…resort to science has rendered modern war so destructive of life and property that it presents a new problem to mankind, such, that unless our civilization shall find some means of making an end to war, war will make an end to our civilization.

…what is man in the midst of nature? A nothing in comparison with the infinite, an all in comparison with nothingness: a mean between nothing and all. Infinitely far from comprehending the extremes, the end of things and their principle are for him inevitably concealed in an impenetrable secret; equally incapable of seeing the nothingness whence he is derived, and the infinity in which he is swallowed up.

...while science gives us implements to use, science alone does not determine for what ends they will be employed. Radio is an amazing invention. Yet now that it is here, one suspects that Hitler never could have consolidated his totalitarian control over Germany without its use. One never can tell what hands will reach out to lay hold on scientific gifts, or to what employment they will be put. Ever the old barbarian emerges, destructively using the new civilization.

'O tell me, when along the line
From my full heart the message flows,
What currents are induced in thine?
One click from thee will end my woes'.
Through many an Ohm the Weber flew,
And clicked the answer back to me,
'I am thy Farad, staunch and true,
Charged to a Volt with love for thee'.

“Men die of the diseases which they have studied most,” remarked the surgeon, snipping off the end of a cigar with all his professional neatness and finish. “It’s as if the morbid condition was an evil creature which, when it found itself closely hunted, flew at the throat of its pursuer. If you worry the microbes too much they may worry you. I’ve seen cases of it, and not necessarily in microbic diseases either. There was, of course, the well-known instance of Liston and the aneurism; and a dozen others that I could mention.”

[1665-06-17] It stroke me very deep this afternoon, going with a hackney-coach from my Lord Treasurer's down Holborne - the coachman I found to drive easily and easily; at last stood still, and came down hardly able to stand; and told me that he was suddenly stroke very sick and almost blind. So I light and went into another coach, with a sad heart for the poor man and trouble for myself, lest he should have been stroke with the plague - being at that end of the town that I took him up. But God have mercy upon us all.

[1665-07-31] ...Thus we end this month, as I said, after the greatest glut of content that ever I had; only, under some difficulty because of the plague, which grows mightily upon us, the last week being about 1700 or 1800 of the plague. ...

[1665-08-31] Up, and after putting several things in order to my removal to Woolwich, the plague having a great increase this week beyond all expectation, of almost 2000 - making the general Bill 7000, odd 100 and the plague above 6000 .... Thus this month ends, with great sadness upon the public through the greateness of the plague, everywhere through the Kingdom almost. Every day sadder and sadder news of its increase. In the City died this week 7496; and all of them, 6102 of the plague. But it is feared that the true number of the dead this week is near 10000 - partly from the poor that cannot be taken notice of through the greatness of the number, and partly from the Quakers and others that will not have any bell ring for them. As to myself, I am very well; only, in fear of the plague, and as much of an Ague, by being forced to go early and late to Woolwich, and my family to lie there continually.

[1665-09-14] ...my finding that although the Bill [total of dead] in general is abated, yet the City within the walls is encreasd and likely to continue so (and is close to our house there) - my meeting dead corps's of the plague, carried to be buried close to me at noonday through the City in Fanchurch-street - to see a person sick of the sores carried close by me by Grace-church in a hackney-coach - my finding the Angell tavern at the lower end of Tower-hill shut up; and more then that, the alehouse at the Tower-stairs; and more then that, that the person was then dying of the plague when I was last there, a little while ago at night, to write a short letter there, and I overheard the mistress of the house sadly saying to her husband somebody was very ill, but did not think it was of the plague - to hear that poor Payne my waterman hath buried a child and is dying himself - to hear that a labourer I sent but the other day to Dagenhams to know how they did there is dead of the plague and that one of my own watermen, that carried me daily, fell sick as soon as he had landed me on Friday morning last, when I had been all night upon the water ... is now dead of the plague - to hear ... that Mr Sidny Mountagu is sick of a desperate fever at my Lady Carteret's at Scott's hall - to hear that Mr. Lewes hath another daughter sick - and lastly, that both my servants, W Hewers and Tom Edwards, have lost their fathers, both in St. Sepulcher's parish, of the plague this week - doth put me into great apprehensions of melancholy, and with good reason. But I put off the thoughts of sadness as much as I can, and the rather to keep my wife in good heart and family also.

[1665-12-31] Thus ends this year ... It is true we have gone through great melancholy because of the great plague, and I put to great charges by it, by keeping my family long at Woolwich, and myself and another part of my family, my clerks, at my charge at Greenwich ... But now the plague is abated almost to nothing ... But many of such as I know very well, dead. Yet to our great joy, the town fills apace, and shops begin to open again. Pray God continue the plague's decrease - for that keeps the Court away from the place of business, and so all goes to wrack as to public matters, they at this distance not thinking of it.

[About any invention] (1) everything that’s already in the world when you’re born is just normal; (2) anything that gets invented between then and before you turn thirty is incredibly exciting and creative and with any luck you can make a career out of it; (3) anything that gets invented after you’re thirty is against the natural order of things and the beginning of the end of civilisation as we know it until it’s been around for about ten years when it gradually turns out to be alright really.

[At the end of the story, its main character, Tom] is now a great man of science, and can plan railroads, and steam-engines, and electric telegraphs, and rifled guns, and so forth; and knows everything about everything, except why a hen's egg don't turn into a crocodile, and two or three other little things that no one will know till the coming of the Cocqcigrues.

[Blackett] came one morning, deep in thought, into the G (technical) Office at Stanmore. It was a bitterly cold day, and the staff were shivering in a garret warmed over only with an oil-stove. Without a word of greeting, Blackett stepped silently up on to the table and stood there pondering with his feet among the plans. After ten minutes somebody coughed uneasily and said, diffidently: “Wouldn’t you like a chair, sir … or something?” “No, thank you,” said Professor Blackett, “it is necessary to apply scientific methods. Hot air rises. The warmest spot in this room, therefore, will be near the ceiling.” At this, Colonel Krohn, my technical G.S.O., stepped up on the table beside the Professor, and for the next half-hour, the two stayed there in silence. At the end of this period Professor Blackett stepped down from the table saying: “Well! That’s that problem solved.” And so it was.

