…with common water. Its substance reaches everywhere; it touches the past and prepares the future; it moves under the poles and wanders thinly in the heights of air. It can assume forms of exquisite perfection in a snowflake, or strip the living to a single shining bone cast up by the sea.

[Aristotle formal logic thus far (1787)] has not been able to advance a single step, and hence is to all appearances closed and completed.

[Everyone should know:] The unity of life that comes about through evolution, since we’re all descended from a single common ancestor. It’s almost too good to be true, that on one planet this extraordinary complexity of life should have come about by what is pretty much an intelligible process. And we're the only species capable of understanding it.

[It] is not the nature of things for any one man to make a sudden, violent discovery; science goes step by step and every man depends on the work of his predecessors. When you hear of a sudden unexpected discovery—a bolt from the blue—you can always be sure that it has grown up by the influence of one man or another, and it is the mutual influence which makes the enormous possibility of scientific advance. Scientists are not dependent on the ideas of a single man, but on the combined wisdom of thousands of men, all thinking of the same problem and each doing his little bit to add to the great structure of knowledge which is gradually being erected.

[Martin Gardner is] the single brightest beacon defending rationality and good science against the mysticism and anti-intellectualism that surround us.

[On common water.] Its substance reaches everywhere; it touches the past and prepares the future; it moves under the poles and wanders thinly in the heights of air. It can assume forms of exquisite perfection in a snowflake, or strip the living to a single shining bone cast up by the sea.

[Simplicio] is much puzzled and perplexed. I think I hear him say, 'To whom then should we repair for the decision of our controversies if Aristotle were removed from the choir? What other author should we follow in the schools, academies, and studies? What philosopher has written all the divisions of Natural Philosophy, and so methodically, without omitting as much as a single conclusion? Shall we then overthrow the building under which so many voyagers find shelter? Shall we destroy that sanctuary, that Prytaneum, where so many students find commodious harbour; where without exposing himself to the injuries of the air, with only the turning over of a few leaves, one may learn all the secrets of Nature.'

[The Royal Society] is quite simply the voice of science in Britain. It is intellectually rigorous, not afraid to be outspoken on controversial issues such as climate change, but it is not aggressively secular either, insisting on a single view of the world. In fact, there are plenty of eminent scientists – Robert Winston, for instance – who are also men of faith.

[The] structural theory is of extreme simplicity. It assumes that the molecule is held together by links between one atom and the next: that every kind of atom can form a definite small number of such links: that these can be single, double or triple: that the groups may take up any position possible by rotation round the line of a single but not round that of a double link: finally that with all the elements of the first short period [of the periodic table], and with many others as well, the angles between the valencies are approximately those formed by joining the centre of a regular tetrahedron to its angular points. No assumption whatever is made as to the mechanism of the linkage. Through the whole development of organic chemistry this theory has always proved capable of providing a different structure for every different compound that can be isolated. Among the hundreds of thousands of known substances, there are never more isomeric forms than the theory permits.

The Mighty Task is Done

At last the mighty task is done;
Resplendent in the western sun
The Bridge looms mountain high;
Its titan piers grip ocean floor,
Its great steel arms link shore with shore,
Its towers pierce the sky.

On its broad decks in rightful pride,
The world in swift parade shall ride,
Throughout all time to be;
Beneath, fleet ships from every port,
Vast landlocked bay, historic fort,
And dwarfing all the sea.

To north, the Redwood Empires gates;
To south, a happy playground waits,
In Rapturous appeal;
Here nature, free since time began,
Yields to the restless moods of man,
Accepts his bonds of steel.

Launched midst a thousand hopes and fears,
Damned by a thousand hostile sneers,
Yet Neer its course was stayed,
But ask of those who met the foe
Who stood alone when faith was low,
Ask them the price they paid.

Ask of the steel, each strut and wire,
Ask of the searching, purging fire,
That marked their natal hour;
Ask of the mind, the hand, the heart,
Ask of each single, stalwart part,
What gave it force and power.

An Honored cause and nobly fought
And that which they so bravely wrought,
Now glorifies their deed,
No selfish urge shall stain its life,
Nor envy, greed, intrigue, nor strife,
Nor false, ignoble creed.

High overhead its lights shall gleam,
Far, far below lifes restless stream,
Unceasingly shall flow;
For this was spun its lithe fine form,
To fear not war, nor time, nor storm,
For Fate had meant it so.

[On Typhoid Fever] How often have I seen in past days, in the single narrow chamber of the day-labourer’s cottage, the father in the coffin, the mother in the sick-bed in muttering delirium, and nothing to relieve the desolation of the children but the devotion of some poor neighbour, who in too many cases paid the penalty of her kindness in becoming herself the victim of the same disorder.

Are coral reefs growing from the depths of the oceans? ... [The] reply is a simple negative; and a single fact establishes its truth. The reef-forming coral zoophytes, as has been shown, cannot grow at greater depths than 100 or 120 feet; and therefore in seas deeper than this, the formation or growth of reefs over the bottom is impossible.

Nature is curious, and such worke may make,
That our dull sense can never finde, but scape.
For Creatures, small as Atomes, may be there,
If every Atome a Creatures Figure beare.
If foure Atomes a World can make, then see
What severall Worlds might in an Eare--ring bee:
For Millions of these Atomes may bee in
The Head of one Small, little, Single Pin.
And if thus Small, then Ladies may well weare
A World of Worlds, as Pendents in each Eare.

