Carcinogenesis Quotes (2 quotes)
Melvin Calvin was a fearless scientist, totally unafraid to venture into new fields such as hot atom chemistry, carcinogenesis, chemical evolution and the origin of life, organic geochemistry, immunochemistry, petroleum production from plants, farming, Moon rock analysis, and development of novel synthetic biomembrane models for plant photosystems.
Co-author with Andrew A. Benson, 'Melvin Calvin', Biographical Memoirs of the US National Academy of Science.
These results demonstrate that there is a new polymerase inside the virions of RNA tumour viruses. It is not present in supernatents of normal cells but is present in virions of avian sarcoma and leukemia RNA tumour viruses. The polymerase seems to catalyse the incorporation of deoxyrinonucleotide triphosphates into DNA from an RNA template. Work is being performed to characterize further the reaction and the product. If the present results and Baltimore's results with Rauscher leukemia virus are upheld, they will constitute strong evidence that the DNA proviruses have a DNA genome when they are in virions. This result would have strong implications for theories of viral carcinogenesis and, possibly, for theories of information transfer in other biological systems. [Co-author with American virologist Satoshi Mizutani]
'RNA-dependent DNA Polymerase in Virions of Rous Sarcoma Virus', Nature (1970), 226, 1213.