… it may happen that small differences in the initial conditions produce very great ones in the final phenomena.

…forcing automakers to sell smaller cars to improve fuel economy [is like]… fighting the nation’s obesity problem by forcing clothing manufacturers to sell garments in only small sizes.

…small, yet they are extremely wise: Ants are creatures of little strength, yet they store up their food in the summer…

...the source of all great mathematics is the special case, the concrete example. It is frequent in mathematics that every instance of a concept of seemingly generality is, in essence, the same as a small and concrete special case.

“Heaven helps those who help themselves” is a well-tried maxim, embodying in a small compass the results of vast human experience. The spirit of self-help is the root of all genuine growth in the individual; and, exhibited in the lives of many, it constitutes the true source of national vigour and strength. Help from without is often enfeebling in its effects, but help from within invariably invigorates. Whatever is done for men or classes, to a certain extent takes away the stimulus and necessity of doing for themselves; and where men are subjected to over-guidance and over-government, the inevitable tendency is to render them comparatively helpless.

“True is it, my incorporate friends,” quoth he, “That I receive the general food at first, Which you do live upon; and fit it is, Because I am the storehouse and the shop Of the whole body. But, if you do remember, I send it through the rivers of your blood, Even to the court, the heart, to th’ seat o’ th’ brain; And, through the cranks and offices of man, The strongest nerves and small inferior veins From me receive that natural competency Whereby they live. And though that all at once”— You, good friends, this says the belly, mark me.

[After the flash of the atomic bomb test explosion] Fermi got up and dropped small pieces of paper … a simple experiment to measure the energy liberated by the explosion … [W]hen the front of the shock wave arrived (some seconds after the flash) the pieces of paper were displaced a few centimeters in the direction of propagation of the shock wave. From the distance of the source and from the displacement of the air due to the shock wave, he could calculate the energy of the explosion. This Fermi had done in advance having prepared himself a table of numbers, so that he could tell immediately the energy liberated from this crude but simple measurement. … It is also typical that his answer closely approximated that of the elaborate official measurements. The latter, however, were available only after several days’ study of the records, whereas Fermi had his within seconds.

[Alchemists] get a small livelihood by some Physical Experiments, as also by some Paints and effeminate Fucusses [cosmetics], which the Scriptures call the Oyntments of harlott; whence the Proverb, Every Alchymist is a Physician or a Sope-boyler.

[At my secondary school] if you were very bright, you did classics; if you were pretty thick, you did woodwork; and if you were neither of those poles, you did science. The number of kids in my school who did science because they were excited by the notion of science was pretty small. You were allocated to those things, you weren’t asked. This was in the late 1930s/early 1940s … Science was seen as something more remote and less to do with everyday life.

[It has been ascertained by statistical observation that in engineering enterprises one man is killed for every million francs that is spent on the works.] Supposing you have to build a bridge at an expense of one hundred million francs, you must be prepared for the death of one hundred men. In building the Eiffel Tower, which was a construction costing six million and a half, we only lost four men, thus remaining below the average. In the construction of the Forth Bridge, 55 men were lost in over 45,000,000 francs’ worth of work. That would appear to be a large number according to the general rule, but when the special risks are remembered, this number shows as a very small one.

[T]he small is great, the great is small; all is in equilibrium in necessity...

[The infinitely small] neither have nor can have theory; it is a dangerous instrument in the hands of beginners [ ... ] anticipating, for my part, the judgement of posterity, I would dare predict that this method will be accused one day, and rightly, of having retarded the progress of the mathematical sciences.

[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.

[To] explain the phenomena of the mineral kingdom ... systems are usually reduced to two classes, according as they refer to the origin of terrestrial bodies to FIRE or to WATER; and ... their followers have of late been distinguished by the fanciful names of Vulcanists and Neptunists. To the former of these Dr HUTTON belongs much more than to the latter; though, as he employs the agency both of fire and water in his system, he cannot, in strict propriety, be arranged with either.

[When nature appears complicated:] The moment we contemplate it as it is, and attain a position from which we can take a commanding view, though but of a small part of its plan, we never fail to recognize that sublime simplicity on which the mind rests satisfied that it has attained the truth.

A stands for atom; it is so small No one has ever seen it at all.
B stands for bomb; the bombs are much bigger,
So, brother, do not be too fast on the trigger.
H has become a most ominous letter.
It means something bigger if not something better.

Error of confounding cause and effect.—There is no more dangerous error than confounding consequence with cause: I call it the intrinsic depravity of reason. … I take an example: everybody knows the book of the celebrated Comaro, in which he recommends his spare diet as a recipe for a long and happy life,—for a virtuous life also. Few books have been read so much… I believe hardly any book … has caused so much harm, has shortened so many lives, as this well-meant curiosity. The source of this mischief is in confounding consequence with cause. The candid Italian saw in his diet the cause of his long life, while the prerequisite to long life, the extraordinary slowness of the metabolic process, small consumption, was the cause of his spare diet. He was not at liberty to eat little or much; his frugality—was not of “free will;” he became sick when he ate more.

L’Astronomie est utile, parce qu’elle nous élève au-dessus de nous-mêmes; elle est utile, parce qu’elle est grande; elle est utile, parce qu’elle est belle… C’est elle qui nous montre combien l’homme est petit par le corps et combien il est grand par l’esprit, puisque cette immensité éclatante où son corps n’est qu’un point obscur, son intelligence peut l’embrasser tout entière et en goûter la silencieuse harmonie.
Astronomy is useful because it raises us above ourselves; it is useful because it is grand[; it is useful because it is beautiful]… It shows us how small is man’s body, how great his mind, since his intelligence can embrace the whole of this dazzling immensity, where his body is only an obscure point, and enjoy its silent harmony.

