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Who said: “I seem to have been only like a boy playing on the seashore, ... finding a smoother pebble or a prettier shell ... whilst the great ocean of truth lay all undiscovered before me.”
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Home > Category Index for Science Quotations > Category Index T > Category: Trial

Trial Quotes (57 quotes)

...they have never affirm'd any thing, concerning the Cause, till the Trial was past: whereas, to do it before, is a most venomous thing in the making of Sciences; for whoever has fix'd on his Cause, before he experimented; can hardly avoid fitting his Experiment to his Observations, to his own Cause, which he had before imagin'd; rather than the Cause to the Truth of the Experiment itself.
Referring to experiments of the Aristotelian mode, whereby a preconceived truth would be illustrated merely to convince people of the validity of the original thought.
Thomas Sprat, Abraham Cowley, History of the Royal Society (1667, 1734), 108.
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Angling may be said to be so like the Mathematics that it can never be fully learnt; at least not so fully but that there will still be more new experiments left for the trial of other men that succeed us.
In The Complete Angler (1653, 1915), 7.
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As Karl Marx once noted: “Hegel remarks somewhere that all great, world-historical facts and personages occur, as it were, twice. He forgot to add: the first time as tragedy, the second as farce.” William Jennings Bryan and the Scopes trial was a tragedy. The creationists and intelligent design theorists are a farce.
In '75 Years and Still No Peace'. Humanist (Sep 2000)
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AZT stood up and said, 'Stop your pessimism. Stop your sense of futility. Go back to the lab. Go back to development. Go back to clinical trials. Things will work.'
[On the impact of AZT emerging as the long-sought first significant AIDS drug.]
As quoted in Emily Langer, 'Researcher Jerome P. Horwitz, 93, created AZT, the first approved treatment for HIV/AIDS' Washington Post (19 Sep 2012). The article was excerpted on blogs, sometimes referring to this quote by saying "AZT was more a cure for fatalism than for AIDS."
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But I believe that there is no philosophical high-road in science, with epistemological signposts. No, we are in a jungle and find our way by trial and error, building our road behind us as we proceed. We do not find signposts at cross-roads, but our own scouts erect them, to help the rest.
Max Born
In Experiment and Theory in Physics (1943), 44.
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Character cannot be developed in ease and quiet. Only through experience of trial and suffering can the soul be strengthened, ambition inspired, and success achieved.
…...
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Coolidge is a better example of evolution than either Bryan or Darrow, for he knows when not to talk, which is the biggest asset the monkey possesses over the human.
[Referring to the Scopes trial, with Darrow defending a teacher being prosecuted for teaching evolution in the state of Tennessee.]
'Rogers Thesaurus'. Saturday Review (25 Aug 1962). In Will Rogers' Weekly Articles (1981), Vol. 2, 66.
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Debate is an art form. It is about the winning of arguments. It is not about the discovery of truth. There are certain rules and procedures to debate that really have nothing to do with establishing fact–which creationists have mastered. Some of those rules are: never say anything positive about your own position because it can be attacked, but chip away at what appear to be the weaknesses in your opponent’s position. They are good at that. I don’t think I could beat the creationists at debate. I can tie them. But in courtrooms they are terrible, because in courtrooms you cannot give speeches. In a courtroom you have to answer direct questions about the positive status of your belief. We destroyed them in Arkansas. On the second day of the two-week trial we had our victory party!
…...
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Edison was by far the most successful and, probably, the last exponent of the purely empirical method of investigation. Everything he achieved was the result of persistent trials and experiments often performed at random but always attesting extraordinary vigor and resource. Starting from a few known elements, he would make their combinations and permutations, tabulate them and run through the whole list, completing test after test with incredible rapidity until he obtained a clue. His mind was dominated by one idea, to leave no stone unturned, to exhaust every possibility.
As quoted in 'Tesla Says Edison Was an Empiricist', The New York Times (19 Oct 1931), 25.
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Every detection of what is false directs us towards what is true: every trial exhausts some tempting form of error.
In 'Lecture 7', Lectures on the History of Moral Philosophy in England (1852), 101.
