“Heaven helps those who help themselves” is a well-tried maxim, embodying in a small compass the results of vast human experience. The spirit of self-help is the root of all genuine growth in the individual; and, exhibited in the lives of many, it constitutes the true source of national vigour and strength. Help from without is often enfeebling in its effects, but help from within invariably invigorates. Whatever is done for men or classes, to a certain extent takes away the stimulus and necessity of doing for themselves; and where men are subjected to over-guidance and over-government, the inevitable tendency is to render them comparatively helpless.

[A man] must learn to understand the motives of human beings, their illusions, and their sufferings human beings, their illusions, and their sufferings in order to acquire a proper relationship to individual fellow-men and to the community. These precious things … primarily constitutes and preserves culture. This is what I have in mind when I recommend the “humanities” as important, not just dry specialized knowledge in the fields of history and philosophy.

[Beyond natural history] Other biological sciences take up the study at other levels of organization: dissecting the individual into organs and tissues and seeing how these work together, as in physiology; reaching down still further to the level of cells, as in cytology; and reaching the final biological level with the study of living molecules and their interactions, as in biochemistry. No one of these levels can be considered as more important than any other.

[Charles Kettering] is unique in that he combines in one individual the interest in pure science with the practical ability to apply knowledge in useful devices.

[Man] … his origin, his growth, his hopes and fears, his loves and his beliefs are but the outcome of accidental collocations of atoms; that no fire, no heroism, no intensity of thought and feeling can preserve an individual life beyond the grave; that all the labour of the ages, all the devotion, all the inspiration, all the noonday brightness of human genius are destined to extinction in the vast death of the solar system, and that the whole temple of Man's achievement must inevitably be buried beneath the debris of a universe in ruins…

[Other than fossils,] the most important of these other records of creation is, without doubt, ontogeny, that is, the history of the developmment of the organic individual (embryology and motamorphology). It briefly repeats in great and marked features the series of forms which the ancestors of the respective individuals have passed through from the beginning of their tribe. We have designated the palaeontological history of the development of the ancestors of a living form as the history of a tribe, or phylogeny, and we may therefore thus enunciate this exceedingly important biogenetic fundamental principle: “Ontogeny is a short and quick repetition, or recapitulation, of Phylogeny, determined by the laws of Inheritance and Adaptation.”

[Shawn Lawrence Otto describes the damaging] strategy used to undermine science in the interest of those industries where science has pointed out the dangers of their products to individuals and human life in general … [It was] used a generation ago by the tobacco industry… First they manufacture uncertainty by raising doubts about even the most indisputable scientific evidence. Then they launder information by using seemingly independent front organizations to promote their desired message and thereby confuse the public. And finally they recruit unscrupulous scientific spokespeople to misrepresent peer-reviewed scientific findings and cherry-pick facts in an attempt to persuade the media and the public that there is still serious debate among scientists on the issue at hand.

[The] erroneous assumption is to the effect that the aim of public education is to fill the young of the species with knowledge and awaken their intelligence, and so make them fit to discharge the duties of citizenship in an enlightened and independent manner. Nothing could be further from the truth. The aim of public education is not to spread enlightenment at all; it is simply to reduce as many individuals as possible to the same safe level, to breed and train a standardised citizenry, to put down dissent and originality.

Πάντα ῥεῖ : all things are in flux. It is inevitable that you are indebted to the past. You are fed and formed by it. The old forest is decomposed for the composition of the new forest. The old animals have given their bodies to the earth to furnish through chemistry the forming race, and every individual is only a momentary fixation of what was yesterday another’s, is today his and will belong to a third to-morrow. So it is in thought.

Branches or types are characterized by the plan of their structure,
Classes, by the manner in which that plan is executed, as far as ways and means are concerned,
Orders, by the degrees of complication of that structure,
Families, by their form, as far as determined by structure,
Genera, by the details of the execution in special parts, and
Species, by the relations of individuals to one another and to the world in which they live, as well as by the proportions of their parts, their ornamentation, etc.

He who doth with the greatest exactness imaginable, weigh every individual thing that shall or hath hapned to his Patient, and may be known from the Observations of his own, or of others, and who afterwards compareth all these with one another, and puts them in an opposite view to such Things as happen in a healthy State; and lastly, from all this with the nicest and severest bridle upon his reasoning faculty riseth to the knowledge of the very first Cause of the Disease, and of the Remedies fit to remove them; He, and only He deserveth the Name of a true Physician.

Judicial astrology, pretended to foretell the fates of nations and individuals. …Astrologer, One who pretends to foretell events, etc.

Les Leucocytes Et L'esprit De Sacrifice. — Il semble, d'après les recherches de De Bruyne (Phagocytose, 1895) et de ceux qui le citent, que les leucocytes des Lamellibranches — probablement lorsqu'ils ont phagocyté, qu'ils se sont chargés de résidus et de déchets, qu'ils ont, en un mot, accompli leur rôle et bien fait leur devoir — sortent du corps de l'animal et vont mourir dans le milieu ambiant. Ils se sacrifient. Après avoir si bien servi l'organisme par leur activité, ils le servent encore par leur mort en faisant place aux cellules nouvelles, plus jeunes.
N'est-ce pas la parfaite image du désintéressement le plus noble, et n'y a-t-il point là un exemple et un modèle? Il faut s'en inspirer: comme eux, nous sommes les unités d'un grand corps social; comme eux, nous pouvons le servir et envisager la mort avec sérénité, en subordonnant notre conscience individuelle à la conscience collective. (30 Jan 1896)
Leukocytes and The Spirit Of Sacrifice. - It seems, according to research by De Bruyne (Phagocytosis, 1885) and those who quote it, that leukocytes of Lamellibranches [bivalves] - likely when they have phagocytized [ingested bacteria], as they become residues and waste, they have, in short, performed their role well and done their duty - leave the body of the animal and will die in the environment. They sacrifice themselves. Having so well served the body by their activities, they still serve in their death by making room for new younger cells.
Isn't this the perfect image of the noblest selflessness, and thereby presents an example and a model? It should be inspiring: like them, we are the units of a great social body, like them, we can serve and contemplate death with equanimity, subordinating our individual consciousness to collective consciousness.

