[D]iscovery should come as an adventure rather than as the result of a logical process of thought. Sharp, prolonged thinking is necessary that we may keep on the chosen road but it does not itself necessarily lead to discovery. The investigator must be ready and on the spot when the light comes from whatever direction.

[Pechblende] einer eigenthümlichen, selbstständigen metallischen Substanz bestehe. Es fallen folglich auch deren bisherige Benennungen, als: Ресhblende Eisenpecherz, hinweg, welche nun durch einen neuen ausschliessend bezeichnenden Namen zu ersetzen sind. Ich habe dazu den Namen: Uranerz (Uranium) erwählt; zu einigem Andenken, dass die chemische Ausfindung dieses neuen Metallkörpers in die Epoche der astronomischen. Entdeckung des Planeten Uranus gefallen sei.
[Pitchblende] consists of a peculiar, distinct, metallic substance. Therefore its former denominations, pitch-blende, pitch-iron-ore, &c. are no longer applicable, and must be supplied by another more appropriate name.—I have chosen that of uranite, (Uranium), as a kind of memorial, that the chemical discovery of this new metal happened in the period of the astronomical discovery of the new planet Uranus.

Boss: Dilbert, You have been chosen to design the world’s safest nuclear power plant.
Dilbert: This is the great assignment that any engineer could hope for. I'm flattered by the trust you have in me.
Boss: By “safe” I mean “not near my house.”

A well-chosen anthology is a complete dispensary of medicine for the more common mental disorders, and may be used as much for prevention as cure.

As time goes on, it becomes increasingly evident that the rules which the mathematician finds interesting are the same as those which Nature has chosen.
At age 36.

But, as we consider the totality of similarly broad and fundamental aspects of life, we cannot defend division by two as a natural principle of objective order. Indeed, the ‘stuff’ of the universe often strikes our senses as complex and shaded continua, admittedly with faster and slower moments, and bigger and smaller steps, along the way. Nature does not dictate dualities, trinities, quarterings, or any ‘objective’ basis for human taxonomies; most of our chosen schemes, and our designated numbers of categories, record human choices from a cornucopia of possibilities offered by natural variation from place to place, and permitted by the flexibility of our mental capacities. How many seasons (if we wish to divide by seasons at all) does a year contain? How many stages shall we recognize in a human life?

By the fruit one judges the tree; the tree of science grows exceedingly slowly; centuries elapse before one can pluck the ripe fruits; even today it is hardly possible for us to shell and appraise the kernel of the teachings that blossomed in the seventeenth century. He who sows cannot therefore judge the worth of the corn. He must have faith in the fruitfulness of the seed in order that he may follow untiringly his chosen furrow when he casts his ideas to the four winds of heaven.

Can I pay any higher tribute to a man [George Gaylord Simpson] than to state that his work both established a profession and sowed the seeds for its own revision? If Simpson had reached final truth, he either would have been a priest or would have chosen a dull profession. The history of life cannot be a dull profession.

Charles Darwin [is my personal favorite Fellow of the Royal Society]. I suppose as a physical scientist I ought to have chosen Newton. He would have won hands down in an IQ test, but if you ask who was the most attractive personality then Darwin is the one you'd wish to meet. Newton was solitary and reclusive, even vain and vindictive in his later years when he was president of the society.

Creative imagination is likely to find corroborating novel evidence even for the most 'absurd' programme, if the search has sufficient drive. This look-out for new confirming evidence is perfectly permissible. Scientists dream up phantasies and then pursue a highly selective hunt for new facts which fit these phantasies. This process may be described as “science creating its own universe” (as long as one remembers that “creating” here is used in a provocative-idiosyncratic sense). A brilliant school of scholars (backed by a rich society to finance a few well-planned tests) might succeed in pushing any fantastic programme ahead, or alternatively, if so inclined, in overthrowing any arbitrarily chosen pillar of “established knowledge”.

Evolution is the conviction that organisms developed their current forms by an extended history of continual transformation, and that ties of genealogy bind all living things into one nexus. Panselectionism is a denial of history, for perfection covers the tracks of time. A perfect wing may have evolved to its current state, but it may have been created just as we find it. We simply cannot tell if perfection be our only evidence. As Darwin himself understood so well, the primary proofs of evolution are oddities and imperfections that must record pathways of historical descent–the panda’s thumb and the flamingo’s smile of my book titles (chosen to illustrate this paramount principle of history).