Nature is curious, and such worke may make,
That our dull sense can never finde, but scape.
For Creatures, small as Atomes, may be there,
If every Atome a Creatures Figure beare.
If foure Atomes a World can make, then see
What severall Worlds might in an Eare--ring bee:
For Millions of these Atomes may bee in
The Head of one Small, little, Single Pin.
And if thus Small, then Ladies may well weare
A World of Worlds, as Pendents in each Eare.

Qu. 31. Have not the small Particles of Bodies certain Powers, Virtues or Forces, by which they act at a distance, not only upon the Rays of Light for reflecting, refracting and reflecting them, but also upon one another for producing a great part of the Phænomena of Nature?

Quand on demande à nos philosophes à quoi sert ce nombre prodigieux d’étoiles fixes, dont une partie suffirait pour faire ce qu’elles font toutes, ils vous répondent froidement qu’elles servent à leur réjouir la vue.
When our philosophers are asked what is the use of these countless myriads of fixed stars, of which a small part would be sufficient to do what they all do, they coolly tell us that they are made to give delight to their eyes.

Trimming consists of clipping off little bits here and there from those observations which differ most in excess from the mean, and in sticking them onto those which are too small; a species of 'equitable adjustment,' as a radical would term it, which cannot be admitted in science.

CALPURNIA: When beggars die there are no comets seen;
The heavens themselves blaze forth the death of princes.
CAESAR: Cowards die many times before their deaths;
The valiant never taste of death but once.
Of all the wonders that I have yet heard,
It seems to me most strange that men should fear,
Seeing that death, a necessary end,
Will come when it will come.

CLAUDIO: Death is a fearful thing.
ISABELLA: And shamed life a hateful.
CLAUDIO: Ay, but to die, and go we know not where;
To lie in cold obstruction, and to rot;
This sensible warm motion to become
A kneaded clod; and the delighted spirit
To bathe in fiery floods, or to reside
In thrilling region of thick-ribbed ice;
To be imprisioned in the viewless winds,
And blown with restless violence round about
The pendant world; or to be worst than worst
Of those lawless and incertain thought
Imagine howling—'tis too horrible!
The weariest and most loathed worldly life
That age, ache, penury, and imprisionment
Can lay on nature is a paradise
To what we fear of death.

GLENDOWER: I can call spirits from the vasty deep.
HOTSPUR: Why, so can I, or so can any man;
But will they come when you do call for them?

LEPIDUS: What manner o’ thing is your crocodile?
ANTONY: It is shaped, sir, like itself, and it is as broad as it hath breadth. It is just so high as it is, and moves with it own organs. It lives by that which nourisheth it, and the elements once out of it, it transmigrates.
LEPIDUS: What colour is it of?
ANTONY:Of its own colour, too.
LEPIDUS:’Tis a strange serpent.
ANTONY:’Tis so, and the tears of it are wet.

QUEEN: Thou know’st ’tis common—all that lives must die,
Passing through nature to eternity.
HAMLET: Ay, madam, it is common.

SCIENCE: a way of finding things out and then making them work. Science explains what is happening around us the whole time. So does RELIGION, but science is better because it comes up with more understandable excuses when it’s wrong.

SIR TOBY: Does not our lives consist of the four elements?
SIR ANDREW: Faith, so they say; but I think it rather consists of eating and drinking.
SIR TOBY: Thou'rt a scholar; let us therefore eat and drink.

Macbeth: How does your patient, doctor?
Doctor: Not so sick, my lord,
As she is troubled with thick-coming fancies,
That keep her from her rest.
Macbeth: Cure her of that.
Canst thou not minister to a mind diseased,
Pluck from the memory a rooted sorrow,
Raze out the written troubles of the brain,
And with some sweet oblivious antidote
Cleanse the stuffed bosom of that perilous stuff
Which weighs upon the heart?
Doctor: Therein the patient
Must minister to himself.
Macbeth: Throw physic to the dogs; I'll none of it.

~~[Dubious]~~ I demonstrate by means of philosophy that the earth is round, and is inhabited on all sides; that it is insignificantly small, and is borne through the stars.

1106. … In the first week of Lent, on the Friday, 16 February, a strange star appeared in the evening, and for a long time afterwards was seen shining for a while each evening. The star made its appearance in the south-west, and seemed to be small and dark, but the light that shone from it was very bright, and appeared like an enormous beam of light shining north-east; and one evening it seemed as if the beam were flashing in the opposite direction towards the star. Some said that they had seen other unknown stars about this time, but we cannot speak about these without reservation, because we did not ourselves see them.

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

A black hole has no hair.
[Summarizing the simplicity of a black hole, which shows only three characteristics to the outside world (mass, charge, spin) and comparing the situation to a room full of bald-pated people who had one characteristic in common, but no differences in hair length, style or color for individual variations.]

A comparatively small variety of species is found in the older rocks, although of some particular ones the remains are very abundant; ... Ascending to the next group of rocks, we find the traces of life become more abundant, the number of species extended.

A drop of old tuberculin, which is an extract of tubercle bacilli, is put on the skin and then a small superficial scarification is made by turning, with some pressure, a vaccination lancet on the surface of the skin. The next day only those individuals show an inflammatory reaction at the point of vaccination who have already been infected with tuberculosis, whereas the healthy individuals show no reaction at all. Every time we find a positive reaction, we can say with certainty that the child is tuberculous.

