lacking. Chess problems are unimportant. The best mathematics is serious as well as beautiful—“important” if you like, but the word is very ambiguous, and “serious” expresses what I mean much better.

A clever person solves a problem. A wise person avoids it.

A designer must always think about the unfortunate production engineer who will have to manufacture what you have designed; try to understand his problems.

A good deal of my research in physics has consisted in not setting out to solve some particular problem, but simply examining mathematical quantities of a kind that physicists use and trying to fit them together in an interesting way, regardless of any application that the work may have. It is simply a search for pretty mathematics. It may turn out later to have an application. Then one has good luck. At age 78.

A good psychologist has to be able to distinguish strongly between problems of process, which are causal, and problems of structure, which are analytic and descriptive. In particular the statistics adequate for the latter are not sufficient for the former.

A great department of thought must have its own inner life, however transcendent may be the importance of its relations to the outside. No department of science, least of all one requiring so high a degree of mental concentration as Mathematics, can be developed entirely, or even mainly, with a view to applications outside its own range. The increased complexity and specialisation of all branches of knowledge makes it true in the present, however it may have been in former times, that important advances in such a department as Mathematics can be expected only from men who are interested in the subject for its own sake, and who, whilst keeping an open mind for suggestions from outside, allow their thought to range freely in those lines of advance which are indicated by the present state of their subject, untrammelled by any preoccupation as to applications to other departments of science. Even with a view to applications, if Mathematics is to be adequately equipped for the purpose of coping with the intricate problems which will be presented to it in the future by Physics, Chemistry and other branches of physical science, many of these problems probably of a character which we cannot at present forecast, it is essential that Mathematics should be allowed to develop freely on its own lines.

A great discovery solves a great problem, but there is a grain of discovery in the solution of any problem. Your problem may be modest, but if it challenges your curiosity and brings into play your inventive faculties, and if you solve it by your own means, you may experience the tension and enjoy the triumph of discovery.

A human being should be able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects.

A man is flying in a hot air balloon and realizes he is lost. He reduces height, spots a man down below and asks,“Excuse me, can you help me? I promised to return the balloon to its owner, but I don’t know where I am.”
The man below says: “You are in a hot air balloon, hovering approximately 350 feet above mean sea level and 30 feet above this field. You are between 40 and 42 degrees north latitude, and between 58 and 60 degrees west longitude.”
“You must be an engineer,” says the balloonist.
“I am,” replies the man.“How did you know?”
“Well,” says the balloonist, “everything you have told me is technically correct, but I have no idea what to make of your information, and the fact is I am still lost.”
The man below says, “You must be a manager.”
“I am,” replies the balloonist,“but how did you know?”
“Well,” says the engineer,“you don’t know where you are, or where you are going. You have made a promise which you have no idea how to keep, and you expect me to solve your problem.The fact is you are in the exact same position you were in before we met, but now it is somehow my fault.”

A mathematical problem should be difficult in order to entice us, yet not completely inaccessible, lest it mock at our efforts. It should be to us a guide post on the mazy paths to hidden truths, and ultimately a reminder of our pleasure in the successful solution.

A mathematician who can only generalise is like a monkey who can only climb UP a tree. ... And a mathematician who can only specialise is like a monkey who can only climb DOWN a tree. In fact neither the up monkey nor the down monkey is a viable creature. A real monkey must find food and escape his enemies and so must be able to incessantly climb up and down. A real mathematician must be able to generalise and specialise. ... There is, I think, a moral for the teacher. A teacher of traditional mathematics is in danger of becoming a down monkey, and a teacher of modern mathematics an up monkey. The down teacher dishing out one routine problem after another may never get off the ground, never attain any general idea. and the up teacher dishing out one definition after the other may never climb down from his verbiage, may never get down to solid ground, to something of tangible interest for his pupils.

A million years is a short time—the shortest worth messing with for most problems. You begin tuning your mind to a time scale that is the planet’s time scale. For me, it is almost unconscious now and is a kind of companionship with the earth.

A modern branch of mathematics, having achieved the art of dealing with the infinitely small, can now yield solutions in other more complex problems of motion, which used to appear insoluble. This modern branch of mathematics, unknown to the ancients, when dealing with problems of motion, admits the conception of the infinitely small, and so conforms to the chief condition of motion (absolute continuity) and thereby corrects the inevitable error which the human mind cannot avoid when dealing with separate elements of motion instead of examining continuous motion. In seeking the laws of historical movement just the same thing happens. The movement of humanity, arising as it does from innumerable human wills, is continuous. To understand the laws of this continuous movement is the aim of history. … Only by taking an infinitesimally small unit for observation (the differential of history, that is, the individual tendencies of man) and attaining to the art of integrating them (that is, finding the sum of these infinitesimals) can we hope to arrive at the laws of history.

