Natura non facit saltum or, Nature does not make leaps… If you assume continuity, you can open the well-stocked mathematical toolkit of continuous functions and differential equations, the saws and hammers of engineering and physics for the past two centuries (and the foreseeable future).

According to Democritus, atoms had lost the qualities like colour, taste, etc., they only occupied space, but geometrical assertions about atoms were admissible and required no further analysis. In modern physics, atoms lose this last property, they possess geometrical qualities in no higher degree than colour, taste, etc. The atom of modern physics can only be symbolized by a partial differential equation in an abstract multidimensional space. Only the experiment of an observer forces the atom to indicate a position, a colour and a quantity of heat. All the qualities of the atom of modern physics are derived, it has no immediate and direct physical properties at all, i.e. every type of visual conception we might wish to design is, eo ipso, faulty. An understanding of 'the first order' is, I would almost say by definition, impossible for the world of atoms.

As an undergraduate who believed himself destined to be a mathematician I happened upon “Man and Superman” and as I read it at a library table I felt like Saul of Tarsus when the light broke. “If literature,” I said to myself, “can be like this then literature is the stuff for me.” And to this day I never see a differential equation written out without breathing a prayer of thanks.

As Herschel ruminated long ago, particles moving in mutual gravitational interaction are, as we human investigators see it forever solving differential equations which, if written out in full, might circle the earth.

Finite systems of deterministic ordinary nonlinear differential equations may be designed to represent forced dissipative hydrodynamic flow. Solutions of these equations can be identified with trajectories in phase space. For those systems with bounded solutions, it is found that nonperiodic solutions are ordinarily unstable with respect to small modifications, so that slightly differing initial states can evolve into considerably different states. Systems with bounded solutions are shown to possess bounded numerical solutions.
A simple system representing cellular convection is solved numerically. All of the solutions are found to be unstable, and almost all of them are nonperiodic.
The feasibility of very-long-range weather prediction is examined in the light of these results

How did Biot arrive at the partial differential equation? [the heat conduction equation] … Perhaps Laplace gave Biot the equation and left him to sink or swim for a few years in trying to derive it. That would have been merely an instance of the way great mathematicians since the very beginnings of mathematical research have effortlessly maintained their superiority over ordinary mortals.

In scientific thought we adopt the simplest theory which will explain all the facts under consideration and enable us to predict new facts of the same kind. The catch in this criterion lies in the world “simplest.” It is really an aesthetic canon such as we find implicit in our criticisms of poetry or painting. The layman finds such a law as dx/dt = κ(d²x/dy²) much less simple than “it oozes,” of which it is the mathematical statement. The physicist reverses this judgment, and his statement is certainly the more fruitful of the two, so far as prediction is concerned. It is, however, a statement about something very unfamiliar to the plain man, namely the rate of change of a rate of change.

It has been the final aim of Lie from the beginning to make progress in the theory of differential equations; as subsidiary to this may be regarded both his geometrical developments and the theory of continuous groups.

It must be admitted that science has its castes. The man whose chief apparatus is the differential equation looks down upon one who uses a galvanometer, and he in turn upon those who putter about with sticky and smelly things in test tubes. But all of these, and most biologists too, join together in their contempt for the pariah who, not through a glass darkly, but with keen unaided vision, observes the massing of a thundercloud on the horizon, the petal as it unfolds, or the swarming of a hive of bees. And yet sometimes I think that our laboratories are but little earthworks which men build about themselves, and whose puny tops too often conceal from view the Olympian heights; that we who work in these laboratories are but skilled artisans compared with the man who is able to observe, and to draw accurate deductions from the world about him.

Newton has shown us that a law is only a necessary relation between the present state of the world and its immediately subsequent state. All the other laws since discovered are nothing else; they are in sum, differential equations.

One of the main purposes of scientific inference is to justify beliefs which we entertain already; but as a rule they are justified with a difference. Our pre-scientific general beliefs are hardly ever without exceptions; in science, a law with exceptions can only be tolerated as a makeshift. Scientific laws, when we have reason to think them accurate, are different in form from the common-sense rules which have exceptions: they are always, at least in physics, either differential equations, or statistical averages. It might be thought that a statistical average is not very different from a rule with exceptions, but this would be a mistake. Statistics, ideally, are accurate laws about large groups; they differ from other laws only in being about groups, not about individuals. Statistical laws are inferred by induction from particular statistics, just as other laws are inferred from particular single occurrences.

Part of the charm in solving a differential equation is in the feeling that we are getting something for nothing. So little information appears to go into the solution that there is a sense of surprise over the extensive results that are derived.

Science is a Differential Equation. Religion is a Boundary Condition.

The integrals which we have obtained are not only general expressions which satisfy the differential equation, they represent in the most distinct manner the natural effect which is the object of the phenomenon… when this condition is fulfilled, the integral is, properly speaking, the equation of the phenomenon; it expresses clearly the character and progress of it, in the same manner as the finite equation of a line or curved surface makes known all the properties of those forms.

The results of mathematics are seldom directly applied; it is the definitions that are really useful. Once you learn the concept of a differential equation, you see differential equations all over, no matter what you do. This you cannot see unless you take a course in abstract differential equations. What applies is the cultural background you get from a course in differential equations, not the specific theorems. If you want to learn French, you have to live the life of France, not just memorize thousands of words. If you want to apply mathematics, you have to live the life of differential equations. When you live this life, you can then go back to molecular biology with a new set of eyes that will see things you could not otherwise see.

The successes of the differential equation paradigm were impressive and extensive. Many problems, including basic and important ones, led to equations that could be solved. A process of self-selection set in, whereby equations that could not be solved were automatically of less interest than those that could.

The traditional mathematics professor of the popular legend is absentminded. He usually appears in public with a lost umbrella in each hand. He prefers to face a blackboard and to turn his back on the class. He writes a, he says b, he means c, but it should be d. Some of his sayings are handed down from generation to generation:
“In order to solve this differential equation you look at it till a solution occurs to you.”
“This principle is so perfectly general that no particular application of it is possible.”
“Geometry is the science of correct reasoning on incorrect figures.”
“My method to overcome a difficulty is to go round it.”
“What is the difference between method and device? A method is a device which you used twice.”

They think that differential equations are not reality. Hearing some colleagues speak, it’s as though theoretical physics was just playing house with plastic building blocks. This absurd idea has gained currency, and now people seem to feel that theoretical physicists are little more than dreamers locked away ivory towers. They think our games, our little houses, bear no relation to their everyday worries, their interests, their problems, or their welfare. But I’m going to tell you something, and I want you to take it as a ground rule for this course. From now on I will be filling this board with equations. … And when I'm done, I want you to do the following: look at those numbers, all those little numbers and Greek letters on the board, and repeat to yourselves, “This is reality,” repeat it over and over.