… our “Physick” and “Anatomy” have embraced such infinite varieties of being, have laid open such new worlds in time and space, have grappled, not unsuccessfully, with such complex problems, that the eyes of Vesalius and of Harvey might be dazzled by the sight of the tree that has grown out of their grain of mustard seed.

… to explore strange new worlds, to seek out new life and new civilizations, to boldly go where no one has gone before.

…it ought to be remembered that there is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to take the lead in the introduction of a new order of things. Because the innovator has for enemies all those who have done well under the old conditions, and lukewarm defenders in those who may do well under the new.

…resort to science has rendered modern war so destructive of life and property that it presents a new problem to mankind, such, that unless our civilization shall find some means of making an end to war, war will make an end to our civilization.

…there is no prescribed route to follow to arrive at a new idea. You have to make the intuitive leap. But the difference is that once you’ve made the intuitive leap you have to justify it by filling in the intermediate steps. In my case, it often happens that I have an idea, but then I try to fill in the intermediate steps and find that they don’t work, so I have to give it up.

...while science gives us implements to use, science alone does not determine for what ends they will be employed. Radio is an amazing invention. Yet now that it is here, one suspects that Hitler never could have consolidated his totalitarian control over Germany without its use. One never can tell what hands will reach out to lay hold on scientific gifts, or to what employment they will be put. Ever the old barbarian emerges, destructively using the new civilization.

“Crawling at your feet,” said the Gnat … “you may observe a Bread-and-Butterfly. …”
“And what does it live on?”
“Weak tea with cream in it.”
A new difficulty came into Alice's head. “Supposing it couldn't find any?” she suggested.
“Then it would die, of course.”
“But that must happen very often,” Alice remarked thoughtfully.
“It always happens,” said the Gnat.

“Half genius and half buffoon,” Freeman Dyson ... wrote. ... [Richard] Feynman struck him as uproariously American—unbuttoned and burning with physical energy. It took him a while to realize how obsessively his new friend was tunneling into the very bedrock of modern science.

[1665-06-11] I out of doors a little to show forsooth my new suit, and back again; and in going, saw poor Dr Burnets door shut. But he hath, I hear, gained goodwill among his neighbours; for he discovered it himself first, and caused himself to be shut up of his own accord - which was very handsome.

[1665-08-31] Up, and after putting several things in order to my removal to Woolwich, the plague having a great increase this week beyond all expectation, of almost 2000 - making the general Bill 7000, odd 100 and the plague above 6000 .... Thus this month ends, with great sadness upon the public through the greateness of the plague, everywhere through the Kingdom almost. Every day sadder and sadder news of its increase. In the City died this week 7496; and all of them, 6102 of the plague. But it is feared that the true number of the dead this week is near 10000 - partly from the poor that cannot be taken notice of through the greatness of the number, and partly from the Quakers and others that will not have any bell ring for them. As to myself, I am very well; only, in fear of the plague, and as much of an Ague, by being forced to go early and late to Woolwich, and my family to lie there continually.

[1665-09-03] Up, and put on my coloured suit on, very fine, and my new periwig, bought a good while since, but durst not wear, because the plague was in westminster when I bought it; and it is a wonder what will be the fashion after the plague is done as to periwigs, for nobody will dare to buy any haire for fear of the infection - that it had been cut off of heads of people dead of the plague. ... but Lord, to consider the madness of people of the town, who will (because they are forbid) come in crowds along with the dead corps to see them buried. ...

[A plant] does not change itself gradually, but remains unaffected during all succeeding generations. It only throws off new forms, which are sharply contrasted with the parent, and which are from the very beginning as perfect and as constant, as narrowly defined, and as pure of type as might be expected of any species.

[A scientist] naturally and inevitably … mulls over the data and guesses at a solution. [He proceeds to] testing of the guess by new data—predicting the consequences of the guess and then dispassionately inquiring whether or not the predictions are verified.

[A]s you know, scientific education is fabulously neglected … This is an evil that is inherited, passed on from generation to generation. The majority of educated persons are not interested in science, and are not aware that scientific knowledge forms part of the idealistic background of human life. Many believe—in their complete ignorance of what science really is—that it has mainly the ancillary task of inventing new machinery, or helping to invent it, for improving our conditions of life. They are prepared to leave this task to the specialists, as they leave the repairing of their pipes to the plumber. If persons with this outlook decide upon the curriculum of our children, the result is necessarily such as I have just described it.

[About research with big particle accelerators such as the Large Hadron Collider.] I think the primary justification for this sort of science that we do is fundamental human curiosity. ... It's true, of course, that every previous generation that's made some breakthrough in understanding nature has seen those discoveries translated into new technologies, new possibilities for the human race. That may well happen with the Higgs boson. Quite frankly, at the moment I don't see how you can use the Higgs boson for anything useful.

[Alchemists] finde out men so covetous of so much happiness, whom they easily perswade that they shall finde greater Riches in Hydargyrie [mercury], than Nature affords in Gold. Such, whom although they have twice or thrice already been deluded, yet they have still a new Device wherewith to deceive um again; there being no greater Madness…. So that the smells of Coles, Sulphur, Dung, Poyson, and Piss, are to them a greater pleasure than the taste of Honey; till their Farms, Goods, and Patrimonies being wasted, and converted into Ashes and Smoak, when they expect the rewards of their Labours, births of Gold, Youth, and Immortality, after all their Time and Expences; at length, old, ragged, famisht, with the continual use of Quicksilver [mercury] paralytick, onely rich in misery, … a laughing-stock to the people: … compell’d to live in the lowest degree of poverty, and … at length compell’d thereto by Penury, they fall to Ill Courses, as Counterfeiting of Money.

[Antarctica has 90 percent of the world’s ice, and God help us if it melts,] whales will be swimming in the streets of New York.

