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Home > Category Index for Science Quotations > Category Index S > Category: Serum

Serum Quotes (7 quotes)

A single kind of red cell is supposed to have an enormous number of different substances on it, and in the same way there are substances in the serum to react with many different animal cells. In addition, the substances which match each kind of cell are different in each kind of serum. The number of hypothetical different substances postulated makes this conception so uneconomical that the question must be asked whether it is the only one possible. ... We ourselves hold that another, simpler, explanation is possible.
Landsteiner and Adriano Sturli, 'Hamagglutinine normaler Sera', Wiener klinische Wochenschrift (1902), 15, 38-40. Trans. Pauline M. H. Mazumdar.
Science quotes on:  |  Blood (95)  |  Immunology (13)  |  Red Cell (2)

According to the older view, for every single effect of a serum, there was a separate substance, or at least a particular chemical group... A normal serum contained as many different haemagglutinins as it agglutinated different cells. The situation was undoubtedly made much simpler if, to use the Ehrlich terminology... the separate haptophore groups can combine with an extremely large number of receptors in stepwise differing quantities as a stain does with different animal tissues, though not always with the same intensity. A normal serum would therefore visibly affect such a large number of different blood cells... not because it contained countless special substances, but because of the colloids of the serum, and therefore of the agglutinins by reason of their chemical constitution and the electrochemical properties resulting from it. That this manner of representation is a considerable simplification is clear; it also opens the way to direct experimental testing by the methods of structural chemistry.
'Die Theorien der Antikorperbildung ... ', Wiener klinische Wöchenschrift (1909), 22, 1623-1631. Trans. Pauline M. H. Mazumdar.
Science quotes on:  |  Blood (95)  |  Cell (125)  |  Chemistry (239)  |  Colloid (5)  |  Experiment (543)  |  Immunology (13)  |  Structure (191)

I have recently observed and stated that the serum of normal people is capable of clumping the red cells of other healthy individuals... As commonly expressed, it can be said that in these cases at least two different kinds of agglutinins exist, one kind in A, the other in B, both together in C. The cells are naturally insensitive to the agglutinins in their own serum.
Ueber Agglutinationserscheinungen normalen menschlichen Blutes', Wiener klinische Wochenschrift (1901), 14, 1132-1134. Trans. Pauline M. H. Mazumdar.
Science quotes on:  |  Blood (95)  |  Immunology (13)  |  Red Cell (2)

It is probable that serum acts on bacteria by changing the relations of molecular attraction between the bacteria and the surrounding fluid.
In Studies in Immunity (1909), 144.
Science quotes on:  |  Action (151)  |  Attraction (32)  |  Bacteria (32)  |  Change (291)  |  Fluid (18)  |  Molecule (125)  |  Probability (83)  |  Relation (96)  |  Surrounding (11)

The conception that antibodies, which should protect against disease, are also responsible for the disease, sounds at first absurd. This has as its basis the fact that we are accustomed to see in disease only the harm done to the organism and to see in the antibodies solely antitoxic [protective] substances. One forgets too easily that the disease represents only a stage in the development of immunity, and that the organism often attains the advantage of immunity only by means of disease. ... Serum sickness represents, so to speak, an unnatural (artificial) form of disease.
C. von Pirquet and B. Schick, Die Serumkrankheit (1906), trans B. Schick, Serum Sickness (1951), 119-20.
Science quotes on:  |  Absurdity (16)  |  Accustomed (8)  |  Antibody (5)  |  Antitoxin (2)  |  Basis (60)  |  Conception (63)  |  Disease (257)  |  Harm (31)  |  Organism (126)  |  Protection (23)  |  Representation (27)  |  Responsibility (47)  |  Sickness (20)  |  Substance (73)  |  Unnatural (10)

The reactions follow a pattern, which is valid for the blood of all humans... Basically, in fact, there are four different types of human blood, the so-called blood groups. The number of the groups follows from the fact that the erythrocytes evidently contain substances (iso-agglutinogens) with two different structures, of which both may be absent, or one or both present, in the erythrocytes of a person. This alone would still not explain the reactions; the active substances of the sera, the iso-agglutinins, must also be present in a specific distribution. This is actually the case, since every serum contains those agglutinins which react with the agglutinogens not present in the cells—a remarkable phenomenon, the cause of which is not yet known for certain.
'On Individual Differences in Human Blood', Nobel Lecture (11 Dec 1930). In Nobel Lectures: Physiology or Medicine 1922-1941 (1965), 235.
Science quotes on:  |  Agglutinin (2)  |  Blood (95)  |  Pattern (56)  |  Reaction (59)

The study of the serum of immunized animals forms a new chapter in the history of the struggle between the animal and infective agents, under which heading practical results of the highest importance are already inscribed. Any explanation of the phenomena is, however, still far from complete.
In Studies in Immunity (1909), 8.
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Carl Sagan Thumbnail In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion. (1987) -- Carl Sagan
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