... an analysis that puts the final link in the chain, for here we see correlations between cytological evidence and genetic results that are so strong and obvious that their validity cannot be denied. This paper has been called a landmark in experimental genetics. It is more than that—it is a cornerstone.
Describing the paper 'A Correlation of Cytological and Genetic Crossings-over in Zea mays' published by Barbara McClintock and her student Harriet Creighton in the Proceedings of the National Academy of Sciences (1931), demonstrating that the exchange of genetic information that occurs during the production of sex cells is accompanied by an exchange of chromosomal material.

… for it is very probable, that the motion of gravity worketh weakly, both far from the earth, and also within the earth: the former because the appetite of union of dense bodies with the earth, in respect of the distance, is more dull: the latter, because the body hath in part attained its nature when it is some depth in the earth.
[Foreshadowing Newton's Universal Law of Gravitation (1687)]

… however useful the words may have been in the past, they have now become handicaps to the further development of knowledge. Words like botany and zoology imply that plants and animals are quite different things. … But the differences rapidly become blurred when we start looking at the world through a microscope. … The similarities between plants and animals became more important than their differences with the discoveries that both were built up of cells, had sexual reproduction,… nutrition and respiration … and with the development of evolutionary theory.

... I should think that anyone who considered it more reasonable for the whole universe to move in order to let the Earth remain fixed would be more irrational than one who should climb to the top of your cupola just to get a view of the city and its environs, and then demand that the whole countryside should revolve around him so that he would not have to take the trouble to turn his head.

... in going over the history of all the inventions for which history could be obtained it became more and more clear that in addition to training and in addition to extensive knowledge, a natural quality of mind was also necessary.

... in real life mistakes are likely to be irrevocable. Computer simulation, however, makes it economically practical to make mistakes on purpose. If you are astute, therefore, you can learn much more than they cost. Furthermore, if you are at all discreet, no one but you need ever know you made a mistake.

... in time of war, soldiers, however sensible, care a great deal more on some occasions about slaking their thirst than about the danger of enteric fever.
[Better known as typhoid, the disease is often spread by drinking contaminated water.]

... one of the main functions of an analogy or model is to suggest extensions of the theory by considering extensions of the analogy, since more is known about the analogy than is known about the subject matter of the theory itself … A collection of observable concepts in a purely formal hypothesis suggesting no analogy with anything would consequently not suggest either any directions for its own development.

… the three positive characteristics that distinguish mathematical knowledge from other knowledge … may be briefly expressed as follows: first, mathematical knowledge bears more distinctly the imprint of truth on all its results than any other kind of knowledge; secondly, it is always a sure preliminary step to the attainment of other correct knowledge; thirdly, it has no need of other knowledge.

...[T]he natural history of the rat is tragically similar to that of man ... some of the more obvious qualities in which rats resemble men — ferocity, omnivorousness, and adaptability to all climates ... the irresponsible fecundity with which both species breed at all seasons of the year with a heedlessness of consequences, which subjects them to wholesale disaster on the inevitable, occasional failure of the food supply.... [G]radually, these two have spread across the earth, keeping pace with each other and unable to destroy each other, though continually hostile. They have wandered from East to West, driven by their physical needs, and — unlike any other species of living things — have made war upon their own kind. The gradual, relentless, progressive extermination of the black rat by the brown has no parallel in nature so close as that of the similar extermination of one race of man by another...

...an idea is no more an even relatively constant thing than is a feeling or emotion or volitional process. There exist only changing and transient ideational processes; there are no permanent ideas that return again and disappear again.

...for our wisdom is better than the strength of men or of horses. ... nor is it right to prefer strength to excellent wisdom. For if there should be in the city [any athlete whose skill] is honoured more than strength ... the city would not on that account be any better governed.

...for the animals, which we resemble and which would be our equals if we did not have reason, do not reflect upon the actions or the passions of their external or internal senses, and do not know what is color, odor or sound, or if there is any differences between these objects, to which they are moved rather than moving themselves there. This comes about by the force of the impression that the different objects make on their organs and on their senses, for they cannot discern if it is more appropriate to go and drink or eat or do something else, and they do not eat or drink or do anything else except when the presence of objects or the animal imagination [l'imagination brutalle], necessitates them and transports them to their objects, without their knowing what they do, whether good or bad; which would happen to us just as to them if we were destitute of reason, for they have no enlightenment except what they must have to take their nourishment and to serve us for the uses to which God has destined them.
[Arguing the uniqueness of man by regarding animals to be merely automatons.].

…indeed what reason may not go to Schoole to the wisdome of Bees, Aunts, and Spiders? what wise hand teacheth them to doe what reason cannot teach us? Ruder heads stand amazed at those prodigious pieces of nature, Whales, Elephants, Dromidaries and Camels; these I confesse, are the Colossus and Majestick pieces of her hand; but in these narrow Engines there is more curious Mathematicks, and the civilitie of these little Citizens more neatly sets forth the wisedome of their Maker.

…it ought to be remembered that there is nothing more difficult to take in hand, more perilous to conduct, or more uncertain in its success, than to take the lead in the introduction of a new order of things. Because the innovator has for enemies all those who have done well under the old conditions, and lukewarm defenders in those who may do well under the new.

...it would be a simple way of solving the goiter problem. And in addition to that it would be the biggest thing in a medical proposition to be carried out in the state of Michigan, and Michigan is a large place. And as I thought of the thing the more convinced I became that this oughtn't to be a personal thing, This ought to be something done by the Michigan State Medical Society as a body.
Recommending the addition of a trace of iodine to table salt.

...neither is it possible to discover the more remote and deeper parts of any science, if you stand but upon the level of the same science, and ascend not to a higher science.

…reality is a system, completely ordered and fully intelligible, with which thought in its advance is more and more identifying itself. We may look at the growth of knowledge … as an attempt by our mind to return to union with things as they are in their ordered wholeness…. and if we take this view, our notion of truth is marked out for us. Truth is the approximation of thought to reality … Its measure is the distance thought has travelled … toward that intelligible system … The degree of truth of a particular proposition is to be judged in the first instance by its coherence with experience as a whole, ultimately by its coherence with that further whole, all comprehensive and fully articulated, in which thought can come to rest.

