[Misquotation? Probably not by Einstein.] We owe a lot to the Indians, who taught us how to count, without which no worthwhile scientific discovery could have been made.

A Dr van’t Hoff of the veterinary college at Utrecht, appears to have no taste for exact chemical investigation. He finds it a less arduous task to mount Pegasus (evidently borrowed from the veterinary school) and to proclaim in his La Chemie dans l’espace how, during his bold fight to the top of the chemical Parnassus, the atoms appeared to him to have grouped themselves together throughout universal space. … I should have taken no notice of this matter had not Wislicenus oddly enough written a preface to the pamphlet, and not by way of a joke but in all seriousness recommended it a worthwhile performance.

Adventure is worthwhile in itself.

Aristotle’s opinion … that comets were nothing else than sublunary vapors or airy meteors … prevailed so far amongst the Greeks, that this sublimest part of astronomy lay altogether neglected; since none could think it worthwhile to observe, and to give an account of the wandering and uncertain paths of vapours floating in the Ether.

Do not enter upon research unless you can not help it. Ask yourself the “why” of every statement that is made and think out your own answer. If through your thoughtful work you get a worthwhile idea, it will get you. The force of the conviction will compel you to forsake all and seek the relief of your mind in research work.

Don’t be afraid of hard work. Nothing worthwhile comes easily. Don’t let others discourage you or tell you that you can’t do it. In my day I was told women didn’t go into chemistry. I saw no reason why we couldn’t.

I feel sorry for the person who can't get genuinely excited about his work. Not only will he never be satisfied, but he will never achieve anything worthwhile.

I had always looked upon the search for the absolute as the noblest and most worth while task of science.

It has been said that computing machines can only carry out the processes that they are instructed to do. This is certainly true in the sense that if they do something other than what they were instructed then they have just made some mistake. It is also true that the intention in constructing these machines in the first instance is to treat them as slaves, giving them only jobs which have been thought out in detail, jobs such that the user of the machine fully understands what in principle is going on all the time. Up till the present machines have only been used in this way. But is it necessary that they should always be used in such a manner? Let us suppose we have set up a machine with certain initial instruction tables, so constructed that these tables might on occasion, if good reason arose, modify those tables. One can imagine that after the machine had been operating for some time, the instructions would have altered out of all recognition, but nevertheless still be such that one would have to admit that the machine was still doing very worthwhile calculations. Possibly it might still be getting results of the type desired when the machine was first set up, but in a much more efficient manner. In such a case one would have to admit that the progress of the machine had not been foreseen when its original instructions were put in. It would be like a pupil who had learnt much from his master, but had added much more by his own work. When this happens I feel that one is obliged to regard the machine as showing intelligence.

Knowledge is necessary too. A child with great intuition could not grow up to become something worthwhile in life without some knowledge. However there comes a point in everyone’s life where only intuition can make the leap ahead, without knowing precisely how.

Let me suggest to you a simple test one can apply to scientific activities to determine whether or not they can constitute the practice of physics. Is what you are doing beautiful? Many beautiful things are created without the use of physical knowledge, but I know of no really worthwhile physics that isn’t beautiful. Indeed, one of the most distressing symptoms of scientific illiteracy is the impression so often given to school children that science is a mechanistic activity subject to algorithmic description.

Only a life lived for others is a life worthwhile.

People are not going to care about animal conservation unless they think that animals are worthwhile.

Science can be thought of as a large pool of knowledge, fed by a steady flow from the tap of basic research. Every now and then the water is dipped out and put to use, but one never knows which part of the water will be needed. This confuses the funding situation for basic science, because usually no specific piece of scientific work can be justified in advance; one cannot know which is going to be decisive. Yet history shows that keeping water flowing into the pool is a very worthwhile enterprise.

Some people have remarked that