[Edison] definitely ended the distinction between the theoretical man of science and the practical man of science, so that today we think of scientific discoveries in connection with their possible present or future application to the needs of man. He took the old rule-of-thumb methods out of industry and substituted exact scientific knowledge, while, on the other hand, he directed scientific research into useful channels.

[J.J.] Sylvester’s methods! He had none. “Three lectures will be delivered on a New Universal Algebra,” he would say; then, “The course must be extended to twelve.” It did last all the rest of that year. The following year the course was to be Substitutions-Théorie, by Netto. We all got the text. He lectured about three times, following the text closely and stopping sharp at the end of the hour. Then he began to think about matrices again. “I must give one lecture a week on those,” he said. He could not confine himself to the hour, nor to the one lecture a week. Two weeks were passed, and Netto was forgotten entirely and never mentioned again. Statements like the following were not unfrequent in his lectures: “I haven’t proved this, but I am as sure as I can be of anything that it must be so. From this it will follow, etc.” At the next lecture it turned out that what he was so sure of was false. Never mind, he kept on forever guessing and trying, and presently a wonderful discovery followed, then another and another. Afterward he would go back and work it all over again, and surprise us with all sorts of side lights. He then made another leap in the dark, more treasures were discovered, and so on forever.

[On research] It’s got to be fun. I don't think anybody should tell you that he’s slogged his way through 25 years on a problem and there's only one reward at the end, and that's the value of the Hubble constant. That’s a bunch of hooey. The reward is learning all the wonderful properties of the things that don’t work.

[Retirement] is a dangerous experiment, and generally ends in either drunkenness or hypochrondriacism.

[The 1957-1961 years of the U.S. space program] were the sad years in which the joke was that our countdowns ended in "Four, three, two, one, oh shit!"

[The root cap of a plant], having the power of directing the movements of the adjoining parts, acts like the brain of one of the lower animals; the brain being seated within the anterior end of the body, receiving impressions from the sense-organs, and directing the several movements.

[To] mechanical progress there is apparently no end: for as in the past so in the future, each step in any direction will remove limits and bring in past barriers which have till then blocked the way in other directions; and so what for the time may appear to be a visible or practical limit will turn out to be but a bend in the road.

The Redwoods

Here, sown by the Creator's hand,
In serried ranks, the Redwoods stand;
No other clime is honored so,
No other lands their glory know.

The greatest of Earth's living forms,
Tall conquerors that laugh at storms;
Their challenge still unanswered rings,
Through fifty centuries of kings.

The nations that with them were young,
Rich empires, with their forts far-flung,
Lie buried now—their splendor gone;
But these proud monarchs still live on.

So shall they live, when ends our day,
When our crude citadels decay;
For brief the years allotted man,
But infinite perennials' span.

This is their temple, vaulted high,
And here we pause with reverent eye,
With silent tongue and awe-struck soul;
For here we sense life's proper goal;

To be like these, straight, true and fine,
To make our world, like theirs, a shrine;
Sink down, oh traveler, on your knees,
God stands before you in these trees.

[Defining Organism] That in which every part is at once means and end.

Atten. Pray of what disease did Mr. Badman die, for now I perceive we are come up to his death? Wise. I cannot so properly say that he died of one disease, for there were many that had consented, and laid their heads together to bring him to his end. He was dropsical, he was consumptive, he was surfeited, was gouty, and, as some say, he had a tang of the pox in his bowels. Yet the captain of all these men of death that came against him to take him away, was the consumption, for it was that that brought him down to the grave.

Copernicus, who rightly did condemn
This eldest systeme, form’d a wiser scheme;
In which he leaves the Sun at Rest, and rolls
The Orb Terrestial on its proper Poles;
Which makes the Night and Day by this Career,
And by its slow and crooked Course the Year.
The famous Dane, who oft the Modern guides,
To Earth and Sun their Provinces divides:
The Earth’s Rotation makes the Night and Day,
The Sun revolving through th’ Eccliptic Way
Effects the various seasons of the Year,
Which in their Turn for happy Ends appear.
This Scheme or that, which pleases best, embrace,
Still we the Fountain of their Motion trace.
Kepler asserts these Wonders may be done
By the Magnetic Vertue of the Sun,
Which he, to gain his End, thinks fit to place
Full in the Center of that mighty Space,
Which does the Spheres, where Planets roll, include,
And leaves him with Attractive Force endu’d.
The Sun, thus seated, by Mechanic Laws,
The Earth, and every distant Planet draws;
By which Attraction all the Planets found
Within his reach, are turn'd in Ether round.

Dans l’étude de la nature, comme dans la pratique de l’art, il n’est pas donné a l’homme d’arriver au but sans laisser des traces des fausses routes qu’il a tenues.
In the study of nature, as in the practice of art, it is not given to man to achieve the goal without leaving a trail of dead ends he had pursued.

Dilbert: And we know mass creates gravity because more dense planets have more gravity.
Dogbert: How do we know which planets are more dense?
Dilbert:They have more gravity.
Dogbert: That's circular reasoning.
Dilbert: I prefer to think of it as having no loose ends.

Goldsmith: If you put a tub full of blood into a stable, the horses are like to go mad.
Johnson: I doubt that.
Goldsmith: Nay, sir, it is a fact well authenticated.
Thrale: You had better prove it before you put it into your book on natural history. You may do it in my stable if you will.
Johnson: Nay, sir, I would not have him prove it. If he is content to take his information from others, he may get through his book with little trouble, and without much endangering his reputation. But if he makes experiments for so comprehensive a book as his, there would be no end to them; his erroneous assertions would then fall upon himself: and he might be blamed for not having made experiments as to every particular.

