Code Quotes (31 quotes)
A DNA sequence for the genome of bacteriophage ΦX174 of approximately 5,375 nucleotides has been determined using the rapid and simple “plus and minus” method. The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs. Two pairs of genes are coded by the same region of DNA using different reading frames.
[Paper co-author]
[Paper co-author]
All attempts to adapt our ethical code to our situation in the technological age have failed.
— Max Born
Animals, even plants, lie to each other all the time, and we could restrict the research to them, putting off the real truth about ourselves for the several centuries we need to catch our breath. What is it that enables certain flowers to resemble nubile insects, or opossums to play dead, or female fireflies to change the code of their flashes in order to attract, and then eat, males of a different species?
Basic research at universities comes in two varieties: research that requires big bucks and research that requires small bucks. Big bucks research is much like government research and in fact usually is government research but done for the government under contract. Like other government research, big bucks academic research is done to understand the nature and structure of the universe or to understand life, which really means that it is either for blowing up the world or extending life, whichever comes first. Again, that's the government's motivation. The universities' motivation for conducting big bucks research is to bring money in to support professors and graduate students and to wax the floors of ivy-covered buildings. While we think they are busy teaching and learning, these folks are mainly doing big bucks basic research for a living, all the while priding themselves on their terrific summer vacations and lack of a dress code.
Smalls bucks research is the sort of thing that requires paper and pencil, and maybe a blackboard, and is aimed primarily at increasing knowledge in areas of study that don't usually attract big bucks - that is, areas that don't extend life or end it, or both. History, political science, and romance languages are typically small bucks areas of basic research. The real purpose of small bucks research to the universities is to provide a means of deciding, by the quality of their small bucks research, which professors in these areas should get tenure.
Smalls bucks research is the sort of thing that requires paper and pencil, and maybe a blackboard, and is aimed primarily at increasing knowledge in areas of study that don't usually attract big bucks - that is, areas that don't extend life or end it, or both. History, political science, and romance languages are typically small bucks areas of basic research. The real purpose of small bucks research to the universities is to provide a means of deciding, by the quality of their small bucks research, which professors in these areas should get tenure.
But let your communication be Yea, yea; Nay, nay: for whatsoever is more than these cometh of evil.
— Bible
Chromosomes … [contain] some kind of code-script the entire pattern of the individual’s future development and of its functioning in the mature state. Every complete set of chromosomes contains the full code.
Creationists have also changed their name ... to intelligent design theorists who study 'irreducible complexity' and the 'abrupt appearance' of life—yet more jargon for 'God did it.' ... Notice that they have no interest in replacing evolution with native American creation myths or including the Code of Hammarabi alongside the posting of the Ten Commandments in public schools.
Earlier this week … scientists announced the completion of a task that once seemed unimaginable; and that is, the deciphering of the entire DNA sequence of the human genetic code. This amazing accomplishment is likely to affect the 21st century as profoundly as the invention of the computer or the splitting of the atom affected the 20th century. I believe that the 21st century will be the century of life sciences, and nothing makes that point more clearly than this momentous discovery. It will revolutionize medicine as we know it today.
Endowed with two qualities, which seemed incompatible with each other, a volcanic imagination and a pertinacity of intellect which the most tedious numerical calculations could not daunt, Kepler conjectured that the movements of the celestial bodies must be connected together by simple laws, or, to use his own expression, by harmonic laws. These laws he undertook to discover. A thousand fruitless attempts, errors of calculation inseparable from a colossal undertaking, did not prevent him a single instant from advancing resolutely toward the goal of which he imagined he had obtained a glimpse. Twenty-two years were employed by him in this investigation, and still he was not weary of it! What, in reality, are twenty-two years of labor to him who is about to become the legislator of worlds; who shall inscribe his name in ineffaceable characters upon the frontispiece of an immortal code; who shall be able to exclaim in dithyrambic language, and without incurring the reproach of anyone, “The die is cast; I have written my book; it will be read either in the present age or by posterity, it matters not which; it may well await a reader, since God has waited six thousand years for an interpreter of his words.”
Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.
Finally one should add that in spite of the great complexity of protein synthesis and in spite of the considerable technical difficulties in synthesizing polynucleotides with defined sequences it is not unreasonable to hope that all these points will be clarified in the near future, and that the genetic code will be completely established on a sound experimental basis within a few years.