A black hole has no hair.
[Summarizing the simplicity of a black hole, which shows only three characteristics to the outside world (mass, charge, spin) and comparing the situation to a room full of bald-pated people who had one characteristic in common, but no differences in hair length, style or color for individual variations.]

A crystal is like a class of children arranged for drill, but standing at ease, so that while the class as a whole has regularity both in time and space, each individual child is a little fidgety!

A drop of old tuberculin, which is an extract of tubercle bacilli, is put on the skin and then a small superficial scarification is made by turning, with some pressure, a vaccination lancet on the surface of the skin. The next day only those individuals show an inflammatory reaction at the point of vaccination who have already been infected with tuberculosis, whereas the healthy individuals show no reaction at all. Every time we find a positive reaction, we can say with certainty that the child is tuberculous.

A fateful process is set in motion when the individual is released “to the freedom of his own impotence” and left to justify his existence by his own efforts. The autonomous individual, striving to realize himself and prove his worth, has created all that is great in literature, art, music, science and technology. The autonomous individual, also, when he can neither realize himself nor justify his existence by his own efforts, is a breeding call of frustration, and the seed of the convulsions which shake our world to its foundations.

A good theoretical physicist today might find it useful to have a wide range of physical viewpoints and mathematical expressions of the same theory (for example, of quantum electrodynamics) available to him. This may be asking too much of one man. Then new students should as a class have this. If every individual student follows the same current fashion in expressing and thinking about electrodynamics or field theory, then the variety of hypotheses being generated to understand strong interactions, say, is limited. Perhaps rightly so, for possibly the chance is high that the truth lies in the fashionable direction. But, on the off-chance that it is in another direction—a direction obvious from an unfashionable view of field theory—who will find it?

A hero is an ordinary individual who finds the strength to persevere and endure in spite of overwhelming obstacles.

A modern branch of mathematics, having achieved the art of dealing with the infinitely small, can now yield solutions in other more complex problems of motion, which used to appear insoluble. This modern branch of mathematics, unknown to the ancients, when dealing with problems of motion, admits the conception of the infinitely small, and so conforms to the chief condition of motion (absolute continuity) and thereby corrects the inevitable error which the human mind cannot avoid when dealing with separate elements of motion instead of examining continuous motion. In seeking the laws of historical movement just the same thing happens. The movement of humanity, arising as it does from innumerable human wills, is continuous. To understand the laws of this continuous movement is the aim of history. … Only by taking an infinitesimally small unit for observation (the differential of history, that is, the individual tendencies of man) and attaining to the art of integrating them (that is, finding the sum of these infinitesimals) can we hope to arrive at the laws of history.

A moral principle in genetic testing is that it should always be done with the consent of the individual. No one wants someone snooping into his DNA.

A political law or a scientific truth may be perilous to the morals or the faith of individuals; but it cannot on this ground be resisted by the Church. … A discovery may be made in science which will shake the faith of thousands; yet religion cannot regret it or object to it. The difference in this respect between a true and a false religion is, that one judges all things by the standard of their truth, the other by the touchstone of its own interests. A false religion fears the progress of all truth; a true religion seeks and recognises truth wherever it can be found.

A schoolteacher or professor cannot educate individuals, he educates only species. A thought that deserves taking to heart.

A scientist can be productive in various ways. One is having the ability to plan and carry out experiments, but the other is having the ability to formulate new ideas, which can be about what experiments can be carried out … by making [the] proper calculations. Individual scientists who are successful in their work are successful for different reasons.

A single tree by itself is dependent upon all the adverse chances of shifting circumstances. The wind stunts it: the variations in temperature check its foliage: the rains denude its soil: its leaves are blown away and are lost for the purpose of fertilisation. You may obtain individual specimens of line trees either in exceptional circumstances, or where human cultivation had intervened. But in nature the normal way in which trees flourish is by their association in a forest. Each tree may lose something of its individual perfection of growth, but they mutually assist each other in preserving the conditions of survival. The soil is preserved and shaded; and the microbes necessary for its fertility are neither scorched, nor frozen, nor washed away. A forest is the triumph of the organisation of mutually dependent species.

A social fact is every way of acting, fixed or not, capable of exercising on the individual an external constraint; or again, every way of acting which is general throughout a given society, while at the same time existing in its own right independent of its individual manifestations.

A society made up of individuals who were capable of original thought would probably be unendurable. The pressure of ideas would simply drive it frantic.

Across the road from my cabin was a huge clear-cut—hundreds of acres of massive spruce stumps interspersed with tiny Douglas firs—products of what they call “Reforestation,” which I guess makes the spindly firs en masse a “Reforest,” which makes an individual spindly fir a “Refir,” which means you could say that Weyerhauser, who owns the joint, has Refir Madness, since they think that sawing down 200-foot-tall spruces and replacing them with puling 2-foot Refirs is no different from farming beans or corn or alfalfa. They even call the towering spires they wipe from the Earth’s face forever a “crop”--as if they’d planted the virgin forest! But I'm just a fisherman and may be missing some deeper significance in their nomenclature and stranger treatment of primordial trees.