A multidisciplinary study group ... estimated that it would be 1980 before developments in artificial intelligence make it possible for machines alone to do much thinking or problem solving of military significance. That would leave, say, five years to develop man-computer symbiosis and 15 years to use it. The 15 may be 10 or 500, but those years should be intellectually the most creative and exciting in the history of mankind.

A principle of induction would be a statement with the help of which we could put inductive inferences into a logically acceptable form. In the eyes of the upholders of inductive logic, a principle of induction is of supreme importance for scientific method: “... this principle”, says Reichenbach, “determines the truth of scientific theories. To eliminate it from science would mean nothing less than to deprive science of the power to decide the truth or falsity of its theories. Without it, clearly, science would no longer have the right to distinguish its theories from the fanciful and arbitrary creations of the poet’s mind.” Now this principle of induction cannot be a purely logical truth like a tautology or an analytic statement. Indeed, if there were such a thing as a purely logical principle of induction, there would be no problem of induction; for in this case, all inductive inferences would have to be regarded as purely logical or tautological transformations, just like inferences in inductive logic. Thus the principle of induction must be a synthetic statement; that is, a statement whose negation is not self-contradictory but logically possible. So the question arises why such a principle should be accepted at all, and how we can justify its acceptance on rational grounds.

A problem is a chance for you to do your best.

A problem is really a springboard for a leap into the unknown.

A problem well stated is a problem half-solved.

A research problem is not solved by apparatus; it is solved in a man's head.

A scientist works largely by intuition. Given enough experience, a scientist examining a problem can leap to an intuition as to what the solution ‘should look like.’ ... Science is ultimately based on insight, not logic.

A strong feeling of adventure is animating those who are working on bacterial viruses, a feeling that they have a small part in the great drive towards a fundamental problem in biology.

A teacher of mathematics has a great opportunity. If he fills his allotted time with drilling his students in routine operations he kills their interest, hampers their intellectual development, and misuses his opportunity. But if he challenges the curiosity of his students by setting them problems proportionate to their knowledge, and helps them to solve their problems with stimulating questions, he may give them a taste for, and some means of, independent thinking.

A troubling question for those of us committed to the widest application of intelligence in the study and solution of the problems of men is whether a general understanding of the social sciences will be possible much longer. Many significant areas of these disciplines have already been removed by the advances of the past two decades beyond the reach of anyone who does not know mathematics; and the man of letters is increasingly finding, to his dismay, that the study of mankind proper is passing from his hands to those of technicians and specialists. The aesthetic effect is admittedly bad: we have given up the belletristic “essay on man” for the barbarisms of a technical vocabulary, or at best the forbidding elegance of mathematical syntax.

A wonderful exhilaration comes from holding in the mind the deepest questions we can ask. Such questions animate all scientists. Many students of science were first attracted to the field as children by popular accounts of important unsolved problems. They have been waiting ever since to begin working on a mystery. [With co-author Arthur Zajonc]

Accordingly, we find Euler and D'Alembert devoting their talent and their patience to the establishment of the laws of rotation of the solid bodies. Lagrange has incorporated his own analysis of the problem with his general treatment of mechanics, and since his time M. Poinsôt has brought the subject under the power of a more searching analysis than that of the calculus, in which ideas take the place of symbols, and intelligent propositions supersede equations.

After Gibbs, one the most distinguished [American scientists] was Langley, of the Smithsonian. … He had the physicist’s heinous fault of professing to know nothing between flashes of intense perception. … Rigidly denying himself the amusement of philosophy, which consists chiefly in suggesting unintelligible answers to insoluble problems, and liked to wander past them in a courteous temper, even bowing to them distantly as though recognizing their existence, while doubting their respectability.

After I had addressed myself to this very difficult and almost insoluble problem, the suggestion at length came to me how it could be solved with fewer and much simpler constructions than were formerly used, if some assumptions (which are called axioms) were granted me. They follow in this order.
There is no one center of all the celestial circles or spheres.
The center of the earth is not the center of the universe, but only of gravity and of the lunar sphere.
All the spheres revolve about the sun as their mid-point, and therefore the sun is the center of the universe.
The ratio of the earth's distance from the sun to the height of the firmament is so much smaller than the ratio of the earth's radius to its distance from the sun that the distance from the earth to the sun is imperceptible in comparison with the height of the firmament.
Whatever motion appears in the firmament arises not from any motion of the firmament, but from the earth's motion. The earth together with its circumjacent elements performs a complete rotation on its fixed poles in a daily motion, while the firmament and highest heaven abide unchanged.
What appears to us as motions of the sun arise not from its motion but from the motion of the earth and our sphere, with which we revolve about the sun like any other planet. The earth has, then, more than one motion.
The apparent retrograde and direct motion of the planets arises not from their motion but from the earth's. The motion of the earth alone, therefore, suffices to explain so many apparent inequalities in the heavens.