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Every discoverer of a new truth, or inventor of the method which evolves it, makes a dozen, perhaps fifty, useless combinations, experiments, or trials for one successful one. In the realm of electricity or of mechanics there is no objection to this. But when such rejected failures involve a torture of animals, sometimes fearful in its character, there is a distinct objection to it.
From 'Vivisection', an original paper in Surgical Anaesthesia: Addresses, and Other Papers (1894, 1900), 369-370.
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He (Anaxagoras) is said to have been twenty years old at the time of Xerxes' crossing, and to have lived to seventy-two. Apollodorus says in his Chronicles that he was born in the seventieth Olympiad (500-497 B.C.) and died in the first year of the eighty-eighth (428/7). He began to be a philosopher at Athens in the archonship of Callias (456/5), at the age of twenty, as Demetrius Phalereus tells us in his Register of Archons, and they say he spent thirty years there. … There are different accounts given of his trial. Sotion, in his Succession of Philosophers, says that he was prosecuted by Cleon for impiety, because he maintained that the sun was a red hot mass of metal, and after that Pericles, his pupil, had made a speech in his defence, he was fined five talents and exiled. Satyrus in his Uves, on the other hand, says that the charge was brought by Thucydides in his political campaign against Pericles; and he adds that the charge was not only for the impiety but for Medism as well; and he was condemned to death in his absence. ... Finally he withdrew to Lampsacus, and there died. It is said that when the rulers of the city asked him what privilege he wished to be granted, he replied that the children should be given a holiday every year in the month in which he died. The custom is preserved to the present day. When he died the Lampsacenes buried him with full honours.
Diogenes Laërtius 2.7. In G. S. Kirk, J. E. Raven and M. Schofield (eds.), The Presocratic Philosophers: A Critical History with a Selection of Texts (1983), p. 353.
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He leads a new crusade, his bald head glistening... One somehow pities him, despite his so palpable imbecilities... But let no one, laughing at him, underestimate the magic that lies in his black, malignant eye, his frayed but still eloquent voice. He can shake and inflame these poor ignoramuses as no other man among us...
[Describing William Jennings Bryan, orator, at the Scopes Monkey Trial.]
Henry Louis Mencken and S.T. Joshi (ed.), H.L. Mencken on Religion (2002), 18.
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I am afraid I am not in the flight for “aerial navigation”. I was greatly interested in your work with kites; but I have not the smallest molecule of faith in aerial navigation other than ballooning or of expectation of good results from any of the trials we hear of. So you will understand that I would not care to be a member of the aëronautical Society.
Letter (8 Dec 1896) to Baden Powell. This is the full text of the letter. An image of the handwritten original is on the zapatopi.net website
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I am very sorry, Pyrophilus, that to the many (elsewhere enumerated) difficulties which you may meet with, and must therefore surmount, in the serious and effectual prosecution of experimental philosophy I must add one discouragement more, which will perhaps is much surprise as dishearten you; and it is, that besides that you will find (as we elsewhere mention) many of the experiments published by authors, or related to you by the persons you converse with, false and unsuccessful (besides this, I say), you will meet with several observations and experiments which, though communicated for true by candid authors or undistrusted eye-witnesses, or perhaps recommended by your own experience, may, upon further trial, disappoint your expectation, either not at all succeeding constantly, or at least varying much from what you expected.
Opening paragraph of The First Essay Concerning the Unsuccessfulness of Experiments (1673), collected in The Works of the Honourable Robert Boyle in Six Volumes to Which is Prefixed the Life of the Author (1772), Vol. 1, 318-319.
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I believe that the Dayton trial marked the beginning of the decline of fundamentalism. … I feel that restrictive legislation on academic freedom is forever a thing of the past, that religion and science may now address one another in an atmosphere of mutual respect and of a common quest for truth. I like to think that the Dayton trial had some part in bringing to birth this new era.
From 'Reflections—Forty Years After', in Jerry R. Tompkins (ed.), D-Days at Dayton: Reflections on the Scopes Trial(1965), 31. As quoted in Stephen Jay Gould, Hen’s Teeth and Horse’s Toes: Further Reflections in Natural History (1983), 274.
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I furnished the body that was needed to sit in the defendant's chair. [Explaining his role in the Scopes Monkey Trial.]
As quoted in Newsweek, Vol. 69, 94.
