Although species may be discrete, they have no immutable essence. Variation is the raw material of evolutionary change. It represents the fundamental reality of nature, not an accident about a created norm. Variation is primary; essences are illusory. Species must be defined as ranges of irreducible variation.

And yet I think that the Full House model does teach us to treasure variety for its own sake–for tough reasons of evolutionary theory and nature’s ontology, and not from a lamentable failure of thought that accepts all beliefs on the absurd rationale that disagreement must imply disrespect. Excellence is a range of differences, not a spot. Each location on the range can be occupied by an excellent or an inadequate representative– and we must struggle for excellence at each of these varied locations. In a society driven, of ten unconsciously, to impose a uniform mediocrity upon a former richness of excellence–where McDonald’s drives out the local diner, and the mega-Stop & Shop eliminates the corner Mom and Pop–an understanding and defense of full ranges as natural reality might help to stem the tide and preserve the rich raw material of any evolving system: variation itself.

As plants convert the minerals into food for animals, so each man converts some raw material in nature to human use. The inventors of fire, electricity, magnetism, iron, lead, glass, linen, silk, cotton; the makers of tools; the inventor of decimal notation, the geometer, the engineer, the musician, severally make an easy way for all, through unknown and impossible confusions.

Differences between individuals are the raw materials for evolutionary change and for the evolution of adaptations, yet of course most physiologists treat these differences as noise that is to be filtered out. From the standpoint of physiological ecology, the traditional emphasis of physiologists on central tendencies rather than on variance has some unhappy consequences. Variation is not just noise; it is also the stuff of evolution and a central attribute of living systems. The physiological differences between individuals in the same species or population, and also the patterns of variation in different groups, must not be ignored.

Engineers apply the theories and principles of science and mathematics to research and develop economical solutions to practical technical problems. Their work is the link between scientific discoveries and commercial applications. Engineers design products, the machinery to build those products, the factories in which those products are made, and the systems that ensure the quality of the product and efficiency of the workforce and manufacturing process. They design, plan, and supervise the construction of buildings, highways, and transit systems. They develop and implement improved ways to extract, process, and use raw materials, such as petroleum and natural gas. They develop new materials that both improve the performance of products, and make implementing advances in technology possible. They harness the power of the sun, the earth, atoms, and electricity for use in supplying the Nation’s power needs, and create millions of products using power. Their knowledge is applied to improving many things, including the quality of health care, the safety of food products, and the efficient operation of financial systems.

Ere land and sea and the all-covering sky
Were made, in the whole world the countenance
Of nature was the same, all one, well named
Chaos, a raw and undivided mass,
Naught but a lifeless bulk, with warring seeds
Of ill-joined elements compressed together.

EXTINCTION, n. The raw material out of which theology created the future state.

He had been eight years upon a project for extracting sunbeams out of cucumbers, which were to be put into vials hermetically sealed, and let out to warm the air in raw, inclement summers.

Humanity stands ... before a great problem of finding new raw materials and new sources of energy that shall never become exhausted. In the meantime we must not waste what we have, but must leave as much as possible for coming generations.

Model-making, the imaginative and logical steps which precede the experiment, may be judged the most valuable part of scientific method because skill and insight in these matters are rare. Without them we do not know what experiment to do. But it is the experiment which provides the raw material for scientific theory. Scientific theory cannot be built directly from the conclusions of conceptual models.

Mutations and chromosomal changes arise in every sufficiently studied organism with a certain finite frequency, and thus constantly and unremittingly supply the raw materials for evolution. But evolution involves something more than origin of mutations. Mutations and chromosomal changes are only the first stage, or level, of the evolutionary process, governed entirely by the laws of the physiology of individuals. Once produced, mutations are injected in the genetic composition of the population, where their further fate is determined by the dynamic regularities of the physiology of populations. A mutation may be lost or increased in frequency in generations immediately following its origin, and this (in the case of recessive mutations) without regard to the beneficial or deleterious effects of the mutation. The influences of selection, migration, and geographical isolation then mold the genetic structure of populations into new shapes, in conformity with the secular environment and the ecology, especially the breeding habits, of the species. This is the second level of the evolutionary process, on which the impact of the environment produces historical changes in the living population.