After the discovery of spectral analysis no one trained in physics could doubt the problem of the atom would be solved when physicists had learned to understand the language of spectra. So manifold was the enormous amount of material that has been accumulated in sixty years of spectroscopic research that it seemed at first beyond the possibility of disentanglement. An almost greater enlightenment has resulted from the seven years of Röntgen spectroscopy, inasmuch as it has attacked the problem of the atom at its very root, and illuminates the interior. What we are nowadays hearing of the language of spectra is a true 'music of the spheres' in order and harmony that becomes ever more perfect in spite of the manifold variety. The theory of spectral lines will bear the name of Bohr for all time. But yet another name will be permanently associated with it, that of Planck. All integral laws of spectral lines and of atomic theory spring originally from the quantum theory. It is the mysterious organon on which Nature plays her music of the spectra, and according to the rhythm of which she regulates the structure of the atoms and nuclei.

All anybody has to say to Edward [Teller] is, ‘We’ve got a problem here, we need you,’ and— zip! he’s into it. It’s helpfulness, plus maybe vanity, but mostly just curiosity.

All interpretations made by a scientist are hypotheses, and all hypotheses are tentative. They must forever be tested and they must be revised if found to be unsatisfactory. Hence, a change of mind in a scientist, and particularly in a great scientist, is not only not a sign of weakness but rather evidence for continuing attention to the respective problem and an ability to test the hypothesis again and again.

All Nature bristles with the marks of interrogation—among the grass and the petals of flowers, amidst the feathers of birds and the hairs of mammals, on mountain and moorland, in sea and sky-everywhere. It is one of the joys of life to discover those marks of interrogation, these unsolved and half-solved problems and try to answer their questions.

All of modern physics is governed by that magnificent and thoroughly confusing discipline called quantum mechanics ... It has survived all tests and there is no reason to believe that there is any flaw in it.... We all know how to use it and how to apply it to problems; and so we have learned to live with the fact that nobody can understand it.

All problems are finally scientific problems.

All stable processes we shall predict. All unstable processes we shall control.
Describing John von Neumann's aspiration for the application of computers sufficiently large to solve the problems of meteorology, despite the sensitivity of the weather to small perturbations.

All that can be said upon the number and nature of elements is, in my opinion, confined to discussions entirely of a metaphysical nature. The subject only furnishes us with indefinite problems, which may be solved in a thousand different ways, not one of which, in all probability, is consistent with nature. I shall therefore only add upon this subject, that if, by the term elements, we mean to express those simple and indivisible atoms of which matter is composed, it is extremely probable we know nothing at all about them; but, if we apply the term elements, or principles of bodies, to express our idea of the last point which analysis is capable of reaching, we must admit, as elements, all the substances into which we are capable, by any means, to reduce bodies by decomposition.

All the events which occur upon the earth result from Law: even those actions which are entirely dependent on the caprices of the memory, or the impulse of the passions, are shown by statistics to be, when taken in the gross, entirely independent of the human will. As a single atom, man is an enigma; as a whole, he is a mathematical problem. As an individual, he is a free agent; as a species, the offspring of necessity.

All the mathematical sciences are founded on relations between physical laws and laws of numbers, so that the aim of exact science is to reduce the problems of nature to the determination of quantities by operations with numbers.

All the more recent work on alkaptonuria has... strengthened the belief that the homogentisic acid excreted is derived from tyrosin, but why alkaptonuric individuals pass the benzene ring of their tyrosin unbroken and how and where the peculiar chemical change from tyrosin to homogentisic acid is brought about, remain unsolved problems.

Almost every major systematic error which has deluded men for thousands of years relied on practical experience. Horoscopes, incantations, oracles, magic, witchcraft, the cures of witch doctors and of medical practitioners before the advent of modern medicine, were all firmly established through the centuries in the eyes of the public by their supposed practical successes. The scientific method was devised precisely for the purpose of elucidating the nature of things under more carefully controlled conditions and by more rigorous criteria than are present in the situations created by practical problems.

Almost everyone... seems to be quite sure that the differences between the methodologies of history and of the natural sciences are vast. For, we are assured, it is well known that in the natural sciences we start from observation and proceed by induction to theory. And is it not obvious that in history we proceed very differently? Yes, I agree that we proceed very differently. But we do so in the natural sciences as well.
In both we start from myths—from traditional prejudices, beset with error—and from these we proceed by criticism: by the critical elimination of errors. In both the role of evidence is, in the main, to correct our mistakes, our prejudices, our tentative theories—that is, to play a part in the critical discussion, in the elimination of error. By correcting our mistakes, we raise new problems. And in order to solve these problems, we invent conjectures, that is, tentative theories, which we submit to critical discussion, directed towards the elimination of error.

Altering a gene in the gene line to produce improved offspring is likely to be very difficult because of the danger of unwanted side effects. It would also raise obvious ethical problems.

Although I must say that research problems I worked on were frequently the result of serendipity and often grew out of my interest in some species or some environment which I found to be particularly appealing—marine birds and tropical islands for example.