The Charms of Statistics.—It is difficult to understand why statisticians commonly limit their inquiries to Averages, and do not revel in more comprehensive views. Their souls seem as dull to the charm of variety as that of the native of one of our flat English counties, whose retrospect of Switzerland was that, if its mountains could be thrown into its lakes, two nuisances would be got rid of at once. An Average is but a solitary fact, whereas if a single other fact be added to it, an entire Normal Scheme, which nearly corresponds to the observed one, starts potentially into existence. Some people hate the very name of statistics, but I find them full of beauty and interest. Whenever they are not brutalised, but delicately handled by the higher methods, and are warily interpreted, their power of dealing with complicated phenomena is extraordinary. They are the only tools by which an opening can be cut through the formidable thicket of difficulties that bars the path of those who pursue the Science of man.

A distinguished writer [Siméon Denis Poisson] has thus stated the fundamental definitions of the science:
“The probability of an event is the reason we have to believe that it has taken place, or that it will take place.”
“The measure of the probability of an event is the ratio of the number of cases favourable to that event, to the total number of cases favourable or contrary, and all equally possible” (equally like to happen).
From these definitions it follows that the word probability, in its mathematical acceptation, has reference to the state of our knowledge of the circumstances under which an event may happen or fail. With the degree of information which we possess concerning the circumstances of an event, the reason we have to think that it will occur, or, to use a single term, our expectation of it, will vary. Probability is expectation founded upon partial knowledge. A perfect acquaintance with all the circumstances affecting the occurrence of an event would change expectation into certainty, and leave neither room nor demand for a theory of probabilities.

A great surgeon performs operations for stone by a single method; later he makes a statistical summary of deaths and recoveries, and he concludes from these statistics that the mortality law for this operation is two out of five. Well, I say that this ratio means literally nothing scientifically and gives us no certainty in performing the next operation; for we do not know whether the next case will be among the recoveries or the deaths. What really should be done, instead of gathering facts empirically, is to study them more accurately, each in its special determinism. We must study cases of death with great care and try to discover in them the cause of mortal accidents so as to master the cause and avoid the accidents.

A single and distinct luminous body causes stronger relief in the objects than a diffused light; as may be seen by comparing one side of a landscape illuminated by the sun, and one overshadowed by clouds, and illuminated only by the diffused light of the atmosphere.

A single axis is harmless, but a murderous mathematician can go on a killing spree with a pair of axes.

A single death is a tragedy, a million deaths is a statistic.

A single idea, if it is right, saves us the labor of an infinity of experiences.

A single kind of red cell is supposed to have an enormous number of different substances on it, and in the same way there are substances in the serum to react with many different animal cells. In addition, the substances which match each kind of cell are different in each kind of serum. The number of hypothetical different substances postulated makes this conception so uneconomical that the question must be asked whether it is the only one possible. ... We ourselves hold that another, simpler, explanation is possible.

A single ray of light from a distant star falling upon the eye of a tyrant in bygone times, may have altered the course of his life, may have changed the destiny of nations, may have transformed the surface of the globe, so intricate, so inconceivably complex are the processes of nature.

A single swallow, it is said, devours ten millions of insects every year. The supplying of these insects I take to be a signal instance of the Creator's bounty in providing for the lives of His creatures.

A single tree by itself is dependent upon all the adverse chances of shifting circumstances. The wind stunts it: the variations in temperature check its foliage: the rains denude its soil: its leaves are blown away and are lost for the purpose of fertilisation. You may obtain individual specimens of line trees either in exceptional circumstances, or where human cultivation had intervened. But in nature the normal way in which trees flourish is by their association in a forest. Each tree may lose something of its individual perfection of growth, but they mutually assist each other in preserving the conditions of survival. The soil is preserved and shaded; and the microbes necessary for its fertility are neither scorched, nor frozen, nor washed away. A forest is the triumph of the organisation of mutually dependent species.

According to the older view, for every single effect of a serum, there was a separate substance, or at least a particular chemical group... A normal serum contained as many different haemagglutinins as it agglutinated different cells. The situation was undoubtedly made much simpler if, to use the Ehrlich terminology... the separate haptophore groups can combine with an extremely large number of receptors in stepwise differing quantities as a stain does with different animal tissues, though not always with the same intensity. A normal serum would therefore visibly affect such a large number of different blood cells... not because it contained countless special substances, but because of the colloids of the serum, and therefore of the agglutinins by reason of their chemical constitution and the electrochemical properties resulting from it. That this manner of representation is a considerable simplification is clear; it also opens the way to direct experimental testing by the methods of structural chemistry.

All interesting issues in natural history are questions of relative frequency, not single examples. Everything happens once amidst the richness of nature. But when an unanticipated phenomenon occurs again and again–finally turning into an expectation–then theories are overturned.

All of the books in the world contain no more information than is broadcast as video in a single large American city in a single year. Not all bits have equal value.

All organs of an animal form a single system, the parts of which hang together, and act and re-act upon one another; and no modifications can appear in one part without bringing about corresponding modifications in all the rest.