Mutations merely furnish random raw material for evolution, and rarely, if ever determine the course of the process.

My life as a surgeon-scientist, combining humanity and science, has been fantastically rewarding. In our daily patients we witness human nature in the raw–fear, despair, courage, understanding, hope, resignation, heroism. If alert, we can detect new problems to solve, new paths to investigate.

No Geologist worth anything is permanently bound to a desk or laboratory, but the charming notion that true science can only be based on unbiased observation of nature in the raw is mythology. Creative work, in geology and anywhere else, is interaction and synthesis: half-baked ideas from a bar room, rocks in the field, chains of thought from lonely walks, numbers squeezed from rocks in a laboratory, numbers from a calculator riveted to a desk, fancy equipment usually malfunctioning on expensive ships, cheap equipment in the human cranium, arguments before a road cut.

One looks back with appreciation to the brilliant teachers, but with gratitude to those who touched our human feelings. The curriculum is so much necessary raw material, but warmth is the vital element for the growing plant and for the soul of the child.

Quantitative work shows clearly that natural selection is a reality, and that, among other things, it selects Mendelian genes, which are known to be distributed at random through wild populations, and to follow the laws of chance in their distribution to offspring. In other words, they are an agency producing variation of the kind which Darwin postulated as the raw material on which selection acts.

Returning to the moon is an important step for our space program. Establishing an extended human presence on the moon could vastly reduce the costs of further space exploration, making possible ever more ambitious missions. Lifting heavy spacecraft and fuel out of the Earth’s gravity is expensive. Spacecraft assembled and provisioned on the moon could escape its far lower gravity using far less energy, and thus, far less cost. Also, the moon is home to abundant resources. Its soil contains raw materials that might be harvested and processed into rocket fuel or breathable air. We can use our time on the moon to develop and test new approaches and technologies and systems that will allow us to function in other, more challenging environments. The moon is a logical step toward further progress and achievement.

Science is, I believe, nothing but trained and organised common-sense, differing from the latter only as a veteran may differ from a raw recruit; and its methods differ from those of common-sense only so far as the guardsman's cut and thrust differ from the manner in which a savage wields his club.

The [mechanical] bird I have described ought to be able by the help of the wind to rise to a great height, and this will prove to be its safety; since even if… revolutions [of the winds] were to befall it, it would still have time to regain a condition of equilibrium; provided that its various parts have a great power of resistance, so that they can safely withstand the fury and violence of the descent, by the aid of the defenses which I have mentioned; and its joints should be made of strong tanned hide, and sewn with cords of strong raw silk. And let no one encumber himself with iron bands, for these are very soon broken at the joints or else they become worn out, and consequently it is well not to encumber oneself with them.

The digestive canal is in its task a complete chemical factory. The raw material passes through a long series of institutions in which it is subjected to certain mechanical and, mainly, chemical processing, and then, through innumerable side-streets, it is brought into the depot of the body. Aside from this basic series of institutions, along which the raw material moves, there is a series of lateral chemical manufactories, which prepare certain reagents for the appropriate processing of the raw material.

The primes are the raw material out of which we have to build arithmetic, and Euclid’s theorem assures us that we have plenty of material for the task.

The process of mutation is the only known source of the raw materials of genetic variability, and hence of evolution. It is subject to experimental study, and considerable progress has been accomplished in this study in recent years. An apparent paradox has been disclosed. Although the living matter becomes adapted to its environment through formation of superior genetic patterns from mutational components, the process of mutation itself is not adaptive. On the contrary, the mutants which arise are, with rare exceptions, deleterious to their carriers, at least in the environments which the species normally encounters. Some of them are deleterious apparently in all environments. Therefore, the mutation process alone, not corrected and guided by natural selection, would result in degeneration and extinction rather than in improved adaptedness.

There has never been an age so full of humbug. Humbug everywhere, even in science. For years now the scientists have been promising us every morning a new miracle, a new element, a new metal, guaranteeing to warm us with copper discs immersed in water, to feed us with nothing, to kill us at no expense whatever on a grand scale, to keep us alive indefinitely, to make iron out of heaven knows what. And all this fantastic, scientific humbugging leads to membership of the Institut, to decorations, to influence, to stipends, to the respect of serious people. In the meantime the cost of living rises, doubles, trebles; there is a shortage of raw materials; even death makes no progress—as we saw at Sebastopol, where men cut each other to ribbons—and the cheapest goods are still the worst goods in the world.
With co-author Jules de Goncourt (French writer, 1830-70)

There is as much difference between a collection of mentally free citizens and a community molded by modern methods of propaganda as there is between a heap of raw materials and a battleship.

