... an analysis that puts the final link in the chain, for here we see correlations between cytological evidence and genetic results that are so strong and obvious that their validity cannot be denied. This paper has been called a landmark in experimental genetics. It is more than that—it is a cornerstone.
Describing the paper 'A Correlation of Cytological and Genetic Crossings-over in Zea mays' published by Barbara McClintock and her student Harriet Creighton in the Proceedings of the National Academy of Sciences (1931), demonstrating that the exchange of genetic information that occurs during the production of sex cells is accompanied by an exchange of chromosomal material.

“Going fishing!” How often the question has been asked by acquaintances, as they have met me, with rod and basket, on an excursion after materials for microscopic study. “Yes!” has been the invariable answer, for it saved much detention and explanation; and now, behold! I offer them the results of that fishing. No fish for the stomach, but, as the old French microscopist Joblet observed, “some of the most remarkable fishes that have ever been seen”; and food-fishes for the intellect.

[Coleridge] selected an instance of what was called the sublime, in DARWIN, who imagined the creation of the universe to have taken place in a moment, by the explosion of a mass of matter in the womb, or centre of space. In one and the same instant of time, suns and planets shot into systems in every direction, and filled and spangled the illimitable void! He asserted this to be an intolerable degradation—referring, as it were, all the beauty and harmony of nature to something like the bursting of a barrel of gunpowder! that spit its combustible materials into a pock-freckled creation!

[In geology,] As in history, the material in hand remains silent if no questions are asked. The nature of these questions depends on the “school” to which the geologist belongs and on the objectivity of his investigations. Hans Cloos called this way of interrogation “the dialogue with the earth,” “das Gesprach mit der Erde.”

[In research on bacteria metabolism] we have indeed much the same position as an observer trying to gain an idea of the life of a household by careful scrutiny of the persons and material arriving or leaving the house; we keep accurate records of the foods and commodities left at the door and patiently examine the contents of the dust-bin and endeavour to deduce from such data the events occurring within the closed doors.

[Modern science] passed through a long period of uncertainty and inconclusive experiment, but as the instrumental aids to research improved, and the results of observation accumulated, phantoms of the imagination were exorcised, idols of the cave were shattered, trustworthy materials were obtained for logical treatment, and hypotheses by long and careful trial were converted into theories.

[T]he habit of scientific analysis … exhausts the material offered to it…

[T]here are depths of thousands of miles which are hidden from our inquiry. The only tidings we have from those unfathomable regions are by means of volcanoes, those burning mountains that seem to discharge their materials from the lowest abysses of the earth.

[The earth’s rocks] were so arranged, in their formation, that they should best serve Man’s purposes. The strata were subjected to metamorphism, and so crystallized, that he might be provided with the most perfect material for his art, his statues, temples, and dwellings; at the same time, they were filled with veins, in order to supply him with gold and silver and other treasures. The rocks were also made to enclose abundant beds of coal and iron ore, that Man might have fuel for his hearths and iron for his utensils and machinery. Mountains were raised to temper hot climates, to diversify the earth’s productiveness, and, pre-eminently, to gather the clouds into river-channels, thence to moisten the fields for agriculture, afford facilities for travel, and supply the world with springs and fountains.

[The sun] … which alone we should judge to be worthy of the most high God, if He should be pleased with a material domicile, and choose a place in which to dwell with the blessed angels.

[To identify ancient sites] The primary requirement is a human skeleton or artifacts that are clearly the work of humans. Next, this evidence must lie in situ within undisturbed geological deposits. The artifacts should be directly associated with stratigraphy. Finally, the minimum age of the site must be determined by a direct link with fossils of known age or with material that has been reliably dated.

Engineering, too, owes its most useful materials to the achievements of chemists in identifying, separating, and transforming materials: structural steel for the framework of bridges and buildings, portland cement for roadways and aqueducts, pure copper for the electrical industries, aluminum alloys for automobiles and airplanes, porcelain for spark plugs and electrical insulators. The triumphs of engineering skill rest on a chemical foundation.

Omnes scientiae sunt connexae et fovent auxiliis sicut partes ejusdem totius, quarum quaelibet opus suum peragit non propter se sed pro aliis.
All sciences are connected; they lend each other material aid as parts of one great whole, each doing its own work, not for itself alone, but for the other parts; as the eye guides the body and the foot sustains it and leads it from place to place.

A mathematician … has no material to work with but ideas, and so his patterns are likely to last longer, since ideas wear less with time than words.

A painter makes patterns with shapes and colours, a poet with words. A painting may embody an “idea,” but the idea is usually commonplace and unimportant. In poetry, ideas count for a good deal more; but, as Housman insisted, the importance of ideas in poetry is habitually exaggerated. … The poverty of ideas seems hardly to affect the beauty of the verbal pattern. A mathematician, on the other hand, has no material to work with but ideas, and so his patterns are likely to last longer, since ideas wear less with time than words.

A physicist will tell me that this armchair is made of vibrations and that it’s not really here at all. But when Samuel Johnson was asked to prove the material existence of reality, he just went up to a big stone and kicked it. I'm with him.

