Tumour Quotes (2 quotes)
A man of about fifty-four years of age, had begun, five or six months before, to be somewhat emaciated in his whole body...a troublesome vomiting came on, of a fluid which resembl’d water, tinctur’d with soot.... Death took place.... In the stomach...was an ulcerated cancerous tumour.... Betwixt the stomach and the spleen were two glandular bodies, of the bigness of a bean, and in their colour, and substance, not much unlike that tumour which I have describ’d in the stomach.
These results demonstrate that there is a new polymerase inside the virions of RNA tumour viruses. It is not present in supernatents of normal cells but is present in virions of avian sarcoma and leukemia RNA tumour viruses. The polymerase seems to catalyse the incorporation of deoxyrinonucleotide triphosphates into DNA from an RNA template. Work is being performed to characterize further the reaction and the product. If the present results and Baltimore's results with Rauscher leukemia virus are upheld, they will constitute strong evidence that the DNA proviruses have a DNA genome when they are in virions. This result would have strong implications for theories of viral carcinogenesis and, possibly, for theories of information transfer in other biological systems. [Co-author with American virologist Satoshi Mizutani]