Base Quotes (43 quotes)
... we must first base such words as “between” upon clear concepts, a thing which is quite feasible but which I have not seen done.
A man who is all theory is like “a rudderless ship on a shoreless sea.” ... Theories and speculations may be indulged in with safety only as long as they are based on facts that we can go back to at all times and know that we are on solid ground.
A scientist works largely by intuition. Given enough experience, a scientist examining a problem can leap to an intuition as to what the solution ‘should look like.’ ... Science is ultimately based on insight, not logic.
All progress is based upon a universal innate desire of every organism to live beyond its means.
As scientific men we have all, no doubt, felt that our fellow men have become more and more satisfying as fish have taken up their work which has been put often to base uses, which must lead to disaster. But what sin is to the moralist and crime to the jurist so to the scientific man is ignorance. On our plane, knowledge and ignorance are the immemorial adversaries. Scientific men can hardly escape the charge of ignorance with regard to the precise effect of the impact of modern science upon the mode of living of the people and upon their civilisation. For them, such a charge is worse than that of crime.
Attempts have been made from a study of the changes produced by mutation to obtain the relative order of the bases within various triplets, but my own view is that these are premature until there is more extensive and more reliable data on the composition of the triplets.
But the strong base and building of my love
Is as the very centre of the earth,
Drawing all things to 't.
Is as the very centre of the earth,
Drawing all things to 't.
Chemistry is one of those branches of human knowledge which has built itself upon methods and instruments by which truth can presumably be determined. It has survived and grown because all its precepts and principles can be re-tested at any time and anywhere. So long as it remained the mysterious alchemy by which a few devotees, by devious and dubious means, presumed to change baser metals into gold, it did not flourish, but when it dealt with the fact that 56 g. of fine iron, when heated with 32 g. of flowers of sulfur, generated extra heat and gave exactly 88 g. of an entirely new substance, then additional steps could be taken by anyone. Scientific research in chemistry, since the birth of the balance and the thermometer, has been a steady growth of test and observation. It has disclosed a finite number of elementary reagents composing an infinite universe, and it is devoted to their inter-reaction for the benefit of mankind.
Evolution is the law of policies: Darwin said it, Socrates endorsed it, Cuvier proved it and established it for all time in his paper on 'The Survival of the Fittest.' These are illustrious names, this is a mighty doctrine: nothing can ever remove it from its firm base, nothing dissolve it, but evolution.
He who joyfully marches to music in rank and file has already earned my contempt. He has been given a large brain by mistake, since for him the spinal cord would fully suffice. This disgrace to civilisation should be done away with at once. Heroism at command, senseless brutality, deplorable love-of-country stance, how violently I hate all this, how despicable and ignoble war is; I would rather be torn to shreds than be part of so base an action! It is my conviction that killing under the cloak of war is nothing but an act of murder.
Historical science is not worse, more restricted, or less capable of achieving firm conclusions because experiment, prediction, and subsumption under invariant laws of nature do not represent its usual working methods. The sciences of history use a different mode of explanation, rooted in the comparative and observational richness in our data. We cannot see a past event directly, but science is usually based on inference, not unvarnished observation (you don’t see electrons, gravity, or black holes either).
How strange is the lot of us mortals! Each of us is here for a brief sojourn; for what purpose he knows not, though he sometimes thinks he senses it. But without deeper reflection one knows from daily life that one exists for other people–first of all for those upon whose smiles and well-being our own happiness is wholly dependent, and then for the many, unknown to us, to whose destinies we are bound by the ties of sympathy. A hundred times every day I remind myself that my inner and outer life are based on the labors of other men, living and dead, and that I must exert myself in order to give in the same measure as I have received and am still receiving.
I am not ... asserting that humans are either genial or aggressive by inborn biological necessity. Obviously, both kindness and violence lie with in the bounds of our nature because we perpetrate both, in spades. I only advance a structural claim that social stability rules nearly all the time and must be based on an overwhelmingly predominant (but tragically ignored) frequency of genial acts, and that geniality is therefore our usual and preferred response nearly all the time ... The center of human nature is rooted in ten thousand ordinary acts of kindness that define our days.