A recognized fact which goes back to the earliest times is that every living organism is not the sum of a multitude of unitary processes, but is, by virtue of interrelationships and of higher and lower levels of control, an unbroken unity. When research, in the efforts of bringing understanding, as a rule examines isolated processes and studies them, these must of necessity be removed from their context. In general, viewed biologically, this experimental separation involves a sacrifice. In fact, quantitative findings of any material and energy changes preserve their full context only through their being seen and understood as parts of a natural order.

A science or an art may be said to be “useful” if its development increases, even indirectly, the material well-being and comfort of men, it promotes happiness, using that word in a crude and commonplace way.

A vital phenomenon can only be regarded as explained if it has been proven that it appears as the result of the material components of living organisms interacting according to the laws which those same components follow in their interactions outside of living systems.

Accountants and second-rate business school jargon are in the ascendant. Costs, which rise rapidly, and are easily ascertained and comprehensible, now weigh more heavily in the scales than the unquantifiable and unpredictable values and future material progress. Perhaps science will only regain its lost primacy as peoples and government begin to recognize that sound scientific work is the only secure basis for the construction of policies to ensure the survival of Mankind without irreversible damage to Planet Earth.

After long reflection in solitude and meditation, I suddenly had the idea, during the year 1923, that the discovery made by Einstein in 1905 should be generalised by extending it to all material particles and notably to electrons.

After the discovery of spectral analysis no one trained in physics could doubt the problem of the atom would be solved when physicists had learned to understand the language of spectra. So manifold was the enormous amount of material that has been accumulated in sixty years of spectroscopic research that it seemed at first beyond the possibility of disentanglement. An almost greater enlightenment has resulted from the seven years of Röntgen spectroscopy, inasmuch as it has attacked the problem of the atom at its very root, and illuminates the interior. What we are nowadays hearing of the language of spectra is a true 'music of the spheres' in order and harmony that becomes ever more perfect in spite of the manifold variety. The theory of spectral lines will bear the name of Bohr for all time. But yet another name will be permanently associated with it, that of Planck. All integral laws of spectral lines and of atomic theory spring originally from the quantum theory. It is the mysterious organon on which Nature plays her music of the spectra, and according to the rhythm of which she regulates the structure of the atoms and nuclei.

Agriculture is the foundation of manufactures, since the productions of nature are the materials of art.

All change is relative. The universe is expanding relatively to our common material standards; our material standards are shrinking relatively to the size of the universe. The theory of the “expanding universe” might also be called the theory of the “shrinking atom”. …
:Let us then take the whole universe as our standard of constancy, and adopt the view of a cosmic being whose body is composed of intergalactic spaces and swells as they swell. Or rather we must now say it keeps the same size, for he will not admit that it is he who has changed. Watching us for a few thousand million years, he sees us shrinking; atoms, animals, planets, even the galaxies, all shrink alike; only the intergalactic spaces remain the same. The earth spirals round the sun in an ever-decreasing orbit. It would be absurd to treat its changing revolution as a constant unit of time. The cosmic being will naturally relate his units of length and time so that the velocity of light remains constant. Our years will then decrease in geometrical progression in the cosmic scale of time. On that scale man’s life is becoming briefer; his threescore years and ten are an ever-decreasing allowance. Owing to the property of geometrical progressions an infinite number of our years will add up to a finite cosmic time; so that what we should call the end of eternity is an ordinary finite date in the cosmic calendar. But on that date the universe has expanded to infinity in our reckoning, and we have shrunk to nothing in the reckoning of the cosmic being.
We walk the stage of life, performers of a drama for the benefit of the cosmic spectator. As the scenes proceed he notices that the actors are growing smaller and the action quicker. When the last act opens the curtain rises on midget actors rushing through their parts at frantic speed. Smaller and smaller. Faster and faster. One last microscopic blurr of intense agitation. And then nothing.

All life is linked together in such a way that no part of the chain is unimportant. Frequently, upon the action of some of these minute beings depends the material success or failure of a great commonwealth.

All material Things seem to have been composed of the hard and solid Particles … variously associated with the first Creation by the Counsel of an intelligent Agent. For it became him who created them to set them in order: and if he did so, it is unphilosophical to seek for any other Origin of the World, or to pretend that it might arise out of a Chaos by the mere Laws of Nature.

All parts of the material universe are in constant motion and though some of the changes may appear to be cyclical, nothing ever exactly returns, so far as human experience extends, to precisely the same condition.

Although species may be discrete, they have no immutable essence. Variation is the raw material of evolutionary change. It represents the fundamental reality of nature, not an accident about a created norm. Variation is primary; essences are illusory. Species must be defined as ranges of irreducible variation.

Although with the majority of those who study and practice in these capacities [engineers, builders, surveyors, geographers, navigators, hydrographers, astronomers], secondhand acquirements, trite formulas, and appropriate tables are sufficient for ordinary purposes, yet these trite formulas and familiar rules were originally or gradually deduced from the profound investigations of the most gifted minds, from the dawn of science to the present day. … The further developments of the science, with its possible applications to larger purposes of human utility and grander theoretical generalizations, is an achievement reserved for a few of the choicest spirits, touched from time to time by Heaven to these highest issues. The intellectual world is filled with latent and undiscovered truth as the material world is filled with latent electricity.