[Davy's] March of Glory, which he has run for the last six weeks—within which time by the aid and application of his own great discovery, of the identity of electricity and chemical attractions, he has placed all the elements and all their inanimate combinations in the power of man; having decomposed both the Alkalies, and three of the Earths, discovered as the base of the Alkalies a new metal... Davy supposes there is only one power in the world of the senses; which in particles acts as chemical attractions, in specific masses as electricity, & on matter in general, as planetary Gravitation... when this has been proved, it will then only remain to resolve this into some Law of vital Intellect—and all human knowledge will be Science and Metaphysics the only Science.
In November 1807 Davy gave his famous Second Bakerian Lecture at the Royal Society, in which he used Voltaic batteries to “decompose, isolate and name” several new chemical elements, notably sodium and potassium.

[Engineers are] the direct and necessary instrument of coalition by which alone the new social order can commence.

[Gut instinct is more important than expertise.] Muscle memory isn't very helpful when you're charting new territory.

[In relation to business:] Invention must be its keynote—a steady progression from one thing to another. As each in turn approaches a saturated market, something new must be produced.

[In] the evolution of ideas… New ideas are thrown up spontaneously like mutations; the vast majority of them are useless crank theories, the equivalent of biological freaks without survival-value.

[In] the realm of science, … what we have achieved will be obsolete in ten, twenty or fifty years. That is the fate, indeed, that is the very meaning of scientific work. … Every scientific “fulfillment” raises new “questions” and cries out to be surpassed and rendered obsolete. Everyone who wishes to serve science has to resign himself to this.

[J.J.] Sylvester’s methods! He had none. “Three lectures will be delivered on a New Universal Algebra,” he would say; then, “The course must be extended to twelve.” It did last all the rest of that year. The following year the course was to be Substitutions-Théorie, by Netto. We all got the text. He lectured about three times, following the text closely and stopping sharp at the end of the hour. Then he began to think about matrices again. “I must give one lecture a week on those,” he said. He could not confine himself to the hour, nor to the one lecture a week. Two weeks were passed, and Netto was forgotten entirely and never mentioned again. Statements like the following were not unfrequent in his lectures: “I haven’t proved this, but I am as sure as I can be of anything that it must be so. From this it will follow, etc.” At the next lecture it turned out that what he was so sure of was false. Never mind, he kept on forever guessing and trying, and presently a wonderful discovery followed, then another and another. Afterward he would go back and work it all over again, and surprise us with all sorts of side lights. He then made another leap in the dark, more treasures were discovered, and so on forever.

[Luis] Alvarez's whole approach to physics was that of an entrepreneur, taking big risks by building large new projects in the hope of large rewards, although his pay was academic rather than financial. He had drawn around him a group of young physicists anxious to try out the exciting ideas he was proposing.

[N]o scientist likes to be criticized. … But you don’t reply to critics: “Wait a minute, wait a minute; this is a really good idea. I’m very fond of it. It’s done you no harm. Please don’t attack it.” That's not the way it goes. The hard but just rule is that if the ideas don't work, you must throw them away. Don't waste any neurons on what doesn’t work. Devote those neurons to new ideas that better explain the data. Valid criticism is doing you a favor.

[On the 11th day of November 1572], in the evening, after sunset, when, according to my habit, I was contemplating the stars in a clear sky, I noticed that a new and unusual star, surpassing all others in brilliancy, was shining almost directly over my head; and since I had, almost from boyhood, known all the stars of the heavens perfectly (there is no great difficulty in gaining that knowledge), it was quite evident to me that there had never before been any star in that place in the sky, even the smallest, to say nothing of a star so conspicuously bright as this. I was so astonished at this sight that I was not ashamed to doubt the trustworthiness of my own eyes. But when I observed that others, too, on having the place pointed out to them, could see that there was a star there, I had no further doubts. A miracle indeed, either the greatest of all that have occurred in the whole range of nature since the beginning of the world, or one certainly that is to be classed with those attested by the Holy Oracles.

[Pavel Yablochkov’s electric lamp is] the starting point for the creation of a new branch of industry.

[Radius]: You will work. You will build ... You will serve them... Robots of the world... The power of man has fallen... A new world has arisen. The rule of the Robots... March!
The word 'robot' was coined in this play for a new working class of automatons (from the Czech word robota meaning compulsory labour)

[Should Britain fail, then the entire world would] sink into the abyss of a new dark age made more sinister ... by the lights of perverted science.

[Some] philosophers have been of opinion that our immortal part acquires during this life certain habits of action or of sentiment, which become forever indissoluble, continuing after death in a future state of existence ... I would apply this ingenious idea to the generation, or production of the embryon, or new animal, which partakes so much of the form and propensities of the parent.

[Technical courage means the] physician-scientist must be brave enough to adopt new methods. It is far too easy to learn one technique and then to repeat the same experiment over and over. In this fashion one can write many papers, receive large research grants, and remain solidly rooted in the middle of a scientific field. But the true innovator has the confidence to drop one set of experimental crutches and leap to another when he or she must move forward.

[The attitude of the Renaissance towards the antique world was that] Archaeology to them was not a mere science for the antiquarian; it was a means by which they could touch the dry dust of antiquity into the very breath and beauty of life, and fill with the new wine of romanticism forms that else had been old and out-worn.

[The compass needle] as the guide of Vasco de Gama to the East Indies, and of Columbus to the West Indies and the New World, it was pre-eminently the precursor and pioneer of the telegraph. Silently, and as with finger on its lips, it led them across the waste of waters to the new homes of the world; but when these were largely filled, and houses divided between the old and new hemispheres longed to exchange affectionate greetings, it removed its finger and broke silence. The quivering magnetic needle which lies in the coil of the galvanometer is the tongue of the electric telegraph, and already engineers talk of it as speaking.

