[Defining Life] The definite combination of heterogeneous changes, both simultaneous and successive, in correspondence with external co-existences and sequences.

[F. Werner, while a student in Princeton,] came to me and expressed his bewilderment with the fact that we make a rather narrow selection when choosing the data on which we test our theories. “How do we know that, if we made a theory which focuses its attention on phenomena we disregard and disregards some of the phenomena now commanding our attention, that we could not build another theory which has little in common with the present one but which, nevertheless, explains just as many phenomena as the present theory?” It has to be admitted that we have no definite evidence that there is no such theory.

[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.

That the general characters of the big group to which the embryo belongs appear in development earlier than the special characters. In agreement with this is the fact that the vesicular form is the most general form of all; for what is common in a greater degree to all animals than the opposition of an internal and an external surface?
The less general structural relations are formed after the more general, and so on until the most special appear.
The embryo of any given form, instead of passing through the state of other definite forms, on the contrary separates itself from them.
Fundamentally the embryo of a higher animal form never resembles the adult of another animal form, but only its embryo.

A general course in mathematics should be required of all officers for its practical value, but no less for its educational value in training the mind to logical forms of thought, in developing the sense of absolute truthfulness, together with a confidence in the accomplishment of definite results by definite means.

A chemical name should not be a phrase, it ought not to require circumlocutions to become definite; it should not be of the type “Glauber’s salt”, which conveys nothing about the composition of the substance; it should recall the constituents of a compound; it should be non-committal if nothing is known about the substance; the names should preferably be coined from Latin or Greek, so that their meaning can be more widely and easily understood; the form of the words should be such that they fit easily into the language into which they are to be incorporated.

According to the conclusion of Dr. Hutton, and of many other geologists, our continents are of definite antiquity, they have been peopled we know not how, and mankind are wholly unacquainted with their origin. According to my conclusions drawn from the same source, that of facts, our continents are of such small antiquity, that the memory of the revolution which gave them birth must still be preserved among men; and thus we are led to seek in the book of Genesis the record of the history of the human race from its origin. Can any object of importance superior to this be found throughout the circle of natural science?

Anaximenes ... also says that the underlying nature is one and infinite ... but not undefined as Anaximander said but definite, for he identifies it as air; and it differs in its substantial nature by rarity and density. Being made finer it becomes fire; being made thicker it becomes wind, then cloud, then (when thickened still more) water, then earth, then stones; and the rest come into being from these.

And do you know what “the world” is to me? Shall I show it to you in my mirror? This world: a monster of energy, without beginning, without end; a firm, iron magnitude of force that does not grow bigger or smaller, that does not expend itself but only transforms itself; as a whole, of unalterable size, a household without expenses or losses, but likewise without increase or income; enclosed by “nothingness”' as by a boundary; not by something blurry or wasted, not something endlessly extended, but set in a definite space as a definite force, and not a space that might be “empty” here or there, but rather as force throughout, as a play of forces and waves of forces, at the same time one and many, increasing here and at the same time decreasing there; a sea of forces flowing and rushing together, eternally changing, eternally flooding back, with tremendous years of recurrence, with an ebb and a flood of its forms; out of the simplest forms striving toward the most complex, out of the stillest, most rigid, coldest forms toward the hottest, most turbulent, most self-contradictory, and then again returning home to the simple out of this abundance, out of the play of contradictions back to the joy of concord, still affirming itself in this uniformity of its courses and its years, blessing itself as that which must return eternally, as a becoming that knows no satiety, no disgust, no weariness: this, my Dionysian world of the eternally self-creating, the eternally self-destroying, this mystery world of the twofold voluptuous delight, my “beyond good and evil,” without goal, unless the joy of the circle itself is a goal; without will, unless a ring feels good will toward itself-do you want a name for this world? A solution for all its riddles? A light for you, too, you best-concealed, strongest, most intrepid, most midnightly men?—This world is the will to power—and nothing besides! And you yourselves are also this will to power—and nothing besides!

Another advantage of a mathematical statement is that it is so definite that it might be definitely wrong; and if it is found to be wrong, there is a plenteous choice of amendments ready in the mathematicians’ stock of formulae. Some verbal statements have not this merit; they are so vague that they could hardly be wrong, and are correspondingly useless.

Any conception which is definitely and completely determined by means of a finite number of specifications, say by assigning a finite number of elements, is a mathematical conception. Mathematics has for its function to develop the consequences involved in the definition of a group of mathematical conceptions. Interdependence and mutual logical consistency among the members of the group are postulated, otherwise the group would either have to be treated as several distinct groups, or would lie beyond the sphere of mathematics.

As a great man’s influence never ends, so also there is no definite finality, no end, to a great survey; it runs along for centuries, ever responsive to the strain of the increasing needs of a growing population and an enlarging domain.

But if we are to control evolution we shall have to find out how to influence gene reproduction in a definite direction, just as organic chemists nowadays work for definite ends. Such a possibility is at present entirely beyond our grasp, but a century hence it may not be so.

But, as Bacon has well pointed out, truth is more likely to come out of error, if this is clear and definite, than out of confusion, and my experience teaches me that it is better to hold a well-understood and intelligible opinion, even if it should turn out to be wrong, than to be content with a muddle-headed mixture of conflicting views, sometimes miscalled impartiality, and often no better than no opinion at all.

Connected by innumerable ties with abstract science, Physiology is yet in the most intimate relation with humanity; and by teaching us that law and order, and a definite scheme of development, regulate even the strangest and wildest manifestations of individual life, she prepares the student to look for a goal even amidst the erratic wanderings of mankind, and to believe that history offers something more than an entertaining chaos—a journal of a toilsome, tragi-comic march nowither.

