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Home > Category Index for Science Quotations > Category Index C > Category: Chromosome

Chromosome Quotes (17 quotes)

At fertilization, these two 'haploid' nuclei are added together to make a 'diploid' nucleus that now contains 2a, 2b and so on; and, by the splitting of each chromosome and the regulated karyokinetic separation of the daughter chromosomes, this double series is inherited by both of the primary blastomeres. In the resulting resting nuclei the individual chromosomes are apparently destroyed. But we have the strongest of indications that, in the stroma of the resting nucleus, every one of the chromosomes that enters the nucleus survives as a well-defined region; and as the cell prepares for its next division this region again gives rise to the same chromosome (Theory of the Individuality of the Chromosomes). In this way the two sets of chromosomes brought together at fertilization are inherited by all the cells of the new individual. It is only in the germinal cells that the so called reduction division converts the double series into a single one. Out of the diploid state, the haploid is once again generated.
Arch. Zellforsch, 1909, 3, 181, trans. Henry Harris, The Birth of the Cell (1999), 171-2.
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Chromosomes … [contain] some kind of code-script the entire pattern of the individual’s future development and of its functioning in the mature state. Every complete set of chromosomes contains the full code.
In What is Life? : The Physical Aspect of the Living Cell (1944), 20.
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Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.
In What is Life? : The Physical Aspect of the Living Cell (1944), 20-21.
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Except for the rare cases of plastid inheritance, the inheritance of all known cooacters can be sufficiently accounted for by the presence of genes in the chromosomes. In a word the cytoplasm may be ignored genetically.
'Genetics and the Physiology of Development', The American Naturalist (1926), 60, 491.
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For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.
Ergebnisse über die Konstitution der chromatischen Substam des Zellkems (1904), 123. Translated in Robert Olby, The Path to the Double Helix: The Discovery of DNA (1994), xx.
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I may finally call attention to the probability that the association of paternal and maternal chromosomes in pairs and their subsequent separation during the reducing division as indicated above may constitute the physical basis of the Mendelian law of heredity.
'On the Morphology of the Chromosome Group in Brachystola Magna', Biological Bulletin (1902), 4, 39.
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I must beg leave to propose a separate technical name ‘chromosome’ for those things which have been called by Boveri ‘chromatic elements’, in which there occurs one of the most important acts in karyokinesis, viz. the longitudinal splitting.
[Coining the word ‘chromosome,’ or ‘chromosom’ in the original German.]
Original German text by Waldeyer in Archiv für Mikroskopische Anatomie (1888), 27, translated by W.B. Benham in Quarterly Journal of Microscopical Science (1889), 30, 181.
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If these d'Hérelle bodies were really genes, fundamentally like our chromosome genes, they would give us an utterly new angle from which to attack the gene problem. They are filterable, to some extent isolable, can be handled in test-tubes, and their properties, as shown by their effects on the bacteria, can then be studied after treatment. It would be very rash to call these bodies genes, and yet at present we must confess that there is no distinction known between the genes and them. Hence we can not categorically deny that perhaps we may be able to grind genes in a mortar and cook them in a beaker after all. Must we geneticists become bacteriologists, physiological chemists and physicists, simultaneously with being zoologists and botanists? Let us hope so.
'Variation Due to Change in the Individual Gene', The American Naturalist (1922), 56, 48-9.
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Mutations and chromosomal changes arise in every sufficiently studied organism with a certain finite frequency, and thus constantly and unremittingly supply the raw materials for evolution. But evolution involves something more than origin of mutations. Mutations and chromosomal changes are only the first stage, or level, of the evolutionary process, governed entirely by the laws of the physiology of individuals. Once produced, mutations are injected in the genetic composition of the population, where their further fate is determined by the dynamic regularities of the physiology of populations. A mutation may be lost or increased in frequency in generations immediately following its origin, and this (in the case of recessive mutations) without regard to the beneficial or deleterious effects of the mutation. The influences of selection, migration, and geographical isolation then mold the genetic structure of populations into new shapes, in conformity with the secular environment and the ecology, especially the breeding habits, of the species. This is the second level of the evolutionary process, on which the impact of the environment produces historical changes in the living population.
Genetics and Origin of Species (1937), 13.
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Now that we locate them [genes] in the chromosomes are we justified in regarding them as material units; as chemical bodies of a higher order than molecules? Frankly, these are questions with which the working geneticist has not much concern himself, except now and then to speculate as to the nature of the postulated elements. There is no consensus of opinion amongst geneticists as to what the genes are—whether they are real or purely fictitious—because at the level at which the genetic experiments lie, it does not make the slightest difference whether the gene is a hypothetical unit, or whether the gene is a material particle. In either case the unit is associated with a specific chromosome, and can be localized there by purely genetic analysis. Hence, if the gene is a material unit, it is a piece of chromosome; if it is a fictitious unit, it must be referred to a definite location in a chromosome—the same place as on the other hypothesis. Therefore, it makes no difference in the actual work in genetics which point of view is taken. Between the characters that are used by the geneticist and the genes that his theory postulates lies the whole field of embryonic development.