Question: A hollow indiarubber ball full of air is suspended on one arm of a balance and weighed in air. The whole is then covered by the receiver of an air pump. Explain what will happen as the air in the receiver is exhausted.
Answer: The ball would expand and entirely fill the vessell, driving out all before it. The balance being of greater density than the rest would be the last to go, but in the end its inertia would be overcome and all would be expelled, and there would be a perfect vacuum. The ball would then burst, but you would not be aware of the fact on account of the loudness of a sound varying with the density of the place in which it is generated, and not on that in which it is heard.

To Wheeler's comment, If you haven't found something strange during the day, it hasn't been much of a day, a student responded, I can't believe that space is that crummy. Wheeler replied: To disagree leads to study, to study leads to understanding, to understand is to appreciate, to appreciate is to love. So maybe I'll end up loving your theory.

Ueber den Glauben lässt sich wissenschaftlich nicht rechten, denn die Wissenschaft und der Glaube schliessen sich aus. Nicht so, dass der eine die andere unmöglich machte oder umgekehrt, sondern so, dass, soweit die Wissenschaft reicht, kein Glaube existirt und der Glaube erst da anfangen darf, wo die Wissenschaft aufhört. Es lässt „sich nicht läugnen, dass, wenn diese Grenze eingehalten wird, der Glaube wirklich reale Objekte haben kann. Die Aufgabe der Wissenschaft ist es daher nicht, die Gegenstände des Glaubens anzugreifen, sondern nur die Grenzen zu stecken, welche die Erkenntniss erreichen kann, und innerhalb derselben das einheitliche Selbstbewusstsein zu begründen.
There is no scientific justification for faith, for science and faith are mutually exclusive. Not that one made the other impossible, or vice versa, but that, as far as science goes, there is no faith, and faith can only begin where science ends. It can not be denied that, if this limit is adhered to, faith can really have real objects. The task of science, therefore, is not to attack the objects of faith, but merely to set the limits which knowledge can attain and to establish within it the unified self-esteem.

Where faith commences, science ends. Both these arts of the human mind must be strictly kept apart from each other. Faith has its origin in the poetic imagination; knowledge, on the other hand, originates in the reasoning intelligence of man. Science has to pluck the blessed fruits from the tree of knowledge, unconcerned whether these conquests trench upon the poetical imaginings of faith or not.

Zweck sein selbst ist jegliches Tier.
Each animal is an end in itself.

CALPURNIA: When beggars die there are no comets seen;
The heavens themselves blaze forth the death of princes.
CAESAR: Cowards die many times before their deaths;
The valiant never taste of death but once.
Of all the wonders that I have yet heard,
It seems to me most strange that men should fear,
Seeing that death, a necessary end,
Will come when it will come.

~~[Misquotation]~~ Every truth starts life as a heresy and ends life as an orthodoxy.

1. Universal CHEMISTRY is the Art of resolving mixt, compound, or aggregate Bodies into their Principles; and of composing such Bodies from those Principles. 2. It has for its Subject all the mix’d, compound, and aggregate Bodies that are and resolvable and combinable and Resolution and Combination, or Destruction and Generation, for its Object. 3. Its Means in general, are either remote or immediate; that is, either Instruments or the Operations themselves. 4. Its End is either philosophical and theoretical; or medicinal, mechanical, œconomical, and practical. 5. Its efficient Cause is the Chemist.

A conflict arises when a religious community insists on the absolute truthfulness of all statements recorded in the Bible. This means an intervention on the part of religion into the sphere of science; this is where the struggle of the Church against the doctrines of Galileo and Darwin belongs. On the other hand, representatives of science have often made an attempt to arrive at fundamental judgments with respect to values and ends on the basis of scientific method, and in this way have set themselves in opposition to religion. These conflicts have all sprung from fatal errors.

A few days afterwards, I went to him [the same actuary referred to in another quote] and very gravely told him that I had discovered the law of human mortality in the Carlisle Table, of which he thought very highly. I told him that the law was involved in this circumstance. Take the table of the expectation of life, choose any age, take its expectation and make the nearest integer a new age, do the same with that, and so on; begin at what age you like, you are sure to end at the place where the age past is equal, or most nearly equal, to the expectation to come. “You don’t mean that this always happens?”—“Try it.” He did try, again and again; and found it as I said. “This is, indeed, a curious thing; this is a discovery!” I might have sent him about trumpeting the law of life: but I contented myself with informing him that the same thing would happen with any table whatsoever in which the first column goes up and the second goes down.

A friend called me up the other day and talked about investing in a dot-com that sells lobsters. Internet lobsters. Where will this end? The next day he sent me a huge package of lobsters on ice. How low can you stoop?

A game is on, at the other end of this infinite distance, and heads or tails will turn up. What will you wager? According to reason you cannot leave either; according to reason you cannot leave either undone... Yes, but wager you must; there is no option, you have embarked on it. So which will you have. Come. Since you must choose, let us see what concerns you least. You have two things to lose: truth and good, and two things to stake: your reason and your will, your knowledge and your happiness. And your nature has two things to shun: error and misery. Your reason does not suffer by your choosing one more than the other, for you must choose. That is one point cleared. But your happiness? Let us weigh gain and loss in calling heads that God is. Reckon these two chances: if you win, you win all; if you lose, you lose naught. Then do not hesitate, wager that He is.

A huge net is being dragged across the sea floor, destroying everything in its path. Ahead of it bloom undersea forests and their hundreds and thousands of living creatures, both plant and animal; behind it is a desert. The net is pulled to the surface and most of the dead and dying life forms in it are thrown out. A few marketable species are retained. [Trawling] is like taking a front-end loader and scraping up your entire front garden and shredding it, keeping a few pebbles, and dumping the rest of it down the drain.

A hundred years ago the study of life was often pursued, and also presented to the public, in a highly unified way. Darwin, as everyone knows, in addressing the world at large began his story with the history of pigeons and ended it with the breeding of primroses, having made excursions on the way into the origins of coral reefs and of the races of Man.

A love affair with knowledge will never end in heartbreak.

A man who is master of himself can end a sorrow as easily as he can invent a pleasure.