Contact means the exchange of specific knowledge, ideas, or at least of findings, definite facts. But what if no exchange is possible? If an elephant is not a giant microbe, the ocean is not a giant brain.

Each ray of light moves in the coordinate system 'at rest' with the definite, constant velocity V independent of whether this ray of light is emitted by a body at rest or a body in motion.

Euclid always contemplates a straight line as drawn between two definite points, and is very careful to mention when it is to be produced beyond this segment. He never thinks of the line as an entity given once for all as a whole. This careful definition and limitation, so as to exclude an infinity not immediately apparent to the senses, was very characteristic of the Greeks in all their many activities. It is enshrined in the difference between Greek architecture and Gothic architecture, and between Greek religion and modern religion. The spire of a Gothic cathedral and the importance of the unbounded straight line in modern Geometry are both emblematic of the transformation of the modern world.

Every great anthropologic and paleontologic discovery fits into its proper place, enabling us gradually to fill out, one after another, the great branching lines of human ascent and to connect with the branches definite phases of industry and art. This gives us a double means of interpretation, archaeological and anatomical. While many branches and links in the chain remain to be discovered, we are now in a position to predict with great confidence not only what the various branches will be like but where they are most like to be found.

Evolution is an integration of matter and concomitant dissipation of motion during which the matter passes from an indefinite incoherent homogeneity to a definite coherent heterogeneity, and during which the retained motion undergoes a parallel transformation.

Facts are certainly the solid and true foundation of all sectors of nature study ... Reasoning must never find itself contradicting definite facts; but reasoning must allow us to distinguish, among facts that have been reported, those that we can fully believe, those that are questionable, and those that are false. It will not allow us to lend faith to those that are directly contrary to others whose certainty is known to us; it will not allow us to accept as true those that fly in the face of unquestionable principles.

From the intensity of the spots near the centre, we can infer that the protein molecules are relatively dense globular bodies, perhaps joined together by valency bridges, but in any event separated by relatively large spaces which contain water. From the intensity of the more distant spots, it can be inferred that the arrangement of atoms inside the protein molecule is also of a perfectly definite kind, although without the periodicities characterising the fibrous proteins. The observations are compatible with oblate spheroidal molecules of diameters about 25 A. and 35 A., arranged in hexagonal screw-axis. ... At this stage, such ideas are merely speculative, but now that a crystalline protein has been made to give X-ray photographs, it is clear that we have the means of checking them and, by examining the structure of all crystalline proteins, arriving at a far more detailed conclusion about protein structure than previous physical or chemical methods have been able to give.

Further study of the division phenomena requires a brief discussion of the material which thus far I have called the stainable substance of the nucleus. Since the term nuclear substance could easily result in misinterpretation..., I shall coin the term chromatin for the time being. This does not indicate that this substance must be a chemical compound of a definite composition, remaining the same in all nuclei. Although this may be the case, we simply do not know enough about the nuclear substances to make such an assumption. Therefore, we will designate as chromatin that substance, in the nucleus, which upon treatment with dyes known as nuclear stains does absorb the dye. From my description of the results of staining resting and dividing cells... it follows that the chromatin is distributed throughout the whole resting nucleus, mostly in the nucleoli, the network, and the membrane, but also in the ground-substance. In nuclear division it accumulates exclusively in the thread figures. The term achromatin suggests itself automatically for the unstainable substance of the nucleus. The terms chromatic and achromatic which will be used henceforth are thus explained.

Geologists have not been slow to admit that they were in error in assuming that they had an eternity of past time for the evolution of the earth’s history. They have frankly acknowledged the validity of the physical arguments which go to place more or less definite limits to the antiquity of the earth. They were, on the whole, disposed to acquiesce in the allowance of 100 millions of years granted to them by Lord Kelvin, for the transaction of the whole of the long cycles of geological history. But the physicists have been insatiable and inexorable. As remorseless as Lear’s daughters, they have cut down their grant of years by successive slices, until some of them have brought the number to something less than ten millions. In vain have the geologists protested that there must somewhere be a flaw in a line of argument which tends to results so entirely at variance with the strong evidence for a higher antiquity, furnished not only by the geological record, but by the existing races of plants and animals. They have insisted that this evidence is not mere theory or imagination, but is drawn from a multitude of facts which become hopelessly unintelligible unless sufficient time is admitted for the evolution of geological history. They have not been able to disapprove the arguments of the physicists, but they have contended that the physicists have simply ignored the geological arguments as of no account in the discussion.

He who seeks for methods without having a definite problem in mind seeks for the most part in vain.

How can cosmic religious feeling be communicated from one person to another, if it can give rise to no definite notion of a God and no theology? In my view, it is the most important function of art and science to awaken this feeling and keep it alive in those who are receptive to it.

Hyper-selectionism has been with us for a long time in various guises; for it represents the late nineteenth century’s scientific version of the myth of natural harmony–all is for the best in the best of all possible worlds (all structures well designed for a definite purpose in this case). It is, indeed, the vision of foolish Dr. Pangloss, so vividly satirized by Voltaire in Candide–the world is not necessarily good, but it is the best we could possibly have.

I am credited with being one of the hardest workers and perhaps I am, if thought is the equivalent of labour, for I have devoted to it almost all of my waking hours. But if work is interpreted to be a definite performance in a specified time according to a rigid rule, then I may be the worst of idlers. Every effort under compulsion demands a sacrifice of life-energy. I never paid such a price. On the contrary, I have thrived on my thoughts.

I assume that each organism which the Creator educed was stamped with an indelible specific character, which made it what it was, and distinguished it from everything else, however near or like. I assume that such character has been, and is, indelible and immutable; that the characters which distinguish species now, were as definite at the first instant of their creation as now and are as distinct now as they were then. If any choose to maintain... that species were gradually bought to their present maturity from humbler forms... he is welcome to his hypothesis, but I have nothing to do with it.