All fossil anthropoids found hitherto have been known only from mandibular or maxillary fragments, so far as crania are concerned, and so the general appearance of the types they represented had been unknown; consequently, a condition of affairs where virtually the whole face and lower jaw, replete with teeth, together with the major portion of the brain pattern, have been preserved, constitutes a specimen of unusual value in fossil anthropoid discovery. Here, as in Homo rhodesiensis, Southern Africa has provided documents of higher primate evolution that are amongst the most complete extant. Apart from this evidential completeness, the specimen is of importance because it exhibits an extinct race of apes intermediate between living anthropoids and man ... Whether our present fossil is to be correlated with the discoveries made in India is not yet apparent; that question can only be solved by a careful comparison of the permanent molar teeth from both localities. It is obvious, meanwhile, that it represents a fossil group distinctly advanced beyond living anthropoids in those two dominantly human characters of facial and dental recession on one hand, and improved quality of the brain on the other. Unlike Pithecanthropus, it does not represent an ape-like man, a caricature of precocious hominid failure, but a creature well advanced beyond modern anthropoids in just those characters, facial and cerebral, which are to be anticipated in an extinct link between man and his simian ancestor. At the same time, it is equally evident that a creature with anthropoid brain capacity and lacking the distinctive, localised temporal expansions which appear to be concomitant with and necessary to articulate man, is no true man. It is therefore logically regarded as a man-like ape. I propose tentatively, then, that a new family of Homo-simidæ be created for the reception of the group of individuals which it represents, and that the first known species of the group be designated Australopithecus africanus, in commemoration, first, of the extreme southern and unexpected horizon of its discovery, and secondly, of the continent in which so many new and important discoveries connected with the early history of man have recently been made, thus vindicating the Darwinian claim that Africa would prove to be the cradle of mankind.

All our knowledge has been built communally; there would be no astrophysics, there would be no history, there would not even be language, if man were a solitary animal. What follows? It follows that we must be able to rely on other people; we must be able to trust their word. That is, it follows that there is a principle, which binds society together because without it the individual would be helpless to tell the truth from the false. This principle is truthfulness.

All religions, arts and sciences are branches of the same tree. All these aspirations are directed toward ennobling man’s life, lifting it from the sphere of mere physical existence and leading the individual towards freedom.

All that is valuable in human society depends upon the opportunity for development accorded the individual.

All the events which occur upon the earth result from Law: even those actions which are entirely dependent on the caprices of the memory, or the impulse of the passions, are shown by statistics to be, when taken in the gross, entirely independent of the human will. As a single atom, man is an enigma; as a whole, he is a mathematical problem. As an individual, he is a free agent; as a species, the offspring of necessity.

All the more recent work on alkaptonuria has... strengthened the belief that the homogentisic acid excreted is derived from tyrosin, but why alkaptonuric individuals pass the benzene ring of their tyrosin unbroken and how and where the peculiar chemical change from tyrosin to homogentisic acid is brought about, remain unsolved problems.

Although gravity is by far the weakest force of nature, its insidious and cumulative action serves to determine the ultimate fate not only of individual astronomical objects but of the entire cosmos. The same remorseless attraction that crushes a star operates on a much grander scale on the universe as a whole.

Amidst the vicissitudes of the earth’s surface, species cannot be immortal, but must perish, one after another, like the individuals which compose them. There is no possibility of escaping from this conclusion.

An individual can’t be judged by his group mean.

An Individual, whatever species it might be, is nothing in the Universe. A hundred, a thousand individuals are still nothing. The species are the only creatures of Nature, perpetual creatures, as old and as permanent as it. In order to judge it better, we no longer consider the species as a collection or as a series of similar individuals, but as a whole independent of number, independent of time, a whole always living, always the same, a whole which has been counted as one in the works of creation, and which, as a consequence, makes only a unity in Nature.

Another great and special excellence of mathematics is that it demands earnest voluntary exertion. It is simply impossible for a person to become a good mathematician by the happy accident of having been sent to a good school; this may give him a preparation and a start, but by his own individual efforts alone can he reach an eminent position.

Anthropologists are highly individual and specialized people. Each of them is marked by the kind of work he or she prefers and has done, which in time becomes an aspect of that individual’s personality.

Any artist or novelist would understand—some of us do not produce their best when directed. We expect the artist, the novelist and the composer to lead solitary lives, often working at home. While a few of these creative individuals exist in institutions or universities, the idea of a majority of established novelists or painters working at the “National Institute for Painting and Fine Art” or a university “Department of Creative Composition” seems mildly amusing. By contrast, alarm greets the idea of a creative scientist working at home. A lone scientist is as unusual as a solitary termite and regarded as irresponsible or worse.

Any experiment may be regarded as forming an individual of a 'population' of experiments which might be performed under the same conditions. A series of experiments is a sample drawn from this population.
Now any series of experiments is only of value in so far as it enables us to form a judgment as to the statistical constants of the population to which the experiments belong. In a great number of cases the question finally turns on the value of a mean, either directly, or as the mean difference between the two qualities.
If the number of experiments be very large, we may have precise information as to the value of the mean, but if our sample be small, we have two sources of uncertainty:— (I) owing to the 'error of random sampling' the mean of our series of experiments deviates more or less widely from the mean of the population, and (2) the sample is not sufficiently large to determine what is the law of distribution of individuals.