Aluminum is at once as white as silver, as incorrodible as gold, as tenacious as iron, as fusible as copper, and as light as glass. It is easily worked; it is widely spread in nature, alumina forming the bases of most rocks; it is three times lighter than iron; in short, it seems to have been created expressly to furnish material for our projectile!

An example of such emergent phenomena is the origin of life from non-living chemical compounds in the oldest, lifeless oceans of the earth. Here, aided by the radiation energy received from the sun, countless chemical materials were synthesized and accumulated in such a way that they constituted, as it were, a primeval “soup.” In this primeval soup, by infinite variations of lifeless growth and decay of substances during some billions of years, the way of life was ultimately reached, with its metabolism characterized by selective assimilation and dissimilation as end stations of a sluiced and canalized flow of free chemical energy.

An optical unit has been devised which will convey optical images along a flexible axis. The unit comprises a bundle of fibres of glass, or other transparent material, and it therefore appears appropriate to introduce the term 'fibrescope' to denote it.
Co-author with Indian-American physicist Narinder Singh Kapany..

Anaximenes son of Eurystratus, of Miletus, was a pupil of Anaximander; some say he was also a pupil of Parmenides. He said that the material principle was air and the infinite; and that the stars move, not under the earth, but round it. He used simple and economical Ionic speech. He was active, according to what Apollodorus says, around the time of the capture of Sardis, and died in the 63rd Olympiad.

And yet I think that the Full House model does teach us to treasure variety for its own sake–for tough reasons of evolutionary theory and nature’s ontology, and not from a lamentable failure of thought that accepts all beliefs on the absurd rationale that disagreement must imply disrespect. Excellence is a range of differences, not a spot. Each location on the range can be occupied by an excellent or an inadequate representative– and we must struggle for excellence at each of these varied locations. In a society driven, of ten unconsciously, to impose a uniform mediocrity upon a former richness of excellence–where McDonald’s drives out the local diner, and the mega-Stop & Shop eliminates the corner Mom and Pop–an understanding and defense of full ranges as natural reality might help to stem the tide and preserve the rich raw material of any evolving system: variation itself.

Any problem can be solved using the materials in the room.

Apprehension by the senses supplies, directly or indirectly, the material of all human knowledge; or, at least, the stimulus necessary to develop every inborn faculty of the mind.

As I have already mentioned, wherever cells are formed, this tough fluid precedes the first solid structures that indicate the presence of future cells. Moreover, we must assume that this substance furnishes the material for the formation of the nucleus and of the primitive sac, not only because these structures are closely apposed to it, but also because,they react to iodine in the same way. We must assume also that the organization of this substance is the process that inaugurates the formation of new cells. It therefore seems justifiable for me to propose a name that refers to its physiological function: I propose the word protoplasma.

As physicists have arranged an extensive series of effects under the general term of Heat, so they have named another series Light, and a third they have called Electricity. We find ... that all these principles are capable of being produced through the medium of living bodies, for nearly all animals have the power of evolving heat; many insects, moreover, can voluntarily emit light; and the property of producing electricity is well evinced in the terrible shock of the electric eel, as well as in that of some other creatures. We are indeed in the habit of talking of the Electric fluid, or the Galvanic fluid, but this in reality is nothing but a licence of expression suitable to our finite and material notions.

As plants convert the minerals into food for animals, so each man converts some raw material in nature to human use. The inventors of fire, electricity, magnetism, iron, lead, glass, linen, silk, cotton; the makers of tools; the inventor of decimal notation, the geometer, the engineer, the musician, severally make an easy way for all, through unknown and impossible confusions.

As we consider the manifold materials that keep us going between breakfast and bedtime, our welfare is served by the wild species that make up the planetary ecosystem with us. To date, scientists have conducted intensive screening of less than 1 percent of all species with a view to determining their economic potential. Yet these preliminary investigations have thrown up thousands of products of everyday use.

As we continue to improve our understanding of the basic science on which applications increasingly depend, material benefits of this and other kinds are secured for the future.

Astronomy was not studied by Kepler, Galileo, or Newton for the practical applications which might result from it, but to enlarge the bounds of knowledge, to furnish new objects of thought and contemplation in regard to the universe of which we form a part; yet how remarkable the influence which this science, apparently so far removed from the sphere of our material interests, has exerted on the destinies of the world!

At the planet’s very heart lies a solid rocky core, at least five times larger than Earth, seething with the appalling heat generated by the inexorable contraction of the stupendous mass of material pressing down to its centre. For more than four billion years Jupiter’s immense gravitational power has been squeezing the planet slowly, relentlessly, steadily, converting gravitational energy into heat, raising the temperature of that rocky core to thirty thousand degrees, spawning the heat flow that warms the planet from within. That hot, rocky core is the original protoplanet seed from the solar system’s primeval time, the nucleus around which those awesome layers of hydrogen and helium and ammonia, methane, sulphur compounds and water have wrapped themselves.

