A few months after a devastating defeat at Fredericksburg,… President Abraham Lincoln signed into law an act creating the National Academy of Sciences—in the midst of civil war. Lincoln refused to accept that our nation’s sole purpose was mere survival. He created this academy, founded the land grant colleges, and began the work of the transcontinental railroad, believing that we must add—and I quote—“the fuel of interest to the fire of genius in the discovery … of new and useful things.”

A magician of old waved a wand that he might banish disease, a physician to-day peers through a microscope to detect the bacillus of that disease and plan its defeat. The belief in miracles was premature, that is all; it was based on dreams now coming true.

A neurotic person can be most simply described as someone who, while he was growing up, learned ways of behaving that are self-defeating in his society.

Defeat never comes to any man until he admits it.

Far better is it to dare mighty things, to win glorious triumphs, even though checkered by failure, than to take rank with those poor spirits who neither enjoy much or suffer much, because they live in the gray twilight that knows not victory nor defeat.

I hardly know of a great physical truth whose universal reception has not been preceded by an epoch in which the most estimable persons have maintained that the phenomena investigated were directly dependent on the Divine Will, and that the attempt to investigate them was not only futile but blasphemous. And there is a wonderful tenacity of life about this sort of opposition to physical science. Crushed and maimed in every battle, it yet seems never to be slain; and after a hundred defeats it is at this day as rampant, though happily not so mischievous, as in the time of Galileo.

I knew, however, that it would cost ten times what I had available in order to build a molecular beam machine. I decided to follow a byway, rather than the highway. It is a procedure I have subsequently recommended to beginning scientists in this country, where research strategy is best modelled on that used by Wolfe at the Plains of Abraham.
(British General James Wolfe defeated the French defending Quebec in 1759 after scaling a cliff for a surprise attack.)

I’ve always thought that my exposure to competitive sports helped me a great deal in the operating room. It teaches you endurance, and it teaches you how to cope with defeat, and with complications of all sort. I think I’m a well-coordinated person, more than average, and I think that came through my interest in sports, and athletics. … [Playing basketball] You have to make decisions promptly, and that’s true in the operating room as well.

In formal logic a contradiction is the signal of a defeat, but in the evolution of real knowledge it marks the first step in progress toward a victory. This is one great reason for the utmost toleration of variety of opinion. Once and forever, this duty of toleration has been summed up in the words, “Let both grow together until the harvest.”

In such sad circumstances I but see myself exalted by my own enemies, for in order to defeat some small works of mine they try to make the whole rational medicine and anatomy fall, as if I were myself these noble disciplines.

Inanimate objects are classified scientifically into three categories—those that don't work, those that break down, and those that get lost. The goal of all inanimate objects is to resist man and ultimately to defeat him, and the three major classifications are based on the method each object uses to achieve its purpose

It must happen that in some cases the author is not understood, or is very imperfectly understood; and the question is what is to be done. After giving a reasonable amount of attention to the passage, let the student pass on, reserving the obscurity for future efforts. … The natural tendency of solitary students, I believe, is not to hurry away prematurely from a hard passage, but to hang far too long over it; the just pride that does not like to acknowledge defeat, and the strong will that cannot endure to be thwarted, both urge to a continuance of effort even when success seems hopeless. It is only by experience we gain the conviction that when the mind is thoroughly fatigued it has neither the power to continue with advantage its course in .an assigned direction, nor elasticity to strike out a new path; but that, on the other hand, after being withdrawn for a time from the pursuit, it may return and gain the desired end.

It’s not the critic who counts; not the man which points out how the strong man stumbles or where the doer of deeds could have done them better. The credit belongs to the man who is actually in the arena, whose face is marred by dust and sweat and blood; who strives valiantly; who errs, who comes short again and again … who knows great enthusiasms, the great devotions; who spends himself in a worthy cause; who at the best knows in the end the triumph of high achievement, and who at the worst, if he fails, at least fails while daring greatly, so that his place shall never be with those cold and timid souls who neither know victory nor defeat.

Our brains seem to be organised to make random comparisons of the contents of our memories. Daydreaming allows the process to go into free fall. Suddenly, there is a new idea, born with intense excitement. We cannot organise this process but we can distort or even defeat it.
[Commenting that creativity is not a method that can be learnt and taught.]

Our highest claim to respect, as a nation, rests not in the gold, nor in the iron and the coal, nor in inventions and discoveries, nor in agricultural productions, nor in our wealth, grown so great that a war debt of billions fades out under ministrations of the revenue collector without fretting the people; nor, indeed, in all these combined. That claim finds its true elements in our systems of education and of unconstrained religious worship; in our wise and just laws, and the purity of their administration; in the conservative spirit with which the minority submits to defeat in a hotly-contested election; in a free press; in that broad humanity which builds hospitals and asylums for the poor, sick, and insane on the confines of every city; in the robust, manly, buoyant spirit of a people competent to admonish others and to rule themselves; and in the achievements of that people in every department of thought and learning.