As a scientist and geneticist I started to feel that science would probably soon reach the point where its interference into the life processes would be counterproductive if a properly designed governing policy was not implemented. A heavily overcrowded planet, ninety-five percent urbanized with nuclear energy as the main source of energy and with all aspects of life highly computerized, is not too pleasant a place for human life. The life of any individual soon will be predictable from birth to death. Medicine, able to cure almost everything, will make the load of accumulated defects too heavy in the next two or three centuries. The artificial prolongation of life, which looked like a very bright idea when I started research in aging about twenty-five years ago, has now lost its attractiveness for me. This is because I now know that the aging process is so multiform and complex that the real technology and chemistry of its prevention by artificial interference must be too complex and expensive. It would be the privilege of a few, not the method for the majority. I also was deeply concerned about the fact that most research is now either directly or indirectly related to military projects and objectives for power.

As far as the meaning of life in general, or in the abstract, as far as I can see, there is none. If all of life were suddenly to disappear from earth and anywhere else it may exist, or if none had ever formed in the first place, I think the Universe would continue to exist without perceptible change. However, it is always possible for an individual to invest his own life with meaning that he can find significant. He can so order his life that he may find as much beauty and wisdom in it as he can, and spread as much of that to others as possible.

As in the domains of practical life so likewise in science there has come about a division of labor. The individual can no longer control the whole field of mathematics: it is only possible for him to master separate parts of it in such a manner as to enable him to extend the boundaries of knowledge by creative research.

As is well known the principle of virtual velocities transforms all statics into a mathematical assignment, and by D'Alembert's principle for dynamics, the latter is again reduced to statics. Although it is is very much in order that in gradual training of science and in the instruction of the individual the easier precedes the more difficult, the simple precedes the more complicated, the special precedes the general, yet the min, once it has arrived at the higher standpoint, demands the reverse process whereby all statics appears only as a very special case of mechanics.

As long as an individual mollusk remains unregistered it is deprived of its full usefulness; but even then it may reveal an important fact—as the trilobite speaks of the Palaeozoic period, and a nummulite of the Tertiary.

As man advances in civilisation, and small tribes are united into larger communities, the simplest reason would tell each individual that he ought to extend his social instincts and sympathies to all the members of the same nation, though personally unknown to him. This point being once reached, there is only an artificial barrier to prevent his sympathies extending to the men of all nations and races.

As regards religion, on the other hand, one is generally agreed that it deals with goals and evaluations and, in general, with the emotional foundation of human thinking and acting, as far as these are not predetermined by the inalterable hereditary disposition of the human species. Religion is concerned with man’s attitude toward nature at large, with the establishing of ideals for the individual and communal life, and with mutual human relationship. These ideals religion attempts to attain by exerting an educational influence on tradition and through the development and promulgation of certain easily accessible thoughts and narratives (epics and myths) which are apt to influence evaluation and action along the lines of the accepted ideals.

As the Director of the Theoretical Division of Los Alamos, I participated at the most senior level in the World War II Manhattan Project that produced the first atomic weapons.
Now, at age 88, I am one of the few remaining such senior persons alive. Looking back at the half century since that time, I feel the most intense relief that these weapons have not been used since World War II, mixed with the horror that tens of thousands of such weapons have been built since that time—one hundred times more than any of us at Los Alamos could ever have imagined.
Today we are rightly in an era of disarmament and dismantlement of nuclear weapons. But in some countries nuclear weapons development still continues. Whether and when the various Nations of the World can agree to stop this is uncertain. But individual scientists can still influence this process by withholding their skills.
Accordingly, I call on all scientists in all countries to cease and desist from work creating, developing, improving and manufacturing further nuclear weapons - and, for that matter, other weapons of potential mass destruction such as chemical and biological weapons.
[On the occasion of the 50th Anniversary of Hiroshima.]

Astronomy concerns itself with the whole of the visible universe, of which our earth forms but a relatively insignificant part; while Geology deals with that earth regarded as an individual. Astronomy is the oldest of the sciences, while Geology is one of the newest. But the two sciences have this in common, that to both are granted a magnificence of outlook, and an immensity of grasp denied to all the rest.

At fertilization, these two “haploid” nuclei are added together to make a “diploid” nucleus that now contains 2a, 2b and so on; and, by the splitting of each chromosome and the regulated karyokinetic separation of the daughter chromosomes, this double series is inherited by both of the primary blastomeres. In the resulting resting nuclei the individual chromosomes are apparently destroyed. But we have the strongest of indications that, in the stroma of the resting nucleus, every one of the chromosomes that enters the nucleus survives as a well-defined region; and as the cell prepares for its next division this region again gives rise to the same chromosome (Theory of the Individuality of the Chromosomes). In this way the two sets of chromosomes brought together at fertilization are inherited by all the cells of the new individual. It is only in the germinal cells that the so called reduction division converts the double series into a single one. Out of the diploid state, the haploid is once again generated.

Before any great scientific principle receives distinct enunciation by individuals, it dwells more or less clearly in the general scientific mind. The intellectual plateau is already high, and our discoverers are those who, like peaks above the plateau, rise a little above the general level of thought at the time.

Being also in accord with Goethe that discoveries are made by the age and not by the individual, I should consider the instances to be exceedingly rare of men who can be said to be living before their age, and to be the repository of knowledge quite foreign to the thought of the time. The rule is that a number of persons are employed at a particular piece of work, but one being a few steps in advance of the others is able to crown the edifice with his name, or, having the ability to generalise already known facts, may become in time to be regarded as their originator. Therefore it is that one name is remembered whilst those of coequals have long been buried in obscurity.

