[The infinitely small] neither have nor can have theory; it is a dangerous instrument in the hands of beginners [ ... ] anticipating, for my part, the judgement of posterity, I would dare predict that this method will be accused one day, and rightly, of having retarded the progress of the mathematical sciences.

A study of Dr. [Florence] Sabin’s work shows the greatness of her achievement and the character of her mind. She has dealt with the primary and fundamental problem of the cell—the unit of plant and animal life. All through her investigations she has followed the cell, seeking the secret of differentiations by newer and finer methods, both physical and chemical. Always through her work runs the great strong, continuous cord of cell differentiations. This is one of the great concepts of man, for all life begins as a single cell. I have known and followed Dr. Sabin’s work since her student days, and have lately been more closely associated with her in her tuberculosis studies. She is all in mind and spirit and ideals that man or woman ever accomplishes. She belongs to the great students of both sexes, for when these have the brains and the will to work I see little difference.

Common integration is only the memory of differentiation...

Ecological differentiation is the necessary condition for coexistence.

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

Finally in a large population, divided and subdivided into partially isolated local races of small size, there is a continually shifting differentiation among the latter (intensified by local differences in selection but occurring under uniform and static conditions) which inevitably brings about an indefinitely continuing, irreversible, adaptive, and much more rapid evolution of the species. Complete isolation in this case, and more slowly in the preceding, originates new species differing for the most part in nonadaptive parallel orthogenetic lines, in accordance with the conditions. It is suggested, in conclusion, that the differing statistical situations to be expected among natural species are adequate to account for the different sorts of evolutionary processes which have been described, and that, in particular, conditions in nature are often such as to bring about the state of poise among opposing tendencies on which an indefinitely continuing evolutionary process depends.

Had there not been in zoology men who devoted themselves to such seemingly unimportant studies as the differentiation of the species of mosquitoes, we should not have been able to place on a firm foundation the aetiology of malaria and yellow fever.

How did Biot arrive at the partial differential equation? [the heat conduction equation] … Perhaps Laplace gave Biot the equation and left him to sink or swim for a few years in trying to derive it. That would have been merely an instance of the way great mathematicians since the very beginnings of mathematical research have effortlessly maintained their superiority over ordinary mortals.

I contend that the continued racial classification of Homo sapiens represents an outmoded approach to the general problem of differentiation within a species. In other words, I reject a racial classification of humans for the same reasons that I prefer not to divide into subspecies the prodigiously variable West Indian land snails that form the subject of my own research.

In summary, very large populations may differentiate rapidly, but their sustained evolution will be at moderate or slow rates and will be mainly adaptive. Populations of intermediate size provide the best conditions for sustained progressive and branching evolution, adaptive in its main lines, but accompanied by inadaptive fluctuations, especially in characters of little selective importance. Small populations will be virtually incapable of differentiation or branching and will often be dominated by random inadaptive trends and peculiarly liable to extinction, but will be capable of the most rapid evolution as long as this is not cut short by extinction.

In the animal world, on the other hand, the process of evolution is characterised by the progressive discrimination of the animal and vegetative functions, and a consequent differentiation of these two great provinces into their separate departments.

In the beginning of the year 1665 I found the Method of approximating series & the Rule for reducing any dignity of any Bionomial into such a series. The same year in May I found the method of Tangents of Gregory & Slusius, & in November had the direct method of fluxions & the next year in January had the Theory of Colours & in May following I had entrance into ye inverse method of fluxions. And the same year I began to think of gravity extending to ye orb of the Moon & (having found out how to estimate the force with wch [a] globe revolving within a sphere presses the surface of the sphere) from Keplers rule of the periodic times of the Planets being in sesquialterate proportion of their distances from the center of their Orbs, I deduced that the forces wch keep the Planets in their Orbs must [be] reciprocally as the squares of their distances from the centers about wch they revolve: & thereby compared the force requisite to keep the Moon in her Orb with the force of gravity at the surface of the earth, & found them answer pretty nearly. All this was in the two plague years of 1665-1666. For in those days I was in the prime of my age for invention & minded Mathematicks & Philosophy more then than at any time since.