A fossil hunter needs sharp eyes and a keen search image, a mental template that subconsciously evaluates everything he sees in his search for telltale clues. A kind of mental radar works even if he isn’t concentrating hard. A fossil mollusk expert has a mollusk search image. A fossil antelope expert has an antelope search image. … Yet even when one has a good internal radar, the search is incredibly more difficult than it sounds. Not only are fossils often the same color as the rocks among which they are found, so they blend in with the background; they are also usually broken into odd-shaped fragments. … In our business, we don’t expect to find a whole skull lying on the surface staring up at us. The typical find is a small piece of petrified bone. The fossil hunter’s search therefore has to have an infinite number of dimensions, matching every conceivable angle of every shape of fragment of every bone on the human body.
Describing the skill of his co-worker, Kamoya Kimeu, who discovered the Turkana Boy, the most complete specimen of Homo erectus, on a slope covered with black lava pebbles.

A man is like a fraction whose numerator is what he is and whose denominator is what he thinks of himself. The larger the denominator the smaller the fraction.

A mathematician of the first rank, Laplace quickly revealed himself as only a mediocre administrator; from his first work we saw that we had been deceived. Laplace saw no question from its true point of view; he sought subtleties everywhere; had only doubtful ideas, and finally carried the spirit of the infinitely small into administration.

A modern branch of mathematics, having achieved the art of dealing with the infinitely small, can now yield solutions in other more complex problems of motion, which used to appear insoluble. This modern branch of mathematics, unknown to the ancients, when dealing with problems of motion, admits the conception of the infinitely small, and so conforms to the chief condition of motion (absolute continuity) and thereby corrects the inevitable error which the human mind cannot avoid when dealing with separate elements of motion instead of examining continuous motion. In seeking the laws of historical movement just the same thing happens. The movement of humanity, arising as it does from innumerable human wills, is continuous. To understand the laws of this continuous movement is the aim of history. … Only by taking an infinitesimally small unit for observation (the differential of history, that is, the individual tendencies of man) and attaining to the art of integrating them (that is, finding the sum of these infinitesimals) can we hope to arrive at the laws of history.

A physician ought to have his shop provided with plenty of all necessary things, as lint, rollers, splinters: let there be likewise in readiness at all times another small cabinet of such things as may serve for occasions of going far from home; let him have also all sorts of plasters, potions, and purging medicines, so contrived that they may keep some considerable time, and likewise such as may be had and used whilst they are fresh.

A propos of Distempers, I am going to tell you a thing that I am sure will make you wish your selfe here. The Small Pox so fatal and so general amongst us is here entirely harmless by the invention of engrafting (which is the term they give it). There is a set of old Women who make it their business to perform the Operation.

A scientist is in a sense a learned small boy. There is something of the scientist in every small boy. Others must outgrow it. Scientists can stay that way all their lives.

A small bubble of air remained unabsorbed... if there is any part of the phlogisticated air [nitrogen] of our atmosphere which differs from the rest, and cannot be reduced to nitrous acid, we may safely conclude that it is not more than 1/120 part of the whole.
Cavendish did not realize the significance of the remaining small bubble. Not until a century later were the air’s Noble Gases appreciated.

A small cabin stands in the Glacier Peak Wilderness, about a hundred yards off a trail that crosses the Cascade Range. In midsummer, the cabin looked strange in the forest. It was only twelve feet square, but it rose fully two stories and then had a high and steeply peaked roof. From the ridge of the roof, moreover, a ten-foot pole stuck straight up. Tied to the top of the pole was a shovel. To hikers shedding their backpacks at the door of the cabin on a cold summer evening—as the five of us did—it was somewhat unnerving to look up and think of people walking around in snow perhaps thirty-five feet above, hunting for that shovel, then digging their way down to the threshold.

A small overweight of knowledge is often a sore impediment to the movements of common sense.

A strict materialist believes that everything depends on the motion of matter. He knows the form of the laws of motion though he does not know all their consequences when applied to systems of unknown complexity.
Now one thing in which the materialist (fortified with dynamical knowledge) believes is that if every motion great & small were accurately reversed, and the world left to itself again, everything would happen backwards the fresh water would collect out of the sea and run up the rivers and finally fly up to the clouds in drops which would extract heat from the air and evaporate and afterwards in condensing would shoot out rays of light to the sun and so on. Of course all living things would regrede from the grave to the cradle and we should have a memory of the future but not of the past.
The reason why we do not expect anything of this kind to take place at any time is our experience of irreversible processes, all of one kind, and this leads to the doctrine of a beginning & an end instead of cyclical progression for ever.

A strong feeling of adventure is animating those who are working on bacterial viruses, a feeling that they have a small part in the great drive towards a fundamental problem in biology.

A theory of physics is not an explanation; it is a system of mathematical oppositions deduced from a small number of principles the aim of which is to represent as simply, as completely, and as exactly as possible, a group of experimental laws.

A time will come when science will transform [our bodies] by means which we cannot conjecture... And then, the earth being small, mankind will migrate into space, and will cross the airless Saharas which separate planet from planet, and sun from sun. The earth will become a Holy Land which will be visited by pilgrims from all quarters of the universe.

A very small cause which escapes our notice determines a considerable effect that we cannot fail to see, and then we say that the effect is due to chance. If we knew exactly the laws of nature and the situation of the universe at the initial moment, we could predict exactly the situation of that same universe at a succeeding moment.

About the year 1821, I undertook to superintend, for the Government, the construction of an engine for calculating and printing mathematical and astronomical tables. Early in the year 1833, a small portion of the machine was put together, and was found to perform its work with all the precision which had been anticipated. At that period circumstances, which I could not control, caused what I then considered a temporary suspension of its progress; and the Government, on whose decision the continuance or discontinuance of the work depended, have not yet communicated to me their wishes on the question.