Available energy is energy which we can direct into any desired channel. Dissipated energy is energy which we cannot lay hold of and direct at pleasure, such as the energy of the confused agitation of molecules which we call heat. Now, confusion, like the correlative term order, is not a property of material things in themselves, but only in relation to the mind which perceives them. A memorandum-book does not, provided it is neatly written, appear confused to an illiterate person, or to the owner who understands it thoroughly, but to any other person able to read it appears to be inextricably confused. Similarly the notion of dissipated energy could not occur to a being who could not turn any of the energies of nature to his own account, or to one who could trace the motion of every molecule and seize it at the right moment. It is only to a being in the intermediate stage, who can lay hold of some forms of energy while others elude his grasp, that energy appears to be passing inevitably from the available to the dissipated state.

Bearing in mind that it is from the vitality of the atmospheric particles that all the mischief arises, it appears that all that is requisite is to dress the wound with some material capable of killing these septic germs, provided that any substance can be found reliable for this purpose, yet not too potent as a caustic. In the course of the year 1864 I was much struck with an account of the remarkable effects produced by carbolic acid upon the sewage of the town of Carlisle, the admixture of a very small proportion not only preventing all odour from the lands irrigated with the refuse material, but, as it was stated, destroying the entozoa which usually infest cattle fed upon such pastures.

Books are merely records of what other people have thought and observed, the material is a far safer guide.

Briefly, in the act of composition, as an instrument there intervenes and is most potent, fire, flaming, fervid, hot; but in the very substance of the compound there intervenes, as an ingredient, as it is commonly called, as a material principle and as a constituent of the whole compound the material and principle of fire, not fire itself. This I was the first to call phlogiston.

But in the heavens we discover by their light, and by their light alone, stars so distant from each other that no material thing can ever have passed from one to another; and yet this light, which is to us the sole evidence of the existence of these distant worlds, tells us also that each of them is built up of molecules of the same kinds as those which we find on earth. A molecule of hydrogen, for example, whether in Sirius or in Arcturus, executes its vibrations in precisely the same time. Each molecule, therefore, throughout the universe, bears impressed on it the stamp of a metric system as distinctly as does the metre of the Archives at Paris, or the double royal cubit of the Temple of Karnac ... the exact quantity of each molecule to all others of same kind gives it, as Sir John Herschel has well said, the essential character of a manufactured article and precludes the idea of its being external and self-existent.

But when it has been shown by the researches of Pasteur that the septic property of the atmosphere depended not on the oxygen, or any gaseous constituent, but on minute organisms suspended in it, which owed their energy to their vitality, it occurred to me that decomposition in the injured part might be avoided without excluding the air, by applying as a dressing some material capable of destroying the life of the floating particles. Upon this principle I have based a practice.

But with regard to the material world, we can at least go so far as this;—we can perceive that events are brought about, not by insulated interpositions of Divine power, exerted in each particular ease, but by the establishment of general laws.

But, further, no animal can live upon a mixture of pure protein, fat and carbohydrate, and even when the necessary inorganic material is carefully supplied, the animal still cannot flourish. The animal body is adjusted to live either upon plant tissues or the tissues of other animals, and these contain countless substances other than the proteins, carbohydrates and fats... In diseases such as rickets, and particularly in scurvy, we have had for long years knowledge of a dietetic factor; but though we know how to benefit these conditions empirically, the real errors in the diet are to this day quite obscure. They are, however, certainly of the kind which comprises these minimal qualitative factors that I am considering.

Call Archimedes from his buried tomb
Upon the plain of vanished Syracuse,
And feelingly the sage shall make report
How insecure, how baseless in itself,
Is the philosophy, whose sway depends
On mere material instruments—how weak
Those arts, and high inventions, if unpropped
By virtue.

Can a physicist visualize an electron? The electron is materially inconceivable and yet, it is so perfectly known through its effects that we use it to illuminate our cities, guide our airlines through the night skies and take the most accurate measurements. What strange rationale makes some physicists accept the inconceivable electrons as real while refusing to accept the reality of a Designer on the ground that they cannot conceive Him?

Can the cultural evolution of higher ethical values gain a direction and momentum of its own and completely replace genetic evolution? I think not. The genes hold culture an a leash. The leash is very long, but inevitably values will be constrained in accordance with their effects in the human gene pool. The brain is a product of evolution. Human behaviour—like the deepest capacities for emotional response which drive and guide it—is the circuitous technique by which human genetic material has been and will be kept intact. Morality has no other demonstrable ultimate function.

Chemical engineering is the profession in which a knowledge of mathematics, chemistry and other natural sciences gained by study, experience and practice is applied with judgment to develop economic ways of using materials and energy for the benefit of mankind.

Chemistry is the study of material transformations. Yet a knowledge of the rate, or time dependence, of chemical change is of critical importance for the successful synthesis of new materials and for the utilization of the energy generated by a reaction. During the past century it has become clear that all macroscopic chemical processes consist of many elementary chemical reactions that are themselves simply a series of encounters between atomic or molecular species. In order to understand the time dependence of chemical reactions, chemical kineticists have traditionally focused on sorting out all of the elementary chemical reactions involved in a macroscopic chemical process and determining their respective rates.

Chlorine is a deadly poison gas employed on European battlefields in World War I. Sodium is a corrosive metal which burns upon contact with water. Together they make a placid and unpoisonous material, table salt. Why each of these substances has the properties it does is a subject called chemistry.

