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...the study of butterflies—creatures selected as the types of airiness and frivolity—instead of being despised, will some day be valued as one of the most important branches of Biological science.
Of Cooking. This is an art of various forms, the object of which is to give ordinary observations the appearance and character of those of the highest degree of accuracy. One of its numerous processes is to make multitudes of observations, and out of these to select only those which agree, or very nearly agree. If a hundred observations are made, the cook must be very unhappy if he cannot pick out fifteen or twenty which will do for serving up.
[When questioned on his longevity] First of all, I selected my ancestors very wisely. ... They were long-lived, healthy people. Then, as a chemist, I know how to eat, how to exercise, keep my blood circulating. ... I don't worry. I don't get angry at people. I don't worry about things I can't help. I do what I can to make the world a better place to live, but I don't complain if things aren't right. As a scientist I take the world as I find it.
[About celebrating his 77th birthday by swimming a half mile in 22 minutes] I used swim fins and webbed gloves because a man of intelligence should apply his power efficiently, not just churn the water.
[About celebrating his 77th birthday by swimming a half mile in 22 minutes] I used swim fins and webbed gloves because a man of intelligence should apply his power efficiently, not just churn the water.
Admit for a moment, as a hypothesis, that the Creator had before his mind a projection of the whole life-history of the globe, commencing with any point which the geologist may imagine to have been a fit commencing point, and ending with some unimaginable acme in the indefinitely distant future. He determines to call this idea into actual existence, not at the supposed commencing point, but at some stage or other of its course. It is clear, then, that at the selected stage it appears, exactly as it would have appeared at that moment of its history, if all the preceding eras of its history had been real.
Animals have genes for altruism, and those genes have been selected in the evolution of many creatures because of the advantage they confer for the continuing survival of the species.
By the act of observation we have selected a ‘real’ history out of the many realities, and once someone has seen a tree in our world it stays there even when nobody is looking at it.
Certain students of genetics inferred that the Mendelian units responsible for the selected character were genes producing only a single effect. This was careless logic. It took a good deal of hammering to get rid of this erroneous idea. As facts accumulated it became evident that each gene produces not a single effect, but in some cases a multitude of effects on the characters of the individual. It is true that in most genetic work only one of these character-effects is selected for study—the one that is most sharply defined and separable from its contrasted character—but in most cases minor differences also are recognizable that are just as much the product of the same gene as is the major effect.
Characteristically skeptical of the idea that living things would faithfully follow mathematical formulas, [Robert Harper] seized upon factors in corn which seemed to blend in the hybrid—rather than be represented by plus or minus signs, and put several seasons into throwing doubt upon the concept of immutable hypothetical units of inheritance concocted to account for selected results.
Every species of plant and animal is determined by a pool of germ plasm that has been most carefully selected over a period of hundreds of millions of years. We can understand now why it is that mutations in these carefully selected organisms almost invariably are detrimental.The situation can be suggested by a statement by Dr. J.B.S. Haldane: “My clock is not keeping perfect time. It is conceivable that it will run better if I shoot a bullet through it; but it is much more probable that it will stop altogether.” Professor George Beadle, in this connection, has asked: “What is the chance that a typographical error would improve Hamlet?”
Give me a dozen healthy infants, well-formed, and my own specified world to bring them up in and I’ll guarantee to take any one at random and train him to become any type of specialist I might select—doctor, lawyer, artist, merchant-chief and, yes, even beggar-man and thief, regardless of his talents, penchants, tendencies, abilities, vocations, and race of his ancestors. (1930)
I have reviewed this work elsewhere under the title 'Natural Products Chemistry 1950 to 1980-A Personal View.' It is with some relish that I recall the flood of reprint requests prompted by the following footnote on the title page: 'Selected personal statements by the author were removed by the editor without Professor Djerassi's consent. An uncensored version of this paper can be obtained by writing to Professor C. Djerassi'.
I think she [Rosalind Franklin] was a good experimentalist but certainly not of the first rank. She was simply not in the same class as Eigen or Bragg or Pauling, nor was she as good as Dorothy Hodgkin. She did not even select DNA to study. It was given to her. Her theoretical crystallography was very average.