I had made up my mind to find that for which I was searching even if it required the remainder of my life. After innumerable failures I finally uncovered the principle for which I was searching, and I was astounded at its simplicity. I was still more astounded to discover the principle I had revealed not only beneficial in the construction of a mechanical hearing aid but it served as well as means of sending the sound of the voice over a wire. Another discovery which came out of my investigation was the fact that when a man gives his order to produce a definite result and stands by that order it seems to have the effect of giving him what might be termed a second sight which enables him to see right through ordinary problems. What this power is I cannot say; all I know is that it exists and it becomes available only when a man is in that state of mind in which he knows exactly what he wants and is fully determined not to quit until he finds it.

I hope you enjoy the absence of pupils … the total oblivion of them for definite intervals is a necessary condition for doing them justice at the proper time.

Iconography becomes even more revealing when processes or concepts, rather than objects, must be depicted–for the constraint of a definite ‘thing’ cedes directly to the imagination. How can we draw ‘evolution’ or ‘social organization,’ not to mention the more mundane ‘digestion’ or ‘self-interest,’ without portraying more of a mental structure than a physical reality? If we wish to trace the history of ideas, iconography becomes a candid camera trained upon the scholar’s mind.

If the world may be thought of as a certain definite quantity of force and as a certain definite number of centers of force—and every other representation remains indefinite and therefore useless—it follows that, in the great dice game of existence, it must pass through calculable number of combinations. In infinite time, every possible combination would at some time or another be realized; more: it would be realized an infinite number of times. And since between every combination and its next recurrence all other possible combinations would have to take place, and each of these combination conditions of the entire sequence of combinations in the same series, a circular movement of absolutely identical series is thus demonstrated: the world as a circular movement that has already repeated itself infinitely often and plays its game in infinitum. This conception is not simply a mechanistic conception; for if it were that, it would not condition an infinite recurrence of identical cases, but a final state. Because the world has not reached this, mechanistic theory must be considered an imperfect and merely provisional hypothesis.

In every case the awakening touch has been the mathematical spirit, the attempt to count, to measure, or to calculate. What to the poet or the seer may appear to be the very death of all his poetry and all his visions—the cold touch of the calculating mind,—this has proved to be the spell by which knowledge has been born, by which new sciences have been created, and hundreds of definite problems put before the minds and into the hands of diligent students. It is the geometrical figure, the dry algebraical formula, which transforms the vague reasoning of the philosopher into a tangible and manageable conception; which represents, though it does not fully describe, which corresponds to, though it does not explain, the things and processes of nature: this clothes the fruitful, but otherwise indefinite, ideas in such a form that the strict logical methods of thought can be applied, that the human mind can in its inner chamber evolve a train of reasoning the result of which corresponds to the phenomena of the outer world.

In like manner, the loadstone has from nature its two poles, a northern and a southern; fixed, definite points in the stone, which are the primary termini of the movements and effects, and the limits and regulators of the several actions and properties. It is to be understood, however, that not from a mathematical point does the force of the stone emanate, but from the parts themselves; and all these parts in the whole—while they belong to the whole—the nearer they are to the poles of the stone the stronger virtues do they acquire and pour out on other bodies. These poles look toward the poles of the earth, and move toward them, and are subject to them. The magnetic poles may be found in very loadstone, whether strong and powerful (male, as the term was in antiquity) or faint, weak, and female; whether its shape is due to design or to chance, and whether it be long, or flat, or four-square, or three-cornered or polished; whether it be rough, broken-off, or unpolished: the loadstone ever has and ever shows its poles.

In order that the facts obtained by observation and experiment may be capable of being used in furtherance of our exact and solid knowledge, they must be apprehended and analysed according to some Conceptions which, applied for this purpose, give distinct and definite results, such as can be steadily taken hold of and reasoned from.

In scientific study, or, as I prefer to phrase it, in creative scholarship, the truth is the single end sought; all yields to that. The truth is supreme, not only in the vague mystical sense in which that expression has come to be a platitude, but in a special, definite, concrete sense. Facts and the immediate and necessary inductions from facts displace all pre-conceptions, all deductions from general principles, all favourite theories. Previous mental constructions are bowled over as childish play-structures by facts as they come rolling into the mind. The dearest doctrines, the most fascinating hypotheses, the most cherished creations of the reason and of the imagination perish from a mind thoroughly inspired with the scientific spirit in the presence of incompatible facts. Previous intellectual affections are crushed without hesitation and without remorse. Facts are placed before reasonings and before ideals, even though the reasonings and the ideals be more beautiful, be seemingly more lofty, be seemingly better, be seemingly truer. The seemingly absurd and the seemingly impossible are sometimes true. The scientific disposition is to accept facts upon evidence, however absurd they may appear to our pre-conceptions.

In the beginning there was an explosion. Not an explosion like those familiar on earth, starting from a definite center and spreading out to engulf more and more of the circumambient air, but an explosion which occurred simultaneously everywhere, filling all space from the beginning, with every particle of matter rushing apart from every other particle. ‘All space’ in this context may mean either all of an infinite universe, or all of a finite universe which curves back on itself like the surface of a sphere. Neither possibility is easy to comprehend, but this will not get in our way; it matters hardly at all in the early universe whether space is finite or infinite. At about one-hundredth of a second, the earliest time about which we can speak with any confidence, the temperature of the universe was about a hundred thousand million (10¹¹) degrees Centigrade. This is much hotter than in the center of even the hottest star, so hot, in fact, that none of the components of ordinary matter, molecules, or atoms, or even the nuclei of atoms, could have held together. Instead, the matter rushing apart in this explosion consisted of various types of the so-called elementary particles, which are the subject of modern high­energy nuclear physics.