All the different classes of beings which taken together make up the universe are, in the ideas of God who knows distinctly their essential gradations, only so many ordinates of a single curve so closely united that it would be impossible to place others between any two of them, since that would imply disorder and imperfection. Thus men are linked with the animals, these with the plants and these with the fossils which in turn merge with those bodies which our senses and our imagination represent to us as absolutely inanimate. And, since the law of continuity requires that when the essential attributes of one being approximate those of another all the properties of the one must likewise gradually approximate those of the other, it is necessary that all the orders of natural beings form but a single chain, in which the various classes, like so many rings, are so closely linked one to another that it is impossible for the senses or the imagination to determine precisely the point at which one ends and the next begins?all the species which, so to say, lie near the borderlands being equivocal, at endowed with characters which might equally well be assigned to either of the neighboring species. Thus there is nothing monstrous in the existence zoophytes, or plant-animals, as Budaeus calls them; on the contrary, it is wholly in keeping with the order of nature that they should exist. And so great is the force of the principle of continuity, to my thinking, that not only should I not be surprised to hear that such beings had been discovered?creatures which in some of their properties, such as nutrition or reproduction, might pass equally well for animals or for plants, and which thus overturn the current laws based upon the supposition of a perfect and absolute separation of the different orders of coexistent beings which fill the universe;?not only, I say, should I not be surprised to hear that they had been discovered, but, in fact, I am convinced that there must be such creatures, and that natural history will perhaps some day become acquainted with them, when it has further studied that infinity of living things whose small size conceals them for ordinary observation and which are hidden in the bowels of the earth and the depth of the sea.

All the events which occur upon the earth result from Law: even those actions which are entirely dependent on the caprices of the memory, or the impulse of the passions, are shown by statistics to be, when taken in the gross, entirely independent of the human will. As a single atom, man is an enigma; as a whole, he is a mathematical problem. As an individual, he is a free agent; as a species, the offspring of necessity.

All the unhappiness of men arises from one single fact, that they cannot stay quietly in their own chamber.

All things are made of atoms—little particles that move around in perpetual motion, attracting each other when they are a little distance apart, but repelling upon being squeezed into one another. In that one sentence ... there is an enormous amount of information about the world.
His suggestion that the most valuable information on scientific knowledge in a single sentence using the fewest words is to state the atomic hypothesis.

Although [Charles Darwin] would patiently go on repeating experiments where there was any good to be gained, he could not endure having to repeat an experiment which ought, if complete care had been taken, to have told its story at first—and this gave him a continual anxiety that the experiment should not be wasted; he felt the experiment to be sacred, however slight a one it was. He wished to learn as much as possible from an experiment, so that he did not confine himself to observing the single point to which the experiment was directed, and his power of seeing a number of other things was wonderful. ... Any experiment done was to be of some use, and ... strongly he urged the necessity of keeping the notes of experiments which failed, and to this rule he always adhered.

Among all the occurrences possible in the universe the a priori probability of any particular one of them verges upon zero. Yet the universe exists; particular events must take place in it, the probability of which (before the event) was infinitesimal. At the present time we have no legitimate grounds for either asserting or denying that life got off to but a single start on earth, and that, as a consequence, before it appeared its chances of occurring were next to nil. ... Destiny is written concurrently with the event, not prior to it.

An amino acid residue (other than glycine) has no symmetry elements. The general operation of conversion of one residue of a single chain into a second residue equivalent to the first is accordingly a rotation about an axis accompanied by translation along the axis. Hence the only configurations for a chain compatible with our postulate of equivalence of the residues are helical configurations.
[Co-author with American chemist, ert B. Corey (1897-1971) and H. R. Branson]

An aromatic compound may be defined as a cyclic compound with a large resonance energy where all the annular atoms take part in a single conjugated system.

An extra-terrestrial philosopher, who had watched a single youth up to the age of twenty-one and had never come across any other human being, might conclude that it is the nature of human beings to grow continually taller and wiser in an indefinite progress towards perfection; and this generalization would be just as well founded as the generalization which evolutionists base upon the previous history of this planet.

An irrefutable proof that such single-celled primaeval animals really existed as the direct ancestors of Man, is furnished according to the fundamental law of biogeny by the fact that the human egg is nothing more than a simple cell.

And now, as a germination of planetary dimensions, comes the thinking layer which over its full extent develops and intertwines its fibres, not to confuse and neutralise them but to reinforce them in the living unity of a single tissue.

Any opinion as to the form in which the energy of gravitation exists in space is of great importance, and whoever can make his opinion probable will have, made an enormous stride in physical speculation. The apparent universality of gravitation, and the equality of its effects on matter of all kinds are most remarkable facts, hitherto without exception; but they are purely experimental facts, liable to be corrected by a single observed exception. We cannot conceive of matter with negative inertia or mass; but we see no way of accounting for the proportionality of gravitation to mass by any legitimate method of demonstration. If we can see the tails of comets fly off in the direction opposed to the sun with an accelerated velocity, and if we believe these tails to be matter and not optical illusions or mere tracks of vibrating disturbance, then we must admit a force in that direction, and we may establish that it is caused by the sun if it always depends upon his position and distance.

Are God and Nature then at strife,
That Nature lends such evil dreams?
So careful of the type she seems,
So careless of the single life; ...
'So careful of the type', but no.
From scarped cliff and quarried stone
She cries, 'A thousand types are gone:
I care for nothing, all shall go' ...
Man, her last work, who seemed so fair,
Such splendid purpose in his eyes,
Who rolled the psalm to wintry skies,
Who built him fanes of fruitless prayer,
Who trusted God was love indeed
And love Creation's final law—
Tho’ Nature red in tooth and claw
With ravine, shrieked against his creed...

Are God and Nature then at strife,
That Nature lends such evil dreams?
So careful of the type she seems,
So careless of the single life…
So careful of the type, but no.
From scarped cliff and quarried stone
She cries, “A thousand types are gone;
I care for nothing, all shall go.”