Beneath multiple specific and individual distinctions, beneath innumerable and incessant transformations, at the bottom of the circular evolution without beginning or end, there hides a law, a unique nature participated in by all beings, in which this common participation produces a ground of common harmony.

Biologically the species is the accumulation of the experiments of all its successful individuals since the beginning.

But … the working scientist … is not consciously following any prescribed course of action, but feels complete freedom to utilize any method or device whatever which in the particular situation before him seems likely to yield the correct answer. … No one standing on the outside can predict what the individual scientist will do or what method he will follow.

But from the time I was in college I learned that there is nothing one could imagine which is so strange and incredible that it was not said by some philosopher; and since that time, I have recognized through my travels that all those whose views are different from our own are not necessarily, for that reason, barbarians or savages, but that many of them use their reason either as much as or even more than we do. I also considered how the same person, with the same mind, who was brought up from infancy either among the French or the Germans, becomes different from what they would have been if they had always lived among the Chinese or among the cannibals, and how, even in our clothes fashions, the very thing that we liked ten years ago, and that we may like again within the next ten years, appears extravagant and ridiculous to us today. Thus our convictions result from custom and example very much more than from any knowledge that is certain... truths will be discovered by an individual rather than a whole people.

But the idea that any of the lower animals have been concerned in any way with the origin of man—is not this degrading? Degrading is a term, expressive of a notion of the human mind, and the human mind is liable to prejudices which prevent its notions from being invariably correct. Were we acquainted for the first time with the circumstances attending the production of an individual of our race, we might equally think them degrading, and be eager to deny them, and exclude them from the admitted truths of nature.

By destroying the biological character of phenomena, the use of averages in physiology and medicine usually gives only apparent accuracy to the results. From our point of view, we may distinguish between several kinds of averages: physical averages, chemical averages and physiological and pathological averages. If, for instance, we observe the number of pulsations and the degree of blood pressure by means of the oscillations of a manometer throughout one day, and if we take the average of all our figures to get the true or average blood pressure and to learn the true or average number of pulsations, we shall simply have wrong numbers. In fact, the pulse decreases in number and intensity when we are fasting and increases during digestion or under different influences of movement and rest; all the biological characteristics of the phenomenon disappear in the average. Chemical averages are also often used. If we collect a man's urine during twenty-four hours and mix all this urine to analyze the average, we get an analysis of a urine which simply does not exist; for urine, when fasting, is different from urine during digestion. A startling instance of this kind was invented by a physiologist who took urine from a railroad station urinal where people of all nations passed, and who believed he could thus present an analysis of average European urine! Aside from physical and chemical, there are physiological averages, or what we might call average descriptions of phenomena, which are even more false. Let me assume that a physician collects a great many individual observations of a disease and that he makes an average description of symptoms observed in the individual cases; he will thus have a description that will never be matched in nature. So in physiology, we must never make average descriptions of experiments, because the true relations of phenomena disappear in the average; when dealing with complex and variable experiments, we must study their various circumstances, and then present our most perfect experiment as a type, which, however, still stands for true facts. In the cases just considered, averages must therefore be rejected, because they confuse, while aiming to unify, and distort while aiming to simplify. Averages are applicable only to reducing very slightly varying numerical data about clearly defined and absolutely simple cases.

By teaching us how to cultivate each ferment in its purity—in other words, by teaching us how to rear the individual organism apart from all others,—Pasteur has enabled us to avoid all these errors. And where this isolation of a particular organism has been duly effected it grows and multiplies indefinitely, but no change of it into another organism is ever observed. In Pasteur’s researches the Bacterium remained a Bacterium, the Vibrio a Vibrio, the Penicillium a Penicillium, and the Torula a Torula. Sow any of these in a state of purity in an appropriate liquid; you get it, and it alone, in the subsequent crop. In like manner, sow smallpox in the human body, your crop is smallpox. Sow there scarlatina, and your crop is scarlatina. Sow typhoid virus, your crop is typhoid—cholera, your crop is cholera. The disease bears as constant a relation to its contagium as the microscopic organisms just enumerated do to their germs, or indeed as a thistle does to its seed.

Certain students of genetics inferred that the Mendelian units responsible for the selected character were genes producing only a single effect. This was careless logic. It took a good deal of hammering to get rid of this erroneous idea. As facts accumulated it became evident that each gene produces not a single effect, but in some cases a multitude of effects on the characters of the individual. It is true that in most genetic work only one of these character-effects is selected for study—the one that is most sharply defined and separable from its contrasted character—but in most cases minor differences also are recognizable that are just as much the product of the same gene as is the major effect.

Chromosomes … [contain] some kind of code-script the entire pattern of the individual’s future development and of its functioning in the mature state. Every complete set of chromosomes contains the full code.

Collective unity is not the result of the brotherly love of the faithful for each other. The loyalty of the true believer is to the whole—the church, party, nation—and not to his fellow true believer. True loyalty between individuals is possible only in a loose and relatively free society.

Common to all these types is the anthropomorphic character of their conception of God. In general, only individuals of exceptional endowments, and exceptionally high-minded communities, rise to any considerable extent above this level. But there is a third stage of religious experience which belongs to all of them, even though it is rarely found in a pure form: I shall call it cosmic religious feeling. It is very difficult to elucidate this feeling to anyone who is entirely without it, especially as there is no anthropomorphic conception of God corresponding to it.