I feel like a white granular mass of amorphous crystals—my formula appears to be isomeric with Spasmotoxin. My aurochloride precipitates into beautiful prismatic needles. My Platinochloride develops octohedron crystals,—with fine blue florescence. My physiological action is not indifferent. One millionth of a grain injected under the skin of a frog produced instantaneous death accompanied by an orange blossom odor. The heart stopped in systole. A base—L3H9NG4—offers analogous reaction to phosmotinigstic acid.
I want to argue that the ‘sudden’ appearance of species in the fossil record and our failure to note subsequent evolutionary change within them is the proper prediction of evolutionary theory as we understand it ... Evolutionary ‘sequences’ are not rungs on a ladder, but our retrospective reconstruction of a circuitous path running like a labyrinth, branch to branch, from the base of the bush to a lineage now surviving at its top.
If the actual order of the bases on one of the pair of chains were given, one could write down the exact order of the bases on the other one, because of the specific pairing. Thus one chain is, as it were, the complement of the other, and it is this feature which suggests how the deoxyribonucleic acid molecule might duplicate itself.
[Co-author with Francis Crick]
[Co-author with Francis Crick]
If the question were, “What ought to be the next objective in science?” my answer would be the teaching of science to the young, so that when the whole population grew up there would be a far more general background of common sense, based on a knowledge of the real meaning of the scientific method of discovering truth.
In the social production of their life, men enter into definite relations that are indispensable and independent of their will; these relations of production correspond to a definite stage of development of their material forces of production. The sum total of these relations of production constitutes the economic structure of society - the real foundation, on which rises a legal and political superstructure and to which correspond definite forms of social consciousness. The mode of production of material life determines the social, political and intellectual life process in general. It is not the consciousness of men that determines their being, but, on the contrary, their social being that determines their consciousness. At a certain stage of their development, the material productive forces in society come in conflict with the existing relations of production, or - what is but a legal expression for the same thing - with the property relations within which they have been at work before. From forms of development of the productive forces these relations turn into fetters. Then begins an epoch of social revolution. With the change of the economic foundation the entire immense superstructure is more or less rapidly transformed. In considering such transformations a distinction should always be made between the material transformation of the economic conditions of production, which can be determined with the precision of natural science, and the legal, political, religious, aesthetic or philosophic - in short, ideological forms in which men become conscious of this conflict and fight it out. Just as our opinion of an individual is not based on what he thinks of himself, so we can not judge of such a period of transformation by its own consciousness; on the contrary, this consciousness must be explained rather from the contradictions of material life, from the existing conflict between the social productive forces and the relations of production. No social order ever disappears before all the productive forces for which there is room in it have been developed; and new, higher relations of production never appear before the material conditions of their existence have matured in the womb of the old society itself. Therefore, mankind always sets itself only such tasks as it can solve; since, looking at the matter more closely, we will always find that the task itself arises only when the material conditions necessary for its solution already exist or are at least in the process of formation. In broad outlines we can designate the Asiatic, the ancient, the feudal, and the modern bourgeois modes of production as so many progressive epochs in the economic formation of society. The bourgeois relations of production are the last antagonistic form of the social process of production - antagonistic not in the sense of individual antagonism, but of one arising from the social conditions of life of the individuals; at the same time the productive forces developing in the womb of bourgeois society create the material conditions for the solution of that antagonism. This social formation constitutes, therefore, the closing chapter of the prehistoric stage of human society.
In Winter, [the Antarctic] is perhaps the dreariest of places. Our base, Little America, lay in a bowl of ice, near the edge of the Ross Ice Barrier. The temperature fell as low as 72 degrees below zero. One could actually hear one's breath freeze.
It is well to remember that most arguments in favor of not trying an experiment are too flimsily based.
Just as the arts of tanning and dyeing were practiced long before the scientific principles upon which they depend were known, so also the practice of Chemical Engineering preceded any analysis or exposition of the principles upon which such practice is based.
Man, the cutting edge of terrestrial life, has no rational alternative but to expand the environmental and resource base beyond earth.
Methods of fishing are becoming more and more efficient, but the whole fishing industry is based on the exploitation of a wild population. This is almost a prehistoric concept on land, but it has never been questioned at sea.