…so slow is moral progress. True, we have the bicycle, the motor-car, the dirigible airship and other marvellous means of breaking our bones; but our morality is not one rung the higher for it all. One would even say that, the farther we proceed in our conquest of matter, the more our morality recedes. The most advanced of our inventions consists in bringing men down with grapeshot and explosives with the swiftness of the reaper mowing the corn.

...the remark attributed to Mrs. [Agatha] Christie that 'the older you get, the more interesting you become to an archaeologist,' was the creation of some pundit whose neck Mrs. Christie would be glad to wring if he would care to identify himself—she neither made the remark nor does she consider it particularly complimentary or amusing.

...those experiments be not only esteemed which have an immediate and present use, but those principally which are of most universal consequence for invention of other experiments, and those which give more light to the invention of causes; for the invention of the mariner's needle, which giveth the direction, is of no less benefit for navigation than the invention of the sails, which give the motion.

...travel is more than the seeing of sights; it is a change that goes on, deep and permanent, in the ideas of living.

“Any specialty, if important, is too important to be left to the specialists.” After all, the specialist cannot function unless he concentrates more or less entirely on his specialty and, in doing so, he will ignore the vast universe lying outside and miss important elements that ought to help guide his judgment. He therefore needs the help of the nonspecialist, who, while relying on the specialist for key information, can yet supply the necessary judgment based on everything else… Science, therefore, has become too important to be left to the scientists.

“Bitzer,” said Thomas Gradgrind. “Your definition of a horse.”
“Quadruped. Graminivorous. Forty teeth; namely, twenty-four grinders, four eye-teeth, and twelve incisive. Sheds coat in the Spring; in marshy countries, sheds hoofs, too. Hoofs hard, but requiring to be shod with iron. Age known by marks in mouth.” Thus (and much more) Bitzer.
“Now girl number twenty,” said Mr. Gradgrind. “You know what a horse is.”

“Divide et impera” is as true in algebra as in statecraft; but no less true and even more fertile is the maxim “auge et impera”.The more to do or to prove, the easier the doing or the proof.

“I should have more faith,” he said; “I ought to know by this time that when a fact appears opposed to a long train of deductions it invariably proves to be capable of bearing some other interpretation.”

“If there are two theories, one simpler man the other, the simpler one is to be preferred.” At first sight this does not seem quite so bad, but a little thought shows that our tendency to prefer the simpler possibility is psychological rather than scientific. It is less trouble to think that way. Experience invariably shows that the more correct a theory becomes, the more complex does it seem. … So this … interpretation of [Ockham’s Razor] is … worthless.

“Normal science” means research firmly based upon one or more past scientific achievements, achievements that some particular scientific community acknowledges for a time as supplying the foundation for its further practice.

“Normal” science, in Kuhn’s sense, exists. It is the activity of the non-revolutionary, or more precisely, the not-too-critical professional: of the science student who accepts the ruling dogma of the day… in my view the 'normal' scientist, as Kuhn describes him, is a person one ought to be sorry for… He has been taught in a dogmatic spirit: he is a victim of indoctrination… I can only say that I see a very great danger in it and in the possibility of its becoming normal… a danger to science and, indeed, to our civilization. And this shows why I regard Kuhn’s emphasis on the existence of this kind of science as so important.

“Science for its own sake” usually means nothing more than science for the sake of the people who happen to be pursuing it.

“Science studies everything,” say the scientists. But, really, everything is too much. Everything is an infinite quantity of objects; it is impossible at one and the same time to study all. As a lantern cannot light up everything, but only lights up the place on which it is turned or the direction in which the man carrying it is walking, so also science cannot study everything, but inevitably only studies that to which its attention is directed. And as a lantern lights up most strongly the place nearest to it, and less and less strongly objects that are more and more remote from it, and does not at all light up those things its light does not reach, so also human science, of whatever kind, has always studied and still studies most carefully what seems most important to the investigators, less carefully what seems to them less important, and quite neglects the whole remaining infinite quantity of objects. ... But men of science to-day ... have formed for themselves a theory of “science for science's sake,” according to which science is to study not what mankind needs, but everything.

“Take some more tea,” the March Hare said to Alice, very earnestly.
“I’ve had nothing yet,” Alice replied in an offended tone, “so I can't take more.”
“You mean you can’t take less,” said the Hatter; “it’s very easy to take more than nothing.”

“These changes in the body,” he wrote in the review paper he sent to the American Journal of Physiology late in 1913, “are, each one of them, directly serviceable in making the organism more efficient in the struggle which fear or rage or pain may involve; for fear and rage are organic preparations for action, and pain is the most powerful known stimulus to supreme exertion. The organism which with the aid of increased adrenal secretion can best muster its energies, can best call forth sugar to supply the labouring muscles, can best lessen fatigue, and can best send blood to the parts essential in the run or the fight for life, is most likely to survive. Such, according to the view here propounded, is the function of the adrenal medulla at times of great emergency.”

“When I use a word,” Humpty Dumpty said, in rather a scornful tone, “it means just what I choose it to mean—neither more nor less.”
“The question is,” said Alice, “whether you can make words mean so many different things.”
“The question is,” said Humpty Dumpty, “which is to be master—that's all.”

“Wu Li” was more than poetic. It was the best definition of physics that the conference would produce. It caught that certain something, that living quality that we were seeking to express in a book, that thing without which physics becomes sterile. “Wu” can mean either “matter” or “energy.” “Li” is a richly poetic word. It means “universal order” or “universal law.” It also means “organic patterns.” The grain in a panel of wood is Li. The organic pattern on the surface of a leaf is also Li, and so is the texture of a rose petal. In short, Wu Li, the Chinese word for physics, means “patterns of organic energy” (“matter/ energy” [Wu] + “universal order/organic patterns” [Li]). This is remarkable since it reflects a world view which the founders of western science (Galileo and Newton) simply did not comprehend, but toward which virtually every physical theory of import in the twentieth century is pointing!