A physician’s subject of study is necessarily the patient, and his first field for observation is the hospital. But if clinical observation teaches him to know the form and course of diseases, it cannot suffice to make him understand their nature; to this end he must penetrate into the body to find which of the internal parts are injured in their functions. That is why dissection of cadavers and microscopic study of diseases were soon added to clinical observation. But to-day these various methods no longer suffice; we must push investigation further and, in analyzing the elementary phenomena of organic bodies, must compare normal with abnormal states. We showed elsewhere how incapable is anatomy alone to take account of vital phenenoma, and we saw that we must add study of all physico-chemical conditions which contribute necessary elements to normal or pathological manifestations of life. This simple suggestion already makes us feel that the laboratory of a physiologist-physician must be the most complicated of all laboratories, because he has to experiment with phenomena of life which are the most complex of all natural phenomena.

A sentence should read as if its author, had he held a plow instead of a pen, could have drawn a furrow deep and straight to the end.

A strict materialist believes that everything depends on the motion of matter. He knows the form of the laws of motion though he does not know all their consequences when applied to systems of unknown complexity.
Now one thing in which the materialist (fortified with dynamical knowledge) believes is that if every motion great & small were accurately reversed, and the world left to itself again, everything would happen backwards the fresh water would collect out of the sea and run up the rivers and finally fly up to the clouds in drops which would extract heat from the air and evaporate and afterwards in condensing would shoot out rays of light to the sun and so on. Of course all living things would regrede from the grave to the cradle and we should have a memory of the future but not of the past.
The reason why we do not expect anything of this kind to take place at any time is our experience of irreversible processes, all of one kind, and this leads to the doctrine of a beginning & an end instead of cyclical progression for ever.

A surprising number [of novels] have been read aloud to me, and I like all if moderately good, and if they do not end unhappily—against which a law ought to be passed.

About ten months ago [1609] a report reached my ears that a certain Fleming [Hans Lippershey] had constructed a spyglass, by means of which visible objects, though very distant from the eye of the observer, were distinctly seen as if nearby... Of this truly remarkable effect several experiences were related, to which some persons gave credence while others denied them. A few days later the report was confirmed to me in a letter from a noble Frenchman at Paris, Jacques Badovere, which caused me to apply myself wholeheartedly to enquire into the means by which I might arrive at the invention of a similar instrument. This I did shortly afterwards, my basis being the theory of refraction. First I prepared a tube of lead, at the ends of which I fitted two glass lenses, both plane on one side while on the other side one was spherically convex and the other concave.

After the planet becomes theirs, many millions of years will have to pass before a beetle particularly loved by God, at the end of its calculations will find written on a sheet of paper in letters of fire that energy is equal to the mass multiplied by the square of the velocity of light. The new kings of the world will live tranquilly for a long time, confining themselves to devouring each other and being parasites among each other on a cottage industry scale.

After what has been premised, I think we may lay down the following Conclusions. First, It is plain Philosophers amuse themselves in vain, when they inquire for any natural efficient Cause, distinct from a Mind or Spirit. Secondly, Considering the whole Creation is the Workmanship of a wise and good Agent, it should seem to become Philosophers, to employ their Thoughts (contrary to what some hold) about the final Causes of Things: And I must confess, I see no reason, why pointing out the various Ends, to which natural Things are adapted and for which they were originally with unspeakable Wisdom contrived, should not be thought one good way of accounting for them, and altogether worthy a Philosopher.

Alike in the external and the internal worlds, the man of science sees himself in the midst of perpetual changes of which he can discover neither the beginning nor the end.

All change is relative. The universe is expanding relatively to our common material standards; our material standards are shrinking relatively to the size of the universe. The theory of the “expanding universe” might also be called the theory of the “shrinking atom”. …
:Let us then take the whole universe as our standard of constancy, and adopt the view of a cosmic being whose body is composed of intergalactic spaces and swells as they swell. Or rather we must now say it keeps the same size, for he will not admit that it is he who has changed. Watching us for a few thousand million years, he sees us shrinking; atoms, animals, planets, even the galaxies, all shrink alike; only the intergalactic spaces remain the same. The earth spirals round the sun in an ever-decreasing orbit. It would be absurd to treat its changing revolution as a constant unit of time. The cosmic being will naturally relate his units of length and time so that the velocity of light remains constant. Our years will then decrease in geometrical progression in the cosmic scale of time. On that scale man’s life is becoming briefer; his threescore years and ten are an ever-decreasing allowance. Owing to the property of geometrical progressions an infinite number of our years will add up to a finite cosmic time; so that what we should call the end of eternity is an ordinary finite date in the cosmic calendar. But on that date the universe has expanded to infinity in our reckoning, and we have shrunk to nothing in the reckoning of the cosmic being.
We walk the stage of life, performers of a drama for the benefit of the cosmic spectator. As the scenes proceed he notices that the actors are growing smaller and the action quicker. When the last act opens the curtain rises on midget actors rushing through their parts at frantic speed. Smaller and smaller. Faster and faster. One last microscopic blurr of intense agitation. And then nothing.

All geologic history is full of the beginning and the ends of species–of their first and last days; but it exhibits no genealogies of development.

All human knowledge begins with intuitions, proceeds from thence to concepts, and ends with ideas.

All the different classes of beings which taken together make up the universe are, in the ideas of God who knows distinctly their essential gradations, only so many ordinates of a single curve so closely united that it would be impossible to place others between any two of them, since that would imply disorder and imperfection. Thus men are linked with the animals, these with the plants and these with the fossils which in turn merge with those bodies which our senses and our imagination represent to us as absolutely inanimate. And, since the law of continuity requires that when the essential attributes of one being approximate those of another all the properties of the one must likewise gradually approximate those of the other, it is necessary that all the orders of natural beings form but a single chain, in which the various classes, like so many rings, are so closely linked one to another that it is impossible for the senses or the imagination to determine precisely the point at which one ends and the next begins?all the species which, so to say, lie near the borderlands being equivocal, at endowed with characters which might equally well be assigned to either of the neighboring species. Thus there is nothing monstrous in the existence zoophytes, or plant-animals, as Budaeus calls them; on the contrary, it is wholly in keeping with the order of nature that they should exist. And so great is the force of the principle of continuity, to my thinking, that not only should I not be surprised to hear that such beings had been discovered?creatures which in some of their properties, such as nutrition or reproduction, might pass equally well for animals or for plants, and which thus overturn the current laws based upon the supposition of a perfect and absolute separation of the different orders of coexistent beings which fill the universe;?not only, I say, should I not be surprised to hear that they had been discovered, but, in fact, I am convinced that there must be such creatures, and that natural history will perhaps some day become acquainted with them, when it has further studied that infinity of living things whose small size conceals them for ordinary observation and which are hidden in the bowels of the earth and the depth of the sea.