In my opinion the English excel in the art of writing text-books for mathematical teaching; as regards the clear exposition of theories and the abundance of excellent examples, carefully selected, very few books exist in other countries which can compete with those of Salmon and many other distinguished English authors that could be named.
In truth, we know causes only by their effects; and in order to learn the nature of the causes which modify the earth, we must study them through all ages of their action, and not select arbitrarily the period in which we live as the standard for all other epochs.
Let us make an arbitrary decision (by a show of hands if necessary) to define the base of every stratigraphical unit in a selected section. This may be called the Principle of the Golden Spike. Then stratigraphical nomenclature can be forgotten and we can get on with the real work of stratigraphy, which is correlation and interpretation.
Natural selection produces systems that function no better than necessary. It results in ad hoc adaptive solutions to immediate problems. Whatever enhances fitness is selected. The product of natural selection is not perfection but adequacy, not final answers but limited, short-term solutions.
Nature has but one plan of operation, invariably the same in the smallest things as well as in the largest, and so often do we see the smallest masses selected for use in Nature, that even enormous ones are built up solely by fitting these together. Indeed, all Nature’s efforts are devoted to uniting the smallest parts of our bodies in such a way that all things whatsoever, however diverse they may be, which coalesce in the structure of living things construct the parts by means of a sort of compendium.
Plant breeding to be successful must be conducted like architecture. Definite plans must be carefully laid for the proposed creation; suitable materials selected with judgment, and these must he securely placed in their proper order and position.
Plants, generally speaking, meet the impact of the terrestrial environment head on, although of course they in turn modify the physical environment by adventitious group activity. The individual plant cannot select its habitat; its location is largely determined by the vagaries of the dispersal of seeds or spores and is thus profoundly affected by chance. Because of their mobility and their capacity for acceptance or rejection terrestrial animals, in contrast, can and do actively seek out and utilize the facets of the environment that allow their physiological capacities to function adequately. This means that an animal by its behavior can fit the environment to its physiology by selecting situations in which its physiological capacities can cope with physical conditions. If one accepts this idea, it follows that there is no such thing as The Environment, for there exist as many different terrestrial environments as there are species of animals.
Quantitative work shows clearly that natural selection is a reality, and that, among other things, it selects Mendelian genes, which are known to be distributed at random through wild populations, and to follow the laws of chance in their distribution to offspring. In other words, they are an agency producing variation of the kind which Darwin postulated as the raw material on which selection acts.
Research may start from definite problems whose importance it recognizes and whose solution is sought more or less directly by all forces. But equally legitimate is the other method of research which only selects the field of its activity and, contrary to the first method, freely reconnoitres in the search for problems which are capable of solution. Different individuals will hold different views as to the relative value of these two methods. If the first method leads to greater penetration it is also easily exposed to the danger of unproductivity. To the second method we owe the acquisition of large and new fields, in which the details of many things remain to be determined and explored by the first method.
Science is composed of laws which were originally based on a small, carefully selected set of observations, often not very accurately measured originally; but the laws have later been found to apply over much wider ranges of observations and much more accurately than the original data justified.
Select such subjects that your pupils cannot walk out without seeing them. Train your pupils to be observers, and have them provided with the specimens about which you speak. If you can find nothing better, take a house-fly or a cricket, and let each one hold a specimen and examine it as you talk.
Since it is necessary for specific ideas to have definite and consequently as far as possible selected terms, I have proposed to call substances of similar composition and dissimilar properties isomeric, from the Greek ίσομερης (composed of equal parts).