Although Rick [Richard Smalley] made enormous contributions to science, I believe his worldwide contributions in making so many of us aware of the huge energy problem is even greater and longer-lasting than the beautiful science that he discovered.

Although the cooking of food presents some unsolved problems, the quick warming of cooked food and the thawing of frozen food both open up some attractive uses. ... There is no important reason why the the housewife of the future should not purchase completely frozen meals at the grocery store just as she buys quick frozen vegetables. With a quick heating, high-frequency unit in her kitchen, food preparation from a pre-cooked, frozen meal becomes a simple matter.
[Predicting home kitchen appliances could be developed from the radionic tube employed to jam enemy radar in World War II.]

Among the current discussions, the impact of new and sophisticated methods in the study of the past occupies an important place. The new 'scientific' or 'cliometric' history—born of the marriage contracted between historical problems and advanced statistical analysis, with economic theory as bridesmaid and the computer as best man—has made tremendous advances in the last generation.

An expert problem solver must be endowed with two incompatible qualities, a restless imagination and a patient pertinacity.

An undefined problem has an infinite number of solutions.

Any problem can be solved using the materials in the room.

Any scientist of any age who wants to make important discoveries must study important problems. Dull or piffling problems yield dull or piffling answers. It is not not enough that a problem should be “interesting.” … The problem must be such that it matters what the answer is—whether to science generally or to mankind.

Apart from its healthful mental training as a branch of ordinary education, geology as an open-air pursuit affords an admirable training in habits of observation, furnishes a delightful relief from the cares and routine of everyday life, takes us into the open fields and the free fresh face of nature, leads us into all manner of sequestered nooks, whither hardly any other occupation or interest would be likely to send us, sets before us problems of the highest interest regarding the history of the ground beneath our feet, and thus gives a new charm to scenery which may be already replete with attractions.

Archimedes … had stated that given the force, any given weight might be moved, and even boasted, we are told, relying on the strength of demonstration, that if there were another earth, by going into it he could remove this. Hiero being struck with amazement at this, and entreating him to make good this problem by actual experiment, and show some great weight moved by a small engine, he fixed accordingly upon a ship of burden out of the king’s arsenal, which could not be drawn out of the dock without great labor and many men; and, loading her with many passengers and a full freight, sitting himself the while far off with no great endeavor, but only holding the head of the pulley in his hand and drawing the cords by degrees, he drew the ship in a straight line, as smoothly and evenly, as if she had been in the sea. The king, astonished at this, and convinced of the power of the art, prevailed upon Archimedes to make him engines accommodated to all the purposes, offensive and defensive, of a siege. … the apparatus was, in most opportune time, ready at hand for the Syracusans, and with it also the engineer himself.

As I look back over my efforts, I would characterize my contributions as being largely in the realm of model building. ... I perceive myself as rather uninhibited, with a certain mathematical facility and more interest in the broad aspect of a problem than the delicate nuances. I am more interested in discovering what is over the next rise than in assiduously cultivating the beautiful garden close at hand.

As long as a branch of science offers an abundance of problems, so long it is alive; a lack of problems foreshadows extinction or the cessation of independent development.

As long as museums and universities send out expeditions to bring to light new forms of living and extinct animals and new data illustrating the interrelations of organisms and their environments, as long as anatomists desire a broad comparative basis human for anatomy, as long as even a few students feel a strong curiosity to learn about the course of evolution and relationships of animals, the old problems of taxonomy, phylogeny and evolution will gradually reassert themselves even in competition with brilliant and highly fruitful laboratory studies in cytology, genetics and physiological chemistry.

As soon as we got rid of the backroom attitude and brought our apparatus fully into the Department with an inexhaustible supply of living patients with fascinating clinical problems, we were able to get ahead really fast. Any new technique becomes more attractive if its clinical usefulness can be demonstrated without harm, indignity or discomfort to the patient... Anyone who is satisfied with his diagnostic ability and with his surgical results is unlikely to contribute much to the launching of a new medical science. He should first be consumed with a divine discontent with things as they are. It greatly helps, of course, to have the right idea at the right time, and quite good ideas may come, Archimedes fashion, in one's bath..

As soon as we touch the complex processes that go on in a living thing, be it plant or animal, we are at once forced to use the methods of this science [chemistry]. No longer will the microscope, the kymograph, the scalpel avail for the complete solution of the problem. For the further analysis of these phenomena which are in flux and flow, the investigator must associate himself with those who have labored in fields where molecules and atoms, rather than multicellular tissues or even unicellular organisms, are the units of study.

As the sun eclipses the stars by his brilliancy, so the man of knowledge will eclipse the fame of others in assemblies of the people if he proposes algebraic problems, and still more if he solves them.

As the world of science has grown in size and in power, its deepest problems have changed from the epistemological to the social.

