Compounds formed by chemical attraction, possess new properties different from those of their component parts... chemists have long believed that the contrary took place in their combination. They thought, in fact, that the compounds possessed properties intermediate between those of their component parts; so that two bodies, very coloured, very sapid, or insapid, soluble or insoluble, fusible or infusible, fixed or volatile, assumed in chemical combination, a shade or colour, or taste, solubility or volatility, intermediate between, and in some sort composed of, the same properties which were considered in their principles. This is an illusion or error which modern chemistry is highly interested to overthrow.

If politics is the art of the possible, research is surely the art of the soluble. Both are immensely practical-minded affairs.

Of the nucleosides from deoxyribonucleic acids, all that was known with any certainty [in the 1940s] was that they were 2-deoxy-­D-ribosides of the bases adenine, guanine, thymine and cytosine and it was assumed that they were structurally analogous to the ribonucleosides. The chemistry of the nucleotides—the phosphates of the nucleosides—was in a correspondingly primitive state. It may well be asked why the chemistry of these groups of compounds was not further advanced, particularly since we recognize today that they occupy a central place in the history of the living cell. True, their full significance was for a long time unrecognized and emerged only slowly as biochemical research got into its stride but I think a more important reason is to be found in the physical properties of compounds of the nucleotide group. As water-soluble polar compounds with no proper melting points they were extremely difficult to handle by the classic techniques of organic chemistry, and were accordingly very discouraging substances to early workers. It is surely no accident that the major advances in the field have coincided with the appearance of new experimental techniques such as paper and ion-exchange chromatography, paper electrophoresis, and countercurrent distribution, peculiarly appropriate to the compounds of this group.

The art of research [is] the art of making difficult problems soluble by devising means of getting at them.

The word, “Vitamine,” served as a catchword which meant something even to the uninitiated, and it was not by mere accident that just at that time, research developed so markedly in this direction. Our view as to the fortunate choice of this name is strengthened, on the one hand, because it has become popular (and a badly chosen catchword, like a folksong without feeling, can never become popular), and on the other, because of the untiring efforts of other workers to introduce a varied nomenclature, for example, “accessory food factors, food hormones, water-soluble B and fat-soluble A, nutramine, and auximone” (for plants). Some of these designations are certainly not better, while others are much worse than “Vitamine.”