As a single footstep will not make a path on the earth, so a single thought will not make a pathway in the mind. To make a deep physical path, we walk again and again. To make a deep mental path, we must think over and over the kind of thoughts we wish to dominate our lives.

As Crystallography was born of a chance observation by Haüy of the cleavage-planes of a single fortunately fragile specimen, … so out of the slender study of the Norwich Spiral has sprung the vast and interminable Calculus of Cyclodes, which strikes such far-spreading and tenacious roots into the profoundest strata of denumeration, and, by this and the multitudinous and multifarious dependent theories which cluster around it, reminds one of the Scriptural comparison of the Kingdom of Heaven “to a grain of mustard-seed which a man took and cast into his garden, and it grew and waxed a great tree, and the fowls of the air lodged in the branches of it.”

As the human fetus develops, its changing form seems to retrace the whole of human evolution from the time we were cosmic dust to the time we were single-celled organisms in the primordial sea to the time we were four-legged, land-dwelling reptiles and beyond, to our current status as large­brained, bipedal mammals. Thus, humans seem to be the sum total of experience since the beginning of the cosmos.

At fertilization, these two “haploid” nuclei are added together to make a “diploid” nucleus that now contains 2a, 2b and so on; and, by the splitting of each chromosome and the regulated karyokinetic separation of the daughter chromosomes, this double series is inherited by both of the primary blastomeres. In the resulting resting nuclei the individual chromosomes are apparently destroyed. But we have the strongest of indications that, in the stroma of the resting nucleus, every one of the chromosomes that enters the nucleus survives as a well-defined region; and as the cell prepares for its next division this region again gives rise to the same chromosome (Theory of the Individuality of the Chromosomes). In this way the two sets of chromosomes brought together at fertilization are inherited by all the cells of the new individual. It is only in the germinal cells that the so called reduction division converts the double series into a single one. Out of the diploid state, the haploid is once again generated.

At the origin, the [space travel] pioneers of the greatest adventure of all times were motivated by the drive to explore, by the pure spirit of conquest, by the lofty desire to open up new fields to human genius. … From their exceptional journeys, they all came back with the revelation of beauty. Beauty of the black sky, beauty and variety of our planet, beauty of the Earth seen from the Moon, girdled by a scintillating belt of equatorial thunderstorms. They all emphasize that our planet is one, that borderlines are artificial, that humankind is one single community on board spaceship Earth. They all insist that this fragile gem is at our mercy and that we must all endeavor to protect it.

At the sight of a single bone, of a single piece of bone, I recognize and reconstruct the portion of the whole from which it would have been taken. The whole being to which this fragment belonged appears in my mind's eye.

At the voice of comparative anatomy, every bone, and fragment of a bone, resumed its place. I cannot find words to express the pleasure I have in seeing, as I discovered one character, how all the consequences, which I predicted from it, were successively confirmed; the feet were found in accordance with the characters announced by the teeth; the teeth in harmony with those indicated beforehand by the feet; the bones of the legs and thighs, and every connecting portion of the extremities, were found set together precisely as I had arranged them, before my conjectures were verified by the discovery of the parts entire: in short, each species was, as it were, reconstructed from a single one of its component elements.

At this point, however, I have no intention whatever of criticizing the false teachings of Galen, who is easily first among the professors of dissection, for I certainly do not wish to start off by gaining a reputation for impiety toward him, the author of all good things, or by seeming insubordinate to his authority. For I am well aware how upset the practitioners (unlike the followers of Aristotle) invariably become nowadays, when they discover in the course of a single dissection that Galen has departed on two hundred or more occasions from the true description of the harmony, function, and action of the human parts, and how grimly they examine the dissected portions as they strive with all the zeal at their command to defend him. Yet even they, drawn by their love of truth, are gradually calming down and placing more faith in their own not ineffective eyes and reason than in Galen’s writings.

Because a child of one doubles its age after the passage of a single year, it can be said to be aging rapidly.

Before the seas and lands had been created, before the sky that covers everything, Nature displayed a single aspect only throughout the cosmos; Chaos was its name, a shapeless, unwrought mass of inert bulk and nothing more, with the discordant seeds of disconnected elements all heaped together in anarchic disarray.

Between the lowest and the highest degree of spiritual and corporal perfection, there is an almost infinite number of intermediate degrees. The succession of degrees comprises the Universal Chain. It unites all beings, ties together all worlds, embraces all the spheres. One SINGLE BEING is outside this chain, and this is HE who made it.

But how is it that they [astrologers] have never been able to explain why, in the life of twins, in their actions, in their experiences, their professions, their accomplishments, their positions—in all the other circumstances of human life, and even in death itself, there is often found such a diversity that in those respects many strangers show more resemblance to them than they show to one another, even though the smallest possible interval separated their births and though they were conceived at the same moment, by a single act of intercourse.

But the dreams about the modes of creation, enquiries whether our globe has been formed by the agency of fire or water, how many millions of years it has cost Vulcan or Neptune to produce what the fiat of the Creator would effect by a single act of will, is too idle to be worth a single hour of any man’s life.

Certain students of genetics inferred that the Mendelian units responsible for the selected character were genes producing only a single effect. This was careless logic. It took a good deal of hammering to get rid of this erroneous idea. As facts accumulated it became evident that each gene produces not a single effect, but in some cases a multitude of effects on the characters of the individual. It is true that in most genetic work only one of these character-effects is selected for study—the one that is most sharply defined and separable from its contrasted character—but in most cases minor differences also are recognizable that are just as much the product of the same gene as is the major effect.