According to the conclusion of Dr. Hutton, and of many other geologists, our continents are of definite antiquity, they have been peopled we know not how, and mankind are wholly unacquainted with their origin. According to my conclusions drawn from the same source, that of facts, our continents are of such small antiquity, that the memory of the revolution which gave them birth must still be preserved among men; and thus we are led to seek in the book of Genesis the record of the history of the human race from its origin. Can any object of importance superior to this be found throughout the circle of natural science?

Accordingly the primordial state of things which I picture is an even distribution of protons and electrons, extremely diffuse and filling all (spherical) space, remaining nearly balanced for an exceedingly long time until its inherent instability prevails. We shall see later that the density of this distribution can be calculated; it was about one proton and electron per litre. There is no hurry for anything to begin to happen. But at last small irregular tendencies accumulate, and evolution gets under way. The first stage is the formation of condensations ultimately to become the galaxies; this, as we have seen, started off an expansion, which then automatically increased in speed until it is now manifested to us in the recession of the spiral nebulae.
As the matter drew closer together in the condensations, the various evolutionary processes followed—evolution of stars, evolution of the more complex elements, evolution of planets and life.

After a short period spent in Brussels as a guest of a neurological institute, I returned to Turin on the verge of the invasion of Belgium by the German army, Spring 1940, to join my family. The two alternatives left then to us were either to emigrate to the United States, or to pursue some activity that needed neither support nor connection with the outside Aryan world where we lived. My family chose this second alternative. I then decided to build a small research unit at home and installed it in my bedroom.

Alexander the king of the Macedonians, began like a wretch to learn geometry, that he might know how little the earth was, whereof he had possessed very little. Thus, I say, like a wretch for this, because he was to understand that he did bear a false surname. For who can be great in so small a thing? Those things that were delivered were subtile, and to be learned by diligent attention: not which that mad man could perceive, who sent his thoughts beyond the ocean sea. Teach me, saith he, easy things. To whom his master said: These things be the same, and alike difficult unto all. Think thou that the nature of things saith this. These things whereof thou complainest, they are the same unto all: more easy things can be given unto none; but whosoever will, shall make those things more easy unto himself. How? With uprightness of mind.

All living things need their instruction manual (even nonliving things like viruses) and that is all they need, carried in one very small suitcase.

All of us who are concerned for peace and triumph of reason and justice must be keenly aware how small an influence reason and honest good will exert upon events in the political field.

All over the world there lingers on the memory of a giant tree, the primal tree, rising up from the centre of the Earth to the heavens and ordering the universe around it. It united the three worlds: its roots plunged down into subterranean abysses, Its loftiest branches touched the empyrean. Thanks to the Tree, it became possible to breathe the air; to all the creatures that then appeared on Earth it dispensed its fruit, ripened by the sun and nourished by the water which it drew from the soil. From the sky it attracted the lightning from which man made fire and, beckoning skyward, where clouds gathered around its fall. The Tree was the source of all life, and of all regeneration. Small wonder then that tree-worship was so prevalent in ancient times.

All rivers, small or large, agree in one character; they like to lean a little on one side; they cannot bear to have their channels deepest in the middle, but will always, if they can, have one bank to sun themselves upon, and another to get cool under.

All stable processes we shall predict. All unstable processes we shall control.
Describing John von Neumann's aspiration for the application of computers sufficiently large to solve the problems of meteorology, despite the sensitivity of the weather to small perturbations.

All the different classes of beings which taken together make up the universe are, in the ideas of God who knows distinctly their essential gradations, only so many ordinates of a single curve so closely united that it would be impossible to place others between any two of them, since that would imply disorder and imperfection. Thus men are linked with the animals, these with the plants and these with the fossils which in turn merge with those bodies which our senses and our imagination represent to us as absolutely inanimate. And, since the law of continuity requires that when the essential attributes of one being approximate those of another all the properties of the one must likewise gradually approximate those of the other, it is necessary that all the orders of natural beings form but a single chain, in which the various classes, like so many rings, are so closely linked one to another that it is impossible for the senses or the imagination to determine precisely the point at which one ends and the next begins?all the species which, so to say, lie near the borderlands being equivocal, at endowed with characters which might equally well be assigned to either of the neighboring species. Thus there is nothing monstrous in the existence zoophytes, or plant-animals, as Budaeus calls them; on the contrary, it is wholly in keeping with the order of nature that they should exist. And so great is the force of the principle of continuity, to my thinking, that not only should I not be surprised to hear that such beings had been discovered?creatures which in some of their properties, such as nutrition or reproduction, might pass equally well for animals or for plants, and which thus overturn the current laws based upon the supposition of a perfect and absolute separation of the different orders of coexistent beings which fill the universe;?not only, I say, should I not be surprised to hear that they had been discovered, but, in fact, I am convinced that there must be such creatures, and that natural history will perhaps some day become acquainted with them, when it has further studied that infinity of living things whose small size conceals them for ordinary observation and which are hidden in the bowels of the earth and the depth of the sea.

All the effects of Nature are only the mathematical consequences of a small number of immutable laws.

Almost daily we shudder as prophets of doom announce the impending end of civilization and universe. We are being asphyxiated, they say, by the smoke of the industry; we are suffocating in the ever growing mountain of rubbish. Every new project depicts its measureable effects and is denounced by protesters screaming about catastrophe, the upsetting of the land, the assault on nature. If we accepted this new mythology we would have to stop pushing roads through the forest, harnessing rivers to produce the electricity, breaking grounds to extract metals, enriching the soil with chemicals, killing insects, combating viruses … But progress—basically, an effort to organise a corner of land and make it more favourable for human life—cannot be baited. Without the science of pomiculture, for example, trees will bear fruits that are small, bitter, hard, indigestible, and sour. Progress is desirable.