All the sciences are, in some measure, linked with each other, and before the one is ended, the other begins.

All the species recognized by Botanists came forth from the Almighty Creator’s hand, and the number of these is now and always will be exactly the same, while every day new and different florists’ species arise from the true species so-called by Botanists, and when they have arisen they finally revert to the original forms. Accordingly to the former have been assigned by Nature fixed limits, beyond which they cannot go: while the latter display without end the infinite sport of Nature.

All things began in Order, so shall they end, and so shall they begin again, according to the Ordainer of Order, and the mystical mathematicks of the City of Heaven.

Almost daily we shudder as prophets of doom announce the impending end of civilization and universe. We are being asphyxiated, they say, by the smoke of the industry; we are suffocating in the ever growing mountain of rubbish. Every new project depicts its measureable effects and is denounced by protesters screaming about catastrophe, the upsetting of the land, the assault on nature. If we accepted this new mythology we would have to stop pushing roads through the forest, harnessing rivers to produce the electricity, breaking grounds to extract metals, enriching the soil with chemicals, killing insects, combating viruses … But progress—basically, an effort to organise a corner of land and make it more favourable for human life—cannot be baited. Without the science of pomiculture, for example, trees will bear fruits that are small, bitter, hard, indigestible, and sour. Progress is desirable.

Although few expressions are more commonly used in writing about science than “science revolution,” there is a continuing debate as to the propriety of applying the concept and term “revolution” to scientific change. There is, furthermore, a wide difference of opinion as to what may constitute a revolution. And although almost all historians would agree that a genuine alteration of an exceptionally radical nature (the Scientific Revolution) occurred in the sciences at some time between the late fifteenth (or early sixteenth) century and the end of the seventeenth century, the question of exactly when this revolution occurred arouses as much scholarly disagreement as the cognate question of precisely what it was.

Although nature commences with reason and ends in experience it is necessary for us to do the opposite, that is to commence as I said before with experience and from this to proceed to investigate the reason.

Among innumerable footsteps of divine providence to be found in the works of nature, there is a very remarkable one to be observed in the exact balance that is maintained, between the numbers of men and women; for by this means is provided, that the species never may fail, nor perish, since every male may have its female, and of proportionable age. This equality of males and females is not the effect of chance but divine providence, working for a good end, which I thus demonstrate.

An act cannot be defined by the end sought by the actor, for an identical system of behaviour may be adjustable to too many different ends without altering its nature.

An egg is a chemical process, but it is not a mere chemical process. It is one that is going places—even when, in our world of chance and contingency, it ends up in an omelet and not in a chicken. Though it surely be a chemical process, we cannot understand it adequately without knowing the kind of chicken it has the power to become.

An example of such emergent phenomena is the origin of life from non-living chemical compounds in the oldest, lifeless oceans of the earth. Here, aided by the radiation energy received from the sun, countless chemical materials were synthesized and accumulated in such a way that they constituted, as it were, a primeval “soup.” In this primeval soup, by infinite variations of lifeless growth and decay of substances during some billions of years, the way of life was ultimately reached, with its metabolism characterized by selective assimilation and dissimilation as end stations of a sluiced and canalized flow of free chemical energy.

An inventor is an opportunist, one who takes occasion by the hand; who, having seen where some want exists, successfully applies the right means to attain the desired end. The means may be largely, or even wholly, something already known, or there may be a certain originality or discovery in the means employed. But in every case the inventor uses the work of others. If I may use a metaphor, I should liken him to the man who essays the conquest of some virgin alp. At the outset he uses the beaten track, and, as he progresses in the ascent, he uses the steps made by those who have preceded him, whenever they lead in the right direction; and it is only after the last footprints have died out that he takes ice-axe in hand and cuts the remaining steps, few or many, that lift him to the crowning height which is his goal.

An iron rod being placed on the outside of a building from the highest part continued down into the moist earth, in any direction strait or crooked, following the form of the roof or other parts of the building, will receive the lightning at its upper end, attracting it so as to prevent it's striking any other part; and, affording it a good conveyance into the earth, will prevent its damaging any part of the building.

An organized product of nature is that in which all the parts are mutually ends and means.

And do you know what “the world” is to me? Shall I show it to you in my mirror? This world: a monster of energy, without beginning, without end; a firm, iron magnitude of force that does not grow bigger or smaller, that does not expend itself but only transforms itself; as a whole, of unalterable size, a household without expenses or losses, but likewise without increase or income; enclosed by “nothingness”' as by a boundary; not by something blurry or wasted, not something endlessly extended, but set in a definite space as a definite force, and not a space that might be “empty” here or there, but rather as force throughout, as a play of forces and waves of forces, at the same time one and many, increasing here and at the same time decreasing there; a sea of forces flowing and rushing together, eternally changing, eternally flooding back, with tremendous years of recurrence, with an ebb and a flood of its forms; out of the simplest forms striving toward the most complex, out of the stillest, most rigid, coldest forms toward the hottest, most turbulent, most self-contradictory, and then again returning home to the simple out of this abundance, out of the play of contradictions back to the joy of concord, still affirming itself in this uniformity of its courses and its years, blessing itself as that which must return eternally, as a becoming that knows no satiety, no disgust, no weariness: this, my Dionysian world of the eternally self-creating, the eternally self-destroying, this mystery world of the twofold voluptuous delight, my “beyond good and evil,” without goal, unless the joy of the circle itself is a goal; without will, unless a ring feels good will toward itself-do you want a name for this world? A solution for all its riddles? A light for you, too, you best-concealed, strongest, most intrepid, most midnightly men?—This world is the will to power—and nothing besides! And you yourselves are also this will to power—and nothing besides!