Civilization is a disease produced by the practice of building societies with rotten material.

Coming to the question of life being found on other planets, Professor Haldane apologized for discoursing, as a mere biologist, on a subject on which we had been expecting a lecture by a physicist [J. D. Bernal]. He mentioned three hypotheses:
(a) That life had a supernatural origin,
(b) That it originated from inorganic materials, and (c) That life is a constituent of the Universe and can only arise from pre-existing life. The first hypothesis, he said, should be taken seriously, and he would proceed to do so. From the fact that there are 400,000 species of beetle on this planet, but only 8,000 species of mammals, he concluded that the Creator, if he exists, has a special preference for beetles, and so we might be more likely to meet them than any other type of animal on a planet which would support life.

Considered from the standpoint of chemistry, living bodies appear to us as laboratories of chemical processes, for they undergo perpetual changes in their material substrate. They draw materials from the outside world and combine them with the mass of their liquid and solid parts.

Constant, or free, life is the third form of life; it belongs to the most highly organized animals. In it, life is not suspended in any circumstance, it unrolls along a constant course, apparently indifferent to the variations in the cosmic environment, or to the changes in the material conditions that surround the animal. Organs, apparatus, and tissues function in an apparently uniform manner, without their activity undergoing those considerable variations exhibited by animals with an oscillating life. This because in reality the internal environment that envelops the organs, the tissues, and the elements of the tissues does not change; the variations in the atmosphere stop there, so that it is true to say that physical conditions of the environment are constant in the higher animals; it is enveloped in an invariable medium, which acts as an atmosphere of its own in the constantly changing cosmic environment. It is an organism that has placed itself in a hot-house. Thus the perpetual changes in the cosmic environment do not touch it; it is not chained to them, it is free and independent.

Differences between individuals are the raw materials for evolutionary change and for the evolution of adaptations, yet of course most physiologists treat these differences as noise that is to be filtered out. From the standpoint of physiological ecology, the traditional emphasis of physiologists on central tendencies rather than on variance has some unhappy consequences. Variation is not just noise; it is also the stuff of evolution and a central attribute of living systems. The physiological differences between individuals in the same species or population, and also the patterns of variation in different groups, must not be ignored.

Dissection … teaches us that the body of man is made up of certain kinds of material, so differing from each other in optical and other physical characters and so built up together as to give the body certain structural features. Chemical examination further teaches us that these kinds of material are composed of various chemical substances, a large number of which have this characteristic that they possess a considerable amount of potential energy capable of being set free, rendered actual, by oxidation or some other chemical change. Thus the body as a whole may, from a chemical point of view, be considered as a mass of various chemical substances, representing altogether a considerable capital of potential energy.

Doctor Johnson said, that in sickness there were three things that were material; the physician, the disease, and the patient: and if any two of these joined, then they get the victory; for, Ne Hercules quidem contra duos [Not even Hercules himself is a match for two]. If the physician and the patient join, then down goes the disease; for then the patient recovers: if the physician and the disease join, that is a strong disease; and the physician mistaking the cure, then down goes the patient: if the patient and the disease join, then down goes the physician; for he is discredited.

Doubtless the reasoning faculty, the mind, is the leading and characteristic attribute of the human race. By the exercise of this, man arrives at the properties of the natural bodies. This is science, properly and emphatically so called. It is the science of pure mathematics; and in the high branches of this science lies the truly sublime of human acquisition. If any attainment deserves that epithet, it is the knowledge, which, from the mensuration of the minutest dust of the balance, proceeds on the rising scale of material bodies, everywhere weighing, everywhere measuring, everywhere detecting and explaining the laws of force and motion, penetrating into the secret principles which hold the universe of God together, and balancing worlds against worlds, and system against system. When we seek to accompany those who pursue studies at once so high, so vast, and so exact; when we arrive at the discoveries of Newton, which pour in day on the works of God, as if a second fiat had gone forth from his own mouth; when, further, we attempt to follow those who set out where Newton paused, making his goal their starting-place, and, proceeding with demonstration upon demonstration, and discovery upon discovery, bring new worlds and new systems of worlds within the limits of the known universe, failing to learn all only because all is infinite; however we may say of man, in admiration of his physical structure, that “in form and moving he is express and admirable,” it is here, and here without irreverence, we may exclaim, “In apprehension how like a god!” The study of the pure mathematics will of course not be extensively pursued in an institution, which, like this [Boston Mechanics’ Institute], has a direct practical tendency and aim. But it is still to be remembered, that pure mathematics lie at the foundation of mechanical philosophy, and that it is ignorance only which can speak or think of that sublime science as useless research or barren speculation.

Dust consisting of fine fibers of asbestos, which are insoluble and virtually indestructible, may become a public health problem in the near future. At a recent international conference on the biological effects of asbestos sponsored by the New York Academy of Sciences, participants pointed out on the one hand that workers exposed to asbestos dust are prone in later life to develop lung cancer, and on the other hand that the use of this family of fibrous silicate compounds has expanded enormously during the past few decades. A laboratory curiosity 100 years ago, asbestos today is a major component of building materials.

