“One and one make two” assumes that the changes in the shift of circumstance are unimportant. But it is impossible for us to analyze this notion of unimportant change.

[Using mice as model systems for genetic engineering in biomedicine, instead of bacterial or yeast systems matters because] this transition will have as big an impact on the future of biology as the shift from printing presses to video technology has had on pop culture. A mouse-based world looks and feels different from one viewed through microorganisms.

A collective learning machine achieves its feats by using five elements … (1) conformity enforcers; (2) diversity generators; (3) inner-judges; (4) resource shifters; and (5) intergroup tournaments.

A grove of giant redwoods or sequoias should be kept just as we keep a great or beautiful cathedral. The extermination of the passenger pigeon meant that mankind was just so much poorer; exactly as in the case of the destruction of the cathedral at Rheims. And to lose the chance to see frigate-birds soaring in circles above the storm, or a file of pelicans winging their way homeward across the crimson afterglow of the sunset, or a myriad terns flashing in the bright light of midday as they hover in a shifting maze above the beach—why, the loss is like the loss of a gallery of the masterpieces of the artists of old time.

A single tree by itself is dependent upon all the adverse chances of shifting circumstances. The wind stunts it: the variations in temperature check its foliage: the rains denude its soil: its leaves are blown away and are lost for the purpose of fertilisation. You may obtain individual specimens of line trees either in exceptional circumstances, or where human cultivation had intervened. But in nature the normal way in which trees flourish is by their association in a forest. Each tree may lose something of its individual perfection of growth, but they mutually assist each other in preserving the conditions of survival. The soil is preserved and shaded; and the microbes necessary for its fertility are neither scorched, nor frozen, nor washed away. A forest is the triumph of the organisation of mutually dependent species.

Are you aware that humanity is just a blip? Not even a blip. Just a fraction of a fraction of what the universe has been and will become? Talk about perspective. I figure I can’t feel so entirely stupid about saying what I said because, first of all, it’s true. And second of all, there will be no remnant of me or my stupidity. No fossil or geographical shift that can document, really, even the most important historical human beings, let alone my paltry admissions.

At the beginning of its existence as a science, biology was forced to take cognizance of the seemingly boundless variety of living things, for no exact study of life phenomena was possible until the apparent chaos of the distinct kinds of organisms had been reduced to a rational system. Systematics and morphology, two predominantly descriptive and observational disciplines, took precedence among biological sciences during the eighteenth and nineteenth centuries. More recently physiology has come to the foreground, accompanied by the introduction of quantitative methods and by a shift from the observationalism of the past to a predominance of experimentation.

Euclid alone has looked on Beauty bare.
Let all who prate of Beauty hold their peace,
And lay them prone upon the earth and cease
To ponder on themselves, the while they stare
At nothing, intricately drawn nowhere
In shapes of shifting lineage; let geese
Gabble and hiss, but heroes seek release
From dusty bondage into luminous air.
O blinding hour, O holy, terrible day,
When first the shaft into his vision shone
Of light anatomized! Euclid alone
Has looked on Beauty bare. Fortunate they
Who, though once only and then but far away,
Have heard her massive sandal set on stone.

For nothing is fixed, forever and forever and forever, it is not fixed; the earth is always shifting, the light is always changing, the sea does not cease to grind down rock. Generations do not cease to be born, and we are responsible to them because we are the only witnesses they have. The sea rises, the light fails, lovers cling to each other, and children cling to us. The moment we cease to hold each other, the sea engulfs us and the light goes out.

How then did we come to the “standard model”? And how has it supplanted other theories, like the steady state model? It is a tribute to the essential objectivity of modern astrophysics that this consensus has been brought about, not by shifts in philosophical preference or by the influence of astrophysical mandarins, but by the pressure of empirical data.

I can hear the sizzle of newborn stars, and know anything of meaning, of the fierce magic emerging here. I am witness to flexible eternity, the evolving past, and I know we will live forever, as dust or breathe in the face of stars, in the shifting pattern of winds.

I like relativity and quantum theories
because I don't understand them
and they make me feel as if space shifted about
like a swan that
can't settle,
refusing to sit still and be measured;
and as if the atom were an impulsive thing
always changing its mind.

I… formerly had two pair of spectacles, which I shifted occasionally, as in travelling I sometimes read, and often wanted to regard the prospects. Finding this change troublesome, and not always sufficiently ready, I had the glasses cut, and half of each kind associated in the same circle. … By this means, as I wear my spectacles constantly, I have only to move my eyes up or down, as I want to see distinctly far or near, the proper glasses being always ready.