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I should object to any experimentation which can justly be called painful, for the purpose of elementary instruction ... [but I regret] a condition of the law which permits a boy to troll for pike, or set lines with live frog bait, for idle amusement; and, at the same time, lays the teacher of that boy open to the penalty of fine and imprisonment, if he uses the same animal for the purpose of exhibiting one of the most beautiful and instructive of physiological spectacles, the circulation in the web of the foot. ... [Maybe the frog is] inconvenienced by being wrapped up in a wet rag, and having his toes tied out ... But you must not inflict the least pain on a vertebrated animal for scientific purposes (though you may do a good deal in that way for gain or for sport) without due licence of the Secretary of State for the Home Department, granted under the authority of the Vivisection Act.
... [Yet, in] 1877, two persons may be charged with cruelty to animals. One has impaled a frog, and suffered the creature to writhe about in that condition for hours; the other has pained the animal no more than one of us would be pained by tying strings round his fingers, and keeping him in the position of a hydropathic patient. The first offender says, 'I did it because I find fishing very amusing,' and the magistrate bids him depart in peace; nay, probably wishes him good sport. The second pleads, 'I wanted to impress a scientific truth, with a distinctness attainable in no other way, on the minds of my scholars,' and the magistrate fines him five pounds.
I cannot but think that this is an anomalous and not wholly creditable state of things.
'On Elementary Instruction in Physiology'. Science and Culture (1882), 92.
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In my opinion the separation of the c- and ac-stars is the most important advancement in stellar classification since the trials by Vogel and Secchi ... To neglect the c-properties in classifying stellar spectra, I think, is nearly the same thing as if a zoologist, who has detected the deciding differences between a whale and a fish, would continue classifying them together.
Letter to Edward Pickering (22 Jul 1908). In Charles Coulston Gillespie (ed.), Dictionary of Scientific Biography (1974), Vol. 9, 194.
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It is well-known that both rude and civilized peoples are capable of showing unspeakable, and as it is erroneously termed, inhuman cruelty towards each other. These acts of cruelty, murder and rapine are often the result of the inexorable logic of national characteristics, and are unhappily truly human, since nothing like them can be traced in the animal world. It would, for instance, be a grave mistake to compare a tiger with the bloodthirsty exectioner of the Reign of Terror, since the former only satisfies his natural appetite in preying on other mammals. The atrocities of the trials for witchcraft, the indiscriminate slaughter committed by the negroes on the coast of Guinea, the sacrifice of human victims made by the Khonds, the dismemberment of living men by the Battas, find no parallel in the habits of animals in their savage state. And such a comparision is, above all, impossible in the case of anthropoids, which display no hostility towards men or other animals unless they are first attacked. In this respect the anthropid ape stands on a higher plane than many men.
Robert Hartmann, Anthropoid Apes, 294-295.
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Last night I invented a new pleasure, and as I was giving it the first trial an angel and a devil came rushing toward my house. They met at my door and fought with each other over my newly created pleasure; the one crying, “It is a sin!” - the other, “It is a virtue!”
In Kahlil Gibran: The Collected Works (207), 21.
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Let no one mistake it for comedy, farcical though it may be in all its details. It serves notice on the country that Neanderthal man is organizing in these forlorn backwaters of the land, led by a fanatic, rid of sense and devoid of conscience.
{Commenting on the Scopes Monkey Trial, while reporting for the Baltimore Sun.]
In Michael Shermer, Why Darwin Matters (2006), 26.
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Let us now recapitulate all that has been said, and let us conclude that by hermetically sealing the vials, one is not always sure to prevent the birth of the animals in the infusions, boiled or done at room temperature, if the air inside has not felt the ravages of fire. If, on the contrary, this air has been powerfully heated, it will never allow the animals to be born, unless new air penetrates from outside into the vials. This means that it is indispensable for the production of the animals that they be provided with air which has not felt the action of fire. And as it would not be easy to prove that there were no tiny eggs disseminated and floating in the volume of air that the vials contain, it seems to me that suspicion regarding these eggs continues, and that trial by fire has not entirely done away with fears of their existence in the infusions. The partisans of the theory of ovaries will always have these fears and will not easily suffer anyone's undertaking to demolish them.
