… our “Physick” and “Anatomy” have embraced such infinite varieties of being, have laid open such new worlds in time and space, have grappled, not unsuccessfully, with such complex problems, that the eyes of Vesalius and of Harvey might be dazzled by the sight of the tree that has grown out of their grain of mustard seed.

… There can be no doubt about faith and not reason being the ultima ratio. Even Euclid, who has laid himself as little open to the charge of credulity as any writer who ever lived, cannot get beyond this. He has no demonstrable first premise. He requires postulates and axioms which transcend demonstration, and without which he can do nothing. His superstructure indeed is demonstration, but his ground his faith. Nor again can he get further than telling a man he is a fool if he persists in differing from him. He says “which is absurd,” and declines to discuss the matter further. Faith and authority, therefore, prove to be as necessary for him as for anyone else.

... there is an external world which can in principle be exhaustively described in scientific language. The scientist, as both observer and language-user, can capture the external facts of the world in prepositions that are true if they correspond to the facts and false if they do not. Science is ideally a linguistic system in which true propositions are in one-to-one relation to facts, including facts that are not directly observed because they involve hidden entities or properties, or past events or far distant events. These hidden events are described in theories, and theories can be inferred from observation, that is the hidden explanatory mechnism of the world can be discovered from what is open to observation. Man as scientist is regarded as standing apart from the world and able to experiment and theorize about it objectively and dispassionately.

[1665-08-22] I went on a walk to Greenwich, on my way seeing a coffin with a dead body in it, dead of plague. It lay in an open yeard. ... It was carried there last night, and the parish has not told anyone to bury it. This disease makes us more cruel to one another than we are to dogs.

[1665-12-31] Thus ends this year ... It is true we have gone through great melancholy because of the great plague, and I put to great charges by it, by keeping my family long at Woolwich, and myself and another part of my family, my clerks, at my charge at Greenwich ... But now the plague is abated almost to nothing ... But many of such as I know very well, dead. Yet to our great joy, the town fills apace, and shops begin to open again. Pray God continue the plague's decrease - for that keeps the Court away from the place of business, and so all goes to wrack as to public matters, they at this distance not thinking of it.

[L]et us not overlook the further great fact, that not only does science underlie sculpture, painting, music, poetry, but that science is itself poetic. The current opinion that science and poetry are opposed is a delusion. … On the contrary science opens up realms of poetry where to the unscientific all is a blank. Those engaged in scientific researches constantly show us that they realize not less vividly, but more vividly, than others, the poetry of their subjects. Whoever will dip into Hugh Miller’s works on geology, or read Mr. Lewes's “Seaside Studies,” will perceive that science excites poetry rather than extinguishes it. And whoever will contemplate the life of Goethe will see that the poet and the man of science can co-exist in equal activity. Is it not, indeed, an absurd and almost a sacrilegious belief that the more a man studies Nature the less he reveres it? Think you that a drop of water, which to the vulgar eye is but a drop of water, loses anything in the eye of the physicist who knows that its elements are held together by a force which, if suddenly liberated, would produce a flash of lightning? Think you that what is carelessly looked upon by the uninitiated as a mere snow-flake, does not suggest higher associations to one who has seen through a microscope the wondrously varied and elegant forms of snow-crystals? Think you that the rounded rock marked with parallel scratches calls up as much poetry in an ignorant mind as in the mind of a geologist, who knows that over this rock a glacier slid a million years ago? The truth is, that those who have never entered upon scientific pursuits know not a tithe of the poetry by which they are surrounded. Whoever has not in youth collected plants and insects, knows not half the halo of interest which lanes and hedge-rows can assume. Whoever has not sought for fossils, has little idea of the poetical associations that surround the places where imbedded treasures were found. Whoever at the seaside has not had a microscope and aquarium, has yet to learn what the highest pleasures of the seaside are. Sad, indeed, is it to see how men occupy themselves with trivialities, and are indifferent to the grandest phenomena—care not to understand the architecture of the Heavens, but are deeply interested in some contemptible controversy about the intrigues of Mary Queen of Scots!—are learnedly critical over a Greek ode, and pass by without a glance that grand epic written by the finger of God upon the strata of the Earth!

[Advice to would-be trippers, simply:] Go to the meadows, go to the garden, go to the woods. Open your eyes!

[Describing the effects of over-indulgence in wine:]
But most too passive, when the blood runs low
Too weakly indolent to strive with pain,
And bravely by resisting conquer fate,
Try Circe's arts; and in the tempting bowl
Of poisoned nectar sweet oblivion swill.
Struck by the powerful charm, the gloom dissolves
In empty air; Elysium opens round,
A pleasing frenzy buoys the lightened soul,
And sanguine hopes dispel your fleeting care;
And what was difficult, and what was dire,
Yields to your prowess and superior stars:
The happiest you of all that e'er were mad,
Or are, or shall be, could this folly last.
But soon your heaven is gone: a heavier gloom
Shuts o'er your head; and, as the thundering stream,
Swollen o'er its banks with sudden mountain rain,
Sinks from its tumult to a silent brook,
So, when the frantic raptures in your breast
Subside, you languish into mortal man;
You sleep, and waking find yourself undone,
For, prodigal of life, in one rash night
You lavished more than might support three days.
A heavy morning comes; your cares return
With tenfold rage. An anxious stomach well
May be endured; so may the throbbing head;
But such a dim delirium, such a dream,
Involves you; such a dastardly despair
Unmans your soul, as maddening Pentheus felt,
When, baited round Citheron's cruel sides,
He saw two suns, and double Thebes ascend.