And I believe there are many Species in Nature, which were never yet taken notice of by Man, and consequently of no use to him, which yet we are not to think were created in vain; but it’s likely … to partake of the overflowing Goodness of the Creator, and enjoy their own Beings. But though in this sense it be not true, that all things were made for Man; yet thus far it is, that all the Creatures in the World may be some way or other useful to us, at least to exercise our Wits and Understandings, in considering and contemplating of them, and so afford us Subject of Admiring and Glorifying their and our Maker. Seeing them, we do believe and assert that all things were in some sense made for us, we are thereby obliged to make use of them for those purposes for which they serve us, else we frustrate this End of their Creation.

Are we using science in ways that it wasn't intended to, in which case we should be a little careful, or are we using faith in ways that faith wasn't really designed for? There are certain questions that are better answered by one approach than the other, and if you start mixing that up, then you end up in … conflict.

Ars est sine arte, cujus principium est mentiri, medium laborare, et finis mendicare.
The art is devoid of art, whose beginning is falsehood, its middle labour, and its end beggary.
[On the character of the delusive science of alchemy].

As a great man’s influence never ends, so also there is no definite finality, no end, to a great survey; it runs along for centuries, ever responsive to the strain of the increasing needs of a growing population and an enlarging domain.

As for hailing [the new term] scientist as 'good', that was mere politeness: Faraday never used the word, describing himself as a natural philosopher to the end of his career.

As for types like my own, obscurely motivated by the conviction that our existence was worthless if we didn’t make a turning point of it, we were assigned to the humanities, to poetry, philosophy, painting—the nursery games of humankind, which had to be left behind when the age of science began. The humanities would be called upon to choose a wallpaper for the crypt, as the end drew near.

As geologists, we learn that it is not only the present condition of the globe that has been suited to the accommodation of myriads of living creatures, but that many former states also have been equally adapted to the organization and habits of prior races of beings. The disposition of the seas, continents, and islands, and the climates have varied; so it appears that the species have been changed, and yet they have all been so modelled, on types analogous to those of existing plants and animals, as to indicate throughout a perfect harmony of design and unity of purpose. To assume that the evidence of the beginning or end of so vast a scheme lies within the reach of our philosophical inquiries, or even of our speculations, appears to us inconsistent with a just estimate of the relations which subsist between the finite powers of man and the attributes of an Infinite and Eternal Being.

As our technology evolves, we will have the capacity to reach new, ever-increasing depths. The question is: What kind of technology, in the end, do we want to deploy in the far reaches of the ocean? Tools of science, ecology and documentation, or the destructive tools of heavy industry? Some parts of our oceans, like the rich and mysterious recesses of our Atlantic submarine canyons and seamounts, are so stunning and sensitive they deserve to be protected from destructive activities.

As the saying goes, the Stone Age did not end because we ran out of stones; we transitioned to better solutions. The same opportunity lies before us with energy efficiency and clean energy.

As there is not in human observation proper means for measuring the waste of land upon the globe, it is hence inferred, that we cannot estimate the duration of what we see at present, nor calculate the period at which it had begun; so that, with respect to human observation, this world has neither a beginning nor an end.

As was the case for Nobel's own invention of dynamite, the uses that are made of increased knowledge can serve both beneficial and potentially harmful ends. Increased knowledge clearly implies increased responsibility. We reject the notion advocated in some quarters that man should stop eating from the tree of knowledge, as if that were humanly possible.

As we look ahead through the vista of science with its tremendous possibilities for progress in peacetime, let us not feel that we are looking beyond the horizon of hope. The outlook is not discouraging, for there is no limit to man’s ingenuity and no end to the opportunities for progress.

As, no matter what cunning system of checks we devise, we must in the end trust some one whom we do not check, but to whom we give unreserved confidence, so there is a point at which the understanding and mental processes must be taken as understood without further question or definition in words. And I should say that this point should be fixed pretty early in the discussion.

Asian Homo erectus died without issue and does not enter our immediate ancestry (for we evolved from African populations); Neanderthal people were collateral cousins, perhaps already living in Europe while we emerged in Africa... In other words, we are an improbable and fragile entity, fortunately successful after precarious beginnings as a small population in Africa, not the predictable end result of a global tendency. We are a thing, an item of history, not an embodiment of general principles.

Astrology is framed by the devil, to the end people may be scared from entering into the state of matrimony, and from every divine and human office and calling.

Astronomers and physicists, dealing habitually with objects and quantities far beyond the reach of the senses, even with the aid of the most powerful aids that ingenuity has been able to devise, tend almost inevitably to fall into the ways of thinking of men dealing with objects and quantities that do not exist at all, e.g., theologians and metaphysicians. Thus their speculations tend almost inevitably to depart from the field of true science, which is that of precise observation, and to become mere soaring in the empyrean. The process works backward, too. That is to say, their reports of what they pretend actually to see are often very unreliable. It is thus no wonder that, of all men of science, they are the most given to flirting with theology. Nor is it remarkable that, in the popular belief, most astronomers end by losing their minds.

Astronomy teaches the correct use of the sun and the planets. These may be put on a frame of little sticks and turned round. This causes the tides. Those at the ends of the sticks are enormously far away. From time to time a diligent searching of the sticks reveals new planets. The orbit of the planet is the distance the stick goes round in going round. Astronomy is intensely interesting; it should be done at night, in a high tower at Spitzbergen. This is to avoid the astronomy being interrupted. A really good astronomer can tell when a comet is coming too near him by the warning buzz of the revolving sticks.

At first it seems obvious, but the more you think about it the stranger the deductions from this axiom seem to become; in the end you cease to understand what is meant by it.