(1) I have told you more than I know about osteoporosis. (2) What I have told you is subject to change without notice. (3) I hope I raised more questions than I have given answers. (4) In any case, as usual, a lot more work is necessary.
Conclusion of one of his papers.

[1.] And first I suppose that there is diffused through all places an aethereal substance capable of contraction & dilatation, strongly elastick, & in a word, much like air in all respects, but far more subtile.
2. I suppose this aether pervades all gross bodies, but yet so as to stand rarer in their pores then in free spaces, & so much ye rarer as their pores are less ...
3. I suppose ye rarer aether within bodies & ye denser without them, not to be terminated in a mathematical superficies, but to grow gradually into one another.

[1665-08-16] ...Hence to the Exchange, which I have not been a great while. But Lord, how sad a sight it is to see the streets empty of people, and very few upon the Change - jealous of every door that one sees shut up, lest it should be the plague - and about us, two shops in three, if not more, generally shut up. ... It was dark before I could get home; and so land at church-yard stairs, where to my great trouble I met a dead Corps, of the plague, in the narrow ally, just bringing down a little pair of stairs - but I thank God I was not much disturbed at it. However, I shall beware of being late abroad again.

[1665-08-22] I went on a walk to Greenwich, on my way seeing a coffin with a dead body in it, dead of plague. It lay in an open yeard. ... It was carried there last night, and the parish has not told anyone to bury it. This disease makes us more cruel to one another than we are to dogs.

[1665-08-28] But now, how few people I see, and those walking like people that have taken leave of the world.... I to the Exchange, and I think there was not 50 people upon it and but few more like to be, as they told me, Sir G Smith and others. Thus I think to take Adieu today of London streets ....

[1665-09-14] ...my finding that although the Bill [total of dead] in general is abated, yet the City within the walls is encreasd and likely to continue so (and is close to our house there) - my meeting dead corps's of the plague, carried to be buried close to me at noonday through the City in Fanchurch-street - to see a person sick of the sores carried close by me by Grace-church in a hackney-coach - my finding the Angell tavern at the lower end of Tower-hill shut up; and more then that, the alehouse at the Tower-stairs; and more then that, that the person was then dying of the plague when I was last there, a little while ago at night, to write a short letter there, and I overheard the mistress of the house sadly saying to her husband somebody was very ill, but did not think it was of the plague - to hear that poor Payne my waterman hath buried a child and is dying himself - to hear that a labourer I sent but the other day to Dagenhams to know how they did there is dead of the plague and that one of my own watermen, that carried me daily, fell sick as soon as he had landed me on Friday morning last, when I had been all night upon the water ... is now dead of the plague - to hear ... that Mr Sidny Mountagu is sick of a desperate fever at my Lady Carteret's at Scott's hall - to hear that Mr. Lewes hath another daughter sick - and lastly, that both my servants, W Hewers and Tom Edwards, have lost their fathers, both in St. Sepulcher's parish, of the plague this week - doth put me into great apprehensions of melancholy, and with good reason. But I put off the thoughts of sadness as much as I can, and the rather to keep my wife in good heart and family also.

[A comparison] of the mind of a bigot to the pupil of the eye; the more light you pour on it, the more it contracts.

[about Fourier] It was, no doubt, partially because of his very disregard for rigor that he was able to take conceptual steps which were inherently impossible to men of more critical genius.

[Agatha Christie] is fond of quoting the witty wife who once said, “an archaeologist is the best husband any woman can have; the older she gets, the more interested he is in her.”

[An artist] will sooner and with more certainty, establish the character of skeletons, than the most learned anatomist, whose eye has not been accustomed to seize on every peculiarity.
Asserting his (incorrect) belief that the fossil teeth of the mastodon revealed it was a carnivorous animal.]

[At my secondary school] if you were very bright, you did classics; if you were pretty thick, you did woodwork; and if you were neither of those poles, you did science. The number of kids in my school who did science because they were excited by the notion of science was pretty small. You were allocated to those things, you weren’t asked. This was in the late 1930s/early 1940s … Science was seen as something more remote and less to do with everyday life.

[Before college] I was almost more interested in literature and history than in the exact sciences; I was equally good in all subjects including the classical languages.

[Beyond natural history] Other biological sciences take up the study at other levels of organization: dissecting the individual into organs and tissues and seeing how these work together, as in physiology; reaching down still further to the level of cells, as in cytology; and reaching the final biological level with the study of living molecules and their interactions, as in biochemistry. No one of these levels can be considered as more important than any other.

[Consider] a fence or gate erected across a road] The more modern type of reformer goes gaily up to it and says, “I don't see the use of this; let us clear it away.” To which the more intelligent type of reformer will do well to answer: “If you don't see the use of it, I certainly won't let you clear it away. Go away and think. Then, when you can come back and tell me that you do see the use of it, I may allow you to destroy it.”

[De Morgan relates that some person had made up 800 anagrams on his name, of which he had seen about 650. Commenting on these he says:]
Two of these I have joined in the title-page:
[Ut agendo surgamus arguendo gustamus.]
A few of the others are personal remarks.
Great gun! do us a sum!
is a sneer at my pursuit; but,
Go! great sum! [integral of a to the power u to the power n with respect to u] is more dignified. …
Adsum, nugator, suge!
is addressed to a student who continues talking after the lecture has commenced: …
Graduatus sum! nego
applies to one who declined to subscribe for an M.A. degree.

[Decimal currency is desirable because] by that means all calculations of interest, exchange, insurance, and the like are rendered much more simple and accurate, and, of course, more within the power of the great mass of people. Whenever such things require much labor, time, and reflection, the greater number who do not know, are made the dupes of the lesser number who do.

[Decoding the human genome sequence] is the most significant undertaking that we have mounted so far in an organized way in all of science. I believe that reading our blueprints, cataloguing our own instruction book, will be judged by history as more significant than even splitting the atom or going to the moon.