Natura non facit saltum or, Nature does not make leaps… If you assume continuity, you can open the well-stocked mathematical toolkit of continuous functions and differential equations, the saws and hammers of engineering and physics for the past two centuries (and the foreseeable future).

1122 … Thereafter there were many sailors on the sea and on inland water who said that they had seen a great and extensive fire near the ground in the northeast which continuously increased in width as it mounted to the sky. And the heavens opened into four parts and fought against it as if determined to put it out, and the fire stopped rising upwards. They saw that fire at the first streak of dawn, and it lasted until full daylight: this happened on 7 December.

A bird maintains itself in the air by imperceptible balancing, when near to the mountains or lofty ocean crags; it does this by means of the curves of the winds which as they strike against these projections, being forced to preserve their first impetus bend their straight course towards the sky with divers revolutions, at the beginning of which the birds come to a stop with their wings open, receiving underneath themselves the continual buffetings of the reflex courses of the winds.

A body of work such as Pasteur’s is inconceivable in our time: no man would be given a chance to create a whole science. Nowadays a path is scarcely opened up when the crowd begins to pour in.

A celebrated medical lecturer began one day “Fumigations, gentlemen, are of essential importance. They make such an abominable smell that they compel you to open the window.” I wish all the disinfecting fluids invented made such an “abominable smell” that they forced you to admit fresh air. That would be a useful invention.

A great department of thought must have its own inner life, however transcendent may be the importance of its relations to the outside. No department of science, least of all one requiring so high a degree of mental concentration as Mathematics, can be developed entirely, or even mainly, with a view to applications outside its own range. The increased complexity and specialisation of all branches of knowledge makes it true in the present, however it may have been in former times, that important advances in such a department as Mathematics can be expected only from men who are interested in the subject for its own sake, and who, whilst keeping an open mind for suggestions from outside, allow their thought to range freely in those lines of advance which are indicated by the present state of their subject, untrammelled by any preoccupation as to applications to other departments of science. Even with a view to applications, if Mathematics is to be adequately equipped for the purpose of coping with the intricate problems which will be presented to it in the future by Physics, Chemistry and other branches of physical science, many of these problems probably of a character which we cannot at present forecast, it is essential that Mathematics should be allowed to develop freely on its own lines.

A great invention for dieters would be a refrigerator which weighs you every time you open the door.

A linguist would be shocked to learn that if a set is not closed this does not mean that it is open, or again that “E is dense in E” does not mean the same thing as “E is dense in itself”.

A work of genius is something like the pie in the nursery song, in which the four and twenty blackbirds are baked. When the pie is opened, the birds begin to sing. Hereupon three fourths of the company run away in a fright; and then after a time, feeling ashamed, they would fain excuse themselves by declaring, the pie stank so, they could not sit near it. Those who stay behind, the men of taste and epicures, say one to another, We came here to eat. What business have birds, after they have been baked, to be alive and singing? This will never do. We must put a stop to so dangerous an innovation: for who will send a pie to an oven, if the birds come to life there? We must stand up to defend the rights of all the ovens in England. Let us have dead birds..dead birds for our money. So each sticks his fork into a bird, and hacks and mangles it a while, and then holds it up and cries, Who will dare assert that there is any music in this bird’s song?

According to the older view, for every single effect of a serum, there was a separate substance, or at least a particular chemical group... A normal serum contained as many different haemagglutinins as it agglutinated different cells. The situation was undoubtedly made much simpler if, to use the Ehrlich terminology... the separate haptophore groups can combine with an extremely large number of receptors in stepwise differing quantities as a stain does with different animal tissues, though not always with the same intensity. A normal serum would therefore visibly affect such a large number of different blood cells... not because it contained countless special substances, but because of the colloids of the serum, and therefore of the agglutinins by reason of their chemical constitution and the electrochemical properties resulting from it. That this manner of representation is a considerable simplification is clear; it also opens the way to direct experimental testing by the methods of structural chemistry.

All change is relative. The universe is expanding relatively to our common material standards; our material standards are shrinking relatively to the size of the universe. The theory of the “expanding universe” might also be called the theory of the “shrinking atom”. …
:Let us then take the whole universe as our standard of constancy, and adopt the view of a cosmic being whose body is composed of intergalactic spaces and swells as they swell. Or rather we must now say it keeps the same size, for he will not admit that it is he who has changed. Watching us for a few thousand million years, he sees us shrinking; atoms, animals, planets, even the galaxies, all shrink alike; only the intergalactic spaces remain the same. The earth spirals round the sun in an ever-decreasing orbit. It would be absurd to treat its changing revolution as a constant unit of time. The cosmic being will naturally relate his units of length and time so that the velocity of light remains constant. Our years will then decrease in geometrical progression in the cosmic scale of time. On that scale man’s life is becoming briefer; his threescore years and ten are an ever-decreasing allowance. Owing to the property of geometrical progressions an infinite number of our years will add up to a finite cosmic time; so that what we should call the end of eternity is an ordinary finite date in the cosmic calendar. But on that date the universe has expanded to infinity in our reckoning, and we have shrunk to nothing in the reckoning of the cosmic being.
We walk the stage of life, performers of a drama for the benefit of the cosmic spectator. As the scenes proceed he notices that the actors are growing smaller and the action quicker. When the last act opens the curtain rises on midget actors rushing through their parts at frantic speed. Smaller and smaller. Faster and faster. One last microscopic blurr of intense agitation. And then nothing.

All people dream, but not equally. Those who dream by night in the dusty recesses of their mind, wake in the morning to find that it was vanity. But the dreamers of the day are dangerous people, for they dream their dreams with open eyes, and make them come true.