Chemistry is an art that has furnished the world with a great number of useful facts, and has thereby contributed to the improvement of many arts; but these facts lie scattered in many different books, involved in obscure terms, mixed with many falsehoods, and joined to a great deal of false philosophy; so that it is not great wonder that chemistry has not been so much studied as might have been expected with regard to so useful a branch of knowledge, and that many professors are themselves but very superficially acquainted with it. But it was particularly to be expected, that, since it has been taught in universities, the difficulties in this study should have been in some measure removed, that the art should have been put into form, and a system of it attempted—the scattered facts collected and arranged in a proper order. But this has not yet been done; chemistry has not yet been taught but upon a very narrow plan. The teachers of it have still confined themselves to the purposes of pharmacy and medicine, and that comprehends a small branch of chemistry; and even that, by being a single branch, could not by itself be tolerably explained.

Considering the difficulties represented by the lack of water, by extremes of temperature, by the full force of gravity unmitigated by the buoyancy of water, it must be understood that the spread to land of life forms that evolved to meet the conditions of the ocean represented the greatest single victory won by life over the inanimate environment.

Controlled research … endeavors to pick out of the web of nature’s activities some single strand and trace it towards its origin and its terminus and determine its relation to other strands.

Do there exist many worlds, or is there but a single world? This is one of the most noble and exalted questions in the study of Nature.

Doctors coin money when they do procedures—family practice doesn’t have any procedures. A urologist has cystoscopies, a gastroenterologist has gastroscopies, a dermatologist has biopsies. They can do three or four of those and make five or six hundred dollars in a single day. We get nothing for the use of our time to understand the lives of our patients. Technology is rewarded in medicine, it seems to me, and not thinking.

Dr. M.L. von Franz has explained the circle (or sphere) as a symbol of Self. It expresses the totality of the psyche in all its aspects, including the relationship between man and the whole of nature. It always points to the single most vital aspect of life, its ultimate wholeness.

E.W. Goodpasture showed that the virus of fowl pox could be grown in the tissues of the developing chick embryo. Nearly all the later practical advances in the control of virus diseases in man and animals sprang from this single discovery.

Each species may have had its origin in a single pair, or individual, where an individual was sufficient, and species may have been created in succession at such times and in such places as to enable them to multiply and endure for an appointed period, and occupy an appointed space on the globe.

Education in my family was not merely emphasized, it was our raison d'être. Virtually all of our aunts and uncles had Ph.D.s in science or engineering, and it was taken for granted that the next generation of Chu's were to follow the family tradition. When the dust had settled, my two brothers and four cousins collected three MDs, four Ph.D.s and a law degree. I could manage only a single advanced degree.

ELECTRICITY, n. The power that causes all natural phenomena not known to be caused by something else. It is the same thing as lightning, and its famous attempt to strike Dr. Franklin is one of the most picturesque incidents in that great and good man's career. The memory of Dr. Franklin is justly held in great reverence, particularly in France, where a waxen effigy of him was recently on exhibition, bearing the following touching account of his life and services to science:
Monsieur Franqulin, inventor of electricity. This illustrious savant, after having made several voyages around the world, died on the Sandwich Islands and was devoured by savages, of whom not a single fragment was ever recovered.
Electricity seems destined to play a most important part in the arts and industries. The question of its economical application to some purposes is still unsettled, but experiment has already proved that it will propel a street car better than a gas jet and give more light than a horse.

Endowed with two qualities, which seemed incompatible with each other, a volcanic imagination and a pertinacity of intellect which the most tedious numerical calculations could not daunt, Kepler conjectured that the movements of the celestial bodies must be connected together by simple laws, or, to use his own expression, by harmonic laws. These laws he undertook to discover. A thousand fruitless attempts, errors of calculation inseparable from a colossal undertaking, did not prevent him a single instant from advancing resolutely toward the goal of which he imagined he had obtained a glimpse. Twenty-two years were employed by him in this investigation, and still he was not weary of it! What, in reality, are twenty-two years of labor to him who is about to become the legislator of worlds; who shall inscribe his name in ineffaceable characters upon the frontispiece of an immortal code; who shall be able to exclaim in dithyrambic language, and without incurring the reproach of anyone, “The die is cast; I have written my book; it will be read either in the present age or by posterity, it matters not which; it may well await a reader, since God has waited six thousand years for an interpreter of his words.”

Enough for me the mystery of the eternity of life, and the inkling of the marvellous structure of reality, together with the single-hearted endeavour to comprehend a portion, be it never so tiny, of the reason that manifests itself in nature.

Even more difficult to explain, than the breaking-up of a single mass into fragments, and the drifting apart of these blocks to form the foundations of the present-day continents, is the explanation of the original production of the single mass, or PANGAEA, by the concentration of the former holosphere of granitic sial into a hemisphere of compressed and crushed gneisses and schists. Creep and the effects of compression, due to shrinking or other causes, have been appealed to but this is hardly a satisfactory explanation. The earth could no more shrug itself out of its outer rock-shell unaided, than an animal could shrug itself out of its hide, or a man wriggle out of his skin, or even out of his closely buttoned coat, without assistance either of his own hands or those of others.

Even those to whom Providence has allotted greater strength of understanding, can expect only to improve a single science. In every other part of learning, they must be content to follow opinions, which they are not able to examine; and, even in that which they claim as peculiarly their own, can seldom add more than some small particle of knowledge, to the hereditary stock devolved to them from ancient times, the collective labour of a thousand intellects.