[Florence Nightingale] was a great administrator, and to reach excellence here is impossible without being an ardent student of statistics. Florence Nightingale has been rightly termed the “Passionate Statistician.” Her statistics were more than a study, they were indeed her religion. For her, Quetelet was the hero as scientist, and the presentation copy of his Physique Sociale is annotated by her on every page. Florence Nightingale believed—and in all the actions of her life acted upon that belief—that the administrator could only be successful if he were guided by statistical knowledge. The legislator—to say nothing of the politician—too often failed for want of this knowledge. Nay, she went further: she held that the universe—including human communities—was evolving in accordance with a divine plan; that it was man's business to endeavour to understand this plan and guide his actions in sympathy with it. But to understand God's thoughts, she held we must study statistics, for these are the measure of his purpose. Thus the study of statistics was for her a religious duty.

[For] those suffering under the thraldom of the vice [of opium eating] … it is well to avoid undue harshness with the patient; and it should be carefully remembered, that in many instances the sufferers are more objects of pity than of blame.

[Fritz Haber's] greatness lies in his scientific ideas and in the depth of his searching. The thought, the plan, and the process are more important to him than the completion. The creative process gives him more pleasure than the yield, the finished piece. Success is immaterial. “Doing it was wonderful.” His work is nearly always uneconomical, with the wastefulness of the rich.

[From uranium] there are present at least two distinct types of radiation one that is very readily absorbed, which will be termed for convenience the α radiation, and the other of a more penetrative character, which will be termed the β radiation.

[Gut instinct is more important than expertise.] Muscle memory isn't very helpful when you're charting new territory.

[Herbert Spencer] has discovered a great law of evolution in nature, which underlies all phenomena, & which is as important & more comprehensive than Newton’s law of gravitation.

[I attach] little importance to physical size. I don’t feel the least humble before the vastness of the heavens. The stars may be large, but they cannot think or love; and these are qualities which impress me far more than size does.

[I doubt that in today's world, I and Francis Crick would ever have had our Eureka moment.] I recently went to my staircase at Clare College, Cambridge and there were women there! he said, with an enormous measure of retrospective sexual frustration. There have been a lot of convincing studies recently about the loss of productivity in the Western male. It may be that entertainment culture now is so engaging that it keeps people satisfied. We didn't have that. Science was much more fun than listening to the radio. When you are 16 or 17 and in that inherently semi-lonely period when you are deciding whether to be an intellectual, many now don't bother.
(Response when asked how he thought the climate of scientific research had changed since he made his discovery of the structure of life in 1953.)

[I predict] the electricity generated by water power is the only thing that is going to keep future generations from freezing. Now we use coal whenever we produce electric power by steam engine, but there will be a time when there’ll be no more coal to use. That time is not in the very distant future. … Oil is too insignificant in its available supply to come into much consideration.

[In addition to classical, literary and philosophical studies,] I devoured without much appetite the Elements of Algebra and Geometry…. From these serious and scientific pursuits I derived a maturity of judgement, a philosophic spirit, of more value than the sciences themselves…. I could extract and digest the nutritive particles of every species of litterary food.

[In childhood, to overcome fear, the] need took me back again and again to a sycamore tree rising from the earth at the edge of a ravine. It was a big, old tree that had grown out over the ravine, so that when you climbed it, you looked straight down fifty feet or more. Every time I climbed that tree, I forced myself to climb to the last possible safe limb and then look down. Every time I did it, I told myself I’d never do it again. But I kept going back because it scared me and I had to know I could overcome that.

[J.J.] Sylvester’s methods! He had none. “Three lectures will be delivered on a New Universal Algebra,” he would say; then, “The course must be extended to twelve.” It did last all the rest of that year. The following year the course was to be Substitutions-Théorie, by Netto. We all got the text. He lectured about three times, following the text closely and stopping sharp at the end of the hour. Then he began to think about matrices again. “I must give one lecture a week on those,” he said. He could not confine himself to the hour, nor to the one lecture a week. Two weeks were passed, and Netto was forgotten entirely and never mentioned again. Statements like the following were not unfrequent in his lectures: “I haven’t proved this, but I am as sure as I can be of anything that it must be so. From this it will follow, etc.” At the next lecture it turned out that what he was so sure of was false. Never mind, he kept on forever guessing and trying, and presently a wonderful discovery followed, then another and another. Afterward he would go back and work it all over again, and surprise us with all sorts of side lights. He then made another leap in the dark, more treasures were discovered, and so on forever.

[Jethro Tull] was the first Englishman—perhaps the first writer, ancient and modern—who has attempted, with any tolerable degree of success, to reduce the art of agriculture to certain and uniform principles; and it must be acknowledged that he has done more towards establishing a rational and practical method of husbandry than all the writers who have gone before him.

[John Scott Haldane] preferred to work on himself or other human beings who were sufficiently interested in the work to ignore pain or fear … [His] object was not to achieve this state of [pain or fear] but to achieve knowledge which could save other men's lives. His attitute was much more like a good soldier who will risk his life and endure wounds in order to gain victory than that of an ascetic who deliberately undergoes pain. The soldier does not get himself wounded deliberately, and my father did not seek pain in his work though he greeted pain which would have made some people writhe or groan, with laughter.

[King Hiero II] requested Archimedes to consider [whether a crown was pure gold or alloyed with silver]. The latter, while the case was still on his mind, happened to go to the bath, and on getting into a tub observed that the more his body sank into it the more water ran out over the tub. As this pointed out the way to explain the case in question, without a moment’s delay, and transported with joy, he jumped out of the tub and rushed home naked, crying with a loud voice that he had found what he was seeking; for as he ran he shouted repeatedly in Greek, “Eὕρηκα, εὕρηκα.”