Although I was four years at the University [of Wisconsin], I did not take the regular course of studies, but instead picked out what I thought would be most useful to me, particularly chemistry, which opened a new world, mathematics and physics, a little Greek and Latin, botany and and geology. I was far from satisfied with what I had learned, and should have stayed longer.
[Enrolled in Feb 1861, left in 1863 without completing a degree, and began his first botanical foot journey.]

Although the cooking of food presents some unsolved problems, the quick warming of cooked food and the thawing of frozen food both open up some attractive uses. ... There is no important reason why the the housewife of the future should not purchase completely frozen meals at the grocery store just as she buys quick frozen vegetables. With a quick heating, high-frequency unit in her kitchen, food preparation from a pre-cooked, frozen meal becomes a simple matter.
[Predicting home kitchen appliances could be developed from the radionic tube employed to jam enemy radar in World War II.]

An old Scotch physician, for whom I had a great respect, and whom I frequently met professionally in the city, used to say, as we were entering the patient's room together, 'Weel, Mister Cooper, we ha' only twa things to keep in meend, and they'll searve us for here and herea'ter; one is always to have the fear of the Laird before our ees; that 'ill do for herea'ter; and t'other is to keep your booels open, and that will do for here.'

And as for other men, who worked in tank-rooms full of steam, and in some of which there were open vats near the level of the floor, their peculiar trouble was that they fell into the vats; and when they were fished out, there was never enough of them left to be worth exhibiting,—sometimes they would be overlooked for days, till all but the bones of them had gone out into the world as Durham's Pure Leaf Lard! This contributed to the passing of the Pure Food Act of 1906.

Apart from its healthful mental training as a branch of ordinary education, geology as an open-air pursuit affords an admirable training in habits of observation, furnishes a delightful relief from the cares and routine of everyday life, takes us into the open fields and the free fresh face of nature, leads us into all manner of sequestered nooks, whither hardly any other occupation or interest would be likely to send us, sets before us problems of the highest interest regarding the history of the ground beneath our feet, and thus gives a new charm to scenery which may be already replete with attractions.

As long as vitalism and spiritualism are open questions so long will the gateway of science be open to mysticism.

As you sit on the hillside, or lie prone under the trees of the forest, or sprawl wet-legged on the shingly beach of a mountain stream, the great door, that does not look like a door, opens.

Astronomers have built telescopes which can show myriads of stars unseen before; but when a man looks through a tear in his own eye, that is a lens which opens reaches into the unknown, and reveals orbs which no telescope, however skilfully constructed, could do.

At the end of 1854 … the aggregate length of railways opened in Great Britain and Ireland at that time measured about 8,054 miles,—about the diameter of the globe, and nearly 500 miles more than the united lengths of the Thames, the Seine, the Rhone, the Ebro, the Tagus, the Rhine, the Elbe, the Vistula, the Dnieper, and the Danube, or the ten chief rivers of Europe. … the work of only twenty-five years.

At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.

At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.

At this stage you must admit that whatever is seen to be sentient is nevertheless composed of atoms that are insentient. The phenomena open to our observation so not contradict this conclusion or conflict with it. Rather they lead us by the hand and compel us to believe that the animate is born, as I maintain, of the insentient.

Attention makes the genius; all learning, fancy, and science depend on it. Newton traced back his discoveries to its unwearied employment. It builds bridges, opens new worlds, and heals diseases; without it Taste is useless, and the beauties of literature are unobserved; as the rarest flowers bloom in vain, if the eye be not fixed upon the bed.

Be not afeard.
The isle is full of noises,
Sounds, and sweet airs, that give delight and hurt not.
Sometimes a thousand twangling instruments
Will hum about mine ears; and sometime voices
That if I then had waked after long sleep
Will make me sleep again; and then, in dreaming
The clouds methought would open and show riches
Ready to drop upon me, that, when I waked,
I cried to dream again.

Break the chains of your prejudices and take up the torch of experience, and you will honour nature in the way she deserves, instead of drawing derogatory conclusions from the ignorance in which she has left you. Simply open your eyes and ignore what you cannot understand, and you will see that a labourer whose mind and knowledge extend no further than the edges of his furrow is no different essentially from the greatest genius, as would have been proved by dissecting the brains of Descartes and Newton; you will be convinced that the imbecile or the idiot are animals in human form, in the same way as the clever ape is a little man in another form; and that, since everything depends absolutely on differences in organisation, a well-constructed animal who has learnt astronomy can predict an eclipse, as he can predict recovery or death when his genius and good eyesight have benefited from some time at the school of Hippocrates and at patients' bedsides.

Chlorine is a poisonous gas. In case I should fall over unconscious in the following demonstration involving chlorine, please pick me up and carry me into the open air. Should this happen, the lecture for the day will be concluded.

Civilization no longer needs to open up wilderness; it needs wilderness to help open up the still largely unexplored human mind.

Conquest has explored more than ever curiosity has done; and the path for science has been commonly opened by the sword.

Definition of Mathematics.—It has now become apparent that the traditional field of mathematics in the province of discrete and continuous number can only be separated from the general abstract theory of classes and relations by a wavering and indeterminate line. Of course a discussion as to the mere application of a word easily degenerates into the most fruitless logomachy. It is open to any one to use any word in any sense. But on the assumption that “mathematics” is to denote a science well marked out by its subject matter and its methods from other topics of thought, and that at least it is to include all topics habitually assigned to it, there is now no option but to employ “mathematics” in the general sense of the “science concerned with the logical deduction of consequences from the general premisses of all reasoning.”