It must be admitted that science has its castes. The man whose chief apparatus is the differential equation looks down upon one who uses a galvanometer, and he in turn upon those who putter about with sticky and smelly things in test tubes. But all of these, and most biologists too, join together in their contempt for the pariah who, not through a glass darkly, but with keen unaided vision, observes the massing of a thundercloud on the horizon, the petal as it unfolds, or the swarming of a hive of bees. And yet sometimes I think that our laboratories are but little earthworks which men build about themselves, and whose puny tops too often conceal from view the Olympian heights; that we who work in these laboratories are but skilled artisans compared with the man who is able to observe, and to draw accurate deductions from the world about him.

It need scarcely be pointed out that with such a mechanism complete isolation of portion of a species should result relatively rapidly in specific differentiation, and one that is not necessarily adaptive. The effective inter­group competition leading to adaptive advance may be between species rather than races. Such isolation is doubtless usually geographic in character at the outset but may be clinched by the development of hybrid sterility. The usual difference of the chromosome complements of related species puts the importance of chromosome aberration as an evolutionary process beyond question, but, as I see it, this importance is not in the character differences which they bring (slight in balanced types), but rather in leading to the sterility of hybrids and thus making permanent the isolation of two groups.
How far do the observations of actual species and their subdivisions conform to this picture? This is naturally too large a subject for more than a few suggestions.
That evolution involves non-adaptive differentiation to a large extent at the subspecies and even the species level is indicated by the kinds of differences by which such groups are actually distinguished by systematics. It is only at the subfamily and family levels that clear-cut adaptive differences become the rule. The principal evolutionary mechanism in the origin of species must thus be an essentially nonadaptive one.

Mathematics is a study which, when we start from its most familiar portions, may be pursued in either of two opposite directions. The more familiar direction is constructive, towards gradually increasing complexity: from integers to fractions, real numbers, complex numbers; from addition and multiplication to differentiation and integration, and on to higher mathematics. The other direction, which is less familiar, proceeds, by analysing, to greater and greater abstractness and logical simplicity; instead of asking what can be defined and deduced from what is assumed to begin with, we ask instead what more general ideas and principles can be found, in terms of which what was our starting-point can be defined or deduced. It is the fact of pursuing this opposite direction that characterises mathematical philosophy as opposed to ordinary mathematics.

My thesis is that what we call 'science' is differentiated from the older myths not by being something distinct from a myth, but by being accompanied by a second-order tradition—that of critically discussing the myth. … In a certain sense, science is myth-making just as religion is.

No branches of historical inquiry have suffered more from fanciful speculation than those which relate to the origin and attributes of the races of mankind. The differentiation of these races began in prehistoric darkness, and the more obscure a subject is, so much the more fascinating. Hypotheses are tempting, because though it may be impossible to verify them, it is, in the paucity of data, almost equally impossible to refute them.

Now, we propose in the first place to show, that this law of organic progress is the law of all progress. Whether it be in the development of the Earth, in the development in Life upon its surface, in the development of Society, of Government, of Manufactures, of Commerce, of Language, Literature, Science, Art, this same evolution of the simple into the complex, through a process of continuous differentiation, holds throughout. From the earliest traceable cosmical changes down to the latest results of civilization, we shall find that the transformation of the homogeneous into the heterogeneous is that in which Progress essentially consists.

Of all the constituents of the human body, bone is the hardest, the driest, the earthiest, and the coldest; and, excepting only the teeth, it is devoid of sensation. God, the great Creator of all things, formed its substance to this specification with good reason, intending it to be like a foundation for the whole body; for in the fabric of the human body bones perform the same function as do walls and beams in houses, poles in tents, and keels and ribs in boats.
Bones Differentiated by Function
Some bones, by reason of their strength, form as it were props for the body; these include the tibia, the femur, the spinal vertebrae, and most of the bony framework. Others are like bastions, defense walls, and ramparts, affording natural protection to other parts; examples are the skull, the spines and transverse processes of the vertebrae, the breast bone, the ribs. Others stand in front of the joints between certain bones, to ensure that the joint does not move too loosely or bend to too acute an angle. This is the function of the tiny bones, likened by the professors of anatomy to the size of a sesame seed, which are attached to the second internode of the thumb, the first internode of the other four fingers and the first internodes of the five toes. The teeth, on the other hand, serve specifically to cut, crush, pound and grind our food, and similarly the two ossicles in the organ of hearing perform a specifically auditory function.