Nouvelles Recherches sur les Découvertes Microscopiques, et la Génération des Corps Organisés (1769), 134-5. Quoted in Jacques Roger, The Life Sciences in Eighteenth-Century French Thought, ed. Keith R. Benson and trans. Robert Ellrich (1997), 510-1.
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Mathematics is not a deductive science—that’s a cliché. When you try to prove a theorem, you don’t just list the hypotheses, and then start to reason. What you do is trial and error, experiment and guesswork.
In I Want to be a Mathematician: an Automathography in Three Parts (1985), 321.
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My entire life consisted of musings, calculations, practical works and trials. Many questions remain unanswered; many works are incomplete or unpublished. The most important things still lie ahead.
As quoted in Air & Space Smithsonian (2002), 17, 69.
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Necessity is not the mother of invention. Knowledge and experiment are its parents. It sometimes happens that successful search is made for unknown materials to fill well-recognized and predetermined requirements. It more often happens that the acquirement of knowledge of the previously unknown properties of a material suggests its trial for some new use. These facts strongly indicate the value of knowledge of properties of materials and indicate a way for research.
Quoted in Guy Suits, 'Willis Rodney Whitney', National Academy of Sciences, Biographical Memoirs (1960), 357.
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No aphorism is more frequently repeated in connection with field trials, than that we must ask Nature few questions, or, ideally, one question, at a time. The writer is convinced that this view is wholly mistaken. Nature, he suggests, will best respond to a logical and carefully thought out questionnaire; indeed, if we ask her a single question, she will often refuse to answer until some other topic has been discussed.
'The Arrangement of Field Experiments', The Journal of the Ministry of Agriculture, 1926, 33, 511.
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None of Darwin’s particular doctrines will necessarily endure the test of time and trial. Into the melting-pot must they go as often as any man of science deems it fitting. But Darwinism as the touch of nature that makes the whole world kin can hardly pass away.
Anthropology (1912), 11.
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On 17th July there came to us at Potsdam the eagerly-awaited news of the trial of the atomic bomb in the [New] Mexican desert. Success beyond all dreams crowded this sombre, magnificent venture of our American allies. The detailed reports ... could leave no doubt in the minds of the very few who were informed, that we were in the presence of a new factor in human affairs, and possessed of powers which were irresistible.
From Churchill's final review of the war and his first major speech as Leader of the Opposition in the House of Commons (16 Aug 1945). In Robert Rhodes James, ed., Winston S. Churchill: His Complete Speeches, 1897-1963 (1974), Vol. 1, 7210.
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Our ancestors, when about to build a town or an army post, sacrificed some of the cattle that were wont to feed on the site proposed and examined their livers. If the livers of the first victims were dark-coloured or abnormal, they sacrificed others, to see whether the fault was due to disease or their food. They never began to build defensive works in a place until after they had made many such trials and satisfied themselves that good water and food had made the liver sound and firm. …healthfulness being their chief object.
Vitruvius
In De Architectura, Book 1, Chap 4, Sec. 9. As translated in Morris Hicky Morgan (trans.), Vitruvius: The Ten Books on Architecture (1914), 20.
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Our system of philosophy is itself on trial; it must stand or fall according as it is broad enough to find room for this experience as an element of life.
Swarthmore Lecture (1929) at Friends’ House, London, printed in Science and the Unseen World (1929), 46.
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Paris ... On this side of the ocean it is difficult to understand the susceptibility of American citizens on the subject and precisely why they should so stubbornly cling to the biblical version. It is said in Genesis the first man came from mud and mud is not anything very clean. In any case if the Darwinian hypothesis should irritate any one it should only be the monkey. The monkey is an innocent animal—a vegetarian by birth. He never placed God on a cross, knows nothing of the art of war, does not practice lynch law and never dreams of assassinating his fellow beings. The day when science definitely recognizes him as the father of the human race the monkey will have no occasion to be proud of his descendants. That is why it must be concluded that the American Association which is prosecuting the teacher of evolution can be no other than the Society for Prevention of Cruelty to Animals.
[A cynical article in the French press on the Scopes Monkey Trial, whether it will decide “a monkey or Adam was the grandfather of Uncle Sam.”]
Newspaper
Article from a French daily newspaper on the day hearings at the Scopes Monkey Trial began, Paris Soir (13 Jul 1925), quoted in 'French Satirize the Case', New York Times (14 Jul 1925), 3.