Connected by innumerable ties with abstract science, Physiology is yet in the most intimate relation with humanity; and by teaching us that law and order, and a definite scheme of development, regulate even the strangest and wildest manifestations of individual life, she prepares the student to look for a goal even amidst the erratic wanderings of mankind, and to believe that history offers something more than an entertaining chaos—a journal of a toilsome, tragi-comic march nowither.

Contingency is rich and fascinating; it embodies an exquisite tension between the power of individuals to modify history and the intelligible limits set by laws of nature. The details of individual and species’s lives are not mere frills, without power to shape the large-scale course of events, but particulars that can alter entire futures, profoundly and forever.

Could Hamlet have been written by a committee, or the “Mona Lisa” painted by a club? Could the New Testament have been composed as a conference report? Creative ideas do not spring from groups. They spring from individuals. The divine spark leaps from the finger of God to the finger of Adam, whether it takes ultimate shape in a law of physics or a law of the land, a poem or a policy, a sonata or a mechanical computer.

Creative activity could be described as a type of learning process where teacher and pupil are located in the same individual.

Culture can be regarded as a constitution of recipes for behavior … which are taught and learned on various levels of awareness; not all of the individuals in any society know all these recipes; and many of the recipes are alternative to one another.

Differences between individuals are the raw materials for evolutionary change and for the evolution of adaptations, yet of course most physiologists treat these differences as noise that is to be filtered out. From the standpoint of physiological ecology, the traditional emphasis of physiologists on central tendencies rather than on variance has some unhappy consequences. Variation is not just noise; it is also the stuff of evolution and a central attribute of living systems. The physiological differences between individuals in the same species or population, and also the patterns of variation in different groups, must not be ignored.

Disease is largely a removable evil. It continues to afflict humanity, not only because of incomplete knowledge of its causes and lack of individual and public hygiene, but also because it is extensively fostered by harsh economic and industrial conditions and by wretched housing in congested communities. ... The reduction of the death rate is the principal statistical expression and index of human social progress. It means the saving and lengthening of lives of thousands of citizens, the extension of the vigorous working period well into old age, and the prevention of inefficiency, misery, and suffering. These advances can be made by organized social effort. Public health is purchasable. (1911)

Disinterestedness is as great a puzzle and paradox as ever. Indeed, strictly speaking, it is a species of irrationality, or insanity, as regards the individual’s self; a contradiction of the most essential nature of a sentient being, which is to move to pleasure and from pain.

During my eighty-seven years I have witnessed a whole succession of technological revolutions. But none of them has done away with the need for character in the individual or the ability to think.

Each species may have had its origin in a single pair, or individual, where an individual was sufficient, and species may have been created in succession at such times and in such places as to enable them to multiply and endure for an appointed period, and occupy an appointed space on the globe.

Education enlarges the child’s survey of the world in which he lives. Education stimulates and develops a child’s individuality. Education should harmonize the individual will and the institutional will.

Equations seem like treasures, spotted in the rough by some discerning individual, plucked and examined, placed in the grand storehouse of knowledge, passed on from generation to generation. This is so convenient a way to present scientific discovery, and so useful for textbooks, that it can be called the treasure-hunt picture of knowledge.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Every individual alive today, even the very highest, is to be derived in an unbroken line from the first and lowest forms.

Every individual is continually exerting himself to find out the most advantageous employment for whatever capital he can command. It is his own advantage, indeed, and not that of society, which he has in view. But the study of his own advantage naturally, or rather necessarily, leads him to prefer that employment which is most advantageous to the society.

Every progress that a church makes in the construction of its dogmas leads to a further taming of the free spirit; every new dogma … narrows the circle of free thought. … Science, on the other hand, liberates with every step of its development, it opens up new paths to thought … In other words, it allows the individual to be truly free.

Every theory of love, from Plato down, teaches that each individual loves in the other sex what he lacks in himself.

Everything that is really great and inspiring is created by the individual who can labor in freedom.

Evolution is a process which favors cooperating rather than disoperating groups and that “fitness” is a function of the group as a whole than of separate individuals. The fitness of the individual is largely derived from his membership on a group.

Evolutionary plasticity can be purchased only at the ruthlessly dear price of continuously sacrificing some individuals to death from unfavourable mutations. Bemoaning this imperfection of nature has, however, no place in a scientific treatment of this subject.

Experiments on ornamental plants undertaken in previous years had proven that, as a rule, hybrids do not represent the form exactly intermediate between the parental strains. Although the intermediate form of some of the more striking traits, such as those relating to shape and size of leaves, pubescence of individual parts, and so forth, is indeed nearly always seen, in other cases one of the two parental traits is so preponderant that it is difficult or quite impossible, to detect the other in the hybrid. The same is true for Pisum hybrids. Each of the seven hybrid traits either resembles so closely one of the two parental traits that the other escapes detection, or is so similar to it that no certain distinction can be made. This is of great importance to the definition and classification of the forms in which the offspring of hybrids appear. In the following discussion those traits that pass into hybrid association entirely or almost entirely unchanged, thus themselves representing the traits of the hybrid, are termed dominating and those that become latent in the association, recessive. The word 'recessive' was chosen because the traits so designated recede or disappear entirely in the hybrids, but reappear unchanged in their progeny, as will be demonstrated later.

Farm animals feel pleasure and sadness, excitement and resentment, depression, fear, and pain. They are far more aware and intelligent than we ever imagined … They are individuals in their own right.