Describing laughter: The sound is produced by a deep inspiration followed by short, interrupted, spasmodic contractions of the chest, and especially the diaphragm... the mouth is open more or less widely, with the corners drawn much backwards, as well as a little upwards; and the upper lip is somewhat raised.

Direct observation of the testimony of the earth … is a matter of the laboratory, of the field naturalist, of indefatigable digging among the ancient archives of the earth’s history. If Mr. Bryan, with an open heart and mind, would drop all his books and all the disputations among the doctors and study first hand the simple archives of Nature, all his doubts would disappear; he would not lose his religion; he would become an evolutionist.

Discoveries that are anticipated are seldom the most valuable. … It’s the scientist free to pilot his vessel across hidden shoals into open seas who gives the best value.

During the half-century that has elapsed since the enunciation of the cell-theory by Schleiden and Schwann, in 1838-39, it has became ever more clearly apparent that the key to all ultimate biological problems must, in the last analysis, be sought in the cell. It was the cell-theory that first brought the structure of plants and animals under one point of view by revealing their common plan of organization. It was through the cell-theory that Kolliker and Remak opened the way to an understanding of the nature of embryological development, and the law of genetic continuity lying at the basis of inheritance. It was the cell-­theory again which, in the hands of Virchaw and Max Schultze, inaugurated a new era in the history of physiology and pathology, by showing that all the various functions of the body, in health and in disease, are but the outward expression of cell­-activities. And at a still later day it was through the cell-theory that Hertwig, Fol, Van Beneden, and Strasburger solved the long-standing riddle of the fertilization of the egg, and the mechanism of hereditary transmission. No other biological generalization, save only the theory of organic evolution, has brought so many apparently diverse phenomena under a common point of view or has accomplished more far the unification of knowledge. The cell-theory must therefore be placed beside the evolution-theory as one of the foundation stones of modern biology.

Even if the open windows of science at first make us shiver after the cozy indoor warmth of traditional humanizing myths, in the end the fresh air brings vigor, and the great spaces have a splendor of their own.

Ever so often in the history of human endeavour, there comes a breakthrough that takes humankind across a frontier into a new era. ... today's announcement is such a breakthrough, a breakthrough that opens the way for massive advancement in the treatment of cancer and hereditary diseases. And that is only the beginning.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Every discovery opens a new field for investigation of facts, shows us the imperfection of our theories. It has justly been said, that the greater the circle of light, the greater the boundary of darkness by which it is surrounded.

Every great advance of science opens our eyes to facts which we had failed before to observe, and makes new demands on our powers of interpretation.

Every progress that a church makes in the construction of its dogmas leads to a further taming of the free spirit; every new dogma … narrows the circle of free thought. … Science, on the other hand, liberates with every step of its development, it opens up new paths to thought … In other words, it allows the individual to be truly free.

Extremely hazardous is the desire to explain everything, and to supply whatever appears a gap in history—for in this propensity lies the first cause and germ of all those violent and arbitrary hypotheses which perplex and pervert the science of history far more than the open avowal of our ignorance, or the uncertainty of our knowledge: hypotheses which give an oblique direction, or an exaggerated and false extension, to a view of the subject originally not incorrect.

False facts are highly injurious to the progress of science, for they often long endure; but false views, if supported by some evidence, do little harm, as every one takes a salutary pleasure in proving their falseness; and when this is done, one path towards error is closed and the road to truth is often at the same time opened.

Few will deny that even in the first scientific instruction in mathematics the most rigorous method is to be given preference over all others. Especially will every teacher prefer a consistent proof to one which is based on fallacies or proceeds in a vicious circle, indeed it will be morally impossible for the teacher to present a proof of the latter kind consciously and thus in a sense deceive his pupils. Notwithstanding these objectionable so-called proofs, so far as the foundation and the development of the system is concerned, predominate in our textbooks to the present time. Perhaps it will be answered, that rigorous proof is found too difficult for the pupil’s power of comprehension. Should this be anywhere the case,—which would only indicate some defect in the plan or treatment of the whole,—the only remedy would be to merely state the theorem in a historic way, and forego a proof with the frank confession that no proof has been found which could be comprehended by the pupil; a remedy which is ever doubtful and should only be applied in the case of extreme necessity. But this remedy is to be preferred to a proof which is no proof, and is therefore either wholly unintelligible to the pupil, or deceives him with an appearance of knowledge which opens the door to all superficiality and lack of scientific method.

Firefly meteorites blazed against a dark background, and sometimes the lightning was frighteningly brilliant. Like a boy, I gazed open-mouthed at the fireworks, and suddenly, before my eyes, something magical occurred. A greenish radiance poured from Earth directly up to the station, a radiance resembling gigantic phosphorescent organ pipes, whose ends were glowing crimson, and overlapped by waves of swirling green mist.
“Consider yourself very lucky, Vladimir,” I said to myself, “to have watched the northern lights.”

For colic, get the bowels open.

For if as scientists we seek simplicity, then obviously we try the simplest surviving theory first, and retreat from it only when it proves false. Not this course, but any other, requires explanation. If you want to go somewhere quickly, and several alternate routes are equally likely to be open, no one asks why you take the shortest. The simplest theory is to be chosen not because it is the most likely to be true but because it is scientifically the most rewarding among equally likely alternatives. We aim at simplicity and hope for truth.

For more than ten years, my theory was in limbo. Then, finally, in the late 1980s, physicists at Princeton said, “There’s nothing wrong with this theory. It’s the only one that works, and we have to open out minds to hyperspace.” We weren’t destined to discover this theory for another 100 years because it’s so bizarre, so different from everything we’d been doing. We didn’t use the normal sequence of discoveries to get to it.
Describing reaction to his superstring theory of hyperspace which mathematically relates the universe’s basic forces.