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Perhaps it is better in this present world of ours that a revolutionary idea or invention instead of being helped and patted be hampered and ill-treated in its adolescence—by want of means, by selfish interest, pedantry, stupidity and ignorance; that it be attacked and stifled; that it pass through bitter trials and tribulations, through the heartless strife of commercial existence. ... So all that was great in the past was ridiculed, condemned, combatted, suppressed—only to emerge all the more powerfully, all the more triumphantly from the struggle.
'The Transmission of Electrical Energy Without Wires As a Means for Furthering Peace', Electrical World and Engineer (7 Jan 1905), 24. Reproduced in John T. Ratzlaff, editor, Tesla Said (1984), 86. Also reprinted in Nikola Tesla, Miscellaneous Writings (2007), 58.
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Philosophy dwells aloft in the Temple of Science, the divinity of its inmost shrine; her dictates descend among men, but she herself descends not : whoso would behold her must climb with long and laborious effort, nay, still linger in the forecourt, till manifold trial have proved him worthy of admission into the interior solemnities.
In James Wood, Dictionary of Quotations from Ancient and Modern, English and Foreign Sources (1893), 347:42.
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Progress is made by trial and failure; the failures are generally a hundred times more numerous than the successes; yet they are usually left unchronicled. The reason is that the investigator feels that even though he has failed in achieving an expected result, some other more fortunate experimenter may succeed, and it is unwise to discourage his attempts.
From 'Radium and its Products', Harper’s Magazine (Dec 1904), 110, No. 655, 52.
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Regardless of communication between man and man, speech is a necessary condition for the thinking of the individual in solitary seclusion. In appearance, however, language develops only socially, and man understands himself only once he has tested the intelligibility of his words by trial upon others.
On Language (1836), trans. Peter Heath (1988), 56.
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Science is not, as so many seem to think, something apart, which has to do with telescopes, retorts, and test-tubes, and especially with nasty smells, but it is a way of searching out by observation, trial and classification; whether the phenomena investigated be the outcome of human activities, or of the more direct workings of nature's laws. Its methods admit of nothing untidy or slip-shod; its keynote is accuracy and its goal is truth.
The University of Utopia (1918), 17.
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Science would have us believe that such accuracy, leading to certainty, is the only criterion of knowledge, would make the trial of Galileo the paradigm of the two points of view which aspire to truth, would suggest, that is, that the cardinals represent only superstition and repression, while Galileo represents freedom. But there is another criterion which is systematically neglected in this elevation of science. Man does not now—and will not ever—live by the bread of scientific method alone. He must deal with life and death, with love and cruelty and despair, and so must make conjectures of great importance which may or may not be true and which do not lend themselves to experimentation: It is better to give than to receive; Love thy neighbor as thyself; Better to risk slavery through non-violence than to defend freedom with murder. We must deal with such propositions, must decide whether they are true, whether to believe them, whether to act on them—and scientific method is no help for by their nature these matters lie forever beyond the realm of science.
In The End of the Modern Age (1973), 89.
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Speaking concretely, when we say “making experiments or making observations,” we mean that we devote ourselves to investigation and to research, that we make attempts and trials in order to gain facts from which the mind, through reasoning, may draw knowledge or instruction.
Speaking in the abstract, when we say “relying on observation and gaining experience,” we mean that observation is the mind's support in reasoning, and experience the mind's support in deciding, or still better, the fruit of exact reasoning applied to the interpretation of facts. It follows from this that we can gain experience without making experiments, solely by reasoning appropriately about well- established facts, just as we can make experiments and observations without gaining experience, if we limit ourselves to noting facts.
Observation, then, is what shows facts; experiment is what teaches about facts and gives experience in relation to anything.
From An Introduction to the Study of Experimental Medicine (1865), as translated by Henry Copley Greene (1957), 11.
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Such is the tendency of the human mind to speculation, that on the least idea of an analogy between a few phenomena, it leaps forward, as it were, to a cause or law, to the temporary neglect of all the rest; so that, in fact, almost all our principal inductions must be regarded as a series of ascents and descents, and of conclusions from a few cases, verified by trial on many.
In A Preliminary Discourse on the Study of Natural Philosophy (1830), 164-165.