For it is not cell nuclei, not even individual chromosomes, but certain parts of certain chromosomes from certain cells that must be isolated and collected in enormous quantities for analysis; that would be the precondition for placing the chemist in such a position as would allow him to analyse [the hereditary material] more minutely than [can] the morphologists ... For the morphology of the nucleus has reference at the very least to the gearing of the clock, but at best the chemistry of the nucleus refers only to the metal from which the gears are formed.

For the biologist there are no classes—only individuals.

Genius can only breathe freely in an atmosphere of freedom. Persons of genius are, ex vi termini, more individual than any other people—less capable, consequently, of fitting themselves, without hurtful compression, into any of the small number of moulds which society provides in order to save its members the trouble of forming their own character.

Goethe said that he who cannot draw on 3,000 years of learning is living hand to mouth. It could just as well be said that individuals who do tap deeply into this rich cultural legacy are wealthy indeed. Yet the paradox is that much of this wisdom is buried in a sea of lesser books or like lost treasure beneath an ocean of online ignorance and trivia. That doesn’t mean that with a little bit of diligence you can’t tap into it. Yet many people, perhaps most, never take advantage of all this human experience. They aren’t obtaining knowledge beyond what they need to know for work or to get by. As a result, their view of our amazing world is diminished and their lives greatly circumscribed.

Groups do not have experiences except insofar as all their members do. And there are no experiences... that all the members of a scientific community must share in the course of a [scientific] revolution. Revolutions should be described not in terms of group experience but in terms of the varied experiences of individual group members. Indeed, that variety itself turns out to play an essential role in the evolution of scientific knowledge.

Having discovered … by observation and comparison that certain objects agree in certain respects, we generalise the qualities in which they coincide,—that is, from a certain number of individual instances we infer a general law; we perform an act of Induction. This induction is erroneously viewed as analytic; it is purely a synthetic process.

Historians constantly rewrite history, reinterpreting (reorganizing) the records of the past. So, too, when the brain's coherent responses become part of a memory, they are organized anew as part of the structure of consciousness. What makes them memories is that they become part of that structure and thus form part of the sense of self; my sense of self derives from a certainty that my experiences refer back to me, the individual who is having them. Hence the sense of the past, of history, of memory, is in part the creation of the self.

Historically, Statistics is no more than State Arithmetic, a system of computation by which differences between individuals are eliminated by the taking of an average. It has been used—indeed, still is used—to enable rulers to know just how far they may safely go in picking the pockets of their subjects.

Hitherto man had to live with the idea of death as an individual; from now onward mankind will have to live with the idea of its death as a species.

How do we discover the individual laws of Physics, and what is their nature? It should be remarked, to begin with, that we have no right to assume that any physical law exists, or if they have existed up to now, that they will continue to exist in a similar manner in the future. It is perfectly conceivable that one fine day Nature should cause an unexpected event to occur which would baffle us all; and if this were to happen we would be powerless to make any objection, even if the result would be that, in spite of our endeavors, we should fail to introduce order into the resulting confusion. In such an event, the only course open to science would be to declare itself bankrupt. For this reason, science is compelled to begin by the general assumption that a general rule of law dominates throughout Nature.

How far do you go to preserve individual human life? … I mean, what are we to do with the NHS? How can you put a value in pounds, shillings and pence on an individual’s life? There was a case with a bowel cancer drug – if you gave that drug, which costs several thousand pounds, it continued life for six weeks on. How can you make that decision?

How many and how curious problems concern the commonest of the sea-snails creeping over the wet sea-weed! In how many points of view may its history be considered! There are its origin and development, the mystery of its generation, the phenomena of its growth, all concerning each apparently insignificant individual; there is the history of the species, the value of its distinctive marks, the features which link it with the higher and lower creatures, the reason why it takes its stand where we place it in the scale of creation, the course of its distribution, the causes of its diffusion, its antiquity or novelty, the mystery (deepest of mysteries) of its first appearance, the changes of the outline of continents and of oceans which have taken place since its advent, and their influence on its own wanderings.

I am absolutely convinced that no wealth in the world can help humanity forward, even in the hands of the most devoted worker. The example of great and pure individuals is the only thing that can lead us to noble thoughts and deeds. Money only appeals to selfishness and irresistibly invites abuse. Can anyone imagine Moses, Jesus or Gandhi armed with the moneybags of Carnegie?

I am an adherent of the ideal of democracy, although I well know the weaknesses of the democratic form of government. Social equality and economic protection of the individual appeared to me always as the important communal aims of the state.

I am entitled to say, if I like, that awareness exists in all the individual creatures on the planet—worms, sea urchins, gnats, whales, subhuman primates, superprimate humans, the lot. I can say this because we do not know what we are talking about: consciousness is so much a total mystery for our own species that we cannot begin to guess about its existence in others.

I am mindful that scientific achievement is rooted in the past, is cultivated to full stature by many contemporaries and flourishes only in favorable environment. No individual is alone responsible for a single stepping stone along the path of progress, and where the path is smooth progress is most rapid. In my own work this has been particularly true.

I am more and more convinced that the ant colony is not so much composed of separate individuals as that the colony is a sort of individual, and each ant like a loose cell in it. Our own blood stream, for instance, contains hosts of white corpuscles which differ little from free-swimming amoebae. When bacteria invade the blood stream, the white corpuscles, like the ants defending the nest, are drawn mechanically to the infected spot, and will die defending the human cell colony. I admit that the comparison is imperfect, but the attempt to liken the individual human warrior to the individual ant in battle is even more inaccurate and misleading. The colony of ants with its component numbers stands half way, as a mechanical, intuitive, and psychical phenomenon, between our bodies as a collection of cells with separate functions and our armies made up of obedient privates. Until one learns both to deny real individual initiative to the single ant, and at the same time to divorce one's mind from the persuasion that the colony has a headquarters which directs activity … one can make nothing but pretty fallacies out of the polity of the ant heap.