If we factor in high-powered women in Europe as well, such as [German Chancellor] Angela Merkel, it seems we are witnessing a seismic shift for women to accede to high-level positions in politics and society. But there may still be a gap between those women achieving high public status and those in the private sector. I welcome these signs of women’s liberation.

In a sense cosmology contains all subjects because it is the story of everything, including biology, psychology and human history. In that single sense it can be said to contain an explanation also of time's arrow. But this is not what is meant by those who advocate the cosmological explanation of irreversibility. They imply that in some way the time arrow of cosmology imposes its sense on the thermodynamic arrow. I wish to disagree with this view. The explanation assumes that the universe is expanding. While this is current orthodoxy, there is no certainty about it. The red-shifts might be due to quite different causes. For example, when light passes through the expanding clouds of gas it will be red-shifted. A large number of such clouds might one day be invoked to explain these red shifts. It seems an odd procedure to attempt to 'explain' everyday occurrences, such as the diffusion of milk into coffee, by means of theories of the universe which are themselves less firmly established than the phenomena to be explained. Most people believe in explaining one set of things in terms of others about which they are more certain, and the explanation of normal irreversible phenomena in terms of the cosmological expansion is not in this category.

It is for these reasons that I regard the decision last year to shift our efforts in space from low to high gear as among the most important decisions that will be made during my incumbency in the office of the Presidency.

It is frivolous to fix pedantically the date of particular inventions. They have all been invented over and over fifty times. Man is the arch machine, of which all these shifts drawn from himself are toy models. He helps himself on each emergency by copying or duplicating his own structure, just so far as the need is.

It is not always possible to know what one has learned, or when the dawning will arrive. You will continue to shift, sift, to shake out and to double back. The synthesis that finally occurs can be in the most unexpected place and the most unexpected time. My charge ... is to be alert to the dawnings.

Life became a science when interest shifted from the dissection of dead bodies to the study of action in living beings and the nature of the environment they live in.

One may summarize by saying that by a combination of behavior and physiology mammals can successfully occupy all but the most extreme environments on earth without anything more than quantitative shifts in the basic physiological pattern common to all.

One of the most striking results of modern investigation has been the way in which several different and quite independent lines of evidence indicate that a very great event occurred about two thousand million years ago. The radio-active evidence for the age of meteorites; and the estimated time for the tidal evolution of the Moon's orbit (though this is much rougher), all agree in their testimony, and, what is far more important, the red-shift in the nebulae indicates that this date is fundamental, not merely in the history of our system, but in that of the material universe as a whole.

Only once in the historical record has a jump on the San Andreas exceeded the jump of 1906. In 1857, near Tejon Pass outside Los Angeles, the two sides shifted thirty feet.

Organisms ... are directed and limited by their past. They must remain imperfect in their form and function, and to that extent unpredictable since they are not optimal machines. We cannot know their future with certainty, if only because a myriad of quirky functional shifts lie within the capacity of any feature, however well adapted to a present role.

Our civilization is shifting from science and technology to rhetoric and litigation.

Perhaps the majority of paleontologists of the present time, who believe in orthogenesis, the irreversibility of evolution and the polyphyletic origin families, will assume that a short molar must keep on getting shorter, that it can never get longer and then again grow relatively shorter and therefore that Propliopithecus with its extremely short third molar and Dryopithecus its long m3 are alike excluded from ancestry of the Gorilla, in which the is a slight retrogression in length of m3. After many years reflection and constant study of the evolution of the vertebrates however, I conclude that 'orthogenesis' should mean solely that structures and races evolve in a certain direction, or toward a certain goal, only until the direction of evolution shifts toward some other goal. I believe that the 'irreversibility of evolution' means only that past changes irreversibly limit and condition future possibilities, and that, as a matter of experience, if an organ is once lost the same (homogenous) organ can be regained, although nature is fertile in substituting imitations. But this not mean, in my judgement, that if one tooth is smaller than its fellows it will in all cases continue to grow smaller.

Pervasive depletion and overuse of water supplies, the high capital cost of new large water projects, rising pumping costs and worsening ecological damage call for a shift in the way water is valued, used and managed.

Professor Bethe … is a man who has this characteristic: If there’s a good experimental number you’ve got to figure it out from theory. So, he forced the quantum electrodynamics of the day to give him an answer [for the experimentally measured Lamb-shift of hydrogen], … and thus, made the most important discovery in the history of the theory of quantum electrodynamics. He worked this out on the train from Ithaca, New York to Schenectady.