Is pure science to be considered as something potentially harmful? Answer: Most certainly! Every child knows that it is potentially exceedingly harmful. … The menace of blowing ourselves up by atom bombs, doing ourselves in by chemical or biological warfare, or by population explosion, is certainly with us. I consider the environment thing a trivial question, by comparison—like housekeeping. In any home, the dishes have to be washed, the floors swept, the beds made, and there must be rules as to who is allowed to produce how much stink and noise, and where in the house: When the garbage piles up, these questions become pressing. But they are momentary problems. Once the house is in order, you still want to live in it, not just sit around enjoying its orderliness. I would be sorry to see Caltech move heavily into this type of applied research. … SCIENCE POTENTIALLY HARMFUL? DEFINITELY.

It is perhaps difficult sufficiently to emphasise Seeking without disparaging its correlative Finding. But I must risk this, for Finding has a clamorous voice that proclaims its own importance; it is definite and assured, something that we can take hold of —that is what we all want, or think we want. Yet how transitory it proves.
The finding of one generation will not serve for the next. It tarnishes rapidly except it be reserved with an ever-renewed spirit of seeking.

It is utterly beyond our power to measure the changes of things by time. Quite the contrary, time is an abstraction, at which we arrive by means of the changes of things; made because we are not restricted to any one definite measure, all being interconnected.

It is very remarkable that while the words Eternal, Eternity, Forever, are constantly in our mouths, and applied without hesitation, we yet experience considerable difficulty in contemplating any definite term which bears a very large proportion to the brief cycles of our petty chronicles. There are many minds that would not for an instant doubt the God of Nature to have existed from all Eternity, and would yet reject as preposterous the idea of going back a million of years in the History of His Works. Yet what is a million, or a million million, of solar revolutions to an Eternity?

It seems to me, he says, that the test of “Do we or not understand a particular subject in physics?” is, “Can we make a mechanical model of it?” I have an immense admiration for Maxwell’s model of electromagnetic induction. He makes a model that does all the wonderful things that electricity docs in inducing currents, etc., and there can be no doubt that a mechanical model of that kind is immensely instructive and is a step towards a definite mechanical theory of electromagnetism.

It will be a vast boon to mankind when we learn to prophesy the precise dates when cycles of various kinds will reach definite stages.

It... [can] be easily shown:
1. That all present mountains did not exist from the beginning of things.
2. That there is no growing of mountains.
3. That the rocks or mountains have nothing in common with the bones of animals except a certain resemblance in hardness, since they agree in neither matter nor manner of production, nor in composition, nor in function, if one may be permitted to affirm aught about a subject otherwise so little known as are the functions of things.
4. That the extension of crests of mountains, or chains, as some prefer to call them, along the lines of certain definite zones of the earth, accords with neither reason nor experience.
5. That mountains can be overthrown, and fields carried over from one side of a high road across to the other; that peaks of mountains can be raised and lowered, that the earth can be opened and closed again, and that other things of this kind occur which those who in their reading of history wish to escape the name of credulous, consider myths.

Just as a tree constitutes a mass arranged in a definite manner, in which, in every single part, in the leaves as in the root, in the trunk as in the blossom, cells are discovered to be the ultimate elements, so is it also with the forms of animal life. Every animal presents itself as a sum of vital unities, every one of which manifests all the characteristics of life. The characteristics and unity of life cannot be limited to anyone particular spot in a highly developed organism (for example, to the brain of man), but are to be found only in the definite, constantly recurring structure, which every individual element displays. Hence it follows that the structural composition of a body of considerable size, a so-called individual, always represents a kind of social arrangement of parts, an arrangement of a social kind, in which a number of individual existences are mutually dependent, but in such a way, that every element has its own special action, and, even though it derive its stimulus to activity from other parts, yet alone effects the actual performance of its duties.

Life is a series of definite and successive changes both in structure and in composition, which take place in an individual without destroying its identity.

Life through many long periods has been manifested in a countless host of varying structures, all circumscribed by one general plan, each appointed to a definite place, and limited to an appointed duration. On the whole the earth has been thus more and more covered by the associated life of plants and animals, filling all habitable space with beings capable of enjoying their own existence or ministering to the enjoyment of others; till finally, after long preparation, a being was created capable of the wonderful power of measuring and weighing all the world of matter and space which surrounds him, of treasuring up the past history of all the forms of life, and considering his own relation to the whole. When he surveys this vast and co-ordinated system, and inquires into its history and origin, can he be at a loss to decide whether it be a work of Divine thought and wisdom, or the fortunate offspring of a few atoms of matter, warmed by the anima mundi, a spark of electricity, or an accidental ray of sunshine?

Light is always propagated in empty space with a definite velocity, “c,” which is independent of the state of motion of the emitting body.

Man is a free moral agent and can be magnanimous and deal disinterestedly, humanity is a definite goal, social justice is desirable and possible, individual lives may be gloriously diversified, uniquely individualized, and yet socially useful; or, these are mere phrases, snares to catch gulls, soothing syrup for our troubled souls.

Mathematics as a science commenced when first someone, probably a Greek, proved propositions about any things or about some things, without specification of definite particular things. These propositions were first enunciated by the Greeks for geometry; and, accordingly, geometry was the great Greek mathematical science.

Mathematics is perfectly free in its development and is subject only to the obvious consideration, that its concepts must be free from contradictions in themselves, as well as definitely and orderly related by means of definitions to the previously existing and established concepts.

Mathematics is the science of definiteness, the necessary vocabulary of those who know.

Mathematics may be compared to a mill of exquisite workmanship, which grinds you stuff of any degree of fineness; but, nevertheless, what you get out depends upon what you put in; and as the grandest mill in the world will not extract wheat-flour from peascods, so pages of formulae will not get a definite result out of loose data.