FORTRAN —’the infantile disorder’—, by now nearly 20 years old, is hopelessly inadequate for whatever computer application you have in mind today: it is now too clumsy, too risky, and too expensive to use. PL/I —’the fatal disease’— belongs more to the problem set than to the solution set. It is practically impossible to teach good programming to students that have had a prior exposure to BASIC: as potential programmers they are mentally mutilated beyond hope of regeneration. The use of COBOL cripples the mind; its teaching should, therefore, be regarded as a criminal offence. APL is a mistake, carried through to perfection. It is the language of the future for the programming techniques of the past: it creates a new generation of coding bums.
How much has happened in these fifty years—a period more remarkable than any, I will venture to say, in the annals of mankind. I am not thinking of the rise and fall of Empires, the change of dynasties, the establishment of Governments. I am thinking of those revolutions of science which have had much more effect than any political causes, which have changed the position and prospects of mankind more than all the conquests and all the codes and all the legislators that ever lived.
I want you to understand I shall not hold you to any [medieval] code of faithfulness to me nor shall I consider myself bound to you similarly.
If a physician make a large incision with an operating knife and cure it, or if he open a tumor (over the eye) with an operating knife, and saves the eye, he shall receive ten shekels in money. …
If a physician make a large incision with an operating knife, and kill him, or open a tumor with an operating knife, and cut out the eye, his hands shall be cut off. ...
If a physician heal the broken bone or diseased soft part of a man, the patient shall pay the physician five shekels in money.
[The Code of Hammurabi (a king of ancient Babylon), the earliest well-preserved ancient law code, circa 1760 B.C.]
If a physician make a large incision with an operating knife, and kill him, or open a tumor with an operating knife, and cut out the eye, his hands shall be cut off. ...
If a physician heal the broken bone or diseased soft part of a man, the patient shall pay the physician five shekels in money.
[The Code of Hammurabi (a king of ancient Babylon), the earliest well-preserved ancient law code, circa 1760 B.C.]
In the twenties the late Dr. Glenn Frank, an eminent social scientist, developed a new statement of the scientific code, which has been referred to as the “Five Fingers of the Scientific Method.” It may be outlined as follows: find the facts; filter the facts; focus the facts; face the facts; follow the facts. The facts or truths are found by experimentation; the motivation is material. The facts are filtered by research into the literature; the motivation is material. The facts are focused by the publication of results; again the motivation is material. Thus the first three-fifths of the scientific method have a material motivation. It is about time scientists acknowledge that there is more to the scientific convention than the material aspect. Returning to the fourth and fifth fingers of Dr. Frank's conception of the scientific method, the facts should be faced by the proper interpretation of them for society. In other words, a scientist must assume social responsibility for his discoveries, which means that he must have a moral motivation. Finally, in the fifth definition of the scientific method, the facts are to be followed by their proper application to everyday life in society, which means moral motivation through responsibility to society.
It is the very strangeness of nature that makes science engrossing. That ought to be at the center of science teaching. There are more than seven-times-seven types of ambiguity in science, awaiting analysis. The poetry of Wallace Stevens is crystal-clear alongside the genetic code.
It is time that science, having destroyed the religious basis for morality, accepted the obligation to provide a new and rational basis for human behavior—a code of ethics concerned with man’s needs on earth, not his rewards in heaven.
It is unreasonable to expect science to produce a system of ethics—ethics are a kind of highway code for traffic among mankind—and the fact that in physics atoms which were yesterday assumed to be square are now assumed to be round is exploited with unjustified tendentiousness by all who are hungry for faith; so long as physics extends our dominion over nature, these changes ought to be a matter of complete indifference to you.
Mapping the human genome has been compared with putting a man on the moon, but I believe it is more than that. This is the outstanding achievement not only of our lifetime, but in terms of human history. A few months ago I compared the project to the invention of the wheel. On reflection, it is more than that. I can well imagine technology making the wheel obsolete. But this code is the essence of mankind, and as long as humans exists, this code is going to be important and will be used.
My own thinking (and that of many of my colleagues) is based on two general principles, which I shall call the Sequence Hypothesis and the Central Dogma. The direct evidence for both of them is negligible, but I have found them to be of great help in getting to grips with these very complex problems. I present them here in the hope that others can make similar use of them. Their speculative nature is emphasized by their names. It is an instructive exercise to attempt to build a useful theory without using them. One generally ends in the wilderness.