At first sight nothing seems more obvious than that everything has a beginning and an end, and that everything can be subdivided into smaller parts. Nevertheless, for entirely speculative reasons the philosophers of Antiquity, especially the Stoics, concluded this concept to be quite unnecessary. The prodigious development of physics has now reached the same conclusion as those philosophers, Empedocles and Democritus in particular, who lived around 500 B.C. and for whom even ancient man had a lively admiration.

At last gleams of light have come, and I am almost convinced (quite contrary to opinion I started with) that species are not (it is like confessing a murder) immutable. Heaven forfend me from Lamarck nonsense of a “tendency to progression”, “adaptations from the slow willing of animals”, &c! But the conclusions I am led to are not widely different from his; though the means of change are wholly so. I think I have found out (here’s presumption!) the simple way by which species become exquisitely adapted to various ends.

At no period of [Michael Faraday’s] unmatched career was he interested in utility. He was absorbed in disentangling the riddles of the universe, at first chemical riddles, in later periods, physical riddles. As far as he cared, the question of utility was never raised. Any suspicion of utility would have restricted his restless curiosity. In the end, utility resulted, but it was never a criterion to which his ceaseless experimentation could be subjected.

At the end of 1854 … the aggregate length of railways opened in Great Britain and Ireland at that time measured about 8,054 miles,—about the diameter of the globe, and nearly 500 miles more than the united lengths of the Thames, the Seine, the Rhone, the Ebro, the Tagus, the Rhine, the Elbe, the Vistula, the Dnieper, and the Danube, or the ten chief rivers of Europe. … the work of only twenty-five years.

At the end of the book [Zoonomia] he sums up his [Erasmus Darwin] views in the following sentences: “The world has been evolved, not created: it has arisen little by little from a small beginning, and has increased through the activity of the elemental forces embodied in itself, and so has rather grown than come into being at an almighty word.” “What a sublime idea of the infinite might of the great Architect, the Cause of all causes, the Father of all fathers, the Ens Entium! For if we would compare the Infinite, it would surely require a greater Infinite to cause the causes of effects than to produce the effects themselves.”
[This is a restatement, not a verbatim quote of the original words of Erasmus Darwin, who attributed the idea he summarized to David Hume.]

At the outset do not be worried about this big question—Truth. It is a very simple matter if each one of you starts with the desire to get as much as possible. No human being is constituted to know the truth, the whole truth, and nothing but the truth; and even the best of men must be content with fragments, with partial glimpses, never the full fruition. In this unsatisfied quest the attitude of mind, the desire, the thirst—a thirst that from the soul must arise!—the fervent longing, are the be-all and the end-all.

Attempt the end and never stand to doubt;
Nothing's so hard, but search will find it out.

Basic research at universities comes in two varieties: research that requires big bucks and research that requires small bucks. Big bucks research is much like government research and in fact usually is government research but done for the government under contract. Like other government research, big bucks academic research is done to understand the nature and structure of the universe or to understand life, which really means that it is either for blowing up the world or extending life, whichever comes first. Again, that's the government's motivation. The universities' motivation for conducting big bucks research is to bring money in to support professors and graduate students and to wax the floors of ivy-covered buildings. While we think they are busy teaching and learning, these folks are mainly doing big bucks basic research for a living, all the while priding themselves on their terrific summer vacations and lack of a dress code.
Smalls bucks research is the sort of thing that requires paper and pencil, and maybe a blackboard, and is aimed primarily at increasing knowledge in areas of study that don't usually attract big bucks - that is, areas that don't extend life or end it, or both. History, political science, and romance languages are typically small bucks areas of basic research. The real purpose of small bucks research to the universities is to provide a means of deciding, by the quality of their small bucks research, which professors in these areas should get tenure.

Belief begins where science leaves off and ends where science begins.

Beneath multiple specific and individual distinctions, beneath innumerable and incessant transformations, at the bottom of the circular evolution without beginning or end, there hides a law, a unique nature participated in by all beings, in which this common participation produces a ground of common harmony.

Beyond lonely Pluto, dark and shadowless, lies the glittering realm of interstellar space, the silent ocean that rolls on and on, past stars and galaxies alike, to the ends of the Universe. What do men know of this vast infinity, this shoreless ocean? Is it hostile or friendly–or merely indifferent?

Beyond these are other suns, giving light and life to systems, not a thousand, or two thousand merely, but multiplied without end, and ranged all around us, at immense distances from each other, attended by ten thousand times ten thousand worlds, all in rapid motion; yet calm, regular and harmonious—all space seems to be illuminated, and every particle of light a world. ... all this vast assemblages of suns and worlds may bear no greater proportion to what lies beyond the utmost boundaries of human vision, than a drop of water to the ocean.

Bigotry and science can have no communication with each other, for science begins where bigotry and absolute certainty end.

Biology as a discipline would benefit enormously if we could bring together the scientists working at the opposite ends of the biological spectrum. Students of organisms who know natural history have abundant questions to offer the students of molecules and cells. And molecular and cellular biologists with their armory of techniques and special insights have much to offer students of organisms and ecology.

Both Religion and science require faith in God. For believers, God is in the beginning, and for physicists He is at the end of all considerations.

Broadly speaking, we are in the middle of a race between human skill as a means and human folly as an end.

But come, hear my words, for truly learning causes the mind to grow. For as I said before in declaring the ends of my words … at one time there grew to be the one alone out of many, and at another time it separated so that there were many out of the one; fire and water and earth and boundless height of air, and baneful Strife apart from these, balancing each of them, and Love among them, their equal in length and breadth.

But if we are to control evolution we shall have to find out how to influence gene reproduction in a definite direction, just as organic chemists nowadays work for definite ends. Such a possibility is at present entirely beyond our grasp, but a century hence it may not be so.