Science is a game—but a game with reality, a game with sharpened knives … If a man cuts a picture carefully into 1000 pieces, you solve the puzzle when you reassemble the pieces into a picture; in the success or failure, both your intelligences compete. In the presentation of a scientific problem, the other player is the good Lord. He has not only set the problem but also has devised the rules of the game—but they are not completely known, half of them are left for you to discover or to deduce. The experiment is the tempered blade which you wield with success against the spirits of darkness—or which defeats you shamefully. The uncertainty is how many of the rules God himself has permanently ordained, and how many apparently are caused by your own mental inertia, while the solution generally becomes possible only through freedom from its limitations.

Surgery is the cry of defeat in medicine.

The 'stream' we call science always flows forward; sometimes reactionary beavers block its flow, but the stream is never defeated by this; it accumulates, gathers strength; its waters get over the barrage and continue on their course. The advancement of science is the advancement of God, for science is nothing but human intelligence, and human intelligence is the most valuable treasure God has bequeathed us.

The fading of ideals is sad evidence of the defeat of human endeavour. In the schools of antiquity philosophers aspired to impart wisdom, in modern colleges our humbler aim is to teach subjects

The heavens call to you, and circle about you, displaying to you their eternal splendors and your eye gazes only to earth.

The idea that our natural resources were inexhaustible still obtained, and there was as yet no real knowledge of their extent and condition. The relation of the conservation of natural resources to the problems of National welfare and National efficiency had not yet dawned on the public mind. The reclamation of arid public lands in the West was still a matter for private enterprise alone; and our magnificent river system, with its superb possibilities for public usefulness, was dealt with by the National Government not as a unit, but as a disconnected series of pork-barrel problems, whose only real interest was in their effect on the re-election or defeat of a Congressman here and there —a theory which, I regret to say, still obtains.

The Royal Navy’s unique ability to combat scurvy was said by one naval physician to have doubled its performance and contributed directly to Britain’s eventual defeat of the French and Spanish fleets at Trafalgar in 1805. (It also meant that British sailors became known as “limeys.”)

To deny education to any people is one of the greatest crimes against human nature. It is to deny them the means of freedom and the rightful pursuit of happiness, and to defeat the very end of their being.

To expect defeat is nine-tenths of defeat itself.

Two lights for guidance. The first, our little glowing atom of community, with all that it signifies. The second, the cold light of the stars, symbol of the hypercosmical reality, with its crystal ecstasy. Strange that in this light, in which even the dearest love is frostily asserted, and even the possible defeat of our half-waking world is contemplated without remission of praise, the human crisis does not lose but gains significance. Strange, that it seems more, not less, urgent to play some part in this struggle, this brief effort of animalcules striving to win for their race some increase of lucidity before the ultimate darkness.

Various accounts of Empedocles’ death are given in ancient sources. His enemies said that his desire to be thought a god led him to throw himself into the crater of Mount Etna so that he might vanish from the world completely and thus lead men to believe he had achieved apotheosis. Unfortunately the volcano defeated his design by throwing out one of the philosopher’s sandals.

War and the steam engine joined forces and forged what was to become one of the most delicate of concepts. Sadi Carnot … formed the opinion that one cause of France’s defeat had been her industrial inferiority. … Carnot saw steam power as a universal motor. … Carnot was a visionary and sharp analyst of what was needed to improve the steam engine. … Carnot’s work … laid the foundations of [thermodynamics].

Western science is a product of the Apollonian mind: its hope is that by naming and classification, by the cold light of intellect, archaic night can be pushed back and defeated.

When Benjamin Franklin invented the lightning-rod, the clergy, both in England and America, with the enthusiastic support of George III, condemned it as an impious attempt to defeat the will of God. For, as all right-thinking people were aware, lightning is sent by God to punish impiety or some other grave sin—the virtuous are never struck by lightning. Therefore if God wants to strike any one, Benjamin Franklin [and his lightning-rod] ought not to defeat His design; indeed, to do so is helping criminals to escape. But God was equal to the occasion, if we are to believe the eminent Dr. Price, one of the leading divines of Boston. Lightning having been rendered ineffectual by the “iron points invented by the sagacious Dr. Franklin,” Massachusetts was shaken by earthquakes, which Dr. Price perceived to be due to God’s wrath at the “iron points.” In a sermon on the subject he said,“In Boston are more erected than elsewhere in New England, and Boston seems to be more dreadfully shaken. Oh! there is no getting out of the mighty hand of God.” Apparently, however, Providence gave up all hope of curing Boston of its wickedness, for, though lightning-rods became more and more common, earthquakes in Massachusetts have remained rare.

When one considers in its length and in its breadth the importance of this question of the education of the nation's young, the broken lives, the defeated hopes, the national failures, which result from the frivolous inertia with which it is treated, it is difficult to restrain within oneself a savage rage. In the conditions of modern life the rule is absolute, the race which does not value trained intelligence is doomed. Not all your heroism, not all your social charm, not all your wit, not all your victories on land or at sea, can move back the finger of fate. To-day we maintain ourselves. To-morrow science will have moved forward yet one more step, and there will be no appeal from the judgment which will then be pronounced on the uneducated.

Yes, Shakespeare foremost and forever (Darwin too). But also teach about the excellence of pygmy bushcraft and Fuegian survival in the world’s harshest climate. Dignity and inspiration come in many guises. Would anyone choose the tinhorn patriotism of George Armstrong Custer over the eloquence of Chief Joseph in defeat?