Although we know nothing of what an atom is, yet we cannot resist forming some idea of a small particle, which represents it to the mind ... there is an immensity of facts which justify us in believing that the atoms of matter are in some way endowed or associated with electrical powers, to which they owe their most striking qualities, and amongst them their mutual chemical affinity.
[Summarizing his investigations in electrolysis.]

America is a constipated nation.... If you pass small stools, you have to have large hospitals.

And from this such small difference of eight minutes [of arc] it is clear why Ptolemy, since he was working with bisection [of the linear eccentricity], accepted a fixed equant point… . For Ptolemy set out that he actually did not get below ten minutes [of arc], that is a sixth of a degree, in making observations. To us, on whom Divine benevolence has bestowed the most diligent of observers, Tycho Brahe, from whose observations this eight-minute error of Ptolemy’s in regard to Mars is deduced, it is fitting that we accept with grateful minds this gift from God, and both acknowledge and build upon it. So let us work upon it so as to at last track down the real form of celestial motions (these arguments giving support to our belief that the assumptions are incorrect). This is the path I shall, in my own way, strike out in what follows. For if I thought the eight minutes in [ecliptic] longitude were unimportant, I could make a sufficient correction (by bisecting the [linear] eccentricity) to the hypothesis found in Chapter 16. Now, because they could not be disregarded, these eight minutes alone will lead us along a path to the reform of the whole of Astronomy, and they are the matter for a great part of this work.

And it has been sarcastically said, that there is a wide difference between a good physician and a bad one, but a small difference between a good physician and no physician at all; by which it is meant to insinuate, that the mischievous officiousness of art does commonly more than counterbalance any benefit derivable from it.

And since the portions of the great and the small are equal in number, so too all things would be in everything. Nor is it possible that they should exist apart, but all things have a portion of everything.

And still they gazed and still the wonder grew,
That one small head could carry all he knew.

And thus Nature will be very conformable to her self and very simple, performing all the great Motions of the heavenly Bodies by the Attraction of Gravity which intercedes those Bodies, and almost all the small ones of their Particles by some other attractive and repelling Powers which intercede the Particles. The Vis inertiae is a passive Principle by which Bodies persist in their Motion or Rest, receive Motion in proportion to the Force impressing it, and resist as much as they are resisted. By this Principle alone there never could have been any Motion in the World. Some other Principle was necessary for putting Bodies into Motion; and now they are in Motion, some other Principle is necessary for conserving the Motion.

And, in this case, science could learn an important lesson from the literati–who love contingency for the same basic reason that scientists tend to regard the theme with suspicion. Because, in contingency lies the power of each person, to make a difference in an unconstrained world bristling with possibilities, and nudgeable by the smallest of unpredictable inputs into markedly different channels spelling either vast improvement or potential disaster.

Any experiment may be regarded as forming an individual of a 'population' of experiments which might be performed under the same conditions. A series of experiments is a sample drawn from this population.
Now any series of experiments is only of value in so far as it enables us to form a judgment as to the statistical constants of the population to which the experiments belong. In a great number of cases the question finally turns on the value of a mean, either directly, or as the mean difference between the two qualities.
If the number of experiments be very large, we may have precise information as to the value of the mean, but if our sample be small, we have two sources of uncertainty:— (I) owing to the 'error of random sampling' the mean of our series of experiments deviates more or less widely from the mean of the population, and (2) the sample is not sufficiently large to determine what is the law of distribution of individuals.

Anyone who doesn’t take truth seriously in small matters cannot be trusted in large ones either.

Archimedes … had stated that given the force, any given weight might be moved, and even boasted, we are told, relying on the strength of demonstration, that if there were another earth, by going into it he could remove this. Hiero being struck with amazement at this, and entreating him to make good this problem by actual experiment, and show some great weight moved by a small engine, he fixed accordingly upon a ship of burden out of the king’s arsenal, which could not be drawn out of the dock without great labor and many men; and, loading her with many passengers and a full freight, sitting himself the while far off with no great endeavor, but only holding the head of the pulley in his hand and drawing the cords by degrees, he drew the ship in a straight line, as smoothly and evenly, as if she had been in the sea. The king, astonished at this, and convinced of the power of the art, prevailed upon Archimedes to make him engines accommodated to all the purposes, offensive and defensive, of a siege. … the apparatus was, in most opportune time, ready at hand for the Syracusans, and with it also the engineer himself.

As a progressive discipline [biochemistry] belongs to the present century. From the experimental physiologists of the last century it obtained a charter, and, from a few pioneers of its own, a promise of success; but for the furtherance of its essential aim that century left it but a small inheritance of facts and methods. By its essential or ultimate aim I myself mean an adequate and acceptable description of molecular dynamics in living cells and tissues.

As for the search for truth, I know from my own painful searching, with its many blind alleys, how hard it is to take a reliable step, be it ever so small, towards the understanding of that which is truly significant.

As man advances in civilisation, and small tribes are united into larger communities, the simplest reason would tell each individual that he ought to extend his social instincts and sympathies to all the members of the same nation, though personally unknown to him. This point being once reached, there is only an artificial barrier to prevent his sympathies extending to the men of all nations and races.

Asian Homo erectus died without issue and does not enter our immediate ancestry (for we evolved from African populations); Neanderthal people were collateral cousins, perhaps already living in Europe while we emerged in Africa... In other words, we are an improbable and fragile entity, fortunately successful after precarious beginnings as a small population in Africa, not the predictable end result of a global tendency. We are a thing, an item of history, not an embodiment of general principles.

