“These changes in the body,” he wrote in the review paper he sent to the American Journal of Physiology late in 1913, “are, each one of them, directly serviceable in making the organism more efficient in the struggle which fear or rage or pain may involve; for fear and rage are organic preparations for action, and pain is the most powerful known stimulus to supreme exertion. The organism which with the aid of increased adrenal secretion can best muster its energies, can best call forth sugar to supply the labouring muscles, can best lessen fatigue, and can best send blood to the parts essential in the run or the fight for life, is most likely to survive. Such, according to the view here propounded, is the function of the adrenal medulla at times of great emergency.”

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

Don’t trust everything you see. Even salt looks like sugar.

Food may be defined as material which, when taken into the body, serves to either form tissue or yield energy, or both. This definition includes all the ordinary food materials, since they both build tissue and yield energy. It includes sugar and starch, because they yield energy and form fatty tissue. It includes alcohol, because the latter is burned to yield energy, though it does not build tissue. It excludes creatin, creatininin, and other so-called nitrogeneous extractives of meat, and likewise thein or caffein of tea and coffee, because they neither build tissue nor yield energy, although they may, at times, be useful aids to nutrition.

How did I discover saccharin? Well, it was partly by accident and partly by study. I had worked a long time on the compound radicals and substitution products of coal tar... One evening I was so interested in my laboratory that I forgot about my supper till quite late, and then rushed off for a meal without stopping to wash my hands. I sat down, broke a piece of bread, and put it to my lips. It tasted unspeakably sweet. I did not ask why it was so, probably because I thought it was some cake or sweetmeat. I rinsed my mouth with water, and dried my moustache with my napkin, when, to my surprise the napkin tasted sweeter than the bread. Then I was puzzled. I again raised my goblet, and, as fortune would have it, applied my mouth where my fingers had touched it before. The water seemed syrup. It flashed on me that I was the cause of the singular universal sweetness, and I accordingly tasted the end of my thumb, and found it surpassed any confectionery I had ever eaten. I saw the whole thing at once. I had discovered some coal tar substance which out-sugared sugar. I dropped my dinner, and ran back to the laboratory. There, in my excitement, I tasted the contents of every beaker and evaporating dish on the table.

I propose to provide proof... that just as always an alcoholic ferment, the yeast of beer, is found where sugar is converted into alcohol and carbonic acid, so always a special ferment, a lactic yeast, is found where sugar is transformed into lactic acid. And, furthermore, when any plastic nitrogenated substance is able to transform sugar into that acid, the reason is that it is a suitable nutrient for the growth of the [lactic] ferment.

I would like to start by emphasizing the importance of surfaces. It is at a surface where many of our most interesting and useful phenomena occur. We live for example on the surface of a planet. It is at a surface where the catalysis of chemical reactions occur. It is essentially at a surface of a plant that sunlight is converted to a sugar. In electronics, most if not all active circuit elements involve non-equilibrium phenomena occurring at surfaces. Much of biology is concerned with reactions at a surface.

If you look at a tree and think of it as a design assignment, it would be like asking you to make something that makes oxygen, sequesters carbon, fixes nitrogen, distills water, provides habitat for hundreds of species, accrues solar energy’s fuel, makes complex sugars and food, changes colors with the seasons, creates microclimates, and self-replicates.

Intravenous injections of extract from dog’s pancreas, removed from seven to ten weeks after ligation of the ducts, invariably exercises a reducing influence upon the percentage sugar of the blood and the amount of sugar excreted in the urine … the extent and duration of the reduction varies directly with the amount of extract injected.

Its immediate significance was as a currency, for it closed the triangle linking spirits, slaves, and sugar. Rum could be used to buy slaves, with which to produce sugar, the leftovers of which could be made into rum to buy more slaves, and so on and on.

Magnetism, galvanism, electricity, are “one form of many names.” Without magnetism we should never have discovered America; to which we are indebted for nothing but evil; diseases in the worst forms that can afflict humanity, and slavery in the worst form in which slavery can exist. The Old World had the sugar-cane and the cotton-plant, though it did not so misuse them.

Man may be the captain of his fate, but he is also the victim of his blood sugar.
Indicating the burden of diabetes.

Now, I must tell you of a strange experience which bore fruit in my later life. … We had a cold [snap] drier that ever observed before. People walking in the snow left a luminous trail behind them and a snowball thrown against an obstacle gave a flare of light like a loaf of sugar hit with a knife. [As I stroked] Mačak’s back, [it became] a sheet of light and my hand produced a shower of sparks. … My father … remarked, this is nothing but electricity, the same thing you see on the trees in a storm. My mother seemed alarmed. Stop playing with the cat, she said, he might start a fire. I was thinking abstractly. Is nature a cat? If so, who strokes its back? It can only be God, I concluded. …
I cannot exaggerate the effect of this marvelous sight on my childish imagination. Day after day I asked myself what is electricity and found no answer. Eighty years have gone by since and I still ask the same question, unable to answer it.

Nurses that attend lying-in women ought to have provided, and in order, every thing that may be necessary for the woman, accoucheur, midwife, and child; such as linnen and cloaths, well aired and warm, for the woman and the bed, which she must know how to prepare when there is occasion; together with nutmeg, sugar, spirit of hartshorn, vinegar, Hungary water, white or brown caudle ready made, and a glyster-pipe fitted.