As was predicted at the beginning of the Human Genome Project, getting the sequence will be the easy part as only technical issues are involved. The hard part will be finding out what it means, because this poses intellectual problems of how to understand the participation of the genes in the functions of living cells.

At a given instant everything the surgeon knows suddenly becomes important to the solution of the problem. You can't do it an hour later, or tomorrow. Nor can you go to the library and look it up.

At night I would return home, set out a lamp before me, and devote myself to reading and writing. Whenever sleep overcame me or I became conscious of weakening, I would turn aside to drink a cup of wine, so that my strength would return to me. Then I would return to reading. And whenever sleep seized me I would see those very problems in my dream; and many questions became clear to me in my sleep. I continued in this until all of the sciences were deeply rooted within me and I understood them as is humanly possible. Everything which I knew at the time is just as I know it now; I have not added anything to it to this day. Thus I mastered the logical, natural, and mathematical sciences, and I had now reached the science.

At the present time there exist problems beyond our ability to solve, not because of theoretical difficulties, but because of insufficient means of mechanical computation.

Atoms for peace. Man is still the greatest miracle and the greatest problem on earth. [Message tapped out by Sarnoff using a telegraph key in a tabletop circuit demonstrating an RCA atomic battery as a power source.]

Behold the mighty dinosaur,
Famous in prehistoric lore,
Not only for his power and strength
But for his intellectual length.
You will observe by these remains
The creature had two sets of brains—
One in his head (the usual place),
The other at his spinal base.
Thus he could reason 'A priori'
As well as 'A posteriori'.
No problem bothered him a bit
He made both head and tail of it.
So wise was he, so wise and solemn,
Each thought filled just a spinal column.
If one brain found the pressure strong
It passed a few ideas along.
If something slipped his forward mind
'Twas rescued by the one behind.
And if in error he was caught
He had a saving afterthought.
As he thought twice before he spoke
He had no judgment to revoke.
Thus he could think without congestion
Upon both sides of every question.
Oh, gaze upon this model beast
Defunct ten million years at least.

Beware of the problem of testing too many hypotheses; the more you torture the data, the more likely they are to confess, but confessions obtained under duress may not be admissible in the court of scientific opinion.

Biology occupies a position among the sciences both marginal and central. Marginal because, the living world, constituting only a tiny and very “special” part of the universe, it does not seem likely that the study of living beings will ever uncover general laws applicable outside the biosphere. But if the ultimate aim of the whole of science is indeed, as I believe, to clarify man's relationship to the universe, then biology must be accorded a central position, since of all the disciplines it is the one that endeavours to go most directly to the heart of the problems that must be resolved before that of “human nature” can even be framed in other than metaphysical terms.

But in its [the corpuscular theory of radiation] relation to the wave theory there is one extraordinary and, at present, insoluble problem. It is not known how the energy of the electron in the X-ray bulb is transferred by a wave motion to an electron in the photographic plate or in any other substance on which the X-rays fall. It is as if one dropped a plank into the sea from the height of 100 ft. and found that the spreading ripple was able, after travelling 1000 miles and becoming infinitesimal in comparison with its original amount, to act upon a wooden ship in such a way that a plank of that ship flew out of its place to a height of 100 ft. How does the energy get from one place to the other?

By relieving the brain of all unnecessary work, a good notation sets it free to concentrate on more advanced problems, and in effect increases the mental power of the race.

Can any thoughtful person admit for a moment that, in a society so constituted that these overwhelming contrasts of luxury and privation are looked upon as necessities, and are treated by the Legislature as matters with which it has practically nothing do, there is the smallest probability that we can deal successfully with such tremendous social problems as those which involve the marriage tie and the family relation as a means of promoting the physical and moral advancement of the race? What a mockery to still further whiten the sepulchre of society, in which is hidden ‘all manner of corruption,’ with schemes for the moral and physical advancement of the race!

Cancer is a biological, not a statistical problem.

Cell and tissue, shell and bone, leaf and flower, are so many portions of matter, and it is in obedience to the laws of physics that their particles have been moved, moulded and confirmed. They are no exception to the rule that God always geometrizes. Their problems of form are in the first instance mathematical problems, their problems of growth are essentially physical problems, and the morphologist is, ipso facto, a student of physical science.

Change requires experimentation. But no problem can be solved by the same consciousness that created it. Our job is to dream—and to make those dreams happen.

Charles Kettering ... said that from studying conventional text-books we fall into a rut and to escape from this takes as much effort as to solve the problem.

Chess problems are the hymn-tunes of mathematics.

Child psychology and animal psychology are of relatively slight importance, as compared with the sciences which deal with the corresponding physiological problems of ontogeny and phylogeny.

Clarity about the aims and problems of socialism is of greatest significance in our age of transition. Since, under present circumstances, free and unhindered discussion of these problems has come under a powerful taboo, I consider the foundation of this magazine to be an important public service.