Ask why God made the GEM so small,
And why so huge the granite?
Because God meant, mankind should set
That higher value on it.

Astronomy is perhaps the science whose discoveries owe least to chance, in which human understanding appears in its whole magnitude, and through which man can best learn how small he is.

Astrophysicists have the formidable privilege of having the largest view of the Universe; particle detectors and large telescopes are today used to study distant stars, and throughout space and time, from the infinitely large to the infinitely small, the Universe never ceases to surprise us by revealing its structures little by little.

At the end of the book [Zoonomia] he sums up his [Erasmus Darwin] views in the following sentences: “The world has been evolved, not created: it has arisen little by little from a small beginning, and has increased through the activity of the elemental forces embodied in itself, and so has rather grown than come into being at an almighty word.” “What a sublime idea of the infinite might of the great Architect, the Cause of all causes, the Father of all fathers, the Ens Entium! For if we would compare the Infinite, it would surely require a greater Infinite to cause the causes of effects than to produce the effects themselves.”
[This is a restatement, not a verbatim quote of the original words of Erasmus Darwin, who attributed the idea he summarized to David Hume.]

Basic research at universities comes in two varieties: research that requires big bucks and research that requires small bucks. Big bucks research is much like government research and in fact usually is government research but done for the government under contract. Like other government research, big bucks academic research is done to understand the nature and structure of the universe or to understand life, which really means that it is either for blowing up the world or extending life, whichever comes first. Again, that's the government's motivation. The universities' motivation for conducting big bucks research is to bring money in to support professors and graduate students and to wax the floors of ivy-covered buildings. While we think they are busy teaching and learning, these folks are mainly doing big bucks basic research for a living, all the while priding themselves on their terrific summer vacations and lack of a dress code.
Smalls bucks research is the sort of thing that requires paper and pencil, and maybe a blackboard, and is aimed primarily at increasing knowledge in areas of study that don't usually attract big bucks - that is, areas that don't extend life or end it, or both. History, political science, and romance languages are typically small bucks areas of basic research. The real purpose of small bucks research to the universities is to provide a means of deciding, by the quality of their small bucks research, which professors in these areas should get tenure.

Bearing in mind that it is from the vitality of the atmospheric particles that all the mischief arises, it appears that all that is requisite is to dress the wound with some material capable of killing these septic germs, provided that any substance can be found reliable for this purpose, yet not too potent as a caustic. In the course of the year 1864 I was much struck with an account of the remarkable effects produced by carbolic acid upon the sewage of the town of Carlisle, the admixture of a very small proportion not only preventing all odour from the lands irrigated with the refuse material, but, as it was stated, destroying the entozoa which usually infest cattle fed upon such pastures.

Because of the way it came into existence, the solar system has only one-way traffic—like Piccadilly Circus. … If we want to make a model to scale, we must take a very tiny object, such as a pea, to represent the sun. On the same scale the nine planets will be small seeds, grains of sand and specks of dust. Even so, Piccadilly Circus is only just big enough to contain the orbit of Pluto. … The whole of Piccadilly Circus was needed to represent the space of the solar system, but a child can carry the whole substance of the model in its hand. All the rest is empty space.

Before I flew I was already aware of how small and vulnerable our planet is; but only when I saw it from space, in all its ineffable beauty and fragility, did I realize that humankind’s most urgent task is to cherish and preserve it for future generations.

Building goes on briskly at the therapeutic Tower of Babel; what one recommends another condemns; what one gives in large doses another scarce dares to prescribe in small doses; and what one vaunts as a novelty another thinks not worth rescuing from merited oblivion. All is confusion, contradiction, inconceivable chaos. Every country, every place, almost every doctor, have their own pet remedies, without which they imagine their patients can not be cured; and all this changes every year, aye every mouth.

But in my opinion we can now be assured sufficiently that no animals, however small they may be, take their origin in putrefaction, but exclusively in procreation… For seeing that animals, from the largest down to the little despised animal, the flea, have animalcules in their semen, seeing also that some of the vessels of the lungs of horses and cows consist of rings and that these rings can occur on the flea's veins, why cannot we come to the conclusion that as well as the male sperm of that large animal the horse and similar animals, and of all manner of little animals, the flea included, is furnished with animalcules (and other intestines, for I have often been astonished when I beheld the numerous vessels in a flea), why, I say should not the male sperm of the smallest animals, smaller than a flea may even the very smallest animalcules have the perfection that we find in a flea.

But of this I can assure you that there is not a movement of any body of Men however small whether on Horse-back or on foot, nor an operation or March of any description nor any Service in the field that is not formed upon some mathematical principle, and in the performance of which the knowledge and practical application of the mathematicks will be found not only useful but necessary. The application of the Mathematicks to Gunnery, Fortification, Tactics, the survey and knowledge of formal Castrenantion etc. cannot be acquired without study.

But the World being once fram’d, and the course of Nature establish’d, the Naturalist, (except in some few cases, where God, or Incorporeal Agents interpose), has recourse to the first Cause but for its general and ordinary Support and Influence, whereby it preserves Matter and Motion from Annihilation or Desition; and in explicating particular phenomena, considers onely the Size, Shape, Motion, (or want of it) Texture, and the resulting Qualities and Attributes of the small particles of Matter.

But, as we consider the totality of similarly broad and fundamental aspects of life, we cannot defend division by two as a natural principle of objective order. Indeed, the ‘stuff’ of the universe often strikes our senses as complex and shaded continua, admittedly with faster and slower moments, and bigger and smaller steps, along the way. Nature does not dictate dualities, trinities, quarterings, or any ‘objective’ basis for human taxonomies; most of our chosen schemes, and our designated numbers of categories, record human choices from a cornucopia of possibilities offered by natural variation from place to place, and permitted by the flexibility of our mental capacities. How many seasons (if we wish to divide by seasons at all) does a year contain? How many stages shall we recognize in a human life?

