I finally saw that the blood, forced by the action of the left ventricle into the arteries, was distributed to the body at large, and its several parts, in the same manner as it is sent through the lungs, impelled by the right ventricle into the pulmonary artery, and that it then passed through the veins and along the vena cava, and so round to the left ventricle in the manner already indicated. Which motion we may be allowed to call circular, in the same way as Aristotle says that the air and the rain emulate the circular motion of the superior bodies; for the moist earth, warmed by the sun, evaporates; the vapours drawn upwards are condensed, and descending in the form of rain, moisten the earth again; and by this arrangement are generations of living things produced.

In man, then, let us take the amount that is extruded by the individual beats, and that cannot return into the heart because of the barrier set in its way by the valves, as half an ounce, or three drachms, or at least one drachm. In half an hour the heart makes over a thousand beats; indeed, in some individuals, and on occasion, two, three, or four thousand. If you multiply the drachms per beat by the number of beats you will see that in half an hour either a thousand times three drachms or times two drachms, or five hundred ounces, or other such proportionate quantity of blood has been passed through the heart into the arteries, that is, in all cases blood in greater amount than can be found in the whole of the body. Similarly in the sheep or the dog. Let us take it that one scruple passes in a single contraction of the heart; then in half an hour a thousand scruples, or three and a half pounds of blood, do so. In a body of this size, as I have found in the sheep, there is often not more than four pounds of blood.
In the above sort of way, by calculating the amount of blood transmitted [at each heart beat] and by making a count of the beats, let us convince ourselves that the whole amount of the blood mass goes through the heart from the veins to the arteries and similarly makes the pulmonary transit.
Even if this may take more than half an hour or an hour or a day for its accomplishment, it does nevertheless show that the beat of the heart is continuously driving through that organ more blood than the ingested food can supply, or all the veins together at any time contain.

This is the right cavity of the two cavities of the heart. When the blood in this cavity has become thin, it must be transferred into the left cavity, where the pneuma is generated. But there is no passage between these two cavities, the substance of the heart there being impermeable. It neither contains a visible passage, as some people have thought, nor does it contain an invisible passage which would permit the passage of blood, as Galen thought. The pores of the heart there are compact and the substance of the heart is thick. It must, therefore, be that when the blood has become thin, it is passed into the arterial vein [pulmonary artery] to the lung, in order to be dispersed inside the substance of the lung, and to mix with the air. The finest parts of the blood are then strained, passing into the venous artery [pulmonary vein] reaching the left of the two cavities of the heart, after mixing with the air and becoming fit for the generation of pneuma.