For the most part we humans live with the false impression of security and a feeling of being at home in a seemingly trustworthy physical and human environment. But when the expected course of everyday life is interrupted, we are like shipwrecked people on a miserable plank in the open sea, having forgotten where they came from and not knowing whither they are drifting. But once we fully accept this, life becomes easier and there is no longer any disappointment.

Fortunate Newton…! Nature to him was an open book, whose letters he could read without effort.

Gardner writes about various kinds of cranks with the conscious superiority of the scientist…. He asserts that the scientist, unlike the crank, does his best to remain open-minded, so how can he be so sure that no sane person has ever seen a flying saucer…? … A.J. Ayer once remarked wryly “I wish I was as certain of anything as he seems to be about everything”.

Given one has before oneself a strong, healthy, youth rich in spirited blood and a powerless, weak, cachectic old man scarcely capable of breathing. If now the physician wishes to practise the rejuvenating art on the latter, he should make silver tubes which fit into each other: open then the artery of the healthy person and introduce one of the tubes into it and fasten it into the artery; thereupon he opens also the artery of the ill person...
[First detailed description of blood transfusion (1615)]

God is love… . We wouldn’t recognize that love. It might even look like hate. It would be enough to scare us—God’s love. It set fire to a bush in the desert, didn’t it, and smashed open graves and set the dead walking in the dark.

Half a century ago Oswald (1910) distinguished classicists and romanticists among the scientific investigators: the former being inclined to design schemes and to use consistently the deductions from working hypotheses; the latter being more fit for intuitive discoveries of functional relations between phenomena and therefore more able to open up new fields of study. Examples of both character types are Werner and Hutton. Werner was a real classicist. At the end of the eighteenth century he postulated the theory of “neptunism,” according to which all rocks including granites, were deposited in primeval seas. It was an artificial scheme, but, as a classification system, it worked quite satisfactorily at the time. Hutton, his contemporary and opponent, was more a romanticist. His concept of “plutonism” supposed continually recurrent circuits of matter, which like gigantic paddle wheels raise material from various depths of the earth and carry it off again. This is a very flexible system which opens the mind to accept the possible occurrence in the course of time of a great variety of interrelated plutonic and tectonic processes.

Half the joy of life is in little things taken on the run… but let us keep our hearts young and our eyes open that nothing worth our while shall escape us. That nothing worth our while shall escape us. And everything is worth its while if we only grasp it and its significance.

He was 40 yeares old before he looked on Geometry; which happened accidentally. Being in a Gentleman's Library, Euclid's Elements lay open, and 'twas the 47 El. Libri 1 [Pythagoras' Theorem]. He read the proposition. By G-, sayd he (he would now and then sweare an emphaticall Oath by way of emphasis) this is impossible! So he reads the Demonstration of it, which referred him back to such a Proposition; which proposition he read. That referred him back to another, which he also read. Et sic deinceps [and so on] that at last he was demonstratively convinced of that trueth. This made him in love with Geometry .
Of Thomas Hobbes, in 1629.

He who opens a school door, closes a prison.

He who works with the door open gets all kinds of interruptions, but he also occasionally gets clues as to what the world is and what might be important.

Here I am: My brain is open.
[As an itinerant scholar, this was greeting he often gave, ready to collaborate, upon arrival at the home of any mathematician colleague.]

His subject is the “Origin of Species,” & not the origin of Organization; & it seems a needless mischief to have opened the latter speculation at all.

Holding then to science with one hand—the left hand—we give the right hand to religion, and cry: ‘Open Thou mine eyes, that I may behold wondrous things, more wondrous than the shining worlds can tell.’ Obedient to the promise, religion does awaken faculties within us, does teach our eyes to the beholding of more wonderful things. Those great worlds blazing like suns die like feeble stars in the glory of the morning, in the presence of this new light. The soul knows that an infinite sea of love is all about it, throbbing through it, everlasting arms of affection lift it, and it bathes itself in the clear consciousness of a Father’s love.

How do we discover the individual laws of Physics, and what is their nature? It should be remarked, to begin with, that we have no right to assume that any physical law exists, or if they have existed up to now, that they will continue to exist in a similar manner in the future. It is perfectly conceivable that one fine day Nature should cause an unexpected event to occur which would baffle us all; and if this were to happen we would be powerless to make any objection, even if the result would be that, in spite of our endeavors, we should fail to introduce order into the resulting confusion. In such an event, the only course open to science would be to declare itself bankrupt. For this reason, science is compelled to begin by the general assumption that a general rule of law dominates throughout Nature.

How doth the little busy bee
Improve each shining hour,
And gather honey all the day
From every opening flower.

How twins are born my discourse will explain thus. The cause is chiefly the nature of the womb in woman. For if it has grown equally on either side of its mouth, and if it opens equally, and also dries equally after menstruation, it can give nourishment, if it conceive the secretion of the man so that it immediately divides into both parts of the womb equally. Now if the seed secreted from both parents be abundant and strong, it can grow in both places, as it masters the nourishment that reaches it. In all other cases twins are not formed. Now when the secretion from both parents is male, of necessity boys are begotten in both places; but when from both it is female, girls are begotten. But when one secretion is female and the other male, whichever masters the other gives the embryo its sex. Twins are like one another for the following reasons. First, the places are alike in which they grow; then they were secreted together; then they grow by the same nourishment, and at birth they reach together the light of day.

I … share an excitement and a certain pride in the wonders opened up by scientific investigation …, and also a recognition of the value in scientific method of keeping the hypotheses as simple as possible—my Oxford tutor gave me a great respect for Occam’s razor.