This Academy [at Lagado] is not an entire single Building, but a Continuation of several Houses on both Sides of a Street; which growing waste, was purchased and applied to that Use.
I was received very kindly by the Warden, and went for many Days to the Academy. Every Room hath in it ' one or more Projectors; and I believe I could not be in fewer than five Hundred Rooms.
The first Man I saw was of a meagre Aspect, with sooty Hands and Face, his Hair and Beard long, ragged and singed in several Places. His Clothes, Shirt, and Skin were all of the same Colour. He had been Eight Years upon a Project for extracting Sun-Beams out of Cucumbers, which were to be put into Vials hermetically sealed, and let out to warm the Air in raw inclement Summers. He told me, he did not doubt in Eight Years more, that he should be able to supply the Governor's Gardens with Sunshine at a reasonable Rate; but he complained that his Stock was low, and interested me to give him something as an Encouragement to Ingenuity, especially since this had been a very dear Season for Cucumbers. I made him a small Present, for my Lord had furnished me with Money on purpose, because he knew their Practice of begging from all who go to see them.
I saw another at work to calcine Ice into Gunpowder; who likewise shewed me a Treatise he had written concerning the Malleability of Fire, which he intended to publish.
There was a most ingenious Architect who had contrived a new Method for building Houses, by beginning at the Roof, and working downwards to the Foundation; which he justified to me by the life Practice of those two prudent Insects the Bee and the Spider.
In another Apartment I was highly pleased with a Projector, who had found a device of plowing the Ground with Hogs, to save the Charges of Plows, Cattle, and Labour. The Method is this: In an Acre of Ground you bury at six Inches Distance, and eight deep, a quantity of Acorns, Dates, Chestnuts, and other Masts or Vegetables whereof these Animals are fondest; then you drive six Hundred or more of them into the Field, where in a few Days they will root up the whole Ground in search of their Food, and make it fit for sowing, at the same time manuring it with their Dung. It is true, upon Experiment they found the Charge and Trouble very great, and they had little or no Crop. However, it is not doubted that this Invention may be capable of great Improvement.
I had hitherto seen only one Side of the Academy, the other being appropriated to the Advancers of speculative Learning.
Some were condensing Air into a dry tangible Substance, by extracting the Nitre, and letting the acqueous or fluid Particles percolate: Others softening Marble for Pillows and Pin-cushions. Another was, by a certain Composition of Gums, Minerals, and Vegetables outwardly applied, to prevent the Growth of Wool upon two young lambs; and he hoped in a reasonable Time to propagate the Breed of naked Sheep all over the Kingdom.

Throughout his last half-dozen books, for example, Arthur Koestler has been conducting a campaign against his own misunderstanding of Darwinism. He hopes to find some ordering force, constraining evolution to certain directions and overriding the influence of natural selection ... Darwinism is not the theory of capricious change that Koestler imagines. Random variation may be the raw material of change, but natural selection builds good design by rejecting most variants while accepting and accumulating the few that improve adaptation to local environments.

Two kinds of symbol must surely be distinguished. The algebraic symbol comes naked into the world of mathematics and is clothed with value by its masters. A poetic symbol—like the Rose, for Love, in Guillaume de Lorris—comes trailing clouds of glory from the real world, clouds whose shape and colour largely determine and explain its poetic use. In an equation, x and y will do as well as a and b; but the Romance of the Rose could not, without loss, be re-written as the Romance of the Onion, and if a man did not see why, we could only send him back to the real world to study roses, onions, and love, all of them still untouched by poetry, still raw.

Under the Providence of God, our means of education are the grand machinery by which the 'raw material' of human nature can be worked up into inventors and discoverers, into skilled artisans and scientific farmers, into scholars and jurists, into the founders of benevolent institutions, and the great expounders of ethical and theological science.