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The actual evolution of mathematical theories proceeds by a process of induction strictly analogous to the method of induction employed in building up the physical sciences; observation, comparison, classification, trial, and generalisation are essential in both cases. Not only are special results, obtained independently of one another, frequently seen to be really included in some generalisation, but branches of the subject which have been developed quite independently of one another are sometimes found to have connections which enable them to be synthesised in one single body of doctrine. The essential nature of mathematical thought manifests itself in the discernment of fundamental identity in the mathematical aspects of what are superficially very different domains. A striking example of this species of immanent identity of mathematical form was exhibited by the discovery of that distinguished mathematician … Major MacMahon, that all possible Latin squares are capable of enumeration by the consideration of certain differential operators. Here we have a case in which an enumeration, which appears to be not amenable to direct treatment, can actually be carried out in a simple manner when the underlying identity of the operation is recognised with that involved in certain operations due to differential operators, the calculus of which belongs superficially to a wholly different region of thought from that relating to Latin squares.
In Presidential Address British Association for the Advancement of Science, Sheffield, Section A, Nature (1 Sep 1910), 84, 290.
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The ancients devoted a lifetime to the study of arithmetic; it required days to extract a square root or to multiply two numbers together. Is there any harm in skipping all that, in letting the school boy learn multiplication sums, and in starting his more abstract reasoning at a more advanced point? Where would be the harm in letting the boy assume the truth of many propositions of the first four books of Euclid, letting him assume their truth partly by faith, partly by trial? Giving him the whole fifth book of Euclid by simple algebra? Letting him assume the sixth as axiomatic? Letting him, in fact, begin his severer studies where he is now in the habit of leaving off? We do much less orthodox things. Every here and there in one’s mathematical studies one makes exceedingly large assumptions, because the methodical study would be ridiculous even in the eyes of the most pedantic of teachers. I can imagine a whole year devoted to the philosophical study of many things that a student now takes in his stride without trouble. The present method of training the mind of a mathematical teacher causes it to strain at gnats and to swallow camels. Such gnats are most of the propositions of the sixth book of Euclid; propositions generally about incommensurables; the use of arithmetic in geometry; the parallelogram of forces, etc., decimals.
In Teaching of Mathematics (1904), 12.
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The difference between the amoeba and Einstein is that, although both make use of the method of trial and error elimination, the amoeba dislikes erring while Einstein is intrigued by it.
In Objective Knowledge: An Evolutionary Approach (1972), 70. As cited in Alexander Naraniecki, Returning to Karl Popper: A Reassessment of his Politics and Philosophy (2014), 89, footnote.
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The generalized theory of relativity has furnished still more remarkable results. This considers not only uniform but also accelerated motion. In particular, it is based on the impossibility of distinguishing an acceleration from the gravitation or other force which produces it. Three consequences of the theory may be mentioned of which two have been confirmed while the third is still on trial: (1) It gives a correct explanation of the residual motion of forty-three seconds of arc per century of the perihelion of Mercury. (2) It predicts the deviation which a ray of light from a star should experience on passing near a large gravitating body, the sun, namely, 1".7. On Newton's corpuscular theory this should be only half as great. As a result of the measurements of the photographs of the eclipse of 1921 the number found was much nearer to the prediction of Einstein, and was inversely proportional to the distance from the center of the sun, in further confirmation of the theory. (3) The theory predicts a displacement of the solar spectral lines, and it seems that this prediction is also verified.
Studies in Optics (1927), 160-1.
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The laws of nature, as we understand them, are the foundation of our knowledge in natural things. So much as we know of them has been developed by the successive energies of the highest intellects, exerted through many ages. After a most rigid and scrutinizing examination upon principle and trial, a definite expression has been given to them; they have become, as it were, our belief or trust. From day to day we still examine and test our expressions of them. We have no interest in their retention if erroneous. On the contrary, the greatest discovery a man could make would be to prove that one of these accepted laws was erroneous, and his greatest honour would be the discovery.
Experimental researches in chemistry and physics (1859), 469.
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The one lesson that comes out of all our theorizing and experimenting is that there is only one really scientific progressive method; and that is the method of trial and error.
…...
