Negligible Quotes (5 quotes)
My own thinking (and that of many of my colleagues) is based on two general principles, which I shall call the Sequence Hypothesis and the Central Dogma. The direct evidence for both of them is negligible, but I have found them to be of great help in getting to grips with these very complex problems. I present them here in the hope that others can make similar use of them. Their speculative nature is emphasized by their names. It is an instructive exercise to attempt to build a useful theory without using them. One generally ends in the wilderness.
The Sequence Hypothesis
This has already been referred to a number of times. In its simplest form it assumes that the specificity of a piece of nucleic acid is expressed solely by the sequence of its bases, and that this sequence is a (simple) code for the amino acid sequence of a particular protein...
The Central Dogma
This states that once 'information' has passed into protein it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein. This is by no means universally held—Sir Macfarlane Burnet, for example, does not subscribe to it—but many workers now think along these lines. As far as I know it has not been explicitly stated before.
The Sequence Hypothesis
This has already been referred to a number of times. In its simplest form it assumes that the specificity of a piece of nucleic acid is expressed solely by the sequence of its bases, and that this sequence is a (simple) code for the amino acid sequence of a particular protein...
The Central Dogma
This states that once 'information' has passed into protein it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein. This is by no means universally held—Sir Macfarlane Burnet, for example, does not subscribe to it—but many workers now think along these lines. As far as I know it has not been explicitly stated before.
'On Protein Synthesis', Symposia of the Society for Experimental Biology: The Biological Replication of Macromolecules, 1958, 12, 152-3.
Our knowledge of stars and interstellar matter must be based primarily on the electromagnetic radiation which reaches us. Nature has thoughtfully provided us with a universe in which radiant energy of almost all wave lengths travels in straight lines over enormous distances with usually rather negligible absorption.
In 'Flying Telescopes', Bulletin of the Atomic Scientists (May 1961), Vol. 17, No. 5, 191.
Perhaps five or even ten per cent of men can do something rather well. It is a tiny minority who can do anything really well, and the number of men who can do two things well is negligible. If a man has any genuine talent, he should be ready to make almost any sacrifice in order to cultivate it to the full.
In A Mathematician's Apology (1940, 2012), 53.
The “seriousness” of a mathematical theorem lies, not in its practical consequences, which are usually negligible, but in the significance of the mathematical ideas which it connects.
In A Mathematician's Apology (1940, 2012), 89.
The scientist takes off from the manifold observations of predecessors, and shows his intelligence, if any, by his ability to discriminate between the important and the negligible, by selecting here and there the significant steppingstones that will lead across the difficulties to new understanding. The one who places the last stone and steps across to the terra firma of accomplished discovery gets all the credit.
In As I Remember Him (1940).
In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion.
(1987) -- 