[The new term] Physicist is both to my mouth and ears so awkward that I think I shall never use it. The equivalent of three separate sounds of i in one word is too much.

[The surplus of basic knowledge of the atomic nucleus was] largely used up [during the war with the atomic bomb as the dividend.] We must, without further delay restore this surplus in preparation for the important peacetime job for the nucleus - power production. ... Many of the proposed applications of atomic power - even for interplanetary rockets - seem to be within the realm of possibility provided the economic factor is ruled out completely, and the doubtful physical and chemical factors are weighted heavily on the optimistic side. ... The development of economic atomic power is not a simple extrapolation of knowledge gained during the bomb work. It is a new and difficult project to reach a satisfactory answer. Needless to say, it is vital that the atomic policy legislation now being considered by the congress recognizes the essential nature of this peacetime job, and that it not only permits but encourages the cooperative research-engineering effort of industrial, government and university laboratories for the task. ... We must learn how to generate the still higher energy particles of the cosmic rays - up to 1,000,000,000 volts, for they will unlock new domains in the nucleus.

[Vikram Sarabhai] always gave new technical knowledge to the engineers and at that moment his face was lit with joy.

[Vikram Sarabhai] informed the whole of his team about any new project and started working on it only after having discussed it with everyone.

[We are] a fragile species, still new to the earth, … here only a few moments as evolutionary time is measured, … in real danger at the moment of leaving behind only a thin layer of of our fossils, radioactive at that.

[When I was a child] I grew up in Brooklyn, New York, and I was a street kid. … [T]here was one aspect of that environment that, for some reason, struck me as different, and that was the stars. … I could tell they were lights in the sky, but that wasn’t an explanation. I mean, what were they? Little electric bulbs on long black wires, so you couldn’t see what they were held up by? What were they? … My mother said to me, "Look, we’ve just got you a library card … get out a book and find the answer.” … It was in there. It was stunning. The answer was that the Sun was a star, except very far away. … The dazzling idea of a universe vast beyond imagining swept over me. … I sensed awe.

[When thinking about the new relativity and quantum theories] I have felt a homesickness for the paths of physical science where there are more or less discernible handrails to keep us from the worst morasses of foolishness.

[Young] was afterwards accustomed to say, that at no period of his life was he particularly fond of repeating experiments, or even of very frequently attempting to originate new ones; considering that, however necessary to the advancement of science, they demanded a great sacrifice of time, and that when the fact was once established, that time was better employed in considering the purposes to which it might be applied, or the principles which it might tend to elucidate.

Πάντα ῥεῖ : all things are in flux. It is inevitable that you are indebted to the past. You are fed and formed by it. The old forest is decomposed for the composition of the new forest. The old animals have given their bodies to the earth to furnish through chemistry the forming race, and every individual is only a momentary fixation of what was yesterday another’s, is today his and will belong to a third to-morrow. So it is in thought.

[About Sir Roderick Impey Murchison:] The enjoyments of elegant life you early chose to abandon, preferring to wander for many successive years over the rudest portions of Europe and Asia—regions new to Science—in the hope, happily realized, of winning new truths.
By a rare union of favourable circumstances, and of personal qualifications equally rare, you have thus been enabled to become the recognized Interpreter and Historian (not without illustrious aid) of the Silurian Period.

[Answering question whether he was tired of life:] Tired! Not so long as there is an undescribed intestinal worm, or the riddle of a fossil bone, or a rhizopod new to me.

[Pechblende] einer eigenthümlichen, selbstständigen metallischen Substanz bestehe. Es fallen folglich auch deren bisherige Benennungen, als: Ресhblende Eisenpecherz, hinweg, welche nun durch einen neuen ausschliessend bezeichnenden Namen zu ersetzen sind. Ich habe dazu den Namen: Uranerz (Uranium) erwählt; zu einigem Andenken, dass die chemische Ausfindung dieses neuen Metallkörpers in die Epoche der astronomischen. Entdeckung des Planeten Uranus gefallen sei.
[Pitchblende] consists of a peculiar, distinct, metallic substance. Therefore its former denominations, pitch-blende, pitch-iron-ore, &c. are no longer applicable, and must be supplied by another more appropriate name.—I have chosen that of uranite, (Uranium), as a kind of memorial, that the chemical discovery of this new metal happened in the period of the astronomical discovery of the new planet Uranus.

[When recording electrical impulses from a frog nerve-muscle preparation seemed to show a tiresomely oscillating electrical artefact—but only when the muscle was hanging unsupported.] The explanation suddenly dawned on me ... a muscle hanging under its own weight ought, if you come to think of it, to be sending sensory impulses up the nerves coming from the muscle spindles ... That particular day’s work, I think, had all the elements that one could wish for. The new apparatus seemed to be misbehaving very badly indeed, and I suddenly found it was behaving so well that it was opening up an entire new range of data ... it didn’t involve any particular hard work, or any particular intelligence on my part. It was just one of those things which sometimes happens in a laboratory if you stick apparatus together and see what results you get.

Air Force Chief of Staff: Doctor, what do you think of our new creation, the … Corporation?
von Kármán: Why, General, I think that corporation has already had an effect on the whole industry.
Air Force Chief of Staff: I’m delighted. What effect is that?
von Kármán: Why, they’ve upset the salary schedule of the whole industry.

An diesen Apparate ist nichts neu als seine Einfachkeit und die vollkommene zu Verlaessigkeit, welche er gewaehst.
In this apparatus is nothing new but its simplicity and thorough trustworthiness.
On his revolutionary method of organic analysis.

Compounds formed by chemical attraction, possess new properties different from those of their component parts... chemists have long believed that the contrary took place in their combination. They thought, in fact, that the compounds possessed properties intermediate between those of their component parts; so that two bodies, very coloured, very sapid, or insapid, soluble or insoluble, fusible or infusible, fixed or volatile, assumed in chemical combination, a shade or colour, or taste, solubility or volatility, intermediate between, and in some sort composed of, the same properties which were considered in their principles. This is an illusion or error which modern chemistry is highly interested to overthrow.