[L]et us not overlook the further great fact, that not only does science underlie sculpture, painting, music, poetry, but that science is itself poetic. The current opinion that science and poetry are opposed is a delusion. … On the contrary science opens up realms of poetry where to the unscientific all is a blank. Those engaged in scientific researches constantly show us that they realize not less vividly, but more vividly, than others, the poetry of their subjects. Whoever will dip into Hugh Miller’s works on geology, or read Mr. Lewes's “Seaside Studies,” will perceive that science excites poetry rather than extinguishes it. And whoever will contemplate the life of Goethe will see that the poet and the man of science can co-exist in equal activity. Is it not, indeed, an absurd and almost a sacrilegious belief that the more a man studies Nature the less he reveres it? Think you that a drop of water, which to the vulgar eye is but a drop of water, loses anything in the eye of the physicist who knows that its elements are held together by a force which, if suddenly liberated, would produce a flash of lightning? Think you that what is carelessly looked upon by the uninitiated as a mere snow-flake, does not suggest higher associations to one who has seen through a microscope the wondrously varied and elegant forms of snow-crystals? Think you that the rounded rock marked with parallel scratches calls up as much poetry in an ignorant mind as in the mind of a geologist, who knows that over this rock a glacier slid a million years ago? The truth is, that those who have never entered upon scientific pursuits know not a tithe of the poetry by which they are surrounded. Whoever has not in youth collected plants and insects, knows not half the halo of interest which lanes and hedge-rows can assume. Whoever has not sought for fossils, has little idea of the poetical associations that surround the places where imbedded treasures were found. Whoever at the seaside has not had a microscope and aquarium, has yet to learn what the highest pleasures of the seaside are. Sad, indeed, is it to see how men occupy themselves with trivialities, and are indifferent to the grandest phenomena—care not to understand the architecture of the Heavens, but are deeply interested in some contemptible controversy about the intrigues of Mary Queen of Scots!—are learnedly critical over a Greek ode, and pass by without a glance that grand epic written by the finger of God upon the strata of the Earth!

[Learning is] the actual process of broadening yourself, of knowing there’s a little extra facet of the universe you know about and can think about and can understand. It seems to me that when it’s time to die, and that will come to all of us, there’ll be a certain pleasure in thinking that you had utilized your life well, that you had learned as much as you could, gathered in as much as possible of the universe, and enjoyed it. I mean, there’s only this universe and only this one lifetime to try to grasp it. And, while it is inconceivable that anyone can grasp more than a tiny portion of it, at least do that much. What a tragedy to just pass through and get nothing out of it.

[Luis] Alvarez could no more refrain from invention than he could from breathing. In the midst of an illness so severe as to incapacitate him for most of a summer, he amused himself by attempting to build a better detector of gallstones.

[M]anufacturing, science and engineering are … incredibly creative. I’d venture to say more so than creative advertising agencies and things that are known as the creative industries.

[M]y work, which I’ve done for a long time, was not pursued in order to gain the praise I now enjoy, but chiefly from a craving after knowledge, which I notice resides in me more than in most other men. And therewithal, whenever I found out anything remarkable, I have thought it my duty to put down my discovery on paper, so that all ingenious people might be informed thereof.

[My Book] will endeavour to establish the principle[s] of reasoning in ... [geology]; and all my geology will come in as illustration of my views of those principles, and as evidence strengthening the system necessarily arising out of the admission of such principles, which... are neither more nor less than that no causes whatever have from the earliest time to which we can look back, to the present, ever acted, but those now acting; and that they never acted with different degrees of energy from that which they now exert.

[My] numberless observations... made on the Strata... [have] made me confident of their uniformity throughout this Country & [have] led me to conclude that the same regularity... will be found to extend to every part of the Globe for Nature has done nothing by piecemeal. [T]here is no inconsistency in her productions. [T]he Horse never becomes an Ass nor the Crab an Apple by any intermixture or artificial combination whatever[. N]or will the Oak ever degenerate into an Ash or an Ash into an Elm. [H]owever varied by Soil or Climate the species will still be distinct on this ground. [T]hen I argue that what is found here may be found elsewhere[.] When proper allowances are made for such irregularities as often occur and the proper situation and natural agreement is well understood I am satisfied there will be no more difficulty in ascertaining the true quality of the Strata and the place of its possition [sic] than there is now in finding the true Class and Character of Plants by the Linean [sic] System.

[No one will be able to] deter the scientific mind from probing into the unknown any more than Canute could command the tides.
Comment upon the U.S. Supreme Court's 1980 decision permitting the patenting of life forms.

[On gold, silver, mercury, platinum, palladium, rhodium, iridium, osmium:] As in their physical properties so in their chemical properties. Their affinities being weaker, (the noble metals) do not present that variety of combinations, belonging to the more common metals, which renders them so extensively useful in the arts; nor are they, in consequence, so necessary and important in the operations of nature. They do not assist in her hands in breaking down rocks and strata into soil, nor do they help man to make that soil productive or to collect for him its products.

[P]ure mathematics is on the whole distinctly more useful than applied. For what is useful above all is technique, and mathematical technique is taught mainly through pure mathematics.

[Plato] was the first to envisage the idea of timeless existence and to emphasize it—against reason—as a reality, more [real] than our actual experience…

[Public cynicism towards professional expertise is] entirely wrong, and it’s the road back to the cave. The way we got out of the caves and into modern civilisation is through the process of understanding and thinking. Those things were not done by gut instinct. Being an expert does not mean that you are someone with a vested interest in something; it means you spend your life studying something. You’re not necessarily right–but you’re more likely to be right than someone who’s not spent their life studying it.

[Regarding mathematics,] there are now few studies more generally recognized, for good reasons or bad, as profitable and praiseworthy. This may be true; indeed it is probable, since the sensational triumphs of Einstein, that stellar astronomy and atomic physics are the only sciences which stand higher in popular estimation.

[Relativist] Rel. There is a well-known proposition of Euclid which states that “Any two sides of a triangle are together greater than the third side.” Can either of you tell me whether nowadays there is good reason to believe that this proposition is true?
[Pure Mathematician] Math. For my part, I am quite unable to say whether the proposition is true or not. I can deduce it by trustworthy reasoning from certain other propositions or axioms, which are supposed to be still more elementary. If these axioms are true, the proposition is true; if the axioms are not true, the proposition is not true universally. Whether the axioms are true or not I cannot say, and it is outside my province to consider.