On the whole, at least in the author's experience, the preparation of species-specific antiserum fractions and the differentiation of closely related species with precipitin sera for serum proteins does not succeed so regularly as with agglutinins and lysins for blood cells. This may be due to the fact that in the evolutional scale the proteins undergo continuous variations whereas cell antigens are subject to sudden changes not linked by intermediary stages.

The advance from the simple to the complex, through a process of successive differentiations, is seen alike in the earliest changes of the Universe to which we can reason our way back, and in the earliest changes which we can inductively establish; it is seen in the geologic and climatic evolution of the Earth; it is seen in the unfolding of every single organism on its surface, and in the multiplication of kinds of organisms; it is seen in the evolution of Humanity, whether contemplated in the civilized individual, or in the aggregate of races; it is seen in the evolution of Society in respect alike of its political, its religious, and its economical organization; and it is seen in the evolution of all those endless concrete and abstract products of human activity which constitute the environment of our daily life. From the remotest past which Science can fathom, up to the novelties of yesterday, that in which Progress essentially consists, is the transformation of the homogeneous into the heterogeneous.

The integers of language are sentences, and their organs are the parts of speech. Linguistic organization, then, consists in the differentiation of the parts of speech and the integration of the sentence.

The Jewish scriptures admirably illustrate the development from the religion of fear to moral religion, a development continued in the New Testament. The religions of all civilized peoples, especially the peoples of the Orient, are primarily moral religions. The development from a religion of fear to moral religion is a great step in peoples’ lives. And yet, that primitive religions are based entirely on fear and the religions of civilized peoples purely on morality is a prejudice against which we must be on our guard. The truth is that all religions are a varying blend of both types, with this differentiation: that on the higher levels of social life the religion of morality predominates.

The proof given by Wright, that non-adaptive differentiation will occur in small populations owing to “drift,” or the chance fixation of some new mutation or recombination, is one of the most important results of mathematical analysis applied to the facts of neo-mendelism. It gives accident as well as adaptation a place in evolution, and at one stroke explains many facts which puzzled earlier selectionists, notably the much greater degree of divergence shown by island than mainland forms, by forms in isolated lakes than in continuous river-systems.

The theory here developed is that mega-evolution normally occurs among small populations that become preadaptive and evolve continuously (without saltation, but at exceptionally rapid rates) to radically different ecological positions. The typical pattern involved is probably this: A large population is fragmented into numerous small isolated lines of descent. Within these, inadaptive differentiation and random fixation of mutations occur. Among many such inadaptive lines one or a few are preadaptive, i.e., some of their characters tend to fit them for available ecological stations quite different from those occupied by their immediate ancestors. Such groups are subjected to strong selection pressure and evolve rapidly in the further direction of adaptation to the new status. The very few lines that successfully achieve this perfected adaptation then become abundant and expand widely, at the same time becoming differentiated and specialized on lower levels within the broad new ecological zone.

Theory always tends to become abstract as it emerges successfully from the chaos of facts by the processes of differentiation and elimination, whereby the essentials and their connections become recognised, whilst minor effects are seen to be secondary or unessential, and are ignored temporarily, to be explained by additional means.

There is an integration of the present impressions with such past ones as they resemble, and a differentiation of them from such past ones as they do not resemble; and this comparison of present with past impressions, dependent on memory, implies classification, and is the germ of what we call Perception and Reasoning.

While up to this time contrary sexual instinct has had but an anthropological, clinical, and forensic interest for science, now, as a result of the latest investigations, there is some thought of therapy in this incurable condition, which so heavily burdens its victims, socially, morally, and mentally. A preparatory step for the application of therapeutic measures is the exact differentiation of the acquired from the congenital cases; and among the latter again, the assignment of the concrete case to its proper position in the categories that have been established empirically.