Dilbert: It took weeks but I’ve calculated a new theory about the origin of the universe. According to my calculations it didn’t start with a “Big Bang” at all—it was more of “Phhbwt” sound. You may be wondering about the practical applications of the “Little Phhbwt” theory.
Dogbert: I was wondering when you’ll go away.

Dilbert: Wow! According to my computer simulation, it should be possible to create new life forms from common household chemicals
Dogbert: This raises some thorny issues.
Dilbert: You mean legal, ethical and religious issues?
Dogbert: I was thinking about parking spaces.

Eine neue wissenschaftliche Wahrheit pflegt sich nicht in der Weise durchzusetzen, daß ihre Gegner überzeugt werden und sich als belehrt erklären, sondern vielmehr dadurch, daß ihre Gegner allmählich aussterben und daß die heranwachsende Generation von vornherein mit der Wahrheit vertraut gemacht ist.
A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather its opponents eventually die, and a new generation grows up that is familiar with it.

Ich have auf eine geringe Vermutung eine gefährliche Reise gewagt und erblicke schon die Vorgebirge neuer Länder. Diejenigen, welche die Herzhaftigheit haben die Untersuchung fortzusetzen, werden sie betreten.
Upon a slight conjecture [on the origin of the solar system] I have ventured on a dangerous journey and I already behold the foothills of new lands. Those who have the courage to continue the search will set foot on them.

If the Indians hadn’t spent the $24. In 1626 Peter Minuit, first governor of New Netherland, purchased Manhattan Island from the Indians for about $24. … Assume for simplicity a uniform rate of 7% from 1626 to the present, and suppose that the Indians had put their $24 at [compound] interest at that rate …. What would be the amount now, after 280 years? 24 x (1.07)280 = more than 4,042,000,000.
The latest tax assessment available at the time of writing gives the realty for the borough of Manhattan as $3,820,754,181. This is estimated to be 78% of the actual value, making the actual value a little more than $4,898,400,000.
The amount of the Indians’ money would therefore be more than the present assessed valuation but less than the actual valuation.

In artibus et scientiis, tanquam in metalli fodinis, omnia novis operibus et ulterioribus progressibus circumstrepere debent
But arts and sciences should be like mines, where the noise of new works and further advances is heard on every side.

La nature veut que dans certains temps les hommes se succèdent les uns aux autres par le moyen de la mort; il leur est permis de se défendre contr’elle jusqu’à un certain point; mais passé cela, on aura beau faire de nouvelles découvertes dans l’Anatomie, on aura beau pénétrer de plus en plus dans les secrets de la structure du corps humain, on ne prendra point la Nature pour dupe, on mourra comme à l’ordinaire.
Nature intends that at fixed periods men should succeed each other by the instrumentality of death. They are allowed to keep it at bay up to a certain point; but when that is passed, it will be of no use to make new discoveries in anatomy, or to penetrate more and more into the secrets of the structure of the human body; we shall never outwit nature, we shall die as usual.

La théorie est l’hypothèse vérifiée, après qu’elle a été soumise au contrôle du raisonnement et de la critique expérimentale. La meilleure théorie est celle qui a été vérifiée par le plus grand nombre de faits. Mais une théorie, pour rester bonne, doit toujours se modifier avec les progrès de la science et demeurer constamment soumise à la vérification et à la critique des faits nouveaux qui apparaissent.
A theory is a verified hypothesis, after it has been submitted to the control of reason and experimental criticism. The soundest theory is one that has been verified by the greatest number of facts. But to remain valid, a theory must be continually altered to keep pace with the progress of science and must be constantly resubmitted to verification and criticism as new facts appear.

Le seul véritable voyage ... ce ne serait pas d’aller vers de nouveaux paysages, mais d’avoir d’autres yeux, de voir l’univers avec les yeux d’un autre, de cent autres, de voir les cent univers que chacun d’eux voit …
The only true voyage of discovery … would be not to visit new landscapes, but to possess other eyes, to see the universe through the eyes of another, of a hundred others, to see the hundred universes that each of them sees.
[Also often seen translated in the shortened form: 'The only real voyage of discovery consists not in seeing new landscapes, but in having new eyes.']

Les Leucocytes Et L'esprit De Sacrifice. — Il semble, d'après les recherches de De Bruyne (Phagocytose, 1895) et de ceux qui le citent, que les leucocytes des Lamellibranches — probablement lorsqu'ils ont phagocyté, qu'ils se sont chargés de résidus et de déchets, qu'ils ont, en un mot, accompli leur rôle et bien fait leur devoir — sortent du corps de l'animal et vont mourir dans le milieu ambiant. Ils se sacrifient. Après avoir si bien servi l'organisme par leur activité, ils le servent encore par leur mort en faisant place aux cellules nouvelles, plus jeunes.
N'est-ce pas la parfaite image du désintéressement le plus noble, et n'y a-t-il point là un exemple et un modèle? Il faut s'en inspirer: comme eux, nous sommes les unités d'un grand corps social; comme eux, nous pouvons le servir et envisager la mort avec sérénité, en subordonnant notre conscience individuelle à la conscience collective. (30 Jan 1896)
Leukocytes and The Spirit Of Sacrifice. - It seems, according to research by De Bruyne (Phagocytosis, 1885) and those who quote it, that leukocytes of Lamellibranches [bivalves] - likely when they have phagocytized [ingested bacteria], as they become residues and waste, they have, in short, performed their role well and done their duty - leave the body of the animal and will die in the environment. They sacrifice themselves. Having so well served the body by their activities, they still serve in their death by making room for new younger cells.
Isn't this the perfect image of the noblest selflessness, and thereby presents an example and a model? It should be inspiring: like them, we are the units of a great social body, like them, we can serve and contemplate death with equanimity, subordinating our individual consciousness to collective consciousness.