The Sequence Hypothesis
This has already been referred to a number of times. In its simplest form it assumes that the specificity of a piece of nucleic acid is expressed solely by the sequence of its bases, and that this sequence is a (simple) code for the amino acid sequence of a particular protein...
The Central Dogma
This states that once 'information' has passed into protein it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein. This is by no means universally held—Sir Macfarlane Burnet, for example, does not subscribe to it—but many workers now think along these lines. As far as I know it has not been explicitly stated before.
The Sequence Hypothesis
This has already been referred to a number of times. In its simplest form it assumes that the specificity of a piece of nucleic acid is expressed solely by the sequence of its bases, and that this sequence is a (simple) code for the amino acid sequence of a particular protein...
The Central Dogma
This states that once 'information' has passed into protein it cannot get out again. In more detail, the transfer of information from nucleic acid to nucleic acid, or from nucleic acid to protein may be possible, but transfer from protein to protein, or from protein to nucleic acid is impossible. Information means here the precise determination of sequence, either of bases in the nucleic acid or of amino acid residues in the protein. This is by no means universally held—Sir Macfarlane Burnet, for example, does not subscribe to it—but many workers now think along these lines. As far as I know it has not been explicitly stated before.
One can say, looking at the papers in this symposium, that the elucidation of the genetic code is indeed a great achievement. It is, in a sense, the key to molecular biology because it shows how the great polymer languages, the nucleic acid language and the protein language, are linked together.
Our ignorance is God; what we know is science. When we abandon the doctrine that some infinite being created matter and force, and enacted a code of laws for their government ... the real priest will then be, not the mouth-piece of some pretended deity, but the interpreter of nature.
Our methods of communication with our fellow men take many forms. We share with other animals the ability to transmit information by such diverse means as the posture of our bodies, by the movements of our eyes, head, arms, and hands, and by our utterances of non-specific sounds. But we go far beyond any other species on earth in that we have evolved sophisticated forms of pictorial representation, elaborate spoken and written languages, ingenious methods of recording music and language on discs, on magnetic tape and in a variety of other kinds of code.
Religion shows a pattern of heredity which I think is similar to genetic heredity. ... There are hundreds of different religious sects, and every religious person is loyal to just one of these. ... The overwhelming majority just happen to choose the one their parents belonged to. Not the sect that has the best evidence in its favour, the best miracles, the best moral code, the best cathedral, the best stained-glass, the best music when it comes to choosing from the smorgasbord of available religions, their potential virtues seem to count for nothing compared to the matter of heredity.
The language of the genes has a simple alphabet, not with twenty-six letters, but just four. These are the four different DNA bases—adenine, guanine, cytosine and thymine (A, G, C and T for short). The bases are arranged in words of three letters such as CGA or TGG. Most of the words code for different amino acids, which themselves are joined together to make proteins, the building blocks of the body.
The microbial global brain—gifted with long-range transport, data trading, genetic variants … and the ability to reinvent genomes—began its operations some 91 trillion bacterial generations before the birth of the Internet. Ancient bacteria, if they functioned like those today, had mastered the art of worldwide information exchange. … The earliest microorganisms would have used planet-sweeping currents of wind and water to carry the scraps of genetic code…
There is a finite number of species of plants and animals—even of insects—upon the earth. … Moreover, the universality of the genetic code, the common character of proteins in different species, the generality of cellular structure and cellular reproduction, the basic similarity of energy metabolism in all species and of photosynthesis in green plants and bacteria, and the universal evolution of living forms through mutation and natural selection all lead inescapably to a conclusion that, although diversity may be great, the laws of life, based on similarities, are finite in number and comprehensible to us in the main even now.
We are the only species that can destroy the Earth or take care of it and nurture all that live on this very special planet. I’m urging you to look on these things. For whatever reason, this planet was built specifically for us. Working on this planet is an absolute moral code. … Let’s go out and do what we were put on Earth to do.
We receive experience from nature in a series of messages. From these messages we extract a content of information: that is, we decode the messages in some way. And from this code of information we then make a basic vocabulary of concepts and a basic grammar of laws, which jointly describe the inner organization that nature translates into the happenings and the appearances we meet.
You do not know our culture, our ethics, or the unwritten codes that already provide our society more order than could be obtained by any of your impositions.