But it is precisely mathematics, and the pure science generally, from which the general educated public and independent students have been debarred, and into which they have only rarely attained more than a very meagre insight. The reason of this is twofold. In the first place, the ascendant and consecutive character of mathematical knowledge renders its results absolutely insusceptible of presentation to persons who are unacquainted with what has gone before, and so necessitates on the part of its devotees a thorough and patient exploration of the field from the very beginning, as distinguished from those sciences which may, so to speak, be begun at the end, and which are consequently cultivated with the greatest zeal. The second reason is that, partly through the exigencies of academic instruction, but mainly through the martinet traditions of antiquity and the influence of mediaeval logic-mongers, the great bulk of the elementary text-books of mathematics have unconsciously assumed a very repellant form,—something similar to what is termed in the theory of protective mimicry in biology “the terrifying form.” And it is mainly to this formidableness and touch-me-not character of exterior, concealing withal a harmless body, that the undue neglect of typical mathematical studies is to be attributed.

But nature flies from the infinite; for the infinite is imperfect, and nature always seeks an end.

But the greatest error of all the rest is the mistaking or misplacing of the last or farthest end of knowledge: for men have entered into a desire of learning and knowledge, sometimes upon a natural curiosity and inquisitive appetite; sometimes to entertain their minds with variety and delight; sometimes for ornament and reputation; and sometimes to enable them to victory of wit and contradiction; and most times for lucre and profession; and seldom sincerely to give a true account of their gift of reason, to the benefit and use of men...

But the whole vital process of the earth takes place so gradually and in periods of time which are so immense compared with the length of our life, that these changes are not observed, and before their course can be recorded from beginning to end whole nations perish and are destroyed.

But who can say that the vapour engine has not a kind of consciousness? Where does consciousness begin, and where end? Who can draw the line? Who can draw any line? Is not everything interwoven with everything? Is not machinery linked with animal life in an infinite variety of ways?

By keenly confronting the enigmas that surround us, and by considering and analyzing the observations that I had made I ended up in the domain of mathematics.

By the end of the next century, the “greenhouse effect” may increase temperatures worldwide to levels that have not been reached for at least 100,000 years. And the effects on sea level and on agriculture and other human activities are likely to be so profound that we should be planning for them now.

By the mid-1950s manatees were already scarce, and monk seals, once common as far north as Galveston, were gone. By the end of the 20th century, up to 90 percent of the sharks, tuna, swordfish, marlins, groupers, turtles, whales, and many other large creatures that prospered in the Gulf for millions of years had been depleted by overfishing.

Cellular pathology is not an end if one cannot see any alteration in the cell. Chemistry brings the clarification of living processes nearer than does anatomy. Each anatomical change must have been preceded by a chemical one.

Chagrined a little that we have been hitherto able to produce nothing in this way of use to mankind; and the hot weather coming on, when electrical experiments are not so agreeable, it is proposed to put an end to them for this season, somewhat humorously, in a party of pleasure, on the banks of Skuylkil. Spirits, at the same time, are to be fired by a spark sent from side to side through the river, without any other conductor that the water; an experiment which we some time since performed, to the amazement of many. A turkey is to be killed for our dinner by the electrified bottle: when the healths of all the famous electricians in England, Holland, France, and Germany are to be drank in electrified bumpers, under the discharge of guns from the electrical battery.

Chaos is the beginning, simplicity is the end.

Chief Seattle, of the Indians that inhabited the Seattle area, wrote a wonderful paper that has to do with putting oneself in tune with the universe. He said, “Why should I lament the disappearance of my people! All things end, and the white man will find this out also.” And this goes for the universe. One can be at peace with that. This doesn’t mean that one shouldn’t participate in efforts to correct the situation. But underlying the effort to change must be an “at peace.” To win a dog sled race is great. To lose is okay too.

Clearly it is not reason that has failed. What has failed—as it has always failed—is the attempt to achieve certainty, to reach an absolute, to find the course of human events to a final end. ... It is not reason that has promised to eliminate risk in human undertakings; it is the emotional needs of men.

Common sense always speaks too late. Common sense is the guy who tells you you ought to have had your brakes relined last week before you smashed a front end this week. Common sense is the Monday morning quarterback who could have won the ball game if he had been on the team. But he never is. He’s high up in the stands with a flask on his hip. Common sense is the little man in a grey suit who never makes a mistake in addition. But it’s always somebody else’s money he’s adding up.

Considered in its entirety, psychoanalysis won’t do. It is an end product, moreover, like a dinosaur or a zeppelin, no better theory can ever be erected on its ruins, which will remain for ever one of the saddest and strangest of all landmarks in the history of twentieth century thought.

Controlled research … endeavors to pick out of the web of nature’s activities some single strand and trace it towards its origin and its terminus and determine its relation to other strands.

Courtship, properly understood, is the process whereby both the male and the female are brought into that state of sexual tumescence which is a more or less necessary condition for sexual intercourse. The play of courtship cannot, therefore, be considered to be definitely brought to an end by the ceremony of marriage; it may more properly be regarded as the natural preliminary to every act of coitus.

Creation came out of chaos, is surrounded by chaos, and will end in chaos.

Creativity is a double-edged sword. The more ideas we have, the less likely we are to stay loyal to one. So the creative mind ends up jumping from idea to idea, and none of them happen.

De Morgan was explaining to an actuary what was the chance that a certain proportion of some group of people would at the end of a given time be alive; and quoted the actuarial formula, involving p [pi], which, in answer to a question, he explained stood for the ratio of the circumference of a circle to its diameter. His acquaintance, who had so far listened to the explanation with interest, interrupted him and exclaimed, “My dear friend, that must be a delusion, what can a circle have to do with the number of people alive at a given time?”

Decades spent in contact with science and its vehicles have directed my mind and senses to areas beyond their reach. I now see scientific accomplishments as a path, not an end; a path leading to and disappearing in mystery. Science, in fact, forms many paths branching from the trunk of human progress; and on every periphery they end in the miraculous. Following these paths far enough, one must eventually conclude that science itself is a miracle—like the awareness of man arising from and then disappearing in the apparent nothingness of space. Rather than nullifying religion and proving that “God is dead,” science enhances spiritual values by revealing the magnitudes and minitudes—from cosmos to atom—through which man extends and of which he is composed.