[Science] dissipates errors born of ignorance about our true relations with nature, errors the more damaging in that the social order should rest only on those relations. TRUTH! JUSTICE! Those are the immutable laws. Let us banish the dangerous maxim that it is sometimes useful to depart from them and to deceive or enslave mankind to assure its happiness.

[Science] is the literature of God written on the stars—the trees—the rocks—and more important because [of] its marked utilitarian character.

[Should Britain fail, then the entire world would] sink into the abyss of a new dark age made more sinister ... by the lights of perverted science.

[The center must be more than just] old junk in a box. [It must be a] living dynamic thing to attract people to public service at all levels.

[The chemical bond] First, it is related to the disposition of two electrons (remember, no one has ever seen an electron!): next, these electrons have their spins pointing in opposite directions (remember, no one can ever measure the spin of a particular electron!): then, the spatial distribution of these electrons is described analytically with some degree of precision (remember, there is no way of distinguishing experimentally the density distribution of one electron from another!): concepts like hybridization, covalent and ionic structures, resonance, all appear, not one of which corresponds to anything that is directly measurable. These concepts make a chemical bond seem so real, so life-like, that I can almost see it. Then I wake with a shock to the realization that a chemical bond does not exist; it is a figment of the imagination that we have invented, and no more real than the square root of - 1. I will not say that the known is explained in terms of the unknown, for that is to misconstrue the sense of intellectual adventure. There is no explanation: there is form: there is structure: there is symmetry: there is growth: and there is therefore change and life.

[The more science discovers and] the more comprehension it gives us of the mechanisms of existence, the more clearly does the mystery of existence itself stand out.

[The Niagara Falls] would be more impressive if it flowed the other way.

[The object of education is] to train the mind to ascertain the sequence of a particular conclusion from certain premises, to detect a fallacy, to correct undue generalisation, to prevent the growth of mistakes in reasoning. Everything in these must depend on the spirit and the manner in which the instruction itself is conveyed and honoured. If you teach scientific knowledge without honouring scientific knowledge as it is applied, you do more harm than good. I do think that the study of natural science is so glorious a school for the mind, that with the laws impressed on all these things by the Creator, and the wonderful unity and stability of matter, and the forces of matter, there cannot be a better school for the education of the mind.

[The original development of the Spinning Mule was a] continual endeavour to realise a more perfect principle of spinning; and though often baffled, I as often renewed the attempt, and at length succeeded to my utmost desire, at the expense of every shilling I had in the world.

[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.

[Theodore Roosevelt] was a naturalist on the broadest grounds, uniting much technical knowledge with knowledge of the daily lives and habits of all forms of wild life. He probably knew tenfold more natural history than all the presidents who had preceded him, and, I think one is safe in saying, more human history also.

[To a man expecting a scientific proof of the impossibility of flying saucers] I might have said to him: “Listen, I mean that from my knowledge of the world that I see around me, I think that it is much more likely that the reports of flying saucers are the results of the known irrational characteristics of terrestrial intelligence than of the unknown rational efforts of extra-terrestrial intelligence.” It is just more likely, that is all. It is a good guess. And we always try to guess the most likely explanation, keeping in the back of the mind the fact that if it does not work we must discuss the other possibilities.

[To] explain the phenomena of the mineral kingdom ... systems are usually reduced to two classes, according as they refer to the origin of terrestrial bodies to FIRE or to WATER; and ... their followers have of late been distinguished by the fanciful names of Vulcanists and Neptunists. To the former of these Dr HUTTON belongs much more than to the latter; though, as he employs the agency both of fire and water in his system, he cannot, in strict propriety, be arranged with either.

[W]e have made a thing, a most terrible weapon, that has altered abruptly and profoundly the nature of the world. We have made a thing that, by all standards of the world we grew up in, is an evil thing. And by doing so, by our participation in making it possible to make these things, we have raised again the question of whether science is good for man, of whether it is good to learn about the world, to try to understand it, to try to control it, to help give to the world of men increased insight, increased power. Because we are scientists, we must say an unalterable yes to these questions; it is our faith and our commitment, seldom made explicit, even more seldom challenged, that knowledge is a good in itself, knowledge and such power as must come with it.

[W]hen Galileo discovered he could use the tools of mathematics and mechanics to understand the motion of celestial bodies, he felt, in the words of one imminent researcher, that he had learned the language in which God recreated the universe. Today we are learning the language in which God created life. We are gaining ever more awe for the complexity, the beauty, the wonder of God's most devine and sacred gift.

[We need not think] that there is any Contradiction, when Philosophy teaches that to be done by Nature; which Religion, and the Sacred Scriptures, teach us to be done by God: no more, than to say, That the balance of a Watch is moved by the next Wheel, is to deny that Wheel, and the rest, to be moved by the Spring; and that both the Spring, and all the other Parts, are caused to move together by the Maker of them. So God may be truly the Cause of This Effect, although a Thousand other Causes should be supposed to intervene: For all Nature is as one Great Engine, made by, and held in His Hand.

[When thinking about the new relativity and quantum theories] I have felt a homesickness for the paths of physical science where there are more or less discernible handrails to keep us from the worst morasses of foolishness.

[William Gull] sought to teach his students not to think they could cure disease. “The best of all remedies,” he would say, “is a warm bed.” “ I can tell you something of how you get ill, but I cannot tell you how you get well.” “ Healing is accomplished ‘By an operation more divine Than tongue or pen can give expression to.’” “Remedies act best when there is a tendency to get well.”

πολλὰ τὰ δεινὰ κοὐδὲν ἀνθρώπου δεινότερον πέλει.
Wonders are many, and none is more wonderful than man.

[About gorillas] You take these fine, regal animals. How many (human) fathers have the same sense of paternity? How many human mothers are more caring? The family structure is unbelievably strong.

[Almost certainly not by Einstein.] The more I study science, the more I believe in God.