Clean water is a great example of something that depends on energy. And if you solve the water problem, you solve the food problem.

Committees are dangerous things that need most careful watching. I believe that a research committee can do one useful thing and one only. It can find the workers best fitted to attack a particular problem, bring them together, give them the facilities they need, and leave them to get on with the work. It can review progress from time to time, and make adjustments; but if it tries to do more, it will do harm.

Consciously and systematically Klein sought to enthrall me with the problems of mathematical physics, and to win me over to his conception of these problems as developed it in lecture courses in previous years. I have always regarded Klein as my real teacher only in things mathematical, but also in mathematical physics and in my conception of mechanics.

Consider a cow. A cow doesn’t have the problem-solving skill of a chimpanzee, which has discovered how to get termites out of the ground by putting a stick into a hole. Evolution has developed the brain’s ability to solve puzzles, and at the same time has produced in our brain a pleasure of solving problems.

Crowds are somewhat like the sphinx of ancient fable: It is necessary to arrive at a solution of the problems offered by their psychology or to resign ourselves to being devoured by them.

Dad [Walter C. Alvarez] … advised me to sit every few months in my reading chair for an entire evening, close my eyes and try to think of new problems to solve. I took his advice very seriously and have been glad ever since that he did.

Dad, how do soldiers killing each other solve the world’s problems?

Daniel Bernoulli used to tell two little adventures, which he said had given him more pleasure than all the other honours he had received. Travelling with a learned stranger, who, being pleased with his conversation, asked his name; “I am Daniel Bernoulli,” answered he with great modesty; “and I,” said the stranger (who thought he meant to laugh at him) “am Isaac Newton.” Another time, having to dine with the celebrated Koenig, the mathematician, who boasted, with some degree of self-complacency, of a difficult problem he had solved with much trouble, Bernoulli went on doing the honours of his table, and when they went to drink coffee he presented Koenig with a solution of the problem more elegant than his own.

Despite the recurrence of events in which the debris-basin system fails in its struggle to contain the falling mountains, people who live on the front line are for the most part calm and complacent. It appears that no amount of front-page or prime-time attention will ever prevent such people from masking out the problem.

Do not worry about your problems in mathematics. I assure you, my problems with mathematics are much greater than yours.

Does it mean, if you don’t understand something, and the community of physicists don’t understand it, that means God did it? Is that how you want to play this game? Because if it is, here’s a list of the things in the past that the physicists—at the time—didn’t understand … [but now we do understand.] If that’s how you want to invoke your evidence for God, then God is an ever-receding pocket of scientific ignorance, that’s getting smaller and smaller and smaller, as time moves on. So just be ready for that to happen, if that’s how you want to come at the problem. That’s simply the “God of the Gaps” argument that’s been around for ever.

During a conversation with the writer in the last weeks of his life, Sylvester remarked as curious that notwithstanding he had always considered the bent of his mind to be rather analytical than geometrical, he found in nearly every case that the solution of an analytical problem turned upon some quite simple geometrical notion, and that he was never satisfied until he could present the argument in geometrical language.

During the half-century that has elapsed since the enunciation of the cell-theory by Schleiden and Schwann, in 1838-39, it has became ever more clearly apparent that the key to all ultimate biological problems must, in the last analysis, be sought in the cell. It was the cell-theory that first brought the structure of plants and animals under one point of view by revealing their common plan of organization. It was through the cell-theory that Kolliker and Remak opened the way to an understanding of the nature of embryological development, and the law of genetic continuity lying at the basis of inheritance. It was the cell-­theory again which, in the hands of Virchaw and Max Schultze, inaugurated a new era in the history of physiology and pathology, by showing that all the various functions of the body, in health and in disease, are but the outward expression of cell­-activities. And at a still later day it was through the cell-theory that Hertwig, Fol, Van Beneden, and Strasburger solved the long-standing riddle of the fertilization of the egg, and the mechanism of hereditary transmission. No other biological generalization, save only the theory of organic evolution, has brought so many apparently diverse phenomena under a common point of view or has accomplished more far the unification of knowledge. The cell-theory must therefore be placed beside the evolution-theory as one of the foundation stones of modern biology.

During the time that [Karl] Landsteiner gave me an education in the field of imununology, I discovered that he and I were thinking about the serologic problem in very different ways. He would ask, What do these experiments force us to believe about the nature of the world? I would ask, What is the most. simple and general picture of the world that we can formulate that is not ruled by these experiments? I realized that medical and biological investigators were not attacking their problems the same way that theoretical physicists do, the way I had been in the habit of doing.

Dust consisting of fine fibers of asbestos, which are insoluble and virtually indestructible, may become a public health problem in the near future. At a recent international conference on the biological effects of asbestos sponsored by the New York Academy of Sciences, participants pointed out on the one hand that workers exposed to asbestos dust are prone in later life to develop lung cancer, and on the other hand that the use of this family of fibrous silicate compounds has expanded enormously during the past few decades. A laboratory curiosity 100 years ago, asbestos today is a major component of building materials.