Every breath you draw, every accelerated beat of your heart in the emotional periods of your oratory depend upon highly elaborated physical and chemical reactions and mechanisms which nature has been building up through a million centuries. If one of these mechanisms, which you owe entirely to your animal ancestry, were to be stopped for a single instant, you would fall lifeless on the stage. Not only this, but some of your highest ideals of human fellowship and comradeship were not created in a moment, but represent the work of ages.

Every cent we earn from Crocodile Hunter goes straight back into conservation. Every single cent.

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

For a stone, when it is examined, will be found a mountain in miniature. The fineness of Nature’s work is so great, that, into a single block, a foot or two in diameter, she can compress as many changes of form and structure, on a small scale, as she needs for her mountains on a large one; and, taking moss for forests, and grains of crystal for crags, the surface of a stone, in by far the plurality of instances, is more interesting than the surface of an ordinary hill; more fantastic in form and incomparably richer in colour—the last quality being, in fact, so noble in most stones of good birth (that is to say, fallen from the crystalline mountain ranges).

For more than half a century, Martin Gardner has been the single brightest beacon defending rationality and good science against the mysticism and anti-intellectualism that surround us.

For nearly twelve years I travelled and lived mostly among uncivilised or completely savage races, and I became convinced that they all possessed good qualities, some of them in a very remarkable degree, and that in all the great characteristics of humanity they are wonderfully like ourselves. Some, indeed, among the brown Polynesians especially, are declared by numerous independent and unprejudiced observers, to be physically, mentally, and intellectually our equals, if not our superiors; and it has always seemed to me one of the disgraces of our civilisation that these fine people have not in a single case been protected from contamination by the vices and follies of our more degraded classes, and allowed to develope their own social and political organislll under the advice of some of our best and wisest men and the protection of our world-wide power. That would have been indeed a worthy trophy of our civilisation. What we have actually done, and left undone, resulting in the degradation and lingering extermination of so fine a people, is one of the most pathetic of its tragedies.

For the sake of our children and our future, we must do more to combat climate change. Now, it’s true that no single event makes a trend. But the fact is the 12 hottest years on record have all come in the last 15. Heat waves, droughts, wildfires, floods—all are now more frequent and more intense. We can choose to believe that Superstorm Sandy, and the most severe drought in decades, and the worst wildfires some states have ever seen were all just a freak coincidence. Or we can choose to believe in the overwhelming judgment of science—and act before it’s too late.

Formerly Milton's Paradise Lost had been my chief favourite, and in my excursions during the voyage of the Beagle, when I could take only a single small volume, I always chose Milton.

From a drop of water a logician could predict an Atlantic or a Niagara without having seen or heard of one or the other. So all life is a great chain, the nature of which is known whenever we are shown a single link of it.

From all we have learnt about the structure of living matter, we must be prepared to find it working in a manner that cannot be reduced to the ordinary laws of physics. And that not on the ground that there is any “new force” or what not, directing the behavior of the single atoms within a living organism, but because the construction is different from anything we have yet tested in the physical laboratory.

Generalisations which are fruitful because they reveal in a single general principle the rationale of a great many particular truths, the connections and common origins of which had not previously been seen, are found in all the sciences, and particularly in mathematics. Such generalisations are the most important of all, and their discovery is the work of genius.

Generality of points of view and of methods, precision and elegance in presentation, have become, since Lagrange, the common property of all who would lay claim to the rank of scientific mathematicians. And, even if this generality leads at times to abstruseness at the expense of intuition and applicability, so that general theorems are formulated which fail to apply to a single special case, if furthermore precision at times degenerates into a studied brevity which makes it more difficult to read an article than it was to write it; if, finally, elegance of form has well-nigh become in our day the criterion of the worth or worthlessness of a proposition,—yet are these conditions of the highest importance to a wholesome development, in that they keep the scientific material within the limits which are necessary both intrinsically and extrinsically if mathematics is not to spend itself in trivialities or smother in profusion.

Genius itself has been analyzed by the shrewdest observers into a higher capacity of attention. “Genius,” says Helvetius … “is nothing but a continued attention,” (une attention suivie). “Genius,” says Buffon, “is only a protracted patience,” (une longue patience). “In the exact sciences, at least,” says Cuvier, “it is the patience of a sound intellect, when invincible, which truly constitutes genius.” And Chesterfield has also observed, that “the power of applying an attention, steady and undissipated, to a single object, is the sure mark of a superior genius.”

God is infinite, so His universe must be too. Thus is the excellence of God magnified and the greatness of His kingdom made manifest; He is glorified not in one, but in countless suns; not in a single earth, a single world, but in a thousand thousand, I say in an infinity of worlds.

Having made a sufficient opening to admit my finger into the abdomen, I passed it between the intestines to the spine, and felt the aorta greatly enlarged, and beating with excessive force. By means of my finger nail, I scratched through the peritoneum on the left side of the aorta, and then gradually passed my finger between the aorta and the spine, and again penetrated the peritoneum, on the right side of the aorta. I had now my finger under the artery, and by its side I conveyed the blunt aneurismal needle, armed with a single ligature behind it...
Describing the first ligation of the aorta in 1817 for left femoral aneurysm.

Her [Nettie Stevens] single-mindedness and devotion, combined with keen powers of observation; her thoughtfulness and patience, united to a well-balanced judgment, account, in part, for her remarkable accomplishment.