Experiments on ornamental plants undertaken in previous years had proven that, as a rule, hybrids do not represent the form exactly intermediate between the parental strains. Although the intermediate form of some of the more striking traits, such as those relating to shape and size of leaves, pubescence of individual parts, and so forth, is indeed nearly always seen, in other cases one of the two parental traits is so preponderant that it is difficult or quite impossible, to detect the other in the hybrid. The same is true for Pisum hybrids. Each of the seven hybrid traits either resembles so closely one of the two parental traits that the other escapes detection, or is so similar to it that no certain distinction can be made. This is of great importance to the definition and classification of the forms in which the offspring of hybrids appear. In the following discussion those traits that pass into hybrid association entirely or almost entirely unchanged, thus themselves representing the traits of the hybrid, are termed dominating and those that become latent in the association, recessive. The word 'recessive' was chosen because the traits so designated recede or disappear entirely in the hybrids, but reappear unchanged in their progeny, as will be demonstrated later.

Factual assertions and fundamental principles are... merely parts of theories: they are given within the framework of a theory; they are chosen and valid within this framework; and subsequently they are dependent upon it. This holds for all empirical sciences—for the natural sciences as well as those pertaining to history.

For if as scientists we seek simplicity, then obviously we try the simplest surviving theory first, and retreat from it only when it proves false. Not this course, but any other, requires explanation. If you want to go somewhere quickly, and several alternate routes are equally likely to be open, no one asks why you take the shortest. The simplest theory is to be chosen not because it is the most likely to be true but because it is scientifically the most rewarding among equally likely alternatives. We aim at simplicity and hope for truth.

I am particularly concerned to determine the probability of causes and results, as exhibited in events that occur in large numbers, and to investigate the laws according to which that probability approaches a limit in proportion to the repetition of events. That investigation deserves the attention of mathematicians because of the analysis required. It is primarily there that the approximation of formulas that are functions of large numbers has its most important applications. The investigation will benefit observers in identifying the mean to be chosen among the results of their observations and the probability of the errors still to be apprehended. Lastly, the investigation is one that deserves the attention of philosophers in showing how in the final analysis there is a regularity underlying the very things that seem to us to pertain entirely to chance, and in unveiling the hidden but constant causes on which that regularity depends. It is on the regularity of the main outcomes of events taken in large numbers that various institutions depend, such as annuities, tontines, and insurance policies. Questions about those subjects, as well as about inoculation with vaccine and decisions of electoral assemblies, present no further difficulty in the light of my theory. I limit myself here to resolving the most general of them, but the importance of these concerns in civil life, the moral considerations that complicate them, and the voluminous data that they presuppose require a separate work.

I despise Birth-Control first because it is ... an entirely meaningless word; and is used so as to curry favour even with those who would first recoil from its real meaning. The proceeding these quack doctors recommend does not control any birth. ... But these people know perfectly well that they dare not write the plain word Birth-Prevention, in any one of the hundred places where they write the hypocritical word Birth-Control. They know as well as I do that the very word Birth-Prevention would strike a chill into the public... Therefore they use a conventional and unmeaning word, which may make the quack medicine sound more innocuous. ... A child is the very sign and sacrament of personal freedom. He is a fresh will added to the wills of the world; he is something that his parents have freely chosen to produce ... he is their own creative contribution to creation.

I have not chosen a career that will lead me to a great fortune, but not my principal ambition.
In fact, later in life he enjoyed comfortable income from his science discoveries.

I notice that, in the lecture … which Prof. Lowry gave recently, in Paris … he brought forward certain freak formulae for tartaric acid, in which hydrogen figures as bigamist … I may say, he but follows the loose example set by certain Uesanians, especially one G. N. Lewis, a Californian thermodynamiter, who has chosen to disregard the fundamental canons of chemistry—for no obvious reason other than that of indulging in premature speculation upon electrons as the cause of valency…

If it were always necessary to reduce everything to intuitive knowledge, demonstration would often be insufferably prolix. This is why mathematicians have had the cleverness to divide the difficulties and to demonstrate separately the intervening propositions. And there is art also in this; for as the mediate truths (which are called lemmas, since they appear to be a digression) may be assigned in many ways, it is well, in order to aid the understanding and memory, to choose of them those which greatly shorten the process, and appear memorable and worthy in themselves of being demonstrated. But there is another obstacle, viz.: that it is not easy to demonstrate all the axioms, and to reduce demonstrations wholly to intuitive knowledge. And if we had chosen to wait for that, perhaps we should not yet have the science of geometry.

