Πάντα ῥεῖ : all things are in flux. It is inevitable that you are indebted to the past. You are fed and formed by it. The old forest is decomposed for the composition of the new forest. The old animals have given their bodies to the earth to furnish through chemistry the forming race, and every individual is only a momentary fixation of what was yesterday another’s, is today his and will belong to a third to-morrow. So it is in thought.

England and all civilised nations stand in deadly peril of not having enough to eat. As mouths multiply, food resources dwindle. Land is a limited quantity, and the land that will grow wheat is absolutely dependent on difficult and capricious natural phenomena... I hope to point a way out of the colossal dilemma. It is the chemist who must come to the rescue of the threatened communities. It is through the laboratory that starvation may ultimately be turned into plenty... The fixation of atmospheric nitrogen is one of the great discoveries, awaiting the genius of chemists.

I prefer the spagyric chemical physicians, for they do not consort with loafers or go about gorgeous in satins, silks and velvets, gold rings on their fingers, silver daggers hanging at their sides and white gloves on their hands, but they tend their work at the fire patiently day and night. They do not go promenading, but seek their recreation in the laboratory, wear plain learthern dress and aprons of hide upon which to wipe their hands, thrust their fingers amongst the coals, into dirt and rubbish and not into golden rings. They are sooty and dirty like the smiths and charcoal burners, and hence make little show, make not many words and gossip with their patients, do not highly praise their own remedies, for they well know that the work must praise the master, not the master praise his work. They well know that words and chatter do not help the sick nor cure them... Therefore they let such things alone and busy themselves with working with their fires and learning the steps of alchemy. These are distillation, solution, putrefaction, extraction, calcination, reverberation, sublimination, fixation, separation, reduction, coagulation, tinction, etc.

The proof given by Wright, that non-adaptive differentiation will occur in small populations owing to “drift,” or the chance fixation of some new mutation or recombination, is one of the most important results of mathematical analysis applied to the facts of neo-mendelism. It gives accident as well as adaptation a place in evolution, and at one stroke explains many facts which puzzled earlier selectionists, notably the much greater degree of divergence shown by island than mainland forms, by forms in isolated lakes than in continuous river-systems.

The theory here developed is that mega-evolution normally occurs among small populations that become preadaptive and evolve continuously (without saltation, but at exceptionally rapid rates) to radically different ecological positions. The typical pattern involved is probably this: A large population is fragmented into numerous small isolated lines of descent. Within these, inadaptive differentiation and random fixation of mutations occur. Among many such inadaptive lines one or a few are preadaptive, i.e., some of their characters tend to fit them for available ecological stations quite different from those occupied by their immediate ancestors. Such groups are subjected to strong selection pressure and evolve rapidly in the further direction of adaptation to the new status. The very few lines that successfully achieve this perfected adaptation then become abundant and expand widely, at the same time becoming differentiated and specialized on lower levels within the broad new ecological zone.