Accountants and second-rate business school jargon are in the ascendant. Costs, which rise rapidly, and are easily ascertained and comprehensible, now weigh more heavily in the scales than the unquantifiable and unpredictable values and future material progress. Perhaps science will only regain its lost primacy as peoples and government begin to recognize that sound scientific work is the only secure basis for the construction of policies to ensure the survival of Mankind without irreversible damage to Planet Earth.

Although I have several agents who know the Niam-Niam country, I did not dare to make anything of their unreliable statements before I could orient myself. These Nubians are unpredictable to a high degree, they have a very poor memory for names and practically no human idea of the points of the compass; the agents of the merchants of Khartoum who are entrusted with such great journeys are to the last man absolute liars, braggarts and habitual fibbers.

And, in this case, science could learn an important lesson from the literati–who love contingency for the same basic reason that scientists tend to regard the theme with suspicion. Because, in contingency lies the power of each person, to make a difference in an unconstrained world bristling with possibilities, and nudgeable by the smallest of unpredictable inputs into markedly different channels spelling either vast improvement or potential disaster.

As a scientist, I am not sure anymore that life can be reduced to a class struggle, to dialectical materialism, or any set of formulas. Life is spontaneous and it is unpredictable, it is magical. I think that we have struggled so hard with the tangible that we have forgotten the intangible.

If one small and odd lineage of fishes had not evolved fins capable of bearing weight on land (though evolved for different reasons in lakes and seas,) terrestrial vertebrates would never have arisen. If a large extraterrestrial object—the ultimate random bolt from the blue—had not triggered the extinction of dinosaurs 65 million years ago, mammals would still be small creatures, confined to the nooks and crannies of a dinosaur's world, and incapable of evolving the larger size that brains big enough for self-consciousness require. If a small and tenuous population of protohumans had not survived a hundred slings and arrows of outrageous fortune (and potential extinction) on the savannas of Africa, then Homo sapiens would never have emerged to spread throughout the globe. We are glorious accidents of an unpredictable process with no drive to complexity, not the expected results of evolutionary principles that yearn to produce a creature capable of understanding the mode of its own necessary construction.

If we lived on a planet where nothing ever changed, there would be little to do. There would be nothing to figure out. There would be no impetus for science. And if we lived in an unpredictable world, where things changed in random or very complex ways, we would not be able to figure things out. But we live in an in-between universe, where things change, but according to patterns, rules, or as we call them, laws of nature. If I throw a stick up in the air, it always falls down. If the sun sets in the west, it always rises again the next morning in the east. And so it becomes possible to figure things out. We can do science, and with it we can improve our lives.

In an enterprise such as the building of the atomic bomb the difference between ideas, hopes, suggestions and theoretical calculations, and solid numbers based on measurement, is paramount. All the committees, the politicking and the plans would have come to naught if a few unpredictable nuclear cross sections had been different from what they are by a factor of two.

In no subject is there a rule, compliance with which will lead to new knowledge or better understanding. Skilful observations, ingenious ideas, cunning tricks, daring suggestions, laborious calculations, all these may be required to advance a subject. Occasionally the conventional approach in a subject has to be studiously followed; on other occasions it has to be ruthlessly disregarded. Which of these methods, or in what order they should be employed is generally unpredictable. Analogies drawn from the history of science are frequently claimed to be a guide; but, as with forecasting the next game of roulette, the existence of the best analogy to the present is no guide whatever to the future. The most valuable lesson to be learnt from the history of scientific progress is how misleading and strangling such analogies have been, and how success has come to those who ignored them.

In this physical world there is no real chaos; all is in fact orderly; all is ordered by the physical principles. Chaos is but unperceived order- it is a word indicating the limitations of the human mind and the paucity of observational facts. The words “chaos,” “accidental,” “chance,” “unpredictable," are conveniences behind which we hide our ignorance.

Included in this ‘almost nothing,’ as a kind of geological afterthought of the last few million years, is the first development of self-conscious intelligence on this planet–an odd and unpredictable invention of a little twig on the mammalian evolutionary bush. Any definition of this uniqueness, embedded as it is in our possession of language, must involve our ability to frame the world as stories and to transmit these tales to others. If our propensity to grasps nature as story has distorted our perceptions, I shall accept this limit of mentality upon knowledge, for we receive in trade both the joys of literature and the core of our being.

It is the individual only who is timeless. Societies, cultures, and civilizations - past and present - are often incomprehensible to outsiders, but the individual’s hunger, anxieties, dreams, and preoccupations have remained unchanged through the millennia. Thus, we are up against the paradox that the individual who is more complex, unpredictable, and mysterious than any communal entity is the one nearest to our understanding; so near that even the interval of millennia cannot weaken our feeling of kinshiIf in some manner the voice of an individual reaches us from the remotest distance of time, it is a timeless voice speaking about ourselves.

Mathematicians … believed that prediction was just a function of keeping track of things. If you knew enough, you could predict anything. … Chaos theory throws it right out the window because … in fact there are great categories of phenomena that are inherently unpredictable.

Organisms ... are directed and limited by their past. They must remain imperfect in their form and function, and to that extent unpredictable since they are not optimal machines. We cannot know their future with certainty, if only because a myriad of quirky functional shifts lie within the capacity of any feature, however well adapted to a present role.

Plasma seems to have the kinds of properties one would like for life. It’s somewhat like liquid water—unpredictable and thus able to behave in an enormously complex fashion. It could probably carry as much information as DNA does. It has at least the potential for organizing itself in interesting ways.

Reality is cruel. All of the naivete is going to be removed. Reality is always changing, and it is always unpredictable. All of the balance is going to be destroyed.

Science and technology, like all original creations of the human spirit, are unpredictable. If we had a reliable way to label our toys good and bad, it would be easy to regulate technology wisely. But we can rarely see far enough ahead to know which road leads to damnation. Whoever concerns himself with big technology, either to push it forward or to stop it, is gambling in human lives.

The hybridoma technology was a by-product of basic research. Its success in practical applications is to a large extent the result of unexpected and unpredictable properties of the method. It thus represents another clear-cut example of the enormous practical impact of an investment in research which might not have been considered commercially worthwhile, or of immediate medical relevance. It resulted from esoteric speculations, for curiosity’s sake, only motivated by a desire to understand nature.

The so-called science of poll-taking is not a science at all but mere necromancy. People are unpredictable by nature, and although you can take a nation's pulse, you can't be sure that the nation hasn't just run up a flight of stairs, and although you can take a nation's blood pressure, you can’t be sure that if you came back in twenty minutes you’d get the same reading. This is a damn fine thing. .