Mathematics, among all school subjects, is especially adapted to further clearness, definite brevity and precision in expression, although it offers no exercise in flights of rhetoric. This is due in the first place to the logical rigour with which it develops thought, avoiding every departure from the shortest, most direct way, never allowing empty phrases to enter. Other subjects excel in the development of expression in other respects: translation from foreign languages into the mother tongue gives exercise in finding the proper word for the given foreign word and gives knowledge of laws of syntax, the study of poetry and prose furnish fit patterns for connected presentation and elegant form of expression, composition is to exercise the pupil in a like presentation of his own or borrowed thoughtsand their development, the natural sciences teach description of natural objects, apparatus and processes, as well as the statement of laws on the grounds of immediate sense-perception. But all these aids for exercise in the use of the mother tongue, each in its way valuable and indispensable, do not guarantee, in the same manner as mathematical training, the exclusion of words whose concepts, if not entirely wanting, are not sufficiently clear. They do not furnish in the same measure that which the mathematician demands particularly as regards precision of expression.

Mathematics, the priestess of definiteness and clearness.

Mr. Dalton's aspect and manner were repulsive. There was no gracefulness belonging to him. His voice was harsh and brawling; his gait stiff and awkward; his style of writing and conversation dry and almost crabbed. In person he was tall, bony, and slender. He never could learn to swim: on investigating this circumstance he found that his spec. grav. as a mass was greater than that of water; and he mentioned this in his lectures on natural philosophy in illustration of the capability of different persons for attaining the art of swimming. Independence and simplicity of manner and originality were his best qualities. Though in comparatively humble circumstances he maintained the dignity of the philosophical character. As the first distinct promulgator of the doctrine that the elements of bodies unite in definite proportions to form chemical compounds, he has acquired an undying fame.
Dr John Davy's (brother of Humphry Davy) impressions of Dalton written in c.1830-31 in Malta.

My position is perfectly definite. Gravitation, motion, heat, light, electricity and chemical action are one and the same object in various forms of manifestation.

Never mind what two tons refers to. What is it? How has it entered in so definite a way into our exprerience? Two tons is the reading of the pointer when the elephant was placed on a weighing machine. Let us pass on. … And so we see that the poetry fades out of the problem, and by the time the serious application of exact science begins we are left only with pointer readings.

No man ever looks at the world with pristine eyes. He sees it edited by a definite set of customs and institutions and ways of thinking.

Nor do I know any study which can compete with mathematics in general in furnishing matter for severe and continued thought. Metaphysical problems may be even more difficult; but then they are far less definite, and, as they rarely lead to any precise conclusion, we miss the power of checking our own operations, and of discovering whether we are thinking and reasoning or merely fancying and dreaming.

Now that we locate them [genes] in the chromosomes are we justified in regarding them as material units; as chemical bodies of a higher order than molecules? Frankly, these are questions with which the working geneticist has not much concern himself, except now and then to speculate as to the nature of the postulated elements. There is no consensus of opinion amongst geneticists as to what the genes are—whether they are real or purely fictitious—because at the level at which the genetic experiments lie, it does not make the slightest difference whether the gene is a hypothetical unit, or whether the gene is a material particle. In either case the unit is associated with a specific chromosome, and can be localized there by purely genetic analysis. Hence, if the gene is a material unit, it is a piece of chromosome; if it is a fictitious unit, it must be referred to a definite location in a chromosome—the same place as on the other hypothesis. Therefore, it makes no difference in the actual work in genetics which point of view is taken. Between the characters that are used by the geneticist and the genes that his theory postulates lies the whole field of embryonic development.

Of all the conceptions of the human mind from unicorns to gargoyles to the hydrogen bomb perhaps the most fantastic is the black hole: a hole in space with a definite edge over which anything can fall and nothing can escape; a hole with a gravitational field so strong that even light is caught and held in its grip; a hole that curves space and warps time.

Plant breeding to be successful must be conducted like architecture. Definite plans must be carefully laid for the proposed creation; suitable materials selected with judgment, and these must he securely placed in their proper order and position.

Pure mathematics is a collection of hypothetical, deductive theories, each consisting of a definite system of primitive, undefined, concepts or symbols and primitive, unproved, but self-consistent assumptions (commonly called axioms) together with their logically deducible consequences following by rigidly deductive processes without appeal to intuition.

Research may start from definite problems whose importance it recognizes and whose solution is sought more or less directly by all forces. But equally legitimate is the other method of research which only selects the field of its activity and, contrary to the first method, freely reconnoitres in the search for problems which are capable of solution. Different individuals will hold different views as to the relative value of these two methods. If the first method leads to greater penetration it is also easily exposed to the danger of unproductivity. To the second method we owe the acquisition of large and new fields, in which the details of many things remain to be determined and explored by the first method.

Science, in the immediate, produces knowledge and, indirectly, means of action. It leads to methodical action if definite goals are set up in advance. For the function of setting up goals and passing statements of value transcends its domain. While it is true that science, to the extent of its grasp of causative connections, may reach important conclusions as to the compatibility and incompatibility of goals and evaluations, the independent and fundamental definitions regarding goals and values remain beyond science’s reach.

Sexual instinct—as emotion, idea, and impulse—is a function of the cerebral cortex. Thus far no definite region of the cortex has been proved to be exclusively the seat of sexual sensations and impulses.

Since it is necessary for specific ideas to have definite and consequently as far as possible selected terms, I have proposed to call substances of similar composition and dissimilar properties isomeric, from the Greek ίσομερης (composed of equal parts).

Subatomic particles do not exist but rather show “tendencies to exist”, and atomic events do not occur with certainty at definite times and in definite ways, but rather show “tendencies to occur”.

Talent is full of thoughts; genius, of thought. One has definite acquisitions; the other, indefinite power.