Neue Phaenomena zu erklären, dieses macht meine Sorgen aus, und wie froh ist der Forscher, wenn er das so fleissig Gesuche findet, eine Ergötzung wobei das Herz lacht.
To explain new phenomena, that is my task; and how happy is the scientist when he finds what he so diligently sought, a pleasure that gladdens the heart.

Remarking about Frederick Sanger who used the new technique of paper chromotography:
They are not chemists there, just a lot of paper hangers.

Science for the Citizen is ... also written for the large and growing number of adolescents, who realize that they will be the first victims of the new destructive powers of science misapplied.

The Annotated Alice, of course, does tie in with math, because Lewis Carroll was, as you know, a professional mathematician. So it wasn’t really too far afield from recreational math, because the two books are filled with all kinds of mathematical jokes. I was lucky there in that I really didn’t have anything new to say in The Annotated Alice because I just looked over the literature and pulled together everything in the form of footnotes. But it was a lucky idea because that’s been the best seller of all my books.

The Water-baby story character, Tom, asks: 'I heard, ma'am, that you were always making new beasts out of old.'
Mother Carey [Mother Nature] replies: 'So people fancy. But I am not going to trouble myself to make things, my little dear. I sit here and make them make themselves.'
[The author's indirect reference to evolution.]

Wenn sich für ein neues Fossil kein, auf eigenthümliche Eigenschaften desselben hinweisender, Name auffinden lassen Will; als in welchem Falle ich mich bei dem gegenwärtigen zu befinden gestehe; so halte ich es für besser, eine solche Benennung auszuwählen, die an sich gar nichts sagt, und folglich auch zu keinen unrichtigen Begriffen Anlass geben kann. Diesem zufolge will ich den Namen für die gegenwärtige metallische Substanz, gleichergestalt wie bei dem Uranium geschehen, aus der Mythologie, und zwar von den Ursöhnen der Erde, den Titanen, entlehnen, und benenne also dieses neue Metallgeschlecht: Titanium.
Wherefore no name can be found for a new fossil [element] which indicates its peculiar and characteristic properties (in which position I find myself at present), I think it is best to choose such a denomination as means nothing of itself and thus can give no rise to any erroneous ideas. In consequence of this, as I did in the case of Uranium, I shall borrow the name for this metallic substance from mythology, and in particular from the Titans, the first sons of the earth. I therefore call this metallic genus TITANIUM.

~~[Attributed, authorship undocumented]~~ Mathematical demonstrations are a logic of as much or more use, than that commonly learned at schools, serving to a just formation of the mind, enlarging its capacity, and strengthening it so as to render the same capable of exact reasoning, and discerning truth from falsehood in all occurrences, even in subjects not mathematical. For which reason it is said, the Egyptians, Persians, and Lacedaemonians seldom elected any new kings, but such as had some knowledge in the mathematics, imagining those, who had not, men of imperfect judgments, and unfit to rule and govern.

~~[Questionable attribution]~~ Travel and change of place impart new vigor to the mind.

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

A carriage (steam) will set out from Washington in the morning, the passengers will breakfast at Baltimore, dine at Philadelphia, and sup in New York the same day.

A child of the new generation
Refused to learn multiplication.
He said “Don’t conclude
That I’m stupid or rude;
I am simply without motivation.”

A child’s world is fresh and new and beautiful, full of wonder and excitement. It is our misfortune that for most of us that clear-eyed vision, that true instinct for what is beautiful and awe-inspiring, is dimmed and even lost before we reach adulthood.

A discovery in science, or a new theory, even when it appears most unitary and most all-embracing, deals with some immediate element of novelty or paradox within the framework of far vaster, unanalysed, unarticulated reserves of knowledge, experience, faith, and presupposition. Our progress is narrow; it takes a vast world unchallenged and for granted. This is one reason why, however great the novelty or scope of new discovery, we neither can, nor need, rebuild the house of the mind very rapidly. This is one reason why science, for all its revolutions, is conservative. This is why we will have to accept the fact that no one of us really will ever know very much. This is why we shall have to find comfort in the fact that, taken together, we know more and more.

A disease which new and obscure to you, Doctor, will be known only after death; and even then not without an autopsy will you examine it with exacting pains. But rare are those among the extremely busy clinicians who are willing or capable of doing this correctly.

A few days afterwards, I went to him [the same actuary referred to in another quote] and very gravely told him that I had discovered the law of human mortality in the Carlisle Table, of which he thought very highly. I told him that the law was involved in this circumstance. Take the table of the expectation of life, choose any age, take its expectation and make the nearest integer a new age, do the same with that, and so on; begin at what age you like, you are sure to end at the place where the age past is equal, or most nearly equal, to the expectation to come. “You don’t mean that this always happens?”—“Try it.” He did try, again and again; and found it as I said. “This is, indeed, a curious thing; this is a discovery!” I might have sent him about trumpeting the law of life: but I contented myself with informing him that the same thing would happen with any table whatsoever in which the first column goes up and the second goes down.

A good theoretical physicist today might find it useful to have a wide range of physical viewpoints and mathematical expressions of the same theory (for example, of quantum electrodynamics) available to him. This may be asking too much of one man. Then new students should as a class have this. If every individual student follows the same current fashion in expressing and thinking about electrodynamics or field theory, then the variety of hypotheses being generated to understand strong interactions, say, is limited. Perhaps rightly so, for possibly the chance is high that the truth lies in the fashionable direction. But, on the off-chance that it is in another direction—a direction obvious from an unfashionable view of field theory—who will find it?