Of the nucleosides from deoxyribonucleic acids, all that was known with any certainty [in the 1940s] was that they were 2-deoxy-D-ribosides of the bases adenine, guanine, thymine and cytosine and it was assumed that they were structurally analogous to the ribonucleosides. The chemistry of the nucleotides—the phosphates of the nucleosides—was in a correspondingly primitive state. It may well be asked why the chemistry of these groups of compounds was not further advanced, particularly since we recognize today that they occupy a central place in the history of the living cell. True, their full significance was for a long time unrecognized and emerged only slowly as biochemical research got into its stride but I think a more important reason is to be found in the physical properties of compounds of the nucleotide group. As water-soluble polar compounds with no proper melting points they were extremely difficult to handle by the classic techniques of organic chemistry, and were accordingly very discouraging substances to early workers. It is surely no accident that the major advances in the field have coincided with the appearance of new experimental techniques such as paper and ion-exchange chromatography, paper electrophoresis, and countercurrent distribution, peculiarly appropriate to the compounds of this group.
Our ideals. laws and customs should he based on the proposition that each, in turn, becomes the custodian rather than the absolute owner of our resources and each generation has the obligation to pass this inheritance on to the future.
Our situation on this earth seems strange. Every one of us appears here involuntarily and uninvited for a short stay, without knowing the whys and the wherefore. In our daily lives we only feel that man is here for the sake of others, for those whom we love and for many other beings whose fate is connected with our own. I am often worried at the thought that my life is based to such a large extent on the work of my fellow human beings and I am aware of my great indebtedness to them.
Our ultimate task is to find interpretative procedures that will uncover each bias and discredit its claims to universality. When this is done the eighteenth century can be formally closed and a new era that has been here a long time can be officially recognised. The individual human being, stripped of his humanity, is of no use as a conceptual base from which to make a picture of human society. No human exists except steeped in the culture of his time and place. The falsely abstracted individual has been sadly misleading to Western political thought. But now we can start again at a point where major streams of thought converge, at the other end, at the making of culture. Cultural analysis sees the whole tapestry as a whole, the picture and the weaving process, before attending to the individual threads.
Recently, we’ve reported that we have made all five bases, the compounds that spell out the instructions for all life and are a part of the nucleic acids, RNA and DNA. Not only did we make all five bases but we found them in a meteorite! So that these two things coming together really assure us that the molecules necessary for life can be found in the absence of life. This was the biggest stumbling block.
Science was born as a result and consequence of philosophy; it cannot survive without a philosophical base. If philosophy perishes, science will be next to go.
— Ayn Rand
Scientists should always state the opinions upon which their facts are based.
The harmony of the universe knows only one musical form - the legato; while the symphony of number knows only its opposite - the staccato. All attempts to reconcile this discrepancy are based on the hope that an accelerated staccato may appear to our senses as a legato.
The individual feels the futility of human desires and aims and the sublimity and marvelous order which reveal themselves both in nature and in the world of thought. Individual existence impresses him as a sort of prison and he wants to experience the universe as a single significant whole. The beginnings of cosmic religious feeling already appear at an early stage of development, e.g., in many of the Psalms of David and in some of the Prophets. Buddhism, as we have learned especially from the wonderful writings of Schopenhauer, contains a much stronger element of this. The religious geniuses of all ages have been distinguished by this kind of religious feeling, which knows no dogma and no God conceived in man’s image; so that there can be no church whose central teachings are based on it. Hence it is precisely among the heretics of every age that we find men who were filled with this highest kind of religious feeling and were in many cases regarded by their contemporaries as atheists, sometimes also as saints. Looked at in this light, men like Democritus, Francis of Assisi, and Spinoza are closely akin to one another.
The Jewish scriptures admirably illustrate the development from the religion of fear to moral religion, a development continued in the New Testament. The religions of all civilized peoples, especially the peoples of the Orient, are primarily moral religions. The development from a religion of fear to moral religion is a great step in peoples’ lives. And yet, that primitive religions are based entirely on fear and the religions of civilized peoples purely on morality is a prejudice against which we must be on our guard. The truth is that all religions are a varying blend of both types, with this differentiation: that on the higher levels of social life the religion of morality predominates.