If three simple questions and one well chosen laboratory test lead to an unambiguous diagnosis, why harry the patient with more?

It follows from the supreme perfection of God, that in creating the universe has chosen the best possible plan, in which there is the greatest variety together with the greatest order; the best arranged ground, place, time; the most results produced in the most simple ways; the most of power, knowledge, happiness and goodness the creatures that the universe could permit. For since all the possibles in I understanding of God laid claim to existence in proportion to their perfections, the actual world, as the resultant of all these claims, must be the most perfect possible. And without this it would not be possible to give a reason why things have turned out so rather than otherwise.

It is admitted by all that a finished or even a competent reasoner is not the work of nature alone; the experience of every day makes it evident that education develops faculties which would otherwise never have manifested their existence. It is, therefore, as necessary to learn to reason before we can expect to be able to reason, as it is to learn to swim or fence, in order to attain either of those arts. Now, something must be reasoned upon, it matters not much what it is, provided it can be reasoned upon with certainty. The properties of mind or matter, or the study of languages, mathematics, or natural history, may be chosen for this purpose. Now of all these, it is desirable to choose the one which admits of the reasoning being verified, that is, in which we can find out by other means, such as measurement and ocular demonstration of all sorts, whether the results are true or not. When the guiding property of the loadstone was first ascertained, and it was necessary to learn how to use this new discovery, and to find out how far it might be relied on, it would have been thought advisable to make many passages between ports that were well known before attempting a voyage of discovery. So it is with our reasoning faculties: it is desirable that their powers should be exerted upon objects of such a nature, that we can tell by other means whether the results which we obtain are true or false, and this before it is safe to trust entirely to reason. Now the mathematics are peculiarly well adapted for this purpose, on the following grounds:
1. Every term is distinctly explained, and has but one meaning, and it is rarely that two words are employed to mean the same thing.
2. The first principles are self-evident, and, though derived from observation, do not require more of it than has been made by children in general.
3. The demonstration is strictly logical, taking nothing for granted except self-evident first principles, resting nothing upon probability, and entirely independent of authority and opinion.
4. When the conclusion is obtained by reasoning, its truth or falsehood can be ascertained, in geometry by actual measurement, in algebra by common arithmetical calculation. This gives confidence, and is absolutely necessary, if, as was said before, reason is not to be the instructor, but the pupil.
5. There are no words whose meanings are so much alike that the ideas which they stand for may be confounded. Between the meaning of terms there is no distinction, except a total distinction, and all adjectives and adverbs expressing difference of degrees are avoided.

It is clear that the twentieth century is the most disturbed century within the memory of humanity. Any contemporary of ours who wants peace and comfort above all has chosen a bad time to be born.

It is strange, but rocks, properly chosen and polished, can be as beautiful as flowers, and much more durable.

It would seem at first sight as if the rapid expansion of the region of mathematics must be a source of danger to its future progress. Not only does the area widen but the subjects of study increase rapidly in number, and the work of the mathematician tends to become more and more specialized. It is, of course, merely a brilliant exaggeration to say that no mathematician is able to understand the work of any other mathematician, but it is certainly true that it is daily becoming more and more difficult for a mathematician to keep himself acquainted, even in a general way, with the progress of any of the branches of mathematics except those which form the field of his own labours. I believe, however, that the increasing extent of the territory of mathematics will always be counteracted by increased facilities in the means of communication. Additional knowledge opens to us new principles and methods which may conduct us with the greatest ease to results which previously were most difficult of access; and improvements in notation may exercise the most powerful effects both in the simplification and accessibility of a subject. It rests with the worker in mathematics not only to explore new truths, but to devise the language by which they may be discovered and expressed; and the genius of a great mathematician displays itself no less in the notation he invents for deciphering his subject than in the results attained. … I have great faith in the power of well-chosen notation to simplify complicated theories and to bring remote ones near and I think it is safe to predict that the increased knowledge of principles and the resulting improvements in the symbolic language of mathematics will always enable us to grapple satisfactorily with the difficulties arising from the mere extent of the subject.