Each species has evolved a special set of solutions to the general problems that all organisms must face. By the fact of its existence, a species demonstrates that its members are able to carry out adequately a series of general functions. … These general functions offer a framework within which one can integrate one’s view of biology and focus one’s research. Such a view helps one to avoid becoming lost in a morass of unstructured detail—even though the ways in which different species perform these functions may differ widely. A few obvious examples will suffice. Organisms must remain functionally integrated. They must obtain materials from their environments, and process and release energy from these materials. … They must differentiate and grow, and they must reproduce. By focusing one’s questions on one or another of these obligatory and universal capacities, one can ensure that one’s research will not be trivial and that it will have some chance of achieving broad general applicability.

Educators may bring upon themselves unnecessary travail by taking a tactless and unjustifiable position about the relation between scientific and religious narratives. … The point is that profound but contradictory ideas may exist side by side, if they are constructed from different materials and methods and have different purposes. Each tells us something important about where we stand in the universe, and it is foolish to insist that they must despise each other.

Electricity is doing for the distribution of energy what the railroads have done for the distribution of materials.

Engineering is an activity other than purely manual and physical work which brings about the utilization of the materials and laws of nature for the good of humanity.

Engineering is quite different from science. Scientists try to understand nature. Engineers try to make things that do not exist in nature. Engineers stress invention. To embody an invention the engineer must put his idea in concrete terms, and design something that people can use. That something can be a device, a gadget, a material, a method, a computing program, an innovative experiment, a new solution to a problem, or an improvement on what is existing. Since a design has to be concrete, it must have its geometry, dimensions, and characteristic numbers. Almost all engineers working on new designs find that they do not have all the needed information. Most often, they are limited by insufficient scientific knowledge. Thus they study mathematics, physics, chemistry, biology and mechanics. Often they have to add to the sciences relevant to their profession. Thus engineering sciences are born.

Engineering is the art of directing the great sources of power in nature for the use and the convenience of people. In its modern form engineering involves people, money, materials, machines, and energy. It is differentiated from science because it is primarily concerned with how to direct to useful and economical ends the natural phenomena which scientists discover and formulate into acceptable theories. Engineering therefore requires above all the creative imagination to innovate useful applications of natural phenomena. It seeks newer, cheaper, better means of using natural sources of energy and materials.

Engineering is the art of organizing and directing men and controlling the forces and materials of nature for the benefit of the human race.

Engineering is the practice of safe and economic application of the scientific laws governing the forces and materials of nature by means of organization, design and construction, for the general benefit of mankind.

Engineering is the profession in which a knowledge of the mathematical and natural sciences gained by study, experience, and practice is applied with judgment to develop ways to utilize, economically, the materials and forces of nature for the benefit of mankind.

Engineering is the science and art of efficient dealing with materials and forces … it involves the most economic design and execution … assuring, when properly performed, the most advantageous combination of accuracy, safety, durability, speed, simplicity, efficiency, and economy possible for the conditions of design and service.

Engineers apply the theories and principles of science and mathematics to research and develop economical solutions to practical technical problems. Their work is the link between scientific discoveries and commercial applications. Engineers design products, the machinery to build those products, the factories in which those products are made, and the systems that ensure the quality of the product and efficiency of the workforce and manufacturing process. They design, plan, and supervise the construction of buildings, highways, and transit systems. They develop and implement improved ways to extract, process, and use raw materials, such as petroleum and natural gas. They develop new materials that both improve the performance of products, and make implementing advances in technology possible. They harness the power of the sun, the earth, atoms, and electricity for use in supplying the Nation’s power needs, and create millions of products using power. Their knowledge is applied to improving many things, including the quality of health care, the safety of food products, and the efficient operation of financial systems.

Ethnologists regard man as the primitive element of tribes, races, and peoples. The anthropologist looks at him as a member of the fauna of the globe, belonging to a zoölogical classification, and subject to the same laws as the rest of the animal kingdom. To study him from the last point of view only would be to lose sight of some of his most interesting and practical relations; but to be confined to the ethnologist’s views is to set aside the scientific rule which requires us to proceed from the simple to the compound, from the known to the unknown, from the material and organic fact to the functional phenomenon.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Every generation has the right to build its own world out of the materials of the past, cemented by the hopes of the future.

Every time a significant discovery is being made one sets in motion a tremendous activity in laboratories and industrial enterprises throughout the world. It is like the ant who suddenly finds food and walks back to the anthill while sending out material called food attracting substance. The other ants follow the path immediately in order to benefit from the finding and continue to do so as long as the supply is rich.

Everything material which is the subject of knowledge has number, order, or position; and these are her first outlines for a sketch of the universe. If our feeble hands cannot follow out the details, still her part has been drawn with an unerring pen, and her work cannot be gainsaid. So wide is the range of mathematical sciences, so indefinitely may it extend beyond our actual powers of manipulation that at some moments we are inclined to fall down with even more than reverence before her majestic presence. But so strictly limited are her promises and powers, about so much that we might wish to know does she offer no information whatever, that at other moments we are fain to call her results but a vain thing, and to reject them as a stone where we had asked for bread. If one aspect of the subject encourages our hopes, so does the other tend to chasten our desires, and he is perhaps the wisest, and in the long run the happiest, among his fellows, who has learned not only this science, but also the larger lesson which it directly teaches, namely, to temper our aspirations to that which is possible, to moderate our desires to that which is attainable, to restrict our hopes to that of which accomplishment, if not immediately practicable, is at least distinctly within the range of conception.