A great ball of fire about a mile in diameter, changing colors as it kept shooting upward, from deep purple to orange, expanding, growing bigger, rising as it was expanding, an elemental force freed from its bonds after being chained for billions of years.
On the first atomic explosion in New Mexico, 16 Jul 1945.

A human being should be able to change a diaper, plan an invasion, butcher a hog, conn a ship, design a building, write a sonnet, balance accounts, build a wall, set a bone, comfort the dying, take orders, give orders, cooperate, act alone, solve equations, analyze a new problem, pitch manure, program a computer, cook a tasty meal, fight efficiently, die gallantly. Specialization is for insects.

A key concept is that security is an enabler, not a disabler. … Security … enables you to keep your job, security enables you to move into new markets, security enables you to have confidence in what you’re doing.

A lot of scientific papers do deal with matters of atheoretical fact ... for example, whenever somebody finds a new “world's largest dinosaur,” which has only slightly more scientific relevance than shooting the record moose. In short, not everything that gets published in scientific journals bears the distinctive hallmarks of science.

A man who writes a great deal and says little that is new writes himself into a daily declining reputation. When he wrote less he stood higher in people’s estimation, even though there was nothing in what he wrote. The reason is that then they still expected better things of him in the future, whereas now they can view the whole progression.

A man with a new idea is a crank until he succeeds.

A million million spermatozoa,
All of them alive:
Out of their cataclysm but one poor Noah
Dare hope to survive.
And among that billion minus one
Might have chanced to be Shakespeare, another Newton, a new Donne—
But the One was Me.

A mind that is stretched by a new idea can never go back to its original dimensions.

A moment’s consideration of this case shows what a really great advance in the theory and practise of breeding has been obtained through the discovery of Mendel’s law. What a puzzle this case would have presented to the biologist ten years ago! Agouti crossed with chocolate gives in the second filial generation (not in the first) four varieties, viz., agouti, chocolate, black and cinnamon. We could only have shaken our heads and looked wise (or skeptical).
Then we had no explanation to offer for such occurrences other than the “instability of color characters under domestication,” the “effects of inbreeding,” “maternal impressions.” Serious consideration would have been given to the proximity of cages containing both black and cinnamon-agouti mice.
Now we have a simple, rational explanation, which anyone can put to the test. We are able to predict the production of new varieties, and to produce them.
We must not, of course, in our exuberance, conclude that the powers of the hybridizer know no limits. The result under consideration consists, after all, only in the making of new combinations of unit characters, but it is much to know that these units exist and that all conceivable combinations of them are ordinarily capable of production. This valuable knowledge we owe to the discoverer and to the rediscoverers of Mendel’s law.

A nation which depends upon others for its new basic scientific knowledge will be slow in its industrial progress and weak in its competitive position in world trade, regardless of its mechanical skill.

A New Arithmetic: “I am not much of a mathematician,” said the cigarette, “but I can add nervous troubles to a boy, I can subtract from his physical energy, I can multiply his aches and pains, I can divide his mental powers, I can take interest from his work and discount his chances for success.”

A new cigarette offers coupons good for a cemetery lot.

A new era of ocean exploration can yield discoveries that will help inform everything from critical medical advances to sustainable forms of energy. Consider that AZT, an early treatment for HIV, is derived from a Caribbean reef sponge, or that a great deal of energy—from offshore wind, to OTEC (ocean thermal energy conservation), to wind and wave energy—is yet untapped in our oceans.

A new species develops if a population which has become geographically isolated from its parental species acquires during this period of isolation characters which promote or guarantee reproductive isolation when the external barriers break down.

A new theory is guilty until proven innocent, and the pre-existing theory innocent until proven guilty ... Continental drift was guilty until proven innocent.

A new truth is a truth, an old error is an error.

A plain, reasonable working man supposes, in the old way which is also the common-sense way, that if there are people who spend their lives in study, whom he feeds and keeps while they think for him—then no doubt these men are engaged in studying things men need to know; and he expects of science that it will solve for him the questions on which his welfare, and that of all men, depends. He expects science to tell him how he ought to live: how to treat his family, his neighbours and the men of other tribes, how to restrain his passions, what to believe in and what not to believe in, and much else. And what does our science say to him on these matters?
It triumphantly tells him: how many million miles it is from the earth to the sun; at what rate light travels through space; how many million vibrations of ether per second are caused by light, and how many vibrations of air by sound; it tells of the chemical components of the Milky Way, of a new element—helium—of micro-organisms and their excrements, of the points on the hand at which electricity collects, of X rays, and similar things.
“But I don't want any of those things,” says a plain and reasonable man—“I want to know how to live.”

A religion old or new, that stressed the magnificence of the universe as revealed by modern science, might be able to draw forth reserves of reverence and awe hardly tapped by the conventional faiths. Sooner or later such a religion will emerge.

A schism has taken place among the chemists. A particular set of them in France have undertaken to remodel all the terms of the science, and to give every substance a new name, the composition, and especially the termination of which, shall define the relation in which it stands to other substances of the same family, But the science seems too much in its infancy as yet, for this reformation; because in fact, the reformation of this year must be reformed again the next year, and so on, changing the names of substances as often as new experiments develop properties in them undiscovered before. The new nomenclature has, accordingly, been already proved to need numerous and important reformations. ... It is espoused by the minority here, and by the very few, indeed, of the foreign chemists. It is particularly rejected in England.

A scientist can be productive in various ways. One is having the ability to plan and carry out experiments, but the other is having the ability to formulate new ideas, which can be about what experiments can be carried out … by making [the] proper calculations. Individual scientists who are successful in their work are successful for different reasons.

A scientist can discover a new star but he cannot make one. He would have to ask an engineer to do it for him.