'The Relation of Genetics to Physiology and Medicine', Nobel Lecture (4 Jun 1934). In Nobel Lectures, Physiology or Medicine 1922-1941 (1965), 315.
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Real knowledge goes into natural man in tidbits. A scrap here, a scrap there; always pertinent, linked to safety or nutrition or pleasure. Human curiosity survives and is catered for, by the twopenny weeklies, 24 lines on chromosomes, six lines on a three-headed calf.
From Culture (1938). Reprinted as Guide to Kulchur (1952, 1970), 99.
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The most fundamental difference between compounds of low molecular weight and macromolecular compounds resides in the fact that the latter may exhibit properties that cannot be deduced from a close examination of the low molecular weight materials. Not very different structures can be obtained from a few building blocks; but if 10,000 or 100,000 blocks are at hand, the most varied structures become possible, such as houses or halls, whose special structure cannot be predicted from the constructions that are possible with only a few building blocks... Thus, a chromosome can be viewed as a material whose macromolecules possess a well defined arrangement, like a living room in which each piece of furniture has its place and not, as in a warehouse, where the pieces of furniture are placed together in a heap without design.
Quoted, without citation, in Ralph E. Oesper (ed.), The Human Side of Scientists (1975), 175.
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The precise equivalence of the chromosomes contributed by the two sexes is a physical correlative of the fact that the two sexes play, on the whole, equal parts in hereditary transmission, and it seems to show that the chromosomal substance, the chromatin, is to be regarded as the physical basis of inheritance. Now, chromatin is known to be closely similar to, if not identical with, a substance known as nuclein (C29H49N9O22, according to Miescher), which analysis shows to be a tolerably definite chemical compased of nucleic acid (a complex organic acid rich in phosphorus) and albumin. And thus we reach the remarkable conclusion that inheritance may, perhaps, be effected by the physical transmission of a particular chemical compound from parent to offspring.
In An Atlas of the Fertilization and Karyokinesis of the Ovum (1895), 4.
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They thought I was crazy, absolutely mad.
The response (1944) of the National Academy of Sciences, to her (later Nobel prize-winning) theory that proposed that genes could transition—'jumping'—to new locations on a chromosome.
Quoted in Claudia Wallis, 'Honoring a Modern Mendel', Time (24 Oct 1983), 43.
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We do not know of any enzymes or other chemical defined organic substances having specifically acting auto-catalytic properties such as to enable them to construct replicas of themselves. Neither was there a general principle known that would result in pattern-copying; if there were, the basis of life would be easier to come by. Moreover, there was no evidence to show that the enzymes were not products of hereditary determiners or genes, rather than these genes themselves, and they might even be products removed by several or many steps from the genes, just as many other known substances in the cell must be. However, the determiners or genes themselves must conduct, or at least guide, their own replication, so as to lead to the formation of genes just like themselves, in such wise that even their own mutations become .incorporated in the replicas. And this would probably take place by some kind of copying of pattern similar to that postulated by Troland for the enzymes, but requiring some distinctive chemical structure to make it possible. By virtue of this ability of theirs to replicate, these genes–or, if you prefer, genetic material–contained in the nuclear chromosomes and in whatever other portion of the cell manifests this property, such as the chloroplastids of plants, must form the basis of all the complexities of living matter that have arisen subsequent to their own appearance on the scene, in the whole course of biological evolution. That is, this genetic material must underlie all evolution based on mutation and selective multiplication.
'Genetic Nucleic Acid', Perspectives in Biology and Medicine (1961), 5, 6-7.
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We have long been seeking a different kind of evolutionary process and have now found one; namely, the change within the pattern of the chromosomes. ... The neo-Darwinian theory of the geneticists is no longer tenable.
The Material Basis of Evolution (1940), 397.
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Within the nucleus [of a cell] is a network of fibers, a sap fills the interstices of the network. The network resolves itself into a definite number of threads at each division of the cell. These threads we call chromosomes. Each species of animals and plants possesses a characteristic number of these threads which have definite size and sometimes a specific shape and even characteristic granules at different levels. Beyond this point our strongest microscopes fail to penetrate.
In A Critique of the Theory of Evolution (1916), 91.
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Carl Sagan Thumbnail In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion. (1987) -- Carl Sagan
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