EXTINCTION, n. The raw material out of which theology created the future state.

Facts are the materials of science, but all Facts involve Ideas. … we must, for the purposes of science, take care that the Ideas are clear and rigorously applied.

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

Few people doubt that the Apollo missions to the Moon as well as the precursory Mercury and Gemini missions not only had a valuable role for the United States in its Cold War with the Soviet Union but also lifted the spirits of humankind. In addition, the returned samples of lunar surface material fueled important scientific discoveries.

Finally, since I thought that we could have all the same thoughts, while asleep, as we have while we are awake, although none of them is true at that time, I decided to pretend that nothing that ever entered my mind was any more true than the illusions of my dreams. But I noticed, immediately afterwards, that while I thus wished to think that everything was false, it was necessarily the case that I, who was thinking this, was something. When I noticed that this truth “I think, therefore I am” was so firm and certain that all the most extravagant assumptions of the sceptics were unable to shake it, I judged that I could accept it without scruple as the first principle of the philosophy for which I was searching. Then, when I was examining what I was, I realized that I could pretend that I had no body, and that there was no world nor any place in which I was present, but I could not pretend in the same way that I did not exist. On the contrary, from the very fact that I was thinking of doubting the truth of other things, it followed very evidently and very certainly that I existed; whereas if I merely ceased to think, even if all the rest of what I had ever imagined were true, I would have no reason to believe that I existed. I knew from this that I was a substance, the whole essence or nature of which was to think and which, in order to exist, has no need of any place and does not depend on anything material. Thus this self—that is, the soul by which I am what I am—is completely distinct from the body and is even easier to know than it, and even if the body did not exist the soul would still be everything that it is.

Food may be defined as material which, when taken into the body, serves to either form tissue or yield energy, or both. This definition includes all the ordinary food materials, since they both build tissue and yield energy. It includes sugar and starch, because they yield energy and form fatty tissue. It includes alcohol, because the latter is burned to yield energy, though it does not build tissue. It excludes creatin, creatininin, and other so-called nitrogeneous extractives of meat, and likewise thein or caffein of tea and coffee, because they neither build tissue nor yield energy, although they may, at times, be useful aids to nutrition.

For a smart material to be able to send out a more complex signal it needs to be nonlinear. If you hit a tuning fork twice as hard it will ring twice as loud but still at the same frequency. That’s a linear response. If you hit a person twice as hard they’re unlikely just to shout twice as loud. That property lets you learn more about the person than the tuning fork. - When Things Start to Think, 1999.

For FRICTION is inevitable because the Universe is FULL of God's works.
For the PERPETUAL MOTION is in all works of Almighty GOD.
For it is not so in the engines of man, which are made of dead materials, neither indeed can be.
For the Moment of bodies, as it is used, is a false term—bless God ye Speakers on the Fifth of November.
For Time and Weight are by their several estimates.
For I bless GOD in the discovery of the LONGITUDE direct by the means of GLADWICK.
For the motion of the PENDULUM is the longest in that it parries resistance.
For the WEDDING GARMENTS of all men are prepared in the SUN against the day of acceptation.
For the wedding Garments of all women are prepared in the MOON against the day of their purification.
For CHASTITY is the key of knowledge as in Esdras, Sir Isaac Newton & now, God be praised, in me.
For Newton nevertheless is more of error than of the truth, but I am of the WORD of GOD.

For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.

For us, an atom shall be a small, spherical, homogeneous body or an essentially indivisible, material point, whereas a molecule shall be a separate group of atoms in any number and of any nature.

Force is no impelling god, no entity separate from the material substratum ; it is inseparable from matter, is one of its eternal indwelling properties.

From packaging materials, through fibers, foams and surface coatings, to continuous extrusions and large-scale moldings, plastics have transformed almost every aspect of life. Without them, much of modern medicine would be impossible and the consumer electronics and computer industries would disappear. Plastic sewage and water pipes alone have made an immeasurable contribution to public health worldwide.

From the aspect of energy, renewed by radio-active phenomena, material corpuscles may now be treated as transient reservoirs of concentrated power. Though never found in a state of purity, but always more or less granulated (even in light) energy nowadays represents for science the most primitive form of universal stuff.

Further study of the division phenomena requires a brief discussion of the material which thus far I have called the stainable substance of the nucleus. Since the term nuclear substance could easily result in misinterpretation..., I shall coin the term chromatin for the time being. This does not indicate that this substance must be a chemical compound of a definite composition, remaining the same in all nuclei. Although this may be the case, we simply do not know enough about the nuclear substances to make such an assumption. Therefore, we will designate as chromatin that substance, in the nucleus, which upon treatment with dyes known as nuclear stains does absorb the dye. From my description of the results of staining resting and dividing cells... it follows that the chromatin is distributed throughout the whole resting nucleus, mostly in the nucleoli, the network, and the membrane, but also in the ground-substance. In nuclear division it accumulates exclusively in the thread figures. The term achromatin suggests itself automatically for the unstainable substance of the nucleus. The terms chromatic and achromatic which will be used henceforth are thus explained.