The analysis of Nature into its individual parts, the grouping of the different natural processes and natural objects in definite classes, the study of the internal anatomy of organic bodies in their manifold forms—these were the fundamental conditions of the gigantic strides in our knowledge of Nature which have been made during the last four hundred years. But this method of investigation has also left us as a legacy the habit of observing natural objects and natural processes in their isolation, detached from the whole vast interconnection of things; and therefore not in their motion, but in their repose; not as essentially changing, but fixed constants; not in their life, but in their death.

The deep study of nature is the most fruitful source of mathematical discoveries. By offering to research a definite end, this study has the advantage of excluding vague questions and useless calculations; besides it is a sure means of forming analysis itself and of discovering the elements which it most concerns us to know, and which natural science ought always to conserve.

The discovery of the laws of definite proportions is one of the most important and wonderful among the great and brilliant achievements of modern chemistry. It is sufficient of itself to convince any reasoning mind, that order and system pervade the universe, and that the minutest atoms of matter, and the vast orbs that move round the heavens are equally under the control of the invariable laws of the creator.

The external impressions which are made on the sensorial nerves are very quickly transmitted along the whole length of the nerves, as far as their origin; and having arrived there, they are reflected by a certain law, and pass on to certain and corresponding motor nerves, through which, being again very quickly transmitted to muscles, they excite certain and definite motions. This part, in which, as in a centre, the sensorial nerves, as well as the motor nerves, meet and communicate, and in which the impressions made on the sensorial nerves are reflected on the motor nerves, is designated by a term, now adopted by most physiologists, the sensorium commune.

The geometrical problems and theorems of the Greeks always refer to definite, oftentimes to rather complicated figures. Now frequently the points and lines of such a figure may assume very many different relative positions; each of these possible cases is then considered separately. On the contrary, present day mathematicians generate their figures one from another, and are accustomed to consider them subject to variation; in this manner they unite the various cases and combine them as much as possible by employing negative and imaginary magnitudes. For example, the problems which Apollonius treats in his two books De sectione rationis, are solved today by means of a single, universally applicable construction; Apollonius, on the contrary, separates it into more than eighty different cases varying only in position. Thus, as Hermann Hankel has fittingly remarked, the ancient geometry sacrifices to a seeming simplicity the true simplicity which consists in the unity of principles; it attained a trivial sensual presentability at the cost of the recognition of the relations of geometric forms in all their changes and in all the variations of their sensually presentable positions.

The Gombe Stream chimpanzees … in their ability to modify a twig or stick to make it suitable for a definite purpose, provide the first examples of free-ranging nonhuman primates actually making very crude tools.

The human mind is not capable of grasping the Universe. We are like a little child entering a huge library. The walls are covered to the ceilings with books in many different tongues. The child knows that someone must have written these books. It does not know who or how. It does not understand the languages in which they are written. But the child notes a definite plan in the arrangement of the books—a mysterious order which it does not comprehend, but only dimly suspects.

The inhibitory nerves are of as fundamental importance in the economy of the body as the motor nerves. No evidence exists that the same nerve fibre is sometimes capable of acting as a motor nerve, sometimes as a nerve of inhibition, but on the contrary the latter nerves form a separate and complete nervous system subject to as definite anatomical and histological laws as the former.

The laws of nature, as we understand them, are the foundation of our knowledge in natural things. So much as we know of them has been developed by the successive energies of the highest intellects, exerted through many ages. After a most rigid and scrutinizing examination upon principle and trial, a definite expression has been given to them; they have become, as it were, our belief or trust. From day to day we still examine and test our expressions of them. We have no interest in their retention if erroneous. On the contrary, the greatest discovery a man could make would be to prove that one of these accepted laws was erroneous, and his greatest honour would be the discovery.

The moment one has offered an original explanation for a phenomenon which seems satisfactory, that moment affection for his intellectual child springs into existence, and as the explanation grows into a definite theory his parental affections cluster about his offspring and it grows more and more dear to him. ... There springs up also unwittingly a pressing of the theory to make it fit the facts and a pressing of the facts to make them fit the theory... To avoid this grave danger, the method of multiple working hypotheses is urged. It differs from the simple working hypothesis in that it distributes the effort and divides the affections... In developing the multiple hypotheses, the effort is to bring up into view every rational exploration of the phenomenon in hand and to develop every tenable hypothesis relative to its nature, cause or origin, and to give to all of these as impartially as possible a working form and a due place in the investigation. The investigator thus becomes the parent of a family of hypotheses; and by his parental relations to all is morally forbidden to fasten his affections unduly upon anyone. ... Each hypothesis suggests its own criteria, its own method of proof, its own method of developing the truth, and if a group of hypotheses encompass the subject on all sides, the total outcome of means and of methods is full and rich.

The most startling result of Faraday’s Law is perhaps this. If we accept the hypothesis that the elementary substances are composed of atoms, we cannot avoid concluding that electricity also, positive as well as negative, is divided into definite elementary portions, which behave like atoms of electricity.

The occurrence of an internal skeleton, in definite relations to the other organ systems, and the articulation of the body into homologous segments, are points in the general organization of Vertebrates to which especial weight must be given. This metameric structure is more or less definitely expressed in most of the organs, and as it extends to the axial skeleton, the latter also gradually articulates into separate segments, the vertebrae. The latter, however, must be regarded only as the partial expression of a general articulation of the body which is all the more important in consequence of its appearing prior to the articulation of the originally inarticulate axial skeleton. Hence this general articulation may be considered as a primitive vertebral structure, to which the articulation of the axial skeleton is related as a secondary process of the same sort.

The peculiar taste both in pure and in mixed nature of those relations about which it is conversant, from its simple and definite phraseology, and from the severe logic so admirably displayed in the concatenation of its innumerable theorems, are indeed immense, and well entitled to separate and ample illustration.