Let the farmer for evermore be honored in his calling, for they who labor in the earth are the chosen people of God.

Matter, though divisible in an extreme degree, is nevertheless not infinitely divisible. That is, there must be some point beyond which we cannot go in the division of matter. ... I have chosen the word “atom” to signify these ultimate particles.

Most variables can show either an upward or downward trend, depending on the base year chosen.

Not every one of our desires can be immediately gratified. We’ve got to learn to wait patiently for our dreams to come true, especially on the path we’ve chosen. But while we wait, we need to prepare symbolically a place for our hopes and dreams.

Now this supreme wisdom, united to goodness that is no less infinite, cannot but have chosen the best. For as a lesser evil is a kind of good, even so a lesser good is a kind of evil if it stands in the way of a greater good; and the would be something to correct in the actions of God if it were possible to the better. As in mathematics, when there is no maximum nor minimum, in short nothing distinguished, everything is done equally, or when that is not nothing at all is done: so it may be said likewise in respect of perfect wisdom, which is no less orderly than mathematics, that if there were not the best (optimum) among all possible worlds, God would not have produced any.

Perhaps the earliest memories I have are of being a stubborn, determined child. Through the years my mother has told me that it was fortunate that I chose to do acceptable things, for if I had chosen otherwise no one could have deflected me from my path. ... The Chairman of the Physics Department, looking at this record, could only say 'That A- confirms that women do not do well at laboratory work'. But I was no longer a stubborn, determined child, but rather a stubborn, determined graduate student. The hard work and subtle discrimination were of no moment.

Pure mathematics and physics are becoming ever more closely connected, though their methods remain different. One may describe the situation by saying that the mathematician plays a game in which he himself invents the rules while the while the physicist plays a game in which the rules are provided by Nature, but as time goes on it becomes increasingly evident that the rules which the mathematician finds interesting are the same as those which Nature has chosen. … Possibly, the two subjects will ultimately unify, every branch of pure mathematics then having its physical application, its importance in physics being proportional to its interest in mathematics.

Somewhere between 1900 and 1912 in this country, according to one sober medical scientist [Henderson] a random patient, with a random disease, consulting a doctor chosen at random had, for the first time in the history of mankind, a better than fifty-fifty chance of profiting from the encounter.

The admirable perfection of the adaptations of organisms and of their parts to the functions they perform has detracted attention from the fact that adaptedness does not consist of perfect fit, but capacity to fit or to adapt in a variety of ways: only in this sense is adaptedness a guarantee of further survival and evolutionary progress, for too perfect a fit is fatal to the species if not to the individual. This, I think, sets phylogeny and ontogeny in the correct perspective. It is the genotype which bears the marks of past experience of the species and defines the range of possible fits. What fit is actually chosen, what phenotype is actually evolved, is determined by the ever renewed individual history.

The existence of these patterns [fractals] challenges us to study forms that Euclid leaves aside as being formless, to investigate the morphology of the amorphous. Mathematicians have disdained this challenge, however, and have increasingly chosen to flee from nature by devising theories unrelated to anything we can see or feel.

The green pre-human earth is the mystery we were chosen to solve, a guide to the birthplace of our spirit.

The history of the word sankhyā shows the intimate connection which has existed for more than 3000 years in the Indian mind between ‘adequate knowledge’ and ‘number.’ As we interpret it, the fundamental aim of statistics is to give determinate and adequate knowledge of reality with the help of numbers and numerical analysis. The ancient Indian word Sankhyā embodies the same idea, and this is why we have chosen this name for the Indian Journal of Statistics.

The indescribable pleasure—which pales the rest of life's joys—is abundant compensation for the investigator who endures the painful and persevering analytical work that precedes the appearance of the new truth, like the pain of childbirth. It is true to say that nothing for the scientific scholar is comparable to the things that he has discovered. Indeed, it would be difficult to find an investigator willing to exchange the paternity of a scientific conquest for all the gold on earth. And if there are some who look to science as a way of acquiring gold instead of applause from the learned, and the personal satisfaction associated with the very act of discovery, they have chosen the wrong profession.

The iron labor of conscious logical reasoning demands great perseverance and great caution; it moves on but slowly, and is rarely illuminated by brilliant flashes of genius. It knows little of that facility with which the most varied instances come thronging into the memory of the philologist or historian. Rather is it an essential condition of the methodical progress of mathematical reasoning that the mind should remain concentrated on a single point, undisturbed alike by collateral ideas on the one hand, and by wishes and hopes on the other, and moving on steadily in the direction it has deliberately chosen.