A scientist strives to understand the work of Nature. But with our insufficient talents as scientists, we do not hit upon the truth all at once. We must content ourselves with tracking it down, enveloped in considerable darkness, which leads us to make new mistakes and errors. By diligent examination, we may at length little by little peel off the thickest layers, but we seldom get the core quite free, so that finally we have to be satisfied with a little incomplete knowledge.

A short, broad man of tremendous vitality, the physical type of Hereward, the last of the English, and his brother-in-arms, Winter, Sylvester’s capacious head was ever lost in the highest cloud-lands of pure mathematics. Often in the dead of night he would get his favorite pupil, that he might communicate the very last product of his creative thought. Everything he saw suggested to him something new in the higher algebra. This transmutation of everything into new mathematics was a revelation to those who knew him intimately. They began to do it themselves. His ease and fertility of invention proved a constant encouragement, while his contempt for provincial stupidities, such as the American hieroglyphics for π and e, which have even found their way into Webster’s Dictionary, made each young worker apply to himself the strictest tests.

A student who wishes now-a-days to study geometry by dividing it sharply from analysis, without taking account of the progress which the latter has made and is making, that student no matter how great his genius, will never be a whole geometer. He will not possess those powerful instruments of research which modern analysis puts into the hands of modern geometry. He will remain ignorant of many geometrical results which are to be found, perhaps implicitly, in the writings of the analyst. And not only will he be unable to use them in his own researches, but he will probably toil to discover them himself, and, as happens very often, he will publish them as new, when really he has only rediscovered them.

Abstruse mathematical researches … are … often abused for having no obvious physical application. The fact is that the most useful parts of science have been investigated for the sake of truth, and not for their usefulness. A new branch of mathematics, which has sprung up in the last twenty years, was denounced by the Astronomer Royal before the University of Cambridge as doomed to be forgotten, on account of its uselessness. Now it turns out that the reason why we cannot go further in our investigations of molecular action is that we do not know enough of this branch of mathematics.

According to Herr Cook's observation, the inhabitants of New Guinea have something they set light to which burns up almost like gunpowder. They also put it into hollow staves, and from a distance you could believe they are shooting. But it does not produce so much as a bang. Presumably they are trying to imitate the Europeans. They have failed to realize its real purpose.

Accurate and minute measurement seems to the non-scientific imagination, a less lofty and dignified work than looking for something new. But nearly all the grandest discoveries of science have been but the rewards of accurate measurement and patient long-continued labour in the minute sifting of numerical results.

Adventure isn’t hanging on a rope off the side of a mountain. Adventure is an attitude that we must apply to the day to day obstacles of life - facing new challenges, seizing new opportunities, testing our resources against the unknown and in the process, discovering our own unique potential.

After a tremendous task has been begun in our time, first by Copernicus and then by many very learned mathematicians, and when the assertion that the earth moves can no longer be considered something new, would it not be much better to pull the wagon to its goal by our joint efforts, now that we have got it underway, and gradually, with powerful voices, to shout down the common herd, which really does not weigh arguments very carefully?

After having a wash I proceeded to the bar where—believe it or not—there was a white-coated barman who was not only serving drinks but also cigarettes! I hastened forward and rather timidly said ‘Can I have some cigarettes?’
‘What’s your rank?’ was the slightly unexpected reply.
‘I am afraid I haven’t got one,’ I answered.
‘Nonsense—everyone who comes here has a rank.’
‘I’m sorry but I just don’t have one.’
‘Now that puts me in a spot,’ said the barman, ‘for orders about cigarettes in this camp are clear—twenty for officers and ten for other ranks. Tell me what exactly are you?’
Now I really wanted those cigarettes so I drew myself up and said ‘I am the Professor of Chemistry at Manchester University.’
The barman contemplated me for about thirty seconds and then said ‘I’ll give you five.’
Since that day I have had few illusions about the importance of professors!

After the birth of printing books became widespread. Hence everyone throughout Europe devoted himself to the study of literature... Every year, especially since 1563, the number of writings published in every field is greater than all those produced in the past thousand years. Through them there has today been created a new theology and a new jurisprudence; the Paracelsians have created medicine anew and the Copernicans have created astronomy anew. I really believe that at last the world is alive, indeed seething, and that the stimuli of these remarkable conjunctions did not act in vain.

After the planet becomes theirs, many millions of years will have to pass before a beetle particularly loved by God, at the end of its calculations will find written on a sheet of paper in letters of fire that energy is equal to the mass multiplied by the square of the velocity of light. The new kings of the world will live tranquilly for a long time, confining themselves to devouring each other and being parasites among each other on a cottage industry scale.

Alike fantastic, if too new, or old;
Be not the first by whom the new are try'd,
Not yet the last to lay the old aside.

All fossil anthropoids found hitherto have been known only from mandibular or maxillary fragments, so far as crania are concerned, and so the general appearance of the types they represented had been unknown; consequently, a condition of affairs where virtually the whole face and lower jaw, replete with teeth, together with the major portion of the brain pattern, have been preserved, constitutes a specimen of unusual value in fossil anthropoid discovery. Here, as in Homo rhodesiensis, Southern Africa has provided documents of higher primate evolution that are amongst the most complete extant. Apart from this evidential completeness, the specimen is of importance because it exhibits an extinct race of apes intermediate between living anthropoids and man ... Whether our present fossil is to be correlated with the discoveries made in India is not yet apparent; that question can only be solved by a careful comparison of the permanent molar teeth from both localities. It is obvious, meanwhile, that it represents a fossil group distinctly advanced beyond living anthropoids in those two dominantly human characters of facial and dental recession on one hand, and improved quality of the brain on the other. Unlike Pithecanthropus, it does not represent an ape-like man, a caricature of precocious hominid failure, but a creature well advanced beyond modern anthropoids in just those characters, facial and cerebral, which are to be anticipated in an extinct link between man and his simian ancestor. At the same time, it is equally evident that a creature with anthropoid brain capacity and lacking the distinctive, localised temporal expansions which appear to be concomitant with and necessary to articulate man, is no true man. It is therefore logically regarded as a man-like ape. I propose tentatively, then, that a new family of Homo-simidæ be created for the reception of the group of individuals which it represents, and that the first known species of the group be designated Australopithecus africanus, in commemoration, first, of the extreme southern and unexpected horizon of its discovery, and secondly, of the continent in which so many new and important discoveries connected with the early history of man have recently been made, thus vindicating the Darwinian claim that Africa would prove to be the cradle of mankind.