The cult of individual personalities is always, in my view, unjustified. To be sure, nature distributes her gifts variously among her children. But there are plenty of the well-endowed ones too, thank God, and I am firmly convinced that most of them live quiet, unregarded lives. It strikes me as unfair, and even in bad taste, to select a few of them for boundless admiration, attributing superhuman powers of mind and character to them. This has been my fate, and the contrast between the popular estimate of my powers and achievements and the reality is simply grotesque. The consciousness of this extraordinary state of affairs would be unbearable but for one great consoling thought: it is a welcome symptom in an age which is commonly denounced as materialistic, that it makes heroes of men whose ambitions lie wholly in the intellectual and moral sphere. This proves that knowledge and justice are ranked above wealth and power by a large section of the human race. My experience teaches me that this idealistic outlook is particularly prevalent in America, which is usually decried as a particularly materialistic country.
The maintenance of biological diversity requires special measures that extend far beyond the establishment of nature reserves. Several reasons for this stand out. Existing reserves have been selected according to a number of criteria, including the desire to protect nature, scenery, and watersheds, and to promote cultural values and recreational opportunities. The actual requirements of individual species, populations, and communities have seldom been known, nor has the available information always been employed in site selection and planning for nature reserves. The use of lands surrounding nature reserves has typically been inimical to conservation, since it has usually involved heavy use of pesticides, industrial development, and the presence of human settlements in which fire, hunting, and firewood gathering feature as elements of the local economy.
The miracle of man is not how far he has sunk but how magnificently he has risen. We are known among the stars by our poems, not our corpses. No creature who began as a mathematical improbability, who was selected through millions of years of unprecedented environmental hardship and change for ruggedness, ruthlessness, cunning, and adaptability, and who in the short ten thousand years of what we may call civilization has achieved such wonders as we find about us, may be regarded as a creature without promise.
The more man inquires into the laws which regulate the material universe, the more he is convinced that all its varied forms arise from the action of a few simple principles. These principles themselves converge, with accelerating force, towards some still more comprehensive law to which all matter seems to be submitted. Simple as that law may possibly be, it must be remembered that it is only one amongst an infinite number of simple laws: that each of these laws has consequences at least as extensive as the existing one, and therefore that the Creator who selected the present law must have foreseen the consequences of all other laws.
The only level of the hierarchy [of biological communities] that is both necessary and sufficient to meet all objectives is the ecosystem or some higher-level approach. The strategy selected should not only ensure the conservation of spotted owls, but all the intricate linkages that are associated with natural populations of spotted owls in naturally functioning ecosystems. Many of these are as yet unknown.
The photons which constitute a ray of light behave like intelligent human beings: out of all possible curves they always select the one which will take them most quickly to their goal.
The physicist, in his study of natural phenomena, has two methods of making progress: (1) the method of experiment and observation, and (2) the method of mathematical reasoning. The former is just the collection of selected data; the latter enables one to infer results about experiments that have not been performed. There is no logical reason why the second method should be possible at all, but one has found in practice that it does work and meets with reasonable success.
The poetic beauty of Davy's mind never seems to have left him. To that circumstance I would ascribe the distinguishing feature in his character, and in his discoveries,—a vivid imagination sketching out new tracts in regions unexplored, for the judgement to select those leading to the recesses of abstract truth.
The progress of science depends less than is usually believed on the efforts and performance of the individual genius ... many important discoveries have been made by men of ordinary talents, simply because chance had made them, at the proper time and in the proper place and circumstances, recipients of a body of doctrines, facts and techniques that rendered almost inevitable the recognition of an important phenomenon. It is surprising that some historian has not taken malicious pleasure in writing an anthology of 'one discovery' scientists. Many exciting facts have been discovered as a result of loose thinking and unimaginative experimentation, and described in wrappings of empty words. One great discovery does not betoken a great scientist; science now and then selects insignificant standard bearers to display its banners.
The Struggle for Existence amongst all organic beings throughout the world, which inevitably follows from their high geometrical powers of increase ... This is the doctrine of Malthus, applied to the whole animal and vegetable kingdoms. As many more individuals of each species are born than can possibly survive; and as, consequently, there is a frequently recurring struggle for existence, it follows that any being, if it vary however slightly in any manner profitable to itself, under the complex and sometimes varying conditions of life, will have a better chance of surviving, and thus be naturally selected. From the strong principle of inheritance, any selected variety will tend to propagate its new and modified form.