I accepted the Copernican position several years ago and discovered from thence the causes of many natural effects which are doubtless inexplicable by the current theories. I have written up many reasons and refutations on the subject, but I have not dared until now to bring them into the open, being warned by the fortunes of Copernicus himself, our master, who procured for himself immortal fame among a few but stepped down among the great crowd (for this is how foolish people are to be numbered), only to be derided and dishonoured. I would dare publish my thoughts if there were many like you; but since there are not, I shall forbear.

I argued that it was important not to place too much reliance on any single piece of experimental evidence. It might turn out to be misleading, as the 5.1 Å reflection undoubtedly was. Jim was a little more brash, stating that no good model ever accounted for all the facts, since some data was bound to be misleading if not plain wrong. A theory that did fit all the data would have been “carpentered” to do so and would thus be open to suspicion.

I became expert at dissecting crayfish. At one point I had a crayfish claw mounted on an apparatus in such a way that I could operate the individual nerves. I could get the several-jointed claw to reach down and pick up a pencil and wave it around. I am not sure that what I was doing had much scientific value, although I did learn which nerve fiber had to be excited to inhibit the effects of another fiber so that the claw would open. And it did get me interested in robotic instrumentation, something that I have now returned to. I am trying to build better micromanipulators for surgery and the like.

I believe that life can go on forever. It takes a million years to evolve a new species, ten million for a new genus, one hundred million for a class, a billion for a phylum—and that’s usually as far as your imagination goes. In a billion years, it seems, intelligent life might be as different from humans as humans are from insects. But what would happen in another ten billion years? It’s utterly impossible to conceive of ourselves changing as drastically as that, over and over again. All you can say is, on that kind of time scale the material form that life would take is completely open. To change from a human being to a cloud may seem a big order, but it’s the kind of change you’d expect over billions of years.

I came by the horror naturally. Surgery is the one branch of medicine that is the most violent. After all, it’s violent to take up a knife and cut open a person’s body and rummage around with your hands. I think I was attracted to the horrific.

I came into the room, which was half dark, and presently spotted Lord Kelvin in the audience and realised that I was in for trouble at the last part of my speech dealing with the age of the earth, where my views conflicted with his. To my relief, Kelvin fell fast asleep, but as I came to the important point, I saw the old bird sit up, open an eye and cock a baleful glance at me! Then a sudden inspiration came, and I said Lord Kelvin had limited the age of the earth, provided no new source was discovered. That prophetic utterance refers to what we are now considering tonight, radium! Behold! the old boy beamed upon me.

I devoted myself to studying the texts—the original and commentaries—in the natural sciences and metaphysics, and the gates of knowledge began opening for me. Next I sought to know medicine, and so read the books written on it. Medicine is not one of the difficult sciences, and therefore, I excelled in it in a very short time, to the point that distinguished physicians began to read the science of medicine under me. I cared for the sick and there opened to me some of the doors of medical treatment that are indescribable and can be learned only from practice. In addition I devoted myself to jurisprudence and used to engage in legal disputations, at that time being sixteen years old.

I discovered that Johns Hopkins [University] was a lot like Bell Labs, where the doors were always open and we were free to collaborate with researchers in other disciplines. I like the fact that I won’t be locked into one small niche here.

I do not forget that Medicine and Veterinary practice are foreign to me. I desire judgment and criticism upon all my contributions. Little tolerant of frivolous or prejudiced contradiction, contemptuous of that ignorant criticism which doubts on principle, I welcome with open arms the militant attack which has a method of doubting and whose rule of conduct has the motto “More light.”

I find that most men would rather have their bellies opened for five hundred dollars than have a tooth pulled for five.

I grew up in Brooklyn, New York … a city neighborhood that included houses, lampposts, walls, and bushes. But with an early bedtime in the winter, I could look out my window and see the stars, and the stars were not like anything else in my neighborhood. [At age 5] I didn’t know what they were.
[At age 9] my mother … said to me, “You have a library card now, and you know how to read. Take the streetcar to the library and get a book on stars.” … I stepped up to the big librarian and asked for a book on stars. … I sat down and found out the answer, which was something really stunning.
I found out that the stars are glowing balls of gas. I also found out that the Sun is a star but really close and that the stars are all suns except really far away I didn’t know any physics or mathematics at that time, but I could imagine how far you’d have to move the Sun away from us till it was only as bright as a star. It was in that library, reading that book, that the scale of the universe opened up to me. There was something beautiful about it.
At that young age, I already knew that I’d be very happy if I could devote my life to finding out more about the stars and the planets that go around them. And it’s been my great good fortune to do just that.

I had at one time a very bad fever of which I almost died. In my fever I had a long consistent delirium. I dreamt that I was in Hell, and that Hell is a place full of all those happenings that are improbable but not impossible. The effects of this are curious. Some of the damned, when they first arrive below, imagine that they will beguile the tedium of eternity by games of cards. But they find this impossible, because, whenever a pack is shuffled, it comes out in perfect order, beginning with the Ace of Spades and ending with the King of Hearts. There is a special department of Hell for students of probability. In this department there are many typewriters and many monkeys. Every time that a monkey walks on a typewriter, it types by chance one of Shakespeare's sonnets. There is another place of torment for physicists. In this there are kettles and fires, but when the kettles are put on the fires, the water in them freezes. There are also stuffy rooms. But experience has taught the physicists never to open a window because, when they do, all the air rushes out and leaves the room a vacuum.

I happen to have discovered a direct relation between magnetism and light, also electricity and light, and the field it opens is so large and I think rich.