Chemistry is an art that has furnished the world with a great number of useful facts, and has thereby contributed to the improvement of many arts; but these facts lie scattered in many different books, involved in obscure terms, mixed with many falsehoods, and joined to a great deal of false philosophy; so that it is not great wonder that chemistry has not been so much studied as might have been expected with regard to so useful a branch of knowledge, and that many professors are themselves but very superficially acquainted with it. But it was particularly to be expected, that, since it has been taught in universities, the difficulties in this study should have been in some measure removed, that the art should have been put into form, and a system of it attempted—the scattered facts collected and arranged in a proper order. But this has not yet been done; chemistry has not yet been taught but upon a very narrow plan. The teachers of it have still confined themselves to the purposes of pharmacy and medicine, and that comprehends a small branch of chemistry; and even that, by being a single branch, could not by itself be tolerably explained.

Civilisations as yet have only been created and directed by a small intellectual aristocracy, never by crowds. Crowds are only powerful for destruction.

Does it mean, if you don’t understand something, and the community of physicists don’t understand it, that means God did it? Is that how you want to play this game? Because if it is, here’s a list of the things in the past that the physicists—at the time—didn’t understand … [but now we do understand.] If that’s how you want to invoke your evidence for God, then God is an ever-receding pocket of scientific ignorance, that’s getting smaller and smaller and smaller, as time moves on. So just be ready for that to happen, if that’s how you want to come at the problem. That’s simply the “God of the Gaps” argument that’s been around for ever.

Dr. Johnson ... sometimes employed himself in chymistry, sometimes in watering and pruning a vine, and sometimes in small experiments, at which those who may smile, should recollect that there are moments which admit of being soothed only by trifles.

Dr. Paget was conducting a school examination, and in the course of his questions he happened to ask a small child the meaning of “Average.” He was utterly bewildered by the reply, “The thing that hens lay on,” until the child explained that he had read in a book that hens lay on an average so many eggs a year.

Each of the major sciences has contributed an essential ingredient in our long retreat from an initial belief in our own cosmic importance. Astronomy defined our home as a small planet tucked away in one corner of an average galaxy among millions; biology took away our status as paragons created in the image of God; geology gave us the immensity of time and taught us how little of it our own species has occupied.

Each of us has read somewhere that in New Guinea pidgin the word for 'piano' is (I use English spelling) 'this fellow you hit teeth belonging to him he squeal all same pig'. I am inclined to doubt whether this expression is authentic; it looks just like the kind of thing a visitor to the Islands would facetiously invent. But I accept 'cut grass belong head belong me' for 'haircut' as genuine... Such phrases seem very funny to us, and make us feel very superior to the ignorant foreigners who use long winded expressions for simple matters. And then it is our turn to name quite a simple thing, a small uncomplicated molecule consisting of nothing more than a measly 11 carbons, seven hydrogens, one nitrogen and six oxygens. We sharpen our pencils, consult our rule books and at last come up with 3-[(1, 3- dihydro-1, 3-dioxo-2H-isoindol-2-yl) oxy]-3-oxopropanoic acid. A name like that could drive any self-respecting Papuan to piano-playing.

Earthquakes may be brought about because wind is caught up in the earth, so the earth is dislocated in small masses and is continually shaken, and that causes it to sway.

Earthworms, though in appearance a small and despicable link in the chain of nature, yet, if lost, would make a lamentable chasm … worms seem to be the great promoters of vegetation, which would proceed but lamely without them.
[Showing an early awareness in ecology.]

Even those to whom Providence has allotted greater strength of understanding, can expect only to improve a single science. In every other part of learning, they must be content to follow opinions, which they are not able to examine; and, even in that which they claim as peculiarly their own, can seldom add more than some small particle of knowledge, to the hereditary stock devolved to them from ancient times, the collective labour of a thousand intellects.

Everyone makes for himself a clear idea of the motion of a point, that is to say, of the motion of a corpuscle which one supposes to be infinitely small, and which one reduces by thought in some way to a mathematical point.

Everything about microscopic life is terribly upsetting. How can things so small be so important?

Everywhere science is enriched by unscientific methods and unscientific results, ... the separation of science and non-science is not only artificial but also detrimental to the advancement of knowledge. If we want to understand nature, if we want to master our physical surroundings, then we must use all ideas, all methods, and not just a small selection of them.

Exper. I. I made a small hole in a window-shutter, and covered it with a piece of thick paper, which I perforated with a fine needle. For greater convenience of observation I placed a small looking-glass without the window-shutter, in such a position as to reflect the sun's light, in a direction nearly horizontal, upon the opposite wall, and to cause the cone of diverging light to pass over a table on which were several little screens of card-paper. I brought into the sunbeam a slip of card, about one-thirtieth of an inch in breadth, and observed its shadow, either on the wall or on other cards held at different distances. Besides the fringes of colour on each side of the shadow, the shadow itself was divided by similar parallel fringes, of smaller dimensions, differing in number, according to the distance at which the shadow was observed, but leaving the middle of the shadow always white. Now these fringes were the joint effects of the portions of light passing on each side of the slip of card and inflected, or rather diffracted, into the shadow. For, a little screen being placed a few inches from the card, so as to receive either edge of the shadow on its margin, all the fringes which had before been observed in the shadow on the wall, immediately disappeared, although the light inflected on the other side was allowed to retain its course, and although this light must have undergone any modification that the proximity of the other edge of the slip of card might have been capable of occasioning... Nor was it for want of a sufficient intensity of light that one of the two portions was incapable of producing the fringes alone; for when they were both uninterrupted, the lines appeared, even if the intensity was reduced to one-tenth or one-twentieth.