Heredity is the general expression of the periodicity of organic life. All generations belong to a continuous succession of waves, in which every single one resembles its predecessors and its followers.

High in the North in a land called Svithjod there is a mountain. It is a hundred miles long and a hundred miles high and once every thousand years a little bird comes to this mountain to sharpen its beak. When the mountain has thus been worn away a single day of eternity will have passed

His Majesty has, with great skill, constructed a cart, containing a corn mill, which is worked by the motion of the carriage. He has also contrived a carriage of such a magnitude as to contain several apartments, with a hot bath; and it is drawn by a single elephant. This movable bath is extremely useful, and refreshing on a journey. … He has also invented several hydraulic machines, which are worked by oxen. The pulleys and wheels of some of them are so adjusted that a single ox will at once draw water out of two wells, and at the same time turn a millstone.

I am a horse for single harness, not cut out for tandem or teamwork.

I am born into an environment–I know not whence I came nor whither I go nor who I am. This is my situation as yours, every single one of you. The fact that everyone always was in this same situation, and always will be, tells me nothing. Our burning question as to the whence and whither–all we can ourselves observe about it is the present environment. That is why we are eager to find out about it as much as we can. That is science, learning, knowledge; it is the true source of every spiritual endeavour of man. We try to find out as much as we can about the spatial and temporal surroundings of the place in which we find ourselves put by birth.

I am mindful that scientific achievement is rooted in the past, is cultivated to full stature by many contemporaries and flourishes only in favorable environment. No individual is alone responsible for a single stepping stone along the path of progress, and where the path is smooth progress is most rapid. In my own work this has been particularly true.

I am more and more convinced that the ant colony is not so much composed of separate individuals as that the colony is a sort of individual, and each ant like a loose cell in it. Our own blood stream, for instance, contains hosts of white corpuscles which differ little from free-swimming amoebae. When bacteria invade the blood stream, the white corpuscles, like the ants defending the nest, are drawn mechanically to the infected spot, and will die defending the human cell colony. I admit that the comparison is imperfect, but the attempt to liken the individual human warrior to the individual ant in battle is even more inaccurate and misleading. The colony of ants with its component numbers stands half way, as a mechanical, intuitive, and psychical phenomenon, between our bodies as a collection of cells with separate functions and our armies made up of obedient privates. Until one learns both to deny real individual initiative to the single ant, and at the same time to divorce one's mind from the persuasion that the colony has a headquarters which directs activity … one can make nothing but pretty fallacies out of the polity of the ant heap.

I am much occupied with the investigation of the physical causes [of motions in the Solar System]. My aim in this is to show that the celestial machine is to be likened not to a divine organism but rather to a clockwork … insofar as nearly all the manifold movements are carried out by means of a single, quite simple magnetic force. This physical conception is to be presented through calculation and geometry.

I am nothing more than a single narrow gasping lung, floating over the mists and summits.

I am perhaps more proud of having helped to redeem the character of the cave-man than of any other single achievement of mine in the field of anthropology.

I argued that it was important not to place too much reliance on any single piece of experimental evidence. It might turn out to be misleading, as the 5.1 Å reflection undoubtedly was. Jim was a little more brash, stating that no good model ever accounted for all the facts, since some data was bound to be misleading if not plain wrong. A theory that did fit all the data would have been “carpentered” to do so and would thus be open to suspicion.

I believe in “intelligence,” and I believe also that there are inherited differences in intellectual ability, but I do not believe that intelligence is a simple scalar endowment that can be quantified by attaching a single figure to it—an I.Q. or the like.

I can’t recall a single problem in my life, of any sort, that I ever started on that I didn't solve, or prove that I couldn’t solve it. I never let up, until I had done everything that I could think of, no matter how absurd it might seem as a means to the end I was after.

I cannot think of a single field in biology or medicine in which we can claim genuine understanding, and it seems to me the more we learn about living creatures, especially ourselves, the stranger life becomes.

I defend the following postulate as an indisputable principle: that each nerve fibre originates as a process from a single cell. This is its genetic, nutritive, and functional center; all other connections of the fibre are either indirect or secondary.

I have devoted my whole life to the study of Nature, and yet a single sentence may express all that I have done. I have shown that there is a correspondence between the succession of Fishes in geological times and the different stages of their growth in the egg,—this is all. It chanced to be a result that was found to apply to other groups and has led to other conclusions of a like nature.

I have mentioned mathematics as a way to settle in the mind a habit of reasoning closely and in train; not that I think it necessary that all men should be deep mathematicians, but that, having got the way of reasoning which that study necessarily brings the mind to, they might be able to transfer it to other parts of knowledge, as they shall have occasion. For in all sorts of reasoning, every single argument should be managed as a mathematical demonstration; the connection and dependence of ideas should be followed till the mind is brought to the source on which it bottoms, and observes the coherence all along; …

I have no patience with attempts to identify science with measurement, which is but one of its tools, or with any definition of the scientist which would exclude a Darwin, a Pasteur or a Kekulé. The scientist is a practical man and his are practical aims. He does not seek the ultimate but the proximate. He does not speak of the last analysis but rather of the next approximation. His are not those beautiful structures so delicately designed that a single flaw may cause the collapse of the whole. The scientist builds slowly and with a gross but solid kind of masonry. If dissatisfied with any of his work, even if it be near the very foundations, he can replace that part without damage to the remainder. On the whole, he is satisfied with his work, for while science may never be wholly right it certainly is never wholly wrong; and it seems to be improving from decade to decade.