All minds quote. Old and new make the warp and woof of every moment. There is no thread that is not a twist of these two strands.

All my life through, the new sights of Nature made me rejoice like a child.

All scientists must focus closely on limited targets. Whether or not one’s findings on a limited subject will have wide applicability depends to some extent on chance, but biologists of superior ability repeatedly focus on questions the answers to which either have wide ramifications or lead to new areas of investigation. One procedure that can be effective is to attempt both reduction and synthesis; that is, direct a question at a phenomenon on one integrative level, identify its mechanism at a simpler level, then extrapolate its consequences to a more complex level of integration.

All the species recognized by Botanists came forth from the Almighty Creator’s hand, and the number of these is now and always will be exactly the same, while every day new and different florists’ species arise from the true species so-called by Botanists, and when they have arisen they finally revert to the original forms. Accordingly to the former have been assigned by Nature fixed limits, beyond which they cannot go: while the latter display without end the infinite sport of Nature.

Almost all really new ideas have a certain aspect of foolishness when they are first produced.

Almost always the men who achieve these fundamental inventions of a new paradigm have been either very young or very new to the field whose paradigm they change.

Almost daily we shudder as prophets of doom announce the impending end of civilization and universe. We are being asphyxiated, they say, by the smoke of the industry; we are suffocating in the ever growing mountain of rubbish. Every new project depicts its measureable effects and is denounced by protesters screaming about catastrophe, the upsetting of the land, the assault on nature. If we accepted this new mythology we would have to stop pushing roads through the forest, harnessing rivers to produce the electricity, breaking grounds to extract metals, enriching the soil with chemicals, killing insects, combating viruses … But progress—basically, an effort to organise a corner of land and make it more favourable for human life—cannot be baited. Without the science of pomiculture, for example, trees will bear fruits that are small, bitter, hard, indigestible, and sour. Progress is desirable.

Almost everyone... seems to be quite sure that the differences between the methodologies of history and of the natural sciences are vast. For, we are assured, it is well known that in the natural sciences we start from observation and proceed by induction to theory. And is it not obvious that in history we proceed very differently? Yes, I agree that we proceed very differently. But we do so in the natural sciences as well.
In both we start from myths—from traditional prejudices, beset with error—and from these we proceed by criticism: by the critical elimination of errors. In both the role of evidence is, in the main, to correct our mistakes, our prejudices, our tentative theories—that is, to play a part in the critical discussion, in the elimination of error. By correcting our mistakes, we raise new problems. And in order to solve these problems, we invent conjectures, that is, tentative theories, which we submit to critical discussion, directed towards the elimination of error.

Although I was four years at the University [of Wisconsin], I did not take the regular course of studies, but instead picked out what I thought would be most useful to me, particularly chemistry, which opened a new world, mathematics and physics, a little Greek and Latin, botany and and geology. I was far from satisfied with what I had learned, and should have stayed longer.
[Enrolled in Feb 1861, left in 1863 without completing a degree, and began his first botanical foot journey.]

America, so far as her physical history is concerned, has been falsely denominated the New World. Hers was the first dry land lifted out of the waters, hers the first shore washed by the ocean that enveloped all the earth beside; and while Europe was represented only by islands rising here and there above the sea, America already stretched an unbroken line of land from Nova Scotia to the Far West.

Among the current discussions, the impact of new and sophisticated methods in the study of the past occupies an important place. The new 'scientific' or 'cliometric' history—born of the marriage contracted between historical problems and advanced statistical analysis, with economic theory as bridesmaid and the computer as best man—has made tremendous advances in the last generation.

Among the multitude of animals which scamper, fly, burrow and swim around us, man is the only one who is not locked into his environment. His imagination, his reason, his emotional subtlety and toughness, make it possible for him not to accept the environment, but to change it. And that series of inventions, by which man from age to age has remade his environment, is a different kind of evolution—not biological, but cultural evolution. I call that brilliant sequence of cultural peaks The Ascent of Man. I use the word ascent with a precise meaning. Man is distinguished from other animals by his imaginative gifts. He makes plans, inventions, new discoveries, by putting different talents together; and his discoveries become more subtle and penetrating, as he learns to combine his talents in more complex and intimate ways. So the great discoveries of different ages and different cultures, in technique, in science, in the arts, express in their progression a richer and more intricate conjunction of human faculties, an ascending trellis of his gifts.

Among the studies to which the [Rockefeller] Foundation is giving support is a series in a relatively new field, which may be called molecular biology, in which delicate modern techniques are being used to investigate ever more minute details of certain life processes.

An article in Bioscience in November 1987 by Julie Ann Miller claimed the cortex was a “quarter-meter square.” That is napkin-sized, about ten inches by ten inches. Scientific American magazine in September 1992 upped the ante considerably with an estimate of 1½ square meters; that’s a square of brain forty inches on each side, getting close to the card-table estimate. A psychologist at the University of Toronto figured it would cover the floor of his living room (I haven’t seen his living room), but the prize winning estimate so far is from the British magazine New Scientist’s poster of the brain published in 1993 which claimed that the cerebral cortex, if flattened out, would cover a tennis court. How can there be such disagreement? How can so many experts not know how big the cortex is? I don’t know, but I’m on the hunt for an expert who will say the cortex, when fully spread out, will cover a football field. A Canadian football field.