[Describing the effects of over-indulgence in wine:]
But most too passive, when the blood runs low
Too weakly indolent to strive with pain,
And bravely by resisting conquer fate,
Try Circe's arts; and in the tempting bowl
Of poisoned nectar sweet oblivion swill.
Struck by the powerful charm, the gloom dissolves
In empty air; Elysium opens round,
A pleasing frenzy buoys the lightened soul,
And sanguine hopes dispel your fleeting care;
And what was difficult, and what was dire,
Yields to your prowess and superior stars:
The happiest you of all that e'er were mad,
Or are, or shall be, could this folly last.
But soon your heaven is gone: a heavier gloom
Shuts o'er your head; and, as the thundering stream,
Swollen o'er its banks with sudden mountain rain,
Sinks from its tumult to a silent brook,
So, when the frantic raptures in your breast
Subside, you languish into mortal man;
You sleep, and waking find yourself undone,
For, prodigal of life, in one rash night
You lavished more than might support three days.
A heavy morning comes; your cares return
With tenfold rage. An anxious stomach well
May be endured; so may the throbbing head;
But such a dim delirium, such a dream,
Involves you; such a dastardly despair
Unmans your soul, as maddening Pentheus felt,
When, baited round Citheron's cruel sides,
He saw two suns, and double Thebes ascend.

[Instead of collecting stamps, he collected dictionaries and encyclopaedias:] Because you can learn more from them.

[Pechblende] einer eigenthümlichen, selbstständigen metallischen Substanz bestehe. Es fallen folglich auch deren bisherige Benennungen, als: Ресhblende Eisenpecherz, hinweg, welche nun durch einen neuen ausschliessend bezeichnenden Namen zu ersetzen sind. Ich habe dazu den Namen: Uranerz (Uranium) erwählt; zu einigem Andenken, dass die chemische Ausfindung dieses neuen Metallkörpers in die Epoche der astronomischen. Entdeckung des Planeten Uranus gefallen sei.
[Pitchblende] consists of a peculiar, distinct, metallic substance. Therefore its former denominations, pitch-blende, pitch-iron-ore, &c. are no longer applicable, and must be supplied by another more appropriate name.—I have chosen that of uranite, (Uranium), as a kind of memorial, that the chemical discovery of this new metal happened in the period of the astronomical discovery of the new planet Uranus.

[Question: Do you feel that scientists correct themselves as often as they should?]
More often than politicians, but not as often as they should.

[When asked “Dr. Einstein, why is it that when the mind of man has stretched so far as to discover the structure of the atom we have been unable to devise the political means to keep the atom from destroying us?”] That is simple, my friend. It is because politics is more difficult than physics.

Ath. There still remain three studies suitable for freemen. Calculation in arithmetic is one of them; the measurement of length, surface, and depth is the second; and the third has to do with the revolutions of the stars in reference to one another … there is in them something that is necessary and cannot be set aside, … if I am not mistaken, [something of] divine necessity; for as to the human necessities of which men often speak when they talk in this manner, nothing can be more ridiculous than such an application of the words.
Cle. And what necessities of knowledge are there, Stranger, which are divine and not human?
Ath. I conceive them to be those of which he who has no use nor any knowledge at all cannot be a god, or demi-god, or hero to mankind, or able to take any serious thought or charge of them.

Bernard: Oh, you’re going to zap me with penicillin and pesticides. Spare me that and I’ll spare you the bomb and aerosols. But don’t confuse progress with perfectibility. A great poet is always timely. A great philosopher is an urgent need. There’s no rush for Isaac Newton. We were quite happy with Aristotle’s cosmos. Personally, I preferred it. Fifty-five crystal spheres geared to God’s crankshaft is my idea of a satisfying universe. I can’t think of anything more trivial than the speed of light. Quarks, quasars—big bangs, black holes—who [cares]? How did you people con us out of all that status? All that money? And why are you so pleased with yourselves?
Chloe: Are you against penicillin, Bernard?
Bernard: Don’t feed the animals.

Between the frontiers of the three super-states Eurasia, Oceania, and Eastasia, and not permanently in possession of any of them, there lies a rough quadrilateral with its corners at Tangier, Brazzaville, Darwin, and Hongkong. These territories contain a bottomless reserve of cheap labour. Whichever power controls equatorial Africa, or the Middle East or Southern India or the Indonesian Archipelago, disposes also of the bodies of hundreds of millions of ill-paid and hardworking coolies, expended by their conquerors like so much coal or oil in the race to turn out more armaments, to capture more territory, to control more labour, to turn out more armaments, to capture more territory, to control…
Thus George Orwell—in his only reference to the less-developed world.
I wish I could disagree with him. Orwell may have erred in not anticipating the withering of direct colonial controls within the “quadrilateral” he speaks about; he may not quite have gauged the vehemence of urges to political self-assertion. Nor, dare I hope, was he right in the sombre picture of conscious and heartless exploitation he has painted. But he did not err in predicting persisting poverty and hunger and overcrowding in 1984 among the less privileged nations.
I would like to live to regret my words but twenty years from now, I am positive, the less-developed world will be as hungry, as relatively undeveloped, and as desperately poor, as today.

Ce grand ouvrage, toujours plus merveilleux à mesure qu’il est plus connu, nous donne une si grande idée de son ouvrier, que nous en sentons notre esprit accablé d’admiration et de respect.
[The Universe] This great work, always more amazing in proportion as it is better known, raises in us so grand an idea of its Maker, that we find our mind overwhelmed with feelings of wonder and adoration.

Ces détails scientifiques qui effarouchent les fabricans d’un certain âge, ne seront qu’un jeu pour leurs enfans, quand ils auront apprit dans leurs collèges un peu plus de mathématiques et un peu moins de Latin; un peu plus de Chimie, et un peu moins de Grec!
The scientific details which now terrify the adult manufacturer will be mere trifles to his children when they shall be taught at school, a little more Mathematics and a little less Latin, a little more Chemistry, and a little less Greek.

Chaos umpire sits
And by decision more embroils the fray
By which he reigns: next him high arbiter
Chance governs all.