Science has not solved difficulties, only shifted the points of difficulty.

Science has not solved problems, only shifted the points of problems.

The balance of nature is not a status quo; it is fluid, ever shifting, in a constant state of adjustment.

The body of the Earth, large, sluggish and inapt for motion, is not to be disturbed by movement (especially three movements), any more than the Aetherial Lights [stars] are to be shifted, so that such ideas are opposed both to physical principles and to the authority of the Holy Writ which many time: confirms the stability of the Earth (as we shall discuss more fully elsewhere).

The burgeoning field of computer science has shifted our view of the physical world from that of a collection of interacting material particles to one of a seething network of information. In this way of looking at nature, the laws of physics are a form of software, or algorithm, while the material world—the hardware—plays the role of a gigantic computer.

The earth holds a silver treasure, cupped between ocean bed and tenting sky. Forever the heavens spend it, in the showers that refresh our temperate lands, the torrents that sluice the tropics. Every suckling root absorbs it, the very soil drains it down; the rivers run unceasing to the sea, the mountains yield it endlessly… Yet none is lost; in vast convection our water is returned, from soil to sky, and sky to soil, and back gain, to fall as pure as blessing. There was never less; there could never be more. A mighty mercy on which life depends, for all its glittering shifts, water is constant.

The edge of the sea is a strange and beautiful place. All through the long history of Earth it has been an area of unrest where waves have broken heavily against the land, where the tides have pressed forward over the continents, receded, and then returned. For no two successive days is the shore line precisely the same. Not only do the tides advance and retreat in their eternal rhythms, but the level of the sea itself is never at rest. It rises or falls as the glaciers melt or grow, as the floor of the deep ocean basins shifts under its increasing load of sediments, or as the Earth’s crust along the continental margins warps up or down in adjustment to strain and tension. Today a little more land may belong to the sea, tomorrow a little less. Always the edge of the sea remains an elusive and indefinable boundary.

The facts of nature are what they are, but we can only view them through the spectacles of our mind. Our mind works largely by metaphor and comparison, not always (or often) by relentless logic. When we are caught in conceptual traps, the best exit is often a change in metaphor–not because the new guideline will be truer to nature (for neither the old nor the new metaphor lies ‘out there’ in the woods), but because we need a shift to more fruitful perspectives, and metaphor is often the best agent of conceptual transition.

The footsteps of Nature are to be trac'd, not only in her ordinary course, but when she seems to be put to her shifts, to make many doublings and turnings, and to use some kind of art in endeavouring to avoid our discovery.

The steady progress of physics requires for its theoretical formulation a mathematics which get continually more advanced. ... it was expected that mathematics would get more and more complicated, but would rest on a permanent basis of axioms and definitions, while actually the modern physical developments have required a mathematics that continually shifts its foundation and gets more abstract. Non-euclidean geometry and noncommutative algebra, which were at one time were considered to be purely fictions of the mind and pastimes of logical thinkers, have now been found to be very necessary for the description of general facts of the physical world. It seems likely that this process of increasing abstraction will continue in the future and the advance in physics is to be associated with continual modification and generalisation of the axioms at the base of mathematics rather than with a logical development of any one mathematical scheme on a fixed foundation.

The Sun is no lonelier than its neighbors; indeed, it is a very common-place star,—dwarfish, though not minute,—like hundreds, nay thousands, of others. By accident the brighter component of Alpha Centauri (which is double) is almost the Sun's twin in brightness, mass, and size. Could this Earth be transported to its vicinity by some supernatural power, and set revolving about it, at a little less than a hundred million miles' distance, the star would heat and light the world just as the Sun does, and life and civilization might go on with no radical change. The Milky Way would girdle the heavens as before; some of our familiar constellations, such as Orion, would be little changed, though others would be greatly altered by the shifting of the nearer stars. An unfamiliar brilliant star, between Cassiopeia and Perseus would be—the Sun. Looking back at it with our telescopes, we could photograph its spectrum, observe its motion among the stars, and convince ourselves that it was the same old Sun; but what had happened to the rest of our planetary system we would not know.