Each new scientific development is due to the pressure of some social need. Of course … insatiable curiosity … is still nothing but a response either to an old problem of nature, or to one arising from new social circumstances.

Each problem that I solved became a rule which served afterwards to solve other problems.

Each species has evolved a special set of solutions to the general problems that all organisms must face. By the fact of its existence, a species demonstrates that its members are able to carry out adequately a series of general functions. … These general functions offer a framework within which one can integrate one’s view of biology and focus one’s research. Such a view helps one to avoid becoming lost in a morass of unstructured detail—even though the ways in which different species perform these functions may differ widely. A few obvious examples will suffice. Organisms must remain functionally integrated. They must obtain materials from their environments, and process and release energy from these materials. … They must differentiate and grow, and they must reproduce. By focusing one’s questions on one or another of these obligatory and universal capacities, one can ensure that one’s research will not be trivial and that it will have some chance of achieving broad general applicability.

Early in my school career, I turned out to be an incorrigible disciplinary problem. I could understand what the teacher was saying as fast as she could say it, I found time hanging heavy, so I would occasionally talk to my neighbor. That was my great crime, I talked in school.

Education has, thus, become the chief problem of the world, its one holy cause. The nations that see this will survive, and those that fail to do so will slowly perish. There must be re-education of the will and of the heart as well as of the intellect, and the ideals of service must supplant those of selfishness and greed. ... Never so much as now is education the one and chief hope of the world.

Electronic calculators can solve problems which the man who made them cannot solve but no government-subsidized commission of engineers and physicists could create a worm.

Engineering is not merely knowing and being knowledgeable, like a walking encyclopedia; engineering is not merely analysis; engineering is not merely the possession of the capacity to get elegant solutions to non-existent engineering problems; engineering is practicing the art of the organizing forces of technological change ... Engineers operate at the interface between science and society.

Engineering is quite different from science. Scientists try to understand nature. Engineers try to make things that do not exist in nature. Engineers stress invention. To embody an invention the engineer must put his idea in concrete terms, and design something that people can use. That something can be a device, a gadget, a material, a method, a computing program, an innovative experiment, a new solution to a problem, or an improvement on what is existing. Since a design has to be concrete, it must have its geometry, dimensions, and characteristic numbers. Almost all engineers working on new designs find that they do not have all the needed information. Most often, they are limited by insufficient scientific knowledge. Thus they study mathematics, physics, chemistry, biology and mechanics. Often they have to add to the sciences relevant to their profession. Thus engineering sciences are born.

Engineering is the conscious application of science to the problems of economic production.

Engineers apply the theories and principles of science and mathematics to research and develop economical solutions to practical technical problems. Their work is the link between scientific discoveries and commercial applications. Engineers design products, the machinery to build those products, the factories in which those products are made, and the systems that ensure the quality of the product and efficiency of the workforce and manufacturing process. They design, plan, and supervise the construction of buildings, highways, and transit systems. They develop and implement improved ways to extract, process, and use raw materials, such as petroleum and natural gas. They develop new materials that both improve the performance of products, and make implementing advances in technology possible. They harness the power of the sun, the earth, atoms, and electricity for use in supplying the Nation’s power needs, and create millions of products using power. Their knowledge is applied to improving many things, including the quality of health care, the safety of food products, and the efficient operation of financial systems.

Enlist a great mathematician and a distinguished Grecian; your problem will be solved. Such men can teach in a dwelling-house as well as in a palace. Part of the apparatus they will bring; part we will furnish.

Equations are Expressions of Arithmetical Computation, and properly have no place in Geometry, except as far as Quantities truly Geometrical (that is, Lines, Surfaces, Solids, and Proportions) may be said to be some equal to others. Multiplications, Divisions, and such sort of Computations, are newly received into Geometry, and that unwarily, and contrary to the first Design of this Science. For whosoever considers the Construction of a Problem by a right Line and a Circle, found out by the first Geometricians, will easily perceive that Geometry was invented that we might expeditiously avoid, by drawing Lines, the Tediousness of Computation. Therefore these two Sciences ought not to be confounded. The Ancients did so industriously distinguish them from one another, that they never introduced Arithmetical Terms into Geometry. And the Moderns, by confounding both, have lost the Simplicity in which all the Elegance of Geometry consists. Wherefore that is Arithmetically more simple which is determined by the more simple Equation, but that is Geometrically more simple which is determined by the more simple drawing of Lines; and in Geometry, that ought to be reckoned best which is geometrically most simple.

Even fairly good students, when they have obtained the solution of the problem and written down neatly the argument, shut their books and look for something else. Doing so, they miss an important and instructive phase of the work. ... A good teacher should understand and impress on his students the view that no problem whatever is completely exhausted.