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The other experiment (which I shall hardly, I confess, make again, because it was cruel) was with a dog, which, by means of a pair of bellows, wherewith I filled his lungs, and suffered them to empty again, I was able to preserve alive as long as I could desire, after I had wholly opened the thorax, and cut off all the ribs, and opened the belly. Nay, I kept him alive above an hour after I had cut off the pericardium and the mediastinum, and had handled and turned his lungs and heart and all the other parts of its body, as I pleased. My design was to make some enquiries into the nature of respiration. But though I made some considerable discovery of the necessity of fresh air, and the motion of the lungs for the continuance of the animal life, yet I could not make the least discovery in this of what I longed for, which was, to see, if I could by any means discover a passage of the air of the lungs into either the vessels or the heart; and I shall hardly be induced to make any further trials of this kind, because of the torture of this creature: but certainly the enquiry would be very noble, if we could any way find a way so to stupify the creature, as that it might not be sensible.
Letter from Robert Hooke to Robert Boyle (10 Nov 1664). In M. Hunter, A. Clericuzio and L. M. Principe (eds.), The Correspondence of Robert Boyle (2001), Vol. 2, 399.
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The Reason of making Experiments is, for the Discovery of the Method of Nature, in its Progress and Operations. Whosoever, therefore doth rightly make Experiments, doth design to enquire into some of these Operations; and, in order thereunto, doth consider what Circumstances and Effects, in the Experiment, will be material and instructive in that Enquiry, whether for the confirming or destroying of any preconceived Notion, or for the Limitation and Bounding thereof, either to this or that Part of the Hypothesis, by allowing a greater Latitude and Extent to one Part, and by diminishing or restraining another Part within narrower Bounds than were at first imagin'd, or hypothetically supposed. The Method therefore of making Experiments by the Royal Society I conceive should be this.
First, To propound the Design and Aim of the Curator in his present Enquiry.
Secondly, To make the Experiment, or Experiments, leisurely, and with Care and Exactness.
Thirdly, To be diligent, accurate, and curious, in taking Notice of, and shewing to the Assembly of Spectators, such Circumstances and Effects therein occurring, as are material, or at least, as he conceives such, in order to his Theory .
Fourthly, After finishing the Experiment, to discourse, argue, defend, and further explain, such Circumstances and Effects in the preceding Experiments, as may seem dubious or difficult: And to propound what new Difficulties and Queries do occur, that require other Trials and Experiments to be made, in order to their clearing and answering: And farther, to raise such Axioms and Propositions, as are thereby plainly demonstrated and proved.
Fifthly, To register the whole Process of the Proposal, Design, Experiment, Success, or Failure; the Objections and Objectors, the Explanation and Explainers, the Proposals and Propounders of new and farther Trials; the Theories and Axioms, and their Authors; and, in a Word the history of every Thing and Person, that is material and circumstantial in the whole Entertainment of the said Society; which shall be prepared and made ready, fairly written in a bound Book, to be read at the Beginning of the Sitting of the Society: The next Day of their Meeting, then to be read over and further discoursed, augmented or diminished, as the Matter shall require, and then to be sign'd by a certain Number of the Persons present, who have been present, and Witnesses of all the said Proceedings, who, by Subscribing their names, will prove undoubted testimony to Posterity of the whole History.
'Dr Hooke's Method of Making Experiments' (1664-5). In W. Derham (ed.), Philosophical Experiments and Observations Of the Late Eminent Dr. Robert Hooke, F.R.S. And Geom. Prof. Gresh. and Other Eminent Virtuoso's in his Time (1726), 26-8.
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The republic has no need of scientists [savants].
Apocryphal remark; supposedly the judge’s reply to Lavoisier when he appealed at his trial for more time to complete his scientific work.
Cited in H. Guerlac, 'Lavoisier', in Charles Gillispie (ed.), Dictionary of Scientific Biography (1973), 8, 85. However, Jean-Pierre Poirier and Rebecca Balinski (trans.) in Lavoisier: Chemist, Biologist, Economist (1998), 379, says about the remark that “It is now known that the statement is apocryphal” [meaning it is of questionable authenticity], and that “Jean Noel Halle, in the name of the Advisory Board for Arts and Trades, had sent the judges a long report detailing the services Lavoisier had rendered to the Republic, but Coffinal [president of the Revolutionary Tribunal] had refused to acknowledge it.” Thus, Lavoisier was guillotined on 8 May 1794. Coffinhal was himself guillotined on 6 Aug 1794.