On the 20th of May 1747, I took twelve patients in the scurvy, on board the Salisbury at sea. Their cases were as similar as I could have them. They all in general had putrid gums, the spots and lassitude, with weakness of their knees. They lay together in one place, being a proper apartment for the sick in the fore-hold; and had one diet common to all, viz, water-gruel sweetened with sugar in the morning; fresh mutton-broth often times for dinner; at other times puddings, boiled biscuit with sugar, &c.; and for supper, barley and raisins, rice and currents, sago and wine, or the like.
Two of these were ordered each a quart of cider a-day. Two others took twenty-five gutta of elixir vitriol three times a-day, upon an empty stomach; using a gargle strongly acidulated with it for their mouths. Two others took two spoonfuls of vinegar three times a-day, upon an empty stomach; having their gruels and their other food well acidulated with it, as also the gargle for their mouth. Two of the worst patients, with the tendons in the ham rigid, (a symptom none of the rest had), were put under a course of sea-water. Of this they drank half a pint every day, and sometimes more or less as it operated, by way of gentle physics. The others had each two oranges and one lemon given them every day. These they eat with greediness, at different times, upon an empty stomach. They continued but six days under this course, having consumed the quantity that could be spared. The two remaining patients, took the bigness of a nutmeg three times a-day, of an electuary recommended by an hospital-surgeon, made of garlic, mustard-seed, rad. raphan. balsam of Peru, and gum myrrh; using for common drink, barley-water well acidulated with tamarinds; by a decoction of which, with the addition of cremor tartar, they were gently purged three or four times during the course.
The consequence was, that the most sudden and visible good effects were perceived from the use of the oranges and lemons; one of those who had taken them, being at the end of six days fit for duty. …
Next to the oranges, I thought the cider had the best effects.

Pancreatic juice emulsifies fat, and we have just seen how greedily worms devour fat; it dissolves fibrin, and worms eat raw meat; it converts starch into grape-sugar with wonderful rapidity, and … the digestive fluid of worms acts on starch.

Philosophy may teach us to bear with equanimity the misfortunes of our neighbours, and science resolve the moral sense into a secretion of sugar, but art is what makes the life of each citizen a sacrament.

The essential molecule of reproduction, DNA, … is composed of only four nitrogen bases (adenine, thymine, guanine, and cytosine), the sugar deoxyribose, and a phosphate. DNA’s intermediary, RNA, differs only by the substitution of the sugar ribose for deoxyribose and the nitrogen base uracil for thymine. The proteins of living organisms are made with a mere 20 amino acids, all arranged in a “left-handed” configuration. Taking into account all 28 building blocks, or “letters” (20 amino acids, five bases, two sugars, and one phosphate), the message is clear: With such a limited alphabet, all life must have had a common chemical origin.

The first entirely vital action, so termed because it is not effected outside the influence of life, consists in the creation of the glycogenic material in the living hepatic tissue. The second entirely chemical action, which can be effected outside the influence of life, consists in the transformation of the glycogenic material into sugar by means of a ferment.

The progress of synthesis, or the building up of natural materials from their constituent elements, proceeds apace. Even some of the simpler albuminoids, a class of substances of great importance in the life process, have recently been artificially prepared. ... Innumerable entirely new compounds have been produced in the last century. The artificial dye-stuffs, prepared from materials occurring in coal-tar, make the natural colours blush. Saccharin, which is hundreds of times sweeter than sugar, is a purely artificial substance. New explosives, drugs, alloys, photographic substances, essences, scents, solvents, and detergents are being poured out in a continuous stream.

These changes—the more rapid pulse, the deeper breathing, the increase of sugar in the blood, the secretion from the adrenal glands—were very diverse and seemed unrelated. Then, one wakeful night, after a considerable collection of these changes had been disclosed, the idea flashed through my mind that they could be nicely integrated if conceived as bodily preparations for supreme effort in flight or in fighting. Further investigation added to the collection and confirmed the general scheme suggested by the hunch.

This is only one step in a much larger project. I discovered (no, not me: my team) the function of sugar nucleotides in cell metabolism. I want others to understood this, but it is not easy to explain: this is not a very noteworthy deed, and we hardly know even a little.
[replying when asked about the significance of his Nobel prize-winning achievement.]

Through the discovery of Buchner, Biology was relieved of another fragment of mysticism. The splitting up of sugar into CO₂ and alcohol is no more the effect of a 'vital principle' than the splitting up of cane sugar by invertase. The history of this problem is instructive, as it warns us against considering problems as beyond our reach because they have not yet found their solution.

To wage war with Marchand or anyone else again will benefit nobody and bring little profit to science. You consume yourself in this way, you ruin your liver and eventually your nerves with Morrison pills. Imagine the year 1900 when we have disintegrated into carbonic acid, ammonia and water and our bone substance is perhaps once more a constituent of the bones of the dog who defiles our graves. Who will then worry his head as to whether we have lived in peace or anger, who then will know about your scientific disputes and of your sacrifice of health and peace of mind for science? Nobody. But your good ideas and the discoveries you have made, cleansed of all that is extraneous to the subject, will still be known and appreciated for many years to come. But why am I trying to advise the lion to eat sugar.

When carbon (C), Oxygen (o) and hydrogen (H) atoms bond in a certain way to form sugar, the resulting compound has a sweet taste. The sweetness resides neither in the C, nor in the O, nor in the H; it resides in the pattern that emerges from their interaction. It is an emergent property. Moreover, strictly speaking, is not a property of the chemical bonds. It is a sensory experience that arises when the sugar molecules interact with the chemistry of our taste buds, which in turns causes a set of neurons to fire in a certain way. The experience of sweetness emerges from that neural activity.

When ultra-violet light acts on a mixture of water, carbon dioxide, and ammonia, a vast variety of organic substances are made, including sugars and apparently some of the materials from which proteins are built up…. But before the origin of life they must have accumulated till the primitive oceans reached the consistency of hot dilute soup…. The first living or half-living things were probably large molecules synthesized under the influence of the sun’s radiation, and only capable of reproduction in the particularly favorable medium in which they originated….