Die Wissenschaft ist ein Land, welches die Eigenschaft hat, um so mehr Menschen beherbergen zu können, je mehr Bewohner sich darin sammeln; sie ist ein Schatz, der um so grösser wird, je mehr man ihn teilt. Darum kann jeder von uns in seiner Art seine Arbeit tun, und die Gemeinsamkeit bedeutet nicht Gleichförmigkeit.
Science is one land, having the ability to accommodate even more people, as more residents gather in it; it is a treasure that is the greater the more it is shared. Because of that, each of us can do his work in his own way, and the common ground does not mean conformity.

Dilbert: And we know mass creates gravity because more dense planets have more gravity.
Dogbert: How do we know which planets are more dense?
Dilbert:They have more gravity.
Dogbert: That's circular reasoning.
Dilbert: I prefer to think of it as having no loose ends.

Dilbert: It took weeks but I’ve calculated a new theory about the origin of the universe. According to my calculations it didn’t start with a “Big Bang” at all—it was more of “Phhbwt” sound. You may be wondering about the practical applications of the “Little Phhbwt” theory.
Dogbert: I was wondering when you’ll go away.

Error of confounding cause and effect.—There is no more dangerous error than confounding consequence with cause: I call it the intrinsic depravity of reason. … I take an example: everybody knows the book of the celebrated Comaro, in which he recommends his spare diet as a recipe for a long and happy life,—for a virtuous life also. Few books have been read so much… I believe hardly any book … has caused so much harm, has shortened so many lives, as this well-meant curiosity. The source of this mischief is in confounding consequence with cause. The candid Italian saw in his diet the cause of his long life, while the prerequisite to long life, the extraordinary slowness of the metabolic process, small consumption, was the cause of his spare diet. He was not at liberty to eat little or much; his frugality—was not of “free will;” he became sick when he ate more.

Every teacher certainly should know something of non-euclidean geometry. Thus, it forms one of the few parts of mathematics which, at least in scattered catch-words, is talked about in wide circles, so that any teacher may be asked about it at any moment. … Imagine a teacher of physics who is unable to say anything about Röntgen rays, or about radium. A teacher of mathematics who could give no answer to questions about non-euclidean geometry would not make a better impression.
On the other hand, I should like to advise emphatically against bringing non-euclidean into regular school instruction (i.e., beyond occasional suggestions, upon inquiry by interested pupils), as enthusiasts are always recommending. Let us be satisfied if the preceding advice is followed and if the pupils learn to really understand euclidean geometry. After all, it is in order for the teacher to know a little more than the average pupil.

Frustra fit per plura, quod fieri potest per pauciora.
It is vain to do with more what can be done with less.

Hominem ad deos nulla re propius accedunt quam salutem hominibus dando,
In nothing do men more nearly approach the gods, than in giving health to men.

If the Indians hadn’t spent the $24. In 1626 Peter Minuit, first governor of New Netherland, purchased Manhattan Island from the Indians for about $24. … Assume for simplicity a uniform rate of 7% from 1626 to the present, and suppose that the Indians had put their $24 at [compound] interest at that rate …. What would be the amount now, after 280 years? 24 x (1.07)280 = more than 4,042,000,000.
The latest tax assessment available at the time of writing gives the realty for the borough of Manhattan as $3,820,754,181. This is estimated to be 78% of the actual value, making the actual value a little more than $4,898,400,000.
The amount of the Indians’ money would therefore be more than the present assessed valuation but less than the actual valuation.

Il ne peut y avoir de langage plus universel et plus simple, plus exempt d’erreurs et d’obscurités, c'est-à-dire plus digne d'exprimer les rapports invariables des êtres naturels.
There cannot be a language more universal and more simple, more free from errors and obscurities, … more worthy to express the invariable relations of all natural things. [About mathematical analysis.]

Il y aura toujours une valeur (ou plusieurs) qui dépassera toutes les autres.
There will always be one (or more) value that will exceed all others.

L’analyse mathématique … dans l’étude de tous les phénomènes; elle les interprète par le même langage, comme pour attester l’unité et la simplicité du plan de l’univers, et rendre encore plus manifeste cet ordre immuable qui préside à toutes les causes naturelles.
Mathematical analysis … in the study of all phenomena, interprets them by the same language, as if to attest the unity and simplicity of the plan of the universe, and to make still more evident that unchangeable order which presides over all natural causes.

La nature veut que dans certains temps les hommes se succèdent les uns aux autres par le moyen de la mort; il leur est permis de se défendre contr’elle jusqu’à un certain point; mais passé cela, on aura beau faire de nouvelles découvertes dans l’Anatomie, on aura beau pénétrer de plus en plus dans les secrets de la structure du corps humain, on ne prendra point la Nature pour dupe, on mourra comme à l’ordinaire.
Nature intends that at fixed periods men should succeed each other by the instrumentality of death. They are allowed to keep it at bay up to a certain point; but when that is passed, it will be of no use to make new discoveries in anatomy, or to penetrate more and more into the secrets of the structure of the human body; we shall never outwit nature, we shall die as usual.

La vérité ne diffère de l'erreur qu'en deux points: elle est un peu plus difficile à prouver et beaucoup plus difficile à faire admettre. (Dec 1880)
Truth is different from error in two respects: it is a little harder to prove and more difficult to admit.

Le savant n’étudie pas la nature parce que cela est utile; il l’étudie parce qu’il y prend plaisir et il y prend plaisir parce qu’elle est belle. Si la nature n’était pas belle, elle ne vaudrait pas la peine d’être connue, la vie ne vaudrait pas la peine d’être vécue.
The scientist does not study nature because it is useful to do so. He studies it because he takes pleasure in it, and he takes pleasure in it because it is beautiful. If nature were not beautiful, it would not be worth knowing, and life would not be worth living. I am not speaking, of course, of the beauty which strikes the senses, of the beauty of qualities and appearances. I am far from despising this, but it has nothing to do with science. What I mean is that more intimate beauty which comes from the harmonious order of its parts, and which a pure intelligence can grasp.

Medicus enim nihil aliud est quam animi consolatio
A doctor is nothing more than consolation for the spirit.