Generality of points of view and of methods, precision and elegance in presentation, have become, since Lagrange, the common property of all who would lay claim to the rank of scientific mathematicians. And, even if this generality leads at times to abstruseness at the expense of intuition and applicability, so that general theorems are formulated which fail to apply to a single special case, if furthermore precision at times degenerates into a studied brevity which makes it more difficult to read an article than it was to write it; if, finally, elegance of form has well-nigh become in our day the criterion of the worth or worthlessness of a proposition,—yet are these conditions of the highest importance to a wholesome development, in that they keep the scientific material within the limits which are necessary both intrinsically and extrinsically if mathematics is not to spend itself in trivialities or smother in profusion.

Genetics has enticed a great many explorers during the past two decades. They have labored with fruit-flies and guinea-pigs, with sweet peas and corn, with thousands of animals and plants in fact, and they have made heredity no longer a mystery but an exact science to be ranked close behind physics and chemistry in definiteness of conception. One is inclined to believe, however, that the unique magnetic attraction of genetics lies in the vision of potential good which it holds for mankind rather than a circumscribed interest in the hereditary mechanisms of the lowly species used as laboratory material. If man had been found to be sharply demarcated from the rest of the occupants of the world, so that his heritage of physical form, of physiological function, and of mental attributes came about in a superior manner setting him apart as lord of creation, interest in the genetics of the humbler organisms—if one admits the truth—would have flagged severely. Biologists would have turned their attention largely to the ways of human heredity, in spite of the fact that the difficulties encountered would have rendered progress slow and uncertain. Since this was not the case, since the laws ruling the inheritance of the denizens of the garden and the inmates of the stable were found to be applicable to prince and potentate as well, one could shut himself up in his laboratory and labor to his heart's content, feeling certain that any truth which it fell to his lot to discover had a real human interest, after all.

Geology ... offers always some material for observation. ... [When] spring and summer come round, how easily may the hammer be buckled round the waist, and the student emerge from the dust of town into the joyous air of the country, for a few delightful hours among the rocks.

Geology has its peculiar difficulties, from which all other sciences are exempt. Questions in chemistry may be settled in the laboratory by experiment. Mathematical and philosophical questions may be discussed, while the materials for discussion are ready furnished by our own intellectual reflections. Plants, animals and minerals, may be arranged in the museum, and all questions relating to their intrinsic principles may be discussed with facility. But the relative positions, the shades of difference, the peculiar complexions, whether continuous or in subordinate beds, are subjects of enquiry in settling the character of rocks, which can be judged of while they are in situ only.

Get rid of every pound of material you can do without; put to yourself the question, ‘What business has this to be there?’

Given any domain of thought in which the fundamental objective is a knowledge that transcends mere induction or mere empiricism, it seems quite inevitable that its processes should be made to conform closely to the pattern of a system free of ambiguous terms, symbols, operations, deductions; a system whose implications and assumptions are unique and consistent; a system whose logic confounds not the necessary with the sufficient where these are distinct; a system whose materials are abstract elements interpretable as reality or unreality in any forms whatsoever provided only that these forms mirror a thought that is pure. To such a system is universally given the name MATHEMATICS.

Great men are they who see that spiritual is stronger than any material force—that thoughts rule the world.

Half a century ago Oswald (1910) distinguished classicists and romanticists among the scientific investigators: the former being inclined to design schemes and to use consistently the deductions from working hypotheses; the latter being more fit for intuitive discoveries of functional relations between phenomena and therefore more able to open up new fields of study. Examples of both character types are Werner and Hutton. Werner was a real classicist. At the end of the eighteenth century he postulated the theory of “neptunism,” according to which all rocks including granites, were deposited in primeval seas. It was an artificial scheme, but, as a classification system, it worked quite satisfactorily at the time. Hutton, his contemporary and opponent, was more a romanticist. His concept of “plutonism” supposed continually recurrent circuits of matter, which like gigantic paddle wheels raise material from various depths of the earth and carry it off again. This is a very flexible system which opens the mind to accept the possible occurrence in the course of time of a great variety of interrelated plutonic and tectonic processes.

How indispensable to a correct study of Nature is a perception of her true meaning. The fact will one day flower out into a truth. The season will mature and fructify what the understanding had cultivated. Mere accumulators of facts—collectors of materials for the master-workmen—are like those plants growing in dark forests, which “put forth only leaves instead of blossoms.”

How much does your building weigh?
A question often used to challenge architects to consider how efficiently materials were used for the space enclosed.

Human civilization is but a few thousand years long. Imagine having the audacity to think that we can devise a program to store lethal radioactive materials for a period of time that is longer than all of human culture to date.

Humanity certainly needs practical men, who get the most out of their work, and, without forgetting the general good, safeguard their own interests. But humanity also needs dreamers, for whom the disinterested development of an enterprise is so captivating that it becomes impossible for them to devote their care to their own material profit. Without the slightest doubt, these dreamers do not deserve wealth, because they do not desire it. Even so, a well-organised society should assure to such workers the efficient means of accomplishing their task, in a life freed from material care and freely consecrated to research.