The people has no definite disbelief in the temples of theology. The people has a very fiery and practical disbelief in the temples of physical science.

The precise equivalence of the chromosomes contributed by the two sexes is a physical correlative of the fact that the two sexes play, on the whole, equal parts in hereditary transmission, and it seems to show that the chromosomal substance, the chromatin, is to be regarded as the physical basis of inheritance. Now, chromatin is known to be closely similar to, if not identical with, a substance known as nuclein (C₂₉H₄₉N₉O₂₂, according to Miescher), which analysis shows to be a tolerably definite chemical compased of nucleic acid (a complex organic acid rich in phosphorus) and albumin. And thus we reach the remarkable conclusion that inheritance may, perhaps, be effected by the physical transmission of a particular chemical compound from parent to offspring.

The present lack of a definitely acceptable account of the origin of life should certainly not be taken as a stumbling block for the whole Darwinian world view.

The publication of the Darwin and Wallace papers in 1858, and still more that of the 'Origin' in 1859, had the effect upon them of the flash of light, which to a man who has lost himself in a dark night, suddenly reveals a road which, whether it takes him straight home or not, certainly goes his way. That which we were looking for, and could not find, was a hypothesis respecting the origin of known organic forms, which assumed the operation of no causes but such as could be proved to be actually at work. We wanted, not to pin our faith to that or any other speculation, but to get hold of clear and definite conceptions which could be brought face to face with facts and have their validity tested. The 'Origin' provided us with the working hypothesis we sought.

The purely formal sciences, logic and mathematics, deal with such relations which are independent of the definite content, or the substance of the objects, or at least can be. In particular, mathematics involves those relations of objects to each other that involve the concept of size, measure, number.

The results of systematic symbolical reasoning must always express general truths, by their nature; and do not, for their justification, require each of the steps of the process to represent some definite operation upon quantity. The absolute universality of the interpretation of symbols is the fundamental principle of their use.

The term ‘community’ implies a diversity but at the same time a certain organized uniformity in the units. The units are the many individual plants that occur in every community, whether this be a beech-forest, a meadow, or a heath. Uniformity is established when certain atmospheric, terrestrial, and any of the other factors discussed in Section I are co-operating, and appears either because a certain, defined economy makes its impress on the community as a whole, or because a number of different growth-forms are combined to form a single aggregate which has a definite and constant guise.

The traditional psychology talks like one who should say a river consists of nothing but pailsful, spoonsful, quartpotsful, barrelsful, and other moulded forms of water. Even were the pails and the pots all actually standing in the stream, still between them the free water would continue to flow. It is just this free water of consciousness that psychologists resolutely overlook. Every definite image in the mind is steeped and dyed in the free water that flows round it. With it goes the sense of its relations, near and remote, the dying echo of whence it came to us, the dawning sense of whither it is to lead.

There can never be two or more equivalent electrons in an atom, for which in a strong field the values of all the quantum numbers n, k₁, k₂ and m are the same. If an electron is present, for which these quantum numbers (in an external field) have definite values, then this state is ‘occupied.’

There is no science which does not spring from pre-existing knowledge, and no certain and definite idea which has not derived its origin from the senses.

These symptoms are formed in such a particular way that they form a disease group in themselves and thus merit being designated and described as a definite disease ... It is this group of symptoms which I wish to designate by the name Alcoholismus chronicus.

Things of all kinds are subject to a universal law which may be called the law of large numbers. It consists in the fact that, if one observes very considerable numbers of events of the same nature, dependent on constant causes and causes which vary irregularly, sometimes in one direction, sometimes in the other, it is to say without their variation being progressive in any definite direction, one shall find, between these numbers, relations which are almost constant.

Those who assert that the mathematical sciences make no affirmation about what is fair or good make a false assertion; for they do speak of these and frame demonstrations of them in the most eminent sense of the word. For if they do not actually employ these names, they do not exhibit even the results and the reasons of these, and therefore can be hardly said to make any assertion about them. Of what is fair, however, the most important species are order and symmetry, and that which is definite, which the mathematical sciences make manifest in a most eminent degree. And since, at least, these appear to be the causes of many things—now, I mean, for example, order, and that which is a definite thing, it is evident that they would assert, also, the existence of a cause of this description, and its subsistence after the same manner as that which is fair subsists in.

To a body of infinite size there can be ascribed neither center nor boundary ... Just as we regard ourselves as at the center of that universally equidistant circle, which is the great horizon and the limit of our own encircling ethereal region, so doubtless the inhabitants of the moon believe themselves to be at the center (of a great horizon) that embraces this earth, the sun, and the stars, and is the boundary of the radii of their own horizon. Thus the earth no more than any other world is at the center; moreover no points constitute determined celestial poles for our earth, just as she herself is not a definite and determined pole to any other point of the ether, or of the world-space; and the same is true for all other bodies. From various points of view these may all be regarded either as centers, or as points on the circumference, as poles, or zeniths and so forth. Thus the earth is not in the center of the universe; it is central only to our own surrounding space.

To say that mind is a product or function of protoplasm, or of its molecular changes, is to use words to which we can attach no clear conception. You cannot have, in the whole, what does not exist in any of the parts; and those who argue thus should put forth a definite conception of matter, with clearly enunciated properties, and show, that the necessary result of a certain complex arrangement of the elements or atoms of that matter, will be the production of self-consciousness. There is no escape from this dilemma—either all matter is conscious, or consciousness is something distinct from matter, and in the latter case, its presence in material forms is a proof of the existence of conscious beings, outside of, and independent of, what we term matter. The foregoing considerations lead us to the very important conclusion, that matter is essentially force, and nothing but force; that matter, as popularly understood, does not exist, and is, in fact, philosophically inconceivable. When we touch matter, we only really experience sensations of resistance, implying repulsive force; and no other sense can give us such apparently solid proofs of the reality of matter, as touch does. This conclusion, if kept constantly present in the mind, will be found to have a most important bearing on almost every high scientific and philosophical problem, and especially on such as relate to our own conscious existence.