Theories should not be used to select observations; on the contrary, it is observations which should be used to select the theories.
There have been many authorities who have asserted that the basis of science lies in counting or measuring, i.e. in the use of mathematics. Neither counting nor measuring can however be the most fundamental processes in our study of the material universe—before you can do either to any purpose you must first select what you propose to count or measure, which presupposes a classification.
This relation logical implication is probably the most rigorous and powerful of all the intellectual enterprises of man. From a properly selected set of the vast number of prepositional functions a set can be selected from which an infinitude of prepositional functions can be implied. In this sense all postulational thinking is mathematics. It can be shown that doctrines in the sciences, natural and social, in history, in jurisprudence and in ethics are constructed on the postulational thinking scheme and to that extent are mathematical. Together the proper enterprise of Science and the enterprise of Mathematics embrace the whole knowledge-seeking activity of mankind, whereby “knowledge” is meant the kind of knowledge that admits of being made articulate in the form of propositions.
We have corrupted the term research to mean study and experiment and development toward selected objectives, and we have even espoused secret and classified projects. This was not the old meaning of university research. We need a new term, or the revival of a still older one, to refer to the dedicated activities of the scholar, the intensive study of special aspects of a subject for its own sake, motivated by the love of knowledge and truth.
What these two sciences of recognition, evolution and immunology, have in common is not found in nonbiological systems such as 'evolving' stars. Such physical systems can be explained in terms of energy transfer, dynamics, causes, and even 'information transfer'. But they do not exhibit repertoires of variants ready for interaction by selection to give a population response according to a hereditary principle. The application of a selective principle in a recognition system, by the way, does not necessarily mean that genes must be involved—it simply means that any state resulting after selection is highly correlated in structure with the one that gave rise to it and that the correlation continues to be propagated. Nor is it the case that selection cannot itself introduce variation. But a constancy or 'memory' of selected events is necessary. If changes occurred so fast that what was selected could not emerge in the population or was destroyed, a recognition system would not survive. Physics proper does not deal with recognition systems, which are by their nature biological and historical systems. But all the laws of physics nevertheless apply to recognition systems.
Why did I decide to undertake my doctorate research in the exotic field of boron hydrides? As it happened, my girl friend, Sarah Baylen, soon to become my wife, presented me with a graduation gift, Alfred Stock's book, The Hydrides of Boron and Silicon. I read this book and became interested in the subject. How did it happen that she selected this particular book? This was the time of the Depression. None of us had much money. It appears she selected as her gift the most economical chemistry book ($2.06) available in the University of Chicago bookstore. Such are the developments that can shape a career.
Why should we limit by dogma or otherwise man’s liberty to select his food and drink? … the great practical rule of life in regard of human diet will not be found in enforcing limitation of the sources of food which Nature has abundantly provided.
You have only to take in what you please and leave out what you please; to select your own conditions of time and place; to multiply and divide at discretion; and you can pay the National Debt in half an hour. Calculation is nothing but cookery.
[Coleridge] selected an instance of what was called the sublime, in DARWIN, who imagined the creation of the universe to have taken place in a moment, by the explosion of a mass of matter in the womb, or centre of space. In one and the same instant of time, suns and planets shot into systems in every direction, and filled and spangled the illimitable void! He asserted this to be an intolerable degradation -referring, as it were, all the beauty and harmony of nature to something like the bursting of a barrel of gunpowder! that spit its combustible materials into a pock-freckled creation!
[To elucidate using models] the different combining powers in elementary atoms, I … select my illustrations from that most delightful of games, croquet. Let the croquet balls represent our atoms, and let us distinguish the atoms of different elements by different colours. The white balls are hydrogen, the green ones chlorine atoms; the atoms of fiery oxygen are red, those of nitrogen, blue; the carbon atoms, lastly, are naturally represented by black balls. But we have, in addition, exhibit the different combining powers of these atoms … by screwing into the balls a number of metallic arms (tubes and pins), which correspond respectively to the combining powers of the atoms represented … to join the balls … in imitation of the atomic edifices represented.