I have always attached great importance to the manner in which an experiment is set up and conducted ... the experiment should be set up to open as many windows as possible on the unforeseen.

I have been arranging certain experiments in reference to the notion that Gravity itself may be practically and directly related by experiment to the other powers of matter and this morning proceeded to make them. It was almost with a feeling of awe that I went to work, for if the hope should prove well founded, how great and mighty and sublime in its hitherto unchangeable character is the force I am trying to deal with, and how large may be the new domain of knowledge that may be opened up to the mind of man.

I hear the scream of a great hawk, sailing with a ragged wing against the high wood-side, apparently to scare his prey and so detect it—shrill, harsh, fitted to excite terror in sparrows and to issue from his split and curved bill. I see his open bill the while against the sky. Spit with force from his mouth with an undulatory quaver imparted to it from his wings or motion as he flies.

I know with sure and certain knowledge that a man’s work is nothing but this slow trek to rediscover, through the detours of art, those two or three great and simple images in whose presence his heart first opened.

I like the scientific spirit—the holding off, the being sure but not too sure, the willingness to surrender ideas when the evidence is against them: this is ultimately fine—it always keeps the way beyond open.

I like to tell students that the jobs I took [at NASA] after my Ph.D. were not in existence only a few years before. New opportunities can open up for you in this ever changing field.

I purpose, in return for the honour you do us by coming to see what are our proceedings here, to bring before you, in the course of these lectures, the Chemical History of a Candle. I have taken this subject on a former occasion; and were it left to my own will, I should prefer to repeat it almost every year—so abundant is the interest that attaches itself to the subject, so wonderful are the varieties of outlet which it offers into the various departments of philosophy. There is not a law under which any part of this universe is governed which does not come into play, and is touched upon in these phenomena. There is no better, there is no more open door by which you can enter the study of natural philosophy, than by considering the physical phenomena of a candle.

I should object to any experimentation which can justly be called painful, for the purpose of elementary instruction ... [but I regret] a condition of the law which permits a boy to troll for pike, or set lines with live frog bait, for idle amusement; and, at the same time, lays the teacher of that boy open to the penalty of fine and imprisonment, if he uses the same animal for the purpose of exhibiting one of the most beautiful and instructive of physiological spectacles, the circulation in the web of the foot. ... [Maybe the frog is] inconvenienced by being wrapped up in a wet rag, and having his toes tied out ... But you must not inflict the least pain on a vertebrated animal for scientific purposes (though you may do a good deal in that way for gain or for sport) without due licence of the Secretary of State for the Home Department, granted under the authority of the Vivisection Act.
... [Yet, in] 1877, two persons may be charged with cruelty to animals. One has impaled a frog, and suffered the creature to writhe about in that condition for hours; the other has pained the animal no more than one of us would be pained by tying strings round his fingers, and keeping him in the position of a hydropathic patient. The first offender says, 'I did it because I find fishing very amusing,' and the magistrate bids him depart in peace; nay, probably wishes him good sport. The second pleads, 'I wanted to impress a scientific truth, with a distinctness attainable in no other way, on the minds of my scholars,' and the magistrate fines him five pounds.
I cannot but think that this is an anomalous and not wholly creditable state of things.

I think at the moment we did not even want to break the seal [on the inner chamber of the tomb of Tutankhamen], for a feeling of intrusion had descended heavily upon us... We felt that we were in the presence of the dead King and must do him reverence, and in imagination could see the doors of the successive shrines open one.

I will build a motor car for the great multitude … constructed of the best materials, by the best men to be hired, after the simplest designs that modern engineering can devise … so low in price that no man making a good salary will be unable to own one—and enjoy with his family the blessing of pleasure in God’s great open spaces.

I would rather see the behavior of one white rat observed carefully from the moment of birth until death than to see a large volume of accurate statistical data on how 2,000 rats learned to open a puzzle box.

I write to discover what I think. After all, the bars aren’t open that early.

I’m saying that the leaders of the church have locked the sacred cow called science in the stable and they won’t let anybody enter; they should open it immediately so that we can milk that cow in the name of humanity and thus find the truth.

I’ve learned that whenever I decide something with an open heart, I usually make the right decision.

If a physician make a large incision with an operating knife and cure it, or if he open a tumor (over the eye) with an operating knife, and saves the eye, he shall receive ten shekels in money. …
If a physician make a large incision with an operating knife, and kill him, or open a tumor with an operating knife, and cut out the eye, his hands shall be cut off. ...
If a physician heal the broken bone or diseased soft part of a man, the patient shall pay the physician five shekels in money.
[The Code of Hammurabi (a king of ancient Babylon), the earliest well-preserved ancient law code, circa 1760 B.C.]

If I had a screwdriver and a pair of pliers, anything that could be opened was in danger. I had this need to know what was inside.

If physical science is dangerous, as I have said, it is dangerous because it necessarily ignores the idea of moral evil; but literature is open to the more grievous imputation of recognizing and understanding it too well.

If the juices of the body were more chymically examined, especially by a naturalist, that knows the ways of making fixed bodies volatile, and volatile fixed, and knows the power of the open air in promoting the former of those operations; it is not improbable, that both many things relating to the nature of the humours, and to the ways of sweetening, actuating, and otherwise altering them, may be detected, and the importance of such discoveries may be discerned.

If the matter is one that can be settled by observation, make the observation yourself. Aristotle could have avoided the mistake of thinking that women have fewer teeth than men, by the simple device of asking Mrs. Aristotle to keep her mouth open while he counted.