We are the accidental result of an unplanned process … the fragile result of an enormous concatenation of improbabilities, not the predictable product of any definite process.

We come no nearer the infinitude of the creative power of God, if we enclose the space of its revelation within a sphere described with the radius of the Milky Way, than if we were to limit it to a ball an inch in diameter. All that is finite, whatever has limits and a definite relation to unity, is equally far removed from the infinite... Eternity is not sufficient to embrace the manifestations of the Supreme Being, if it is not combined with the infinitude of space.

We have just introduced the term gene for the hypothetical material carrier of a definite hereditary feature.

We have now got what seems to be definite proof that an X ray which spreads out in a spherical form from a source as a wave through the aether can when it meets an atom collect up all its energy from all round and concentrate it on the atom. It is as if when a circular wave on water met an obstacle, the wave were all suddenly to travel round the circle and disappear all round and concentrate its energy on attacking the obstacle. Mechanically of course this is absurd, but mechanics have in this direction been for some time a broken reed.

We inhabit a complex world. Some boundaries are sharp and permit clean and definite distinctions. But nature also includes continua that cannot be neatly parceled into two piles of unambiguous yeses and noes. Biologists have rejected, as fatally flawed in principle, all attempts by antiabortionists to define an unambiguous ‘beginning of life,’ because we know so well that the sequence from ovulation or spermatogenesis to birth is an unbreakable continuum–and surely no one will define masturbation as murder.

We may assume the existence of an aether; only we must give up ascribing a definite state of motion to it, I.e. we must by abstraction take from it the last mechanical characteristic which Lorentz had still left it.

We must make the following remark: a proof, that after a certain time t₁, the spheres must necessarily be mixed uniformly, whatever may be the initial distribution of states, cannot be given. This is in fact a consequence of probability theory, for any non-uniform distribution of states, no matter how improbable it may be, is still not absolutely impossible. Indeed it is clear that any individual uniform distribution, which might arise after a certain time from some particular initial state, is just as improbable as an individual non-uniform distribution; just as in the game of Lotto, any individual set of five numbers is as improbable as the set 1, 2, 3, 4, 5. It is only because there are many more uniform distributions than non-uniform ones that the distribution of states will become uniform in the course of time. One therefore cannot prove that, whatever may be the positions and velocities of the spheres at the beginning, the distributions must become uniform after a long time; rather one can only prove that infinitely many more initial states will lead to a uniform one after a definite length of time than to a non-uniform one. Loschmidt's theorem tells us only about initial states which actually lead to a very non-uniform distribution of states after a certain time t₁; but it does not prove that there are not infinitely many more initial conditions that will lead to a uniform distribution after the same time. On the contrary, it follows from the theorem itself that, since there are infinitely many more uniform distributions, the number of states which lead to uniform distributions after a certain time t₁, is much greater than the number that leads to non-uniform ones, and the latter are the ones that must be chosen, according to Loschmidt, in order to obtain a non-uniform distribution at t₁.

We set out, therefore, with the supposition that an organised body is not produced by a fundamental power which is guided in its operation by a definite idea, but is developed, according to blind laws of necessity, by powers which, like those of inorganic nature, are established by the very existence of matter. As the elementary materials of organic nature are not different from those of the inorganic kingdom, the source of the organic phenomena can only reside in another combination of these materials, whether it be in a peculiar mode of union of the elementary atoms to form atoms of the second order, or in the arrangement of these conglomerate molecules when forming either the separate morphological elementary parts of organisms, or an entire organism.

We should therefore, with grace and optimism, embrace NOMA’s tough-minded demand: Acknowledge the personal character of these human struggles about morals and meanings, and stop looking for definite answers in nature’s construction. But many people cannot bear to surrender nature as a ‘transitional object’–a baby’s warm blanket for our adult comfort. But when we do (for we must) , nature can finally emerge in her true form: not as a distorted mirror of our needs, but as our most fascinating companion. Only then can we unite the patches built by our separate magisteria into a beautiful and coherent quilt called wisdom.

What renders a problem definite, and what leaves it indefinite, may best be understood from mathematics. The very important idea of solving a problem within limits of error is an element of rational culture, coming from the same source. The art of totalizing fluctuations by curves is capable of being carried, in conception, far beyond the mathematical domain, where it is first learnt. The distinction between laws and co-efficients applies in every department of causation. The theory of Probable Evidence is the mathematical contribution to Logic, and is of paramount importance.

When an observation is made on any atomic system that has been prepared in a given way and is thus in a given state, the result will not in general be determinate, i.e. if the experiment is repeated several times under identical conditions several different results may be obtained. If the experiment is repeated a large number of times it will be found that each particular result will be obtained a definite fraction of the total number of times, so that one can say there is a definite probability of its being obtained any time that the experiment is performed. This probability the theory enables one to calculate. (1930)

When Galileo caused balls, the weights of which he had himself previously determined, to roll down an inclined plane; when Torricelli made the air carry a weight which he had calculated beforehand to be equal to that of a definite volume of water; or in more recent times, when Stahl changed metal into lime, and lime back into metal, by withdrawing something and then restoring it, a light broke upon all students of nature. They learned that reason has insight only into that which it produces after a plan of its own, and that it must not allow itself to be kept, as it were, in nature's leading-strings, but must itself show the way with principles of judgement based upon fixed laws, constraining nature to give answer to questions of reason's own determining. Accidental observations, made in obedience to no previously thought-out plan, can never be made to yield a necessary law, which alone reason is concerned to discover.