I am of opinion, then, ... that, if there is any circumstance thoroughly established in geology, it is, that the crust of our globe has been subjected to a great and sudden revolution, the epoch of which cannot be dated much farther back than five or six thousand years ago; that this revolution had buried all the countries which were before inhabited by men and by the other animals that are now best known; that the same revolution had laid dry the bed of the last ocean, which now forms all the countries at present inhabited; that the small number of individuals of men and other animals that escaped from the effects of that great revolution, have since propagated and spread over the lands then newly laid dry; and consequently, that the human race has only resumed a progressive state of improvement since that epoch, by forming established societies, raising monuments, collecting natural facts, and constructing systems of science and of learning.

I became expert at dissecting crayfish. At one point I had a crayfish claw mounted on an apparatus in such a way that I could operate the individual nerves. I could get the several-jointed claw to reach down and pick up a pencil and wave it around. I am not sure that what I was doing had much scientific value, although I did learn which nerve fiber had to be excited to inhibit the effects of another fiber so that the claw would open. And it did get me interested in robotic instrumentation, something that I have now returned to. I am trying to build better micromanipulators for surgery and the like.

I believe natural beauty has a necessary place in the spiritual development of any individual or any society. I believe that whenever we substitute something man-made and artificial for a natural feature of the earth, we have retarded some part of man’s spiritual growth.

I can say, if I like, that social insects behave like the working parts of an immense central nervous system: the termite colony is an enormous brain on millions of legs; the individual termite is a mobile neurone.

I cannot conceive of a God who rewards and punishes his creatures, or has a will of the type of which we are conscious in ourselves. An individual who should survive his physical death is also beyond my comprehension, nor do I wish it otherwise; such notions are for the fears or absurd egoism of feeble souls.

I cannot imagine a God who rewards and punishes the objects of his creation, whose purposes are modeled after our own–a God, in short, who is but a reflection of human frailty. Neither can I believe that the individual survives the death of his body, although feeble souls harbor such thoughts through fear or ridiculous egotism. It is enough for me to contemplate the mystery of conscious life perpetuating itself through all eternity, to reflect upon the marvelous structure of the universe which we can dimly perceive, and to try humbly to comprehend even an infinitesimal part of the intelligence manifested in nature.

I do not believe in freedom of the will. Schopenhauer’s words: ‘Man can do what he wants, but he cannot will what he wills’ accompany me in all situations throughout my life and reconcile me with the actions of others even if they are rather painful to me. This awareness of the lack of freedom of will preserves me from taking too seriously myself and my fellow men as acting and deciding individuals and from losing my temper.

I do not claim that intelligence, however defined, has no genetic basis–I regard it as trivially true, uninteresting, and unimportant that it does. The expression of any trait represents a complex interaction of heredity and environment ... a specific claim purporting to demonstrate a mean genetic deficiency in the intelligence of American blacks rests upon no new facts whatever and can cite no valid data in its support. It is just as likely that blacks have a genetic advantage over whites. And, either way, it doesn’t matter a damn. An individual can’t be judged by his group mean.

I do not intend to go deeply into the question how far mathematical studies, as the representatives of conscious logical reasoning, should take a more important place in school education. But it is, in reality, one of the questions of the day. In proportion as the range of science extends, its system and organization must be improved, and it must inevitably come about that individual students will find themselves compelled to go through a stricter course of training than grammar is in a position to supply. What strikes me in my own experience with students who pass from our classical schools to scientific and medical studies, is first, a certain laxity in the application of strictly universal laws. The grammatical rules, in which they have been exercised, are for the most part followed by long lists of exceptions; accordingly they are not in the habit of relying implicitly on the certainty of a legitimate deduction from a strictly universal law. Secondly, I find them for the most part too much inclined to trust to authority, even in cases where they might form an independent judgment. In fact, in philological studies, inasmuch as it is seldom possible to take in the whole of the premises at a glance, and inasmuch as the decision of disputed questions often depends on an aesthetic feeling for beauty of expression, or for the genius of the language, attainable only by long training, it must often happen that the student is referred to authorities even by the best teachers. Both faults are traceable to certain indolence and vagueness of thought, the sad effects of which are not confined to subsequent scientific studies. But certainly the best remedy for both is to be found in mathematics, where there is absolute certainty in the reasoning, and no authority is recognized but that of one’s own intelligence.

I feel that the recent ruling of the United States Army and Navy regarding the refusal of colored blood donors is an indefensible one from any point of view. As you know, there is no scientific basis for the separation of the bloods of different races except on the basis of the individual blood types or groups. (1942)

I have now reached the point where I may indicate briefly what to me constitutes the essence of the crisis of our time. It concerns the relationship of the individual to society. The individual has become more conscious than ever of his dependence upon society. But he does not experience this dependence as a positive asset, as an organic tie, as a protective force, but rather as a threat to his natural rights, or even to his economic existence. Moreover, his position in society is such that the egotistical drives of his make-up are constantly being accentuated, while his social drives, which are by nature weaker, progressively deteriorate. All human beings, whatever their position in society, are suffering from this process of deterioration. Unknowingly prisoners of their own egotism, they feel insecure, lonely, and deprived of the naive, simple, and unsophisticated enjoyment of life. Man can find meaning in life, short and perilous as it is, only through devoting himself to society.