If this fire determined by the sun, be received on the blackest known bodies, its heat will be long retain'd therein; and hence such bodies are the soonest and the strongest heated by the flame fire, as also the quickest dried, after having been moisten'd with water; and it may be added, that they also burn by much the readiest: all which points are confirm'd by daily observations. Let a piece of cloth be hung in the air, open to the sun, one part of it dyed black, another part of a white colour, others of scarlet, and diverse other colours; the black part will always be found to heat the most, and the quickest of all; and the others will each be found to heat more slowly, by how much they reflect the rays more strongly to the eye; thus the white will warm the slowest of them all, and next to that the red, and so of the rest in proportion, as their colour is brighter or weaker.

Immediately after the separation of the formative materials into the two layers of the germ-primule, there appears in the ectoderm a groove, open above, at the bottom of which is a streak of darker tissue.

In addition to this it [mathematics] provides its disciples with pleasures similar to painting and music. They admire the delicate harmony of the numbers and the forms; they marvel when a new discovery opens up to them an unexpected vista; and does the joy that they feel not have an aesthetic character even if the senses are not involved at all? … For this reason I do not hesitate to say that mathematics deserves to be cultivated for its own sake, and I mean the theories which cannot be applied to physics just as much as the others.

In attempting to discover how much blood passes from the veins into the arteries I made dissections of living animals, opened up arteries in them, and carried out various other investigations. I also considered the symmetry and size of the ventricles of the heart and of the vessels which enter and leave them (since Nature, who does nothing purposelessly, would not purposelessly have given these vessels such relatively large size). I also recalled the elegant and carefully contrived valves and fibres and other structural artistry of the heart; and many other points. I considered rather often and with care all this evidence, and took correspondingly long trying to assess how much blood was transmitted and in how short a time. I also noted that the juice of the ingested food could not supply this amount without our having the veins, on the one hand, completely emptied and the arteries, on the other hand, brought to bursting through excessive inthrust of blood, unless the blood somehow flowed back again from the arteries into the veins and returned to the right ventricle of the heart. In consequence, I began privately to consider that it had a movement, as it were, in a circle.

In early times, when the knowledge of nature was small, little attempt was made to divide science into parts, and men of science did not specialize. Aristotle was a master of all science known in his day, and wrote indifferently treatises on physics or animals. As increasing knowledge made it impossible for any one man to grasp all scientific subjects, lines of division were drawn for convenience of study and of teaching. Besides the broad distinction into physical and biological science, minute subdivisions arose, and, at a certain stage of development, much attention was, given to methods of classification, and much emphasis laid on the results, which were thought to have a significance beyond that of the mere convenience of mankind.
But we have reached the stage when the different streams of knowledge, followed by the different sciences, are coalescing, and the artificial barriers raised by calling those sciences by different names are breaking down. Geology uses the methods and data of physics, chemistry and biology; no one can say whether the science of radioactivity is to be classed as chemistry or physics, or whether sociology is properly grouped with biology or economics. Indeed, it is often just where this coalescence of two subjects occurs, when some connecting channel between them is opened suddenly, that the most striking advances in knowledge take place. The accumulated experience of one department of science, and the special methods which have been developed to deal with its problems, become suddenly available in the domain of another department, and many questions insoluble before may find answers in the new light cast upon them. Such considerations show us that science is in reality one, though we may agree to look on it now from one side and now from another as we approach it from the standpoint of physics, physiology or psychology.

In experimenting on the arc, my aim was not so much to add to the large number of isolated facts that had already been discovered, as to form some idea of the bearing of these upon one another, and thus to arrive at a clear conception of what takes place in each part of the arc and carbons at every moment. The attempt to correlate all the known phenomena, and to bind them together into one consistent whole, led to the deduction of new facts, which, when duly tested by experiment, became parts of the growing body, and, themselves, opened up fresh questions, to be answered in their turn by experiment.

In July [1837] opened first note-book on Transmutation of Species. Had been greatly struck from about the month of previous March on character of South American fossils, and species on Galapagos Archipelago. These facts (especially latter), origin of all my views.

In my youth I regarded the universe as an open book, printed in the language of physical equations, whereas now it appears to me as a text written in invisible ink, of which in our rare moments of grace we are able to decipher a small fragment.

In physical science the discovery of new facts is open to every blockhead with patience, manual dexterity, and acute senses; it is less effectually promoted by genius than by co-operation, and more frequently the result of accident than of design.

In the animal world we have seen that the vast majority of species live in societies, and that they find in association the best arms for the struggle for life: understood, of course, in its wide Darwinian sense—not as a struggle for the sheer means of existence, but as a struggle against all natural conditions unfavourable to the species. The animal species, in which individual struggle has been reduced to its narrowest limits, and the practice of mutual aid has attained the greatest development, are invariably the most numerous, the most prosperous, and the most open to further progress. The mutual protection which is obtained in this case, the possibility of attaining old age and of accumulating experience, the higher intellectual development, and the further growth of sociable habits, secure the maintenance of the species, its extension, and its further progressive evolution. The unsociable species, on the contrary, are doomed to decay.

In the distant future I see open fields for far more important researches. Psychology will be based on a new foundation, that of the necessary acquirement of each mental power and capacity by gradation. Light will be thrown on the origin of man and his history.

In the future I see open fields for more important researches. Psychology will be securely based on the foundation already laid by Mr. Herbert Spencer, that of the necessary acquirement of each mental power and capacity by graduation.

In those days in the South, the only professional jobs that seemed to be open to a black man were a teacher, a preacher, a doctor or a lawyer.

It [space travel] will free man from his remaining chains, the chains of gravity which still tie him to this planet. It will open to him the gates of heaven.