Fear of something is at the root of hate for others and hate within will eventually destroy the hater. Keep your thoughts free from hate, and you will have no fear from those who hate you. ...
David, though small, was filled with truth, right thinking and good will for others. Goliath represents one who let fear into his heart, and it stayed there long enough to grow into hate for others.

Finally in a large population, divided and subdivided into partially isolated local races of small size, there is a continually shifting differentiation among the latter (intensified by local differences in selection but occurring under uniform and static conditions) which inevitably brings about an indefinitely continuing, irreversible, adaptive, and much more rapid evolution of the species. Complete isolation in this case, and more slowly in the preceding, originates new species differing for the most part in nonadaptive parallel orthogenetic lines, in accordance with the conditions. It is suggested, in conclusion, that the differing statistical situations to be expected among natural species are adequate to account for the different sorts of evolutionary processes which have been described, and that, in particular, conditions in nature are often such as to bring about the state of poise among opposing tendencies on which an indefinitely continuing evolutionary process depends.

Finite systems of deterministic ordinary nonlinear differential equations may be designed to represent forced dissipative hydrodynamic flow. Solutions of these equations can be identified with trajectories in phase space. For those systems with bounded solutions, it is found that nonperiodic solutions are ordinarily unstable with respect to small modifications, so that slightly differing initial states can evolve into considerably different states. Systems with bounded solutions are shown to possess bounded numerical solutions.
A simple system representing cellular convection is solved numerically. All of the solutions are found to be unstable, and almost all of them are nonperiodic.
The feasibility of very-long-range weather prediction is examined in the light of these results

For a stone, when it is examined, will be found a mountain in miniature. The fineness of Nature’s work is so great, that, into a single block, a foot or two in diameter, she can compress as many changes of form and structure, on a small scale, as she needs for her mountains on a large one; and, taking moss for forests, and grains of crystal for crags, the surface of a stone, in by far the plurality of instances, is more interesting than the surface of an ordinary hill; more fantastic in form and incomparably richer in colour—the last quality being, in fact, so noble in most stones of good birth (that is to say, fallen from the crystalline mountain ranges).

For any two portions of fire, small or great, will exhibit the same ratio of solid to void; but the upward movement of the greater is quicker than that of the less, just as the downward movement of a mass of gold or lead, or of any other body endowed with weight, is quicker in proportion to its size.

For if there is any truth in the dynamical theory of gases the different molecules in a gas at uniform temperature are moving with very different velocities. Put such a gas into a vessel with two compartments [A and B] and make a small hole in the wall about the right size to let one molecule through. Provide a lid or stopper for this hole and appoint a doorkeeper, very intelligent and exceedingly quick, with microscopic eyes but still an essentially finite being.
Whenever he sees a molecule of great velocity coming against the door from A into B he is to let it through, but if the molecule happens to be going slow he is to keep the door shut. He is also to let slow molecules pass from B to A but not fast ones ... In this way the temperature of B may be raised and that of A lowered without any expenditure of work, but only by the intelligent action of a mere guiding agent (like a pointsman on a railway with perfectly acting switches who should send the express along one line and the goods along another).
I do not see why even intelligence might not be dispensed with and the thing be made self-acting.
Moral The 2nd law of Thermodynamics has the same degree of truth as the statement that if you throw a tumblerful of water into the sea you cannot get the same tumblerful of water out again.

For many planet hunters, though, the ultimate goal is still greater (or actually, smaller) prey: terrestrial planets, like Earth, circling a star like the Sun. Astronomers already know that three such planets orbit at least one pulsar. But planet hunters will not rest until they are in sight of a small blue world, warm and wet, in whose azure skies and upon whose wind-whipped oceans shines a bright yellow star like our own.

For small creatures such as we the vastness is bearable only through love.

For terrestrial vertebrates, the climate in the usual meteorological sense of the term would appear to be a reasonable approximation of the conditions of temperature, humidity, radiation, and air movement in which terrestrial vertebrates live. But, in fact, it would be difficult to find any other lay assumption about ecology and natural history which has less general validity. … Most vertebrates are much smaller than man and his domestic animals, and the universe of these small creatures is one of cracks and crevices, holes in logs, dense underbrush, tunnels, and nests—a world where distances are measured in yards rather than miles and where the difference between sunshine and shadow may be the difference between life and death. Actually, climate in the usual sense of the term is little more than a crude index to the physical conditions in which most terrestrial animals live.

For us, an atom shall be a small, spherical, homogeneous body or an essentially indivisible, material point, whereas a molecule shall be a separate group of atoms in any number and of any nature.

Formerly Milton's Paradise Lost had been my chief favourite, and in my excursions during the voyage of the Beagle, when I could take only a single small volume, I always chose Milton.

Four circles to the kissing come,
The smaller are the benter.
The bend is just the inverse of
The distance from the centre.
Though their intrigue left Euclid dumb
There’s now no need for rule of thumb.
Since zero bend’s a dead straight line
And concave bends have minus sign,
The sum of squares of all four bends
Is half the square of their sum.

From the infinitely great down to the infinitely small, all things are subject to [the laws of nature]. The sun and the planets follow the laws discovered by Newton and Laplace, just as the atoms in their combinations follow the laws of chemistry, as living creatures follow the laws of biology. It is only the imperfections of the human mind which multiply the divisions of the sciences, separating astronomy from physics or chemistry, the natural sciences from the social sciences. In essence, science is one. It is none other than the truth.