The mathematician plays a game in which he himself invents the rules while the physicist plays a game in which the rules are provided by nature, but as time goes on it becomes increasingly evident that the rules which the mathematician finds interesting are the same as those which nature has chosen.

The scientist is not responsible for the laws of nature. It is his job to find out how these laws operate. It is the scientist’s job to find the ways in which these laws can serve the human will. However, it is not the scientist’s job to determine whether a hydrogen bomb should be constructed, whether it should be used, or how it should be used. This responsibility rests with the American people and with their chosen representatives.

The word, “Vitamine,” served as a catchword which meant something even to the uninitiated, and it was not by mere accident that just at that time, research developed so markedly in this direction. Our view as to the fortunate choice of this name is strengthened, on the one hand, because it has become popular (and a badly chosen catchword, like a folksong without feeling, can never become popular), and on the other, because of the untiring efforts of other workers to introduce a varied nomenclature, for example, “accessory food factors, food hormones, water-soluble B and fat-soluble A, nutramine, and auximone” (for plants). Some of these designations are certainly not better, while others are much worse than “Vitamine.”

There are … two fields for human thought and action—the actual and the possible, the realized and the real. In the actual, the tangible, the realized, the vast proportion of mankind abide. The great, region of the possible, whence all discovery, invention, creation proceed, and which is to the actual as a universe to a planet, is the chosen region of genius. As almost every thing which is now actual was once only possible, as our present facts and axioms were originally inventions or discoveries, it is, under God, to genius that we owe our present blessings. In the past, it created the present; in the present, it is creating the future.

There are no mistakes. The events we bring upon ourselves, no matter how unpleasant, are necessary in order to learn what we need to learn; whatever steps we take, they're necessary to reach the places we've chosen to go.

We have chosen to write the biography of our disease because we love it platonically — as Amy Lowell loved Keats — and have sought its acquaintance wherever we could find it. And in this growing intimacy we have become increasingly impressed with the influence that this and other infectious diseases, which span — in their protoplasmic continuities — the entire history of mankind, have had upon the fates of men.

We must make the following remark: a proof, that after a certain time t₁, the spheres must necessarily be mixed uniformly, whatever may be the initial distribution of states, cannot be given. This is in fact a consequence of probability theory, for any non-uniform distribution of states, no matter how improbable it may be, is still not absolutely impossible. Indeed it is clear that any individual uniform distribution, which might arise after a certain time from some particular initial state, is just as improbable as an individual non-uniform distribution; just as in the game of Lotto, any individual set of five numbers is as improbable as the set 1, 2, 3, 4, 5. It is only because there are many more uniform distributions than non-uniform ones that the distribution of states will become uniform in the course of time. One therefore cannot prove that, whatever may be the positions and velocities of the spheres at the beginning, the distributions must become uniform after a long time; rather one can only prove that infinitely many more initial states will lead to a uniform one after a definite length of time than to a non-uniform one. Loschmidt's theorem tells us only about initial states which actually lead to a very non-uniform distribution of states after a certain time t₁; but it does not prove that there are not infinitely many more initial conditions that will lead to a uniform distribution after the same time. On the contrary, it follows from the theorem itself that, since there are infinitely many more uniform distributions, the number of states which lead to uniform distributions after a certain time t₁, is much greater than the number that leads to non-uniform ones, and the latter are the ones that must be chosen, according to Loschmidt, in order to obtain a non-uniform distribution at t₁.

We must not forget … that “influence” is not a simple, but on the contrary, a very complex, bilateral relation. We are not influenced by everything we read or learn. In one sense, and perhaps the deepest, we ourselves determine the influences we are submitting to; our intellectual ancestors are by no means given to, but are freely chosen by, us.

You have chosen the most fascinating and dynamic profession there is, a profession with the highest potential for greatness, since the physician’s daily work is wrapped up in the subtle web of history. Your labors are linked with those of your colleagues who preceded you in history, and those who are now working all over the world. It is this spiritual unity with our colleagues of all periods and all countries that has made medicine so universal and eternal. For this reason we must study and try to imitate the lives of the “Great Doctors” of history.