Even mistaken hypotheses and theories are of use in leading to discoveries. This remark is true in all the sciences. The alchemists founded chemistry by pursuing chimerical problems and theories which are false. In physical science, which is more advanced than biology, we might still cite men of science who make great discoveries by relying on false theories. It seems, indeed, a necessary weakness of our mind to be able to reach truth only across a multitude of errors and obstacles.

Every new theory as it arises believes in the flush of youth that it has the long sought goal; it sees no limits to its applicability, and believes that at last it is the fortunate theory to achieve the 'right' answer. This was true of electron theory—perhaps some readers will remember a book called The Electrical Theory of the Universe by de Tunzelman. It is true of general relativity theory with its belief that we can formulate a mathematical scheme that will extrapolate to all past and future time and the unfathomed depths of space. It has been true of wave mechanics, with its first enthusiastic claim a brief ten years ago that no problem had successfully resisted its attack provided the attack was properly made, and now the disillusionment of age when confronted by the problems of the proton and the neutron. When will we learn that logic, mathematics, physical theory, are all only inventions for formulating in compact and manageable form what we already know, like all inventions do not achieve complete success in accomplishing what they were designed to do, much less complete success in fields beyond the scope of the original design, and that our only justification for hoping to penetrate at all into the unknown with these inventions is our past experience that sometimes we have been fortunate enough to be able to push on a short distance by acquired momentum.

Every thoughtful man who hopes for the creation of a contemporary culture knows that this hinges on one central problem: to find a coherent relation between science and the humanities.

Everybody’s a mad scientist, and life is their lab. We’re all trying to experiment to find a way to live, to solve problems, to fend off madness and chaos.

Everyone admits that the male is the primary efficient cause in generation, as being that in whom the species or form resides, and they further assert that his genitures emitted in coitus causes the egg both to exist and to be fertile. But how the semen of the cock produces the chick from the egg, neither the philosophers nor the physicians of yesterday or today have satisfactorily explained, or solved the problem formulated by Aristotle.

Experience hobbles progress and leads to abandonment of difficult problems; it encourages the initiated to walk on the shady side of the street in the direction of experiences that have been pleasant. Youth without experience attacks the unsolved problems which maturer age with experience avoids, and from the labors of youth comes progress. Youth has dreams and visions, and will not be denied.

Experimental psychology itself has, it is true, now and again suffered relapse into a metaphysical treatment of its problems.

Few problems are less recognized, but more important than, the accelerating disappearance of the earth’s biological resources. In pushing other species to extinction, humanity is busy sawing off the limb on which it is perched.

Fine, fine; don't do anything to patch it up. The way things are going, gangrene will set in. Then we can amputate and clean up the problem once and for all.

For me, the first challenge for computing science is to discover how to maintain order in a finite, but very large, discrete universe that is intricately intertwined. And a second, but not less important challenge is how to mould what you have achieved in solving the first problem, into a teachable discipline: it does not suffice to hone your own intellect (that will join you in your grave), you must teach others how to hone theirs. The more you concentrate on these two challenges, the clearer you will see that they are only two sides of the same coin: teaching yourself is discovering what is teachable.

For some months the astronomer Halley and other friends of Newton had been discussing the problem in the following precise form: what is the path of a body attracted by a force directed toward a fixed point, the force varying in intensity as the inverse of the distance? Newton answered instantly, “An ellipse.” “How do you know?” he was asked. “Why, I have calculated it.” Thus originated the imperishable Principia, which Newton later wrote out for Halley. It contained a complete treatise on motion.

For the saving the long progression of the thoughts to remote and first principles in every case, the mind should provide itself several stages; that is to say, intermediate principles, which it might have recourse to in the examining those positions that come in its way. These, though they are not self-evident principles, yet, if they have been made out from them by a wary and unquestionable deduction, may be depended on as certain and infallible truths, and serve as unquestionable truths to prove other points depending upon them, by a nearer and shorter view than remote and general maxims. … And thus mathematicians do, who do not in every new problem run it back to the first axioms through all the whole train of intermediate propositions. Certain theorems that they have settled to themselves upon sure demonstration, serve to resolve to them multitudes of propositions which depend on them, and are as firmly made out from thence as if the mind went afresh over every link of the whole chain that tie them to first self-evident principles.

FORTRAN —’the infantile disorder’—, by now nearly 20 years old, is hopelessly inadequate for whatever computer application you have in mind today: it is now too clumsy, too risky, and too expensive to use. PL/I —’the fatal disease’— belongs more to the problem set than to the solution set. It is practically impossible to teach good programming to students that have had a prior exposure to BASIC: as potential programmers they are mentally mutilated beyond hope of regeneration. The use of COBOL cripples the mind; its teaching should, therefore, be regarded as a criminal offence. APL is a mistake, carried through to perfection. It is the language of the future for the programming techniques of the past: it creates a new generation of coding bums.