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The statistical method is required in the interpretation of figures which are at the mercy of numerous influences, and its object is to determine whether individual influences can be isolated and their effects measured. The essence of the method lies in the determination that we are really comparing like with like, and that we have not overlooked a relevant factor which is present in Group A and absent from Group B. The variability of human beings in their illnesses and in their reactions to them is a fundamental reason for the planned clinical trial and not against it.
Principles of Medical Statistics (1971), 13.
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There is, it appears, a conspiracy of scientists afoot. Their purpose is to break down religion, propagate immorality, and so reduce mankind to the level of brutes. They are the sworn and sinister agents of Beelzebub, who yearns to conquer the world, and has his eye especially upon Tennessee.
[Report on the Scopes Monkey Trial.]
Baltimore Evening Sun (11 Jul 1925). In H.L. Mencken, S. T. Joshi (Ed.), H.L. Mencken on Religion (2002), 178.
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Truth, like Gold, is not the less so, for being newly brought out of the Mine. ’Tis Trial and Examination must give it price, and not any antick Fashion: And though it be not yet current by the publick stamp; yet it may, for all that, be as old as Nature, and is certainly not the less genuine.
In 'The Epistle Dedicatory', Essay Concerning Human Understanding (1690), second unnumbered page.
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We are told that “Mathematics is that study which knows nothing of observation, nothing of experiment, nothing of induction, nothing of causation.” I think no statement could have been made more opposite to the facts of the case; that mathematical analysis is constantly invoking the aid of new principles, new ideas, and new methods, not capable of being defined by any form of words, but springing direct from the inherent powers and activities of the human mind, and from continually renewed introspection of that inner world of thought of which the phenomena are as varied and require as close attention to discern as those of the outer physical world (to which the inner one in each individual man may, I think, be conceived to stand somewhat in the same relation of correspondence as a shadow to the object from which it is projected, or as the hollow palm of one hand to the closed fist which it grasps of the other), that it is unceasingly calling forth the faculties of observation and comparison, that one of its principal weapons is induction, that it has frequent recourse to experimental trial and verification, and that it affords a boundless scope for the exercise of the highest efforts of the imagination and invention.
In Presidential Address to British Association, Exeter British Association Report (1869), pp. 1-9, in Collected Mathematical Papers, Vol. 2, 654.
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We know the laws of trial and error, of large numbers and probabilities. We know that these laws are part of the mathematical and mechanical fabric of the universe, and that they are also at play in biological processes. But, in the name of the experimental method and out of our poor knowledge, are we really entitled to claim that everything happens by chance, to the exclusion of all other possibilities?
From Nobel Prize Lecture (Dec 1974), 'The Coming Age of the Cell'. Collected in Jan Lindsten (ed.) Nobel Lectures, Physiology or Medicine 1971-1980 (1992).
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When Bonner writes that ‘natural selection for optimal feeding is then presumed to be the cause of non-motility in all forms,’ I can’t help suspecting that some plants might do even better if they could walk from shade to sun–but the inherited constraints of design never permitted a trial of this intriguing option.
…...
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When you're talking deaths in clinical trials, mistakes are not an option. It's just an area where we have to have absolute, foolproof reporting in place.
Stephanie Saul, 'U.S. Not Told of 2 Deaths During Study of Heart Drug ', New York Times (4 Jan 2006).
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[Modern science] passed through a long period of uncertainty and inconclusive experiment, but as the instrumental aids to research improved, and the results of observation accumulated, phantoms of the imagination were exorcised, idols of the cave were shattered, trustworthy materials were obtained for logical treatment, and hypotheses by long and careful trial were converted into theories.
In The Present Relations of Science and Religion (1913, 2004), 3
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Carl Sagan Thumbnail In science it often happens that scientists say, 'You know that's a really good argument; my position is mistaken,' and then they would actually change their minds and you never hear that old view from them again. They really do it. It doesn't happen as often as it should, because scientists are human and change is sometimes painful. But it happens every day. I cannot recall the last time something like that happened in politics or religion. (1987) -- Carl Sagan
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- 90 -
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