The man who is thoroughly convinced of the universal operation of the law of causation cannot for a moment entertain the idea of a being who interferes in the course of events–provided, of course, that he takes the hypothesis of causality really seriously. He has no use for the religion of fear and equally little for social or moral religion. A God who rewards and punishes is inconceivable to him for the simple reason that a man’s actions are determined by necessity, external and internal, so that in God’s eyes he cannot be responsible, any more than an inanimate object is responsible for the motions it undergoes. Science has therefore been charged with undermining morality, but the charge is unjust. A man’s ethical behavior should be based effectually on sympathy, education, and social tie s and needs; no religious basis is necessary. Man would indeed be in a poor way if he had to be restrained by fear of punishment and hopes of reward after death.
The moral faculties are generally and justly esteemed as of higher value than the intellectual powers. But we should bear in mind that the activity of the mind in vividly recalling past impressions is one of the fundamental though secondary bases of conscience. This affords the strongest argument for educating and stimulating in all possible ways the intellectual faculties of every human being.
The novel feature of the structure is the manner in which the two chains are held together by the purine and pyrimidine bases. The planes of the bases are perpendicular to the fibre axis. They are joined together in pairs, a single base from one chain being hydrogen-bonded to a single base from the other chain, so that the two lie side by side with identical z-co-ordinates. One of the pair must be 11 purine and the other a pyrimidine for bonding to occur. The hydrogen bonds are made as follows: purine position I to pyrimidine position I; purine position 6 to pyrimidine position 6.
[Co-author with Francis Crick]
[Co-author with Francis Crick]
The theory of the earth is the science which describes and explains changes that the terrestrial globe has undergone from its beginning until today, and which allows the prediction of those it shall undergo in the future. The only way to understand these changes and their causes is to study the present-day state of the globe in order to gradually reconstruct its earlier stages, and to develop probable hypotheses on its future state. Therefore, the present state of the earth is the only solid base on which the theory can rely.
There is no field of biological inquiry in which the influence of the Origin of Species is not traceable; the foremost men of science in every country are either avowed champions of its leading doctrines, or at any rate abstain from opposing them; a host of young and ardent investigators seek for and find inspiration and guidance in Mr. Darwin’s great work; and the general doctrine of Evolution, to one side of which it gives expression, finds in the phenomena of biology a firm base of operations whence it may conduct its conquest of the whole realm of nature.
There is no sharp boundary line separating the reactions of the immune bodies from chemical processes between crystalloids, just as in nature there exists every stage between crystalloid and colloid. The nearer the colloid particle approximates to the normal electrolyte, the nearer its compounds must obviously come to conforming to the law of simple stoichiometric proportions, and the compounds themselves to simple chemical compounds. At this point, it should be recalled that Arrhenius has shown that the quantitative relationship between toxin and antitoxin is very similar to that between acid and base.
Thus, remarkably, we do not know the true number of species on earth even to the nearest order of magnitude. My own guess, based on the described fauna and flora and many discussions with entomologists and other specialists, is that the absolute number falls somewhere between five and thirty million.
To write the true natural history of the world, we should need to be able to follow it from within. It would thus appear no longer as an interlocking succession of structural types replacing one another, but as an ascension of inner sap spreading out in a forest of consolidated instincts. Right at its base, the living world is constituted by conscious clothes in flesh and bone.
What intellectual phenomenon can be older, or more oft repeated, than the story of a large research program that impaled itself upon a false central assumption accepted by all practitioners? Do we regard all people who worked within such traditions as dishonorable fools? What of the scientists who assumed that the continents were stable, that the hereditary material was protein, or that all other galaxies lay within the Milky Way? These false and abandoned efforts were pursued with passion by brilliant and honorable scientists. How many current efforts, now commanding millions of research dollars and the full attention of many of our best scientists, will later be exposed as full failures based on false premises?
You may drink the ocean dry; you may uproot from its base the mountain Meru: you may swallow fire. But more difficult than all these, oh Good One! is control over the mind.