The unprecedented identification of the spectrum of an apparently stellar object in terms of a large red-shift suggests either of the two following explanations.
The stellar object is a star with a large gravitational red-shift. Its radius would then be of the order of 10km. Preliminary considerations show that it would be extremely difficult, if not impossible, to account for the occurrence of permitted lines and a forbidden line with the same red-shift, and with widths of only 1 or 2 per cent of the wavelength.
The stellar object is the nuclear region of a galaxy with a cosmological red-shift of 0.158, corresponding to an apparent velocity of 47,400 km/sec. The distance would be around 500 megaparsecs, and the diameter of the nuclear region would have to be less than 1 kiloparsec. This nuclear region would be about 100 times brighter optically than the luminous galaxies which have been identified with radio sources thus far. If the optical jet and component A of the radio source are associated with the galaxy, they would be at a distance of 50 kiloparsecs implying a time-scale in excess of 105 years. The total energy radiated in the optical range at constant luminosity would be of the order of 1059 ergs.
Only the detection of irrefutable proper motion or parallax would definitively establish 3C 273 as an object within our Galaxy. At the present time, however, the explanation in terms of an extragalactic origin seems more direct and less objectionable.

The world of mathematics and theoretical physics is hierarchical. That was my first exposure to it. There's a limit beyond which one cannot progress. The differences between the limiting abilities of those on successively higher steps of the pyramid are enormous. I have not seen described anywhere the shock a talented man experiences when he finds, late in his academic life, that there are others enormously more talented than he. I have personally seen more tears shed by grown men and women over this discovery than I would have believed possible. Most of those men and women shift to fields where they can compete on more equal terms

There appears to be a total absence of place names [in southern Sudan]; there are indeed names for regions, areas, but all hamlets (there are scarcely any villages) bear the name of their headman or district head…, which is as ephemeral as the existence of the bearer himself in this unquiet country. Furthermore, residences are shifted every few years, in order to have fresh farmland; added to this the frequent wars, many deaths etc. In contrast, all bodies of water, even the most insignificant ditches, are permanently named. These will be the only guides if future travelers follow my path in this country or wish to trace it.

They were in orbit around the planet now, and its giant curving bulk loomed so huge that he could see nothing else, nothing but the bands and swirls of clouds that raced fiercely across Jupiter’s face. The clouds shifted and flowed before his eyes, spun into eddies the size of Asia, moved and throbbed and pulsed like living creatures. Lightning flashed down there, sudden explosions of light that flickered back and forth across the clouds, like signalling lamps.

To Nature nothing can be added; from Nature nothing can be taken away; the sum of her energies is constant, and the utmost man can do in the pursuit of physical truth, or in the applications of physical knowledge, is to shift the constituents of the never-varying total. The law of conservation rigidly excludes both creation and annihilation. Waves may change to ripples, and ripples to waves; magnitude may be substituted for number, and number for magnitude; asteroids may aggregate to suns, suns may resolve themselves into florae and faunae, and floras and faunas melt in air: the flux of power is eternally the same. It rolls in music through the ages, and all terrestrial energy—the manifestations of life as well as the display of phenomena—are but the modulations of its rhythm.

We are at that very point in time when a four-hundred-year-old age is rattling in its deathbed and another is struggling to be born. A shifting of culture, science, society and institutions enormously greater and swifter than the world has ever experienced. Ahead, lies the possibility of regeneration of individuality, liberty, community and ethics such as the world has never known, and a harmony with nature, with one another and with the divine intelligence such as the world has always dreamed.

Why Become Extinct? Authors with varying competence have suggested that dinosaurs disappeared because the climate deteriorated (became suddenly or slowly too hot or cold or dry or wet), or that the diet did (with too much food or not enough of such substances as fern oil; from poisons in water or plants or ingested minerals; by bankruptcy of calcium or other necessary elements). Other writers have put the blame on disease, parasites, wars, anatomical or metabolic disorders (slipped vertebral discs, malfunction or imbalance of hormone and endocrine systems, dwindling brain and consequent stupidity, heat sterilization, effects of being warm-blooded in the Mesozoic world), racial old age, evolutionary drift into senescent overspecialization, changes in the pressure or composition of the atmosphere, poison gases, volcanic dust, excessive oxygen from plants, meteorites, comets, gene pool drainage by little mammalian egg-eaters, overkill capacity by predators, fluctuation of gravitational constants, development of psychotic suicidal factors, entropy, cosmic radiation, shift of Earth’s rotational poles, floods, continental drift, extraction of the moon from the Pacific Basin, draining of swamp and lake environments, sunspots, God’s will, mountain building, raids by little green hunters in flying saucers, lack of standing room in Noah’s Ark, and palaeoweltschmerz.