I have often thought that an interesting essay might be written on the influence of race on the selection of mathematical methods. methods. The Semitic races had a special genius for arithmetic and algebra, but as far as I know have never produced a single geometrician of any eminence. The Greeks on the other hand adopted a geometrical procedure wherever it was possible, and they even treated arithmetic as a branch of geometry by means of the device of representing numbers by lines.

I much prefer the sharpest criticism of a single intelligent man to the thoughtless approval of the great masses.

I see nothing wrong ethically with the idea of correcting single gene defects [through genetic engineering]. But I am concerned about any other kind of intervention, for anything else would be an experiment, [which would] impose our will on future generations [and take unreasonable chances] with their welfare ... [Thus] such intervention is beyond the scope of consideration.

I see the whole of humankind becoming a single, integrated organism. … I look upon each of us as I would an individual cell in the organism, each of us playing his or her respective role.

I should be the last to discard the law of organic heredity ... but the single word “heredity” cannot dispense science from the duty of making every possible inquiry into the mechanism of organic growth and of organic formation. To think that heredity will build organic beings without mechanical means is a piece of unscientific mysticism.

I sometimes think there is a malign force loose in the universe that is the social equivalent of cancer, and it’s plastic. It infiltrates everything. It’s metastasis. It gets into every single pore of productive life. I mean there won’t be anything that isn’t made of plastic before long. They’ll be paving the roads with plastic before they’re done. Our bodies, our skeletons, will be replaced with plastic.

I think each individual is never a plane but a polyhedron. Naturally, whenever a ray of light falls on a face, a vertex, an edge of this polyhedron; the arc that it reflects is undoubtedly variable, very complex and single or multicoloured. I don’t believe in plane men, I think we’re all multiple. We don’t have a double life, we have a multiple life. However, it is no less true that we’re thought to have a common denominator. I think I am or I aspire to be an honest man that tries not to bother too many people in this valley of tears.

I think there probably is life, maybe primitive life, in outer space. There might be very primitive life in our solar system—single-cell animals, that sort of thing. We may know the answer to that in five or ten years. There is very likely to be life in other solar systems, in planets around other stars. But we won’t know about that for a long time.

I trust ... I have succeeded in convincing you that modern chemistry is not, as it has so long appeared, an ever-growing accumulation of isolated facts, as impossible for a single intellect to co-ordinate as for a single memory to grasp.
The intricate formulae that hang upon these walls, and the boundless variety of phenomena they illustrate, are beginning to be for us as a labyrinth once impassable, but to which we have at length discovered the clue. A sense of mastery and power succeeds in our minds to the sort of weary despair with which we at first contemplated their formidable array. For now, by the aid of a few general principles, we find ourselves able to unravel the complexities of these formulae, to marshal the compounds which they represent in orderly series; nay, even to multiply their numbers at our will, and in a great measure to forecast their nature ere we have called them into existence. It is the great movement of modern chemistry that we have thus, for an hour, seen passing before us. It is a movement as of light spreading itself over a waste of obscurity, as of law diffusing order throughout a wilderness of confusion, and there is surely in its contemplation something of the pleasure which attends the spectacle of a beautiful daybreak, something of the grandeur belonging to the conception of a world created out of chaos.

I trust I may be enabled in the treatment of patients always to act with a single eye to their good.

I would trade all my experimental works for the single idea of the benzene theory.

I wouldn’t miss this opportunity for anything. For the chance to work on these conservation issues, to serve my country, to work for this president, I’d do it all over again, every single minute.

If a single cell, under appropriate conditions, becomes a man in the space of a few years, there can surely be no difficulty in understanding how, under appropriate conditions, a cell may, in the course of untold millions of years, give origin to the human race.

If all the parts of the universe are interchained in a certain measure, any one phenomenon will not be the effect of a single cause, but the resultant of causes infinitely numerous.

If I had to define life in a single phrase, I should clearly express my thought of throwing into relief one characteristic which, in my opinion, sharply differentiates biological science. I should say: life is creation.

If the views we have ventured to advance be correct, we may almost consider {greek words} of the ancients to be realised in hydrogen, an opinion, by the by, not altogether new. If we actually consider the specific gravities of bodies in their gaseous state to represent the number of volumes condensed into one; or in other words, the number of the absolute weight of a single volume of the first matter ({greek words}) which they contain, which is extremely probable, multiples in weight must always indicate multiples in volume, and vice versa; and the specific gravities, or absolute weights of all bodies in a gaseous state, must be multiples of the specific gravity or absolute weight of the first matter, ({Greek words}), because all bodies in the gaseous state which unite with one another unite with reference to their volume.

If the world has begun with a single quantum, the notions of space and would altogether fail to have any meaning at the beginning; they would only begin to have a sensible meaning when the original quantum had been divided into a sufficient number of quanta. If this suggestion is correct, the beginning of the world happened a little before the beginning of space and time. I think that such a beginning of the world is far enough from the present order of Nature to be not at all repugnant. It may be difficult to follow up the idea in detail as we are not yet able to count the quantum packets in every case. For example, it may be that an atomic nucleus must be counted as a unique quantum, the atomic number acting as a kind of quantum number. If the future development of quantum theory happens to turn in that direction, we could conceive the beginning of the universe in the form of a unique atom, the atomic weight of which is the total mass of the universe. This highly unstable atom would divide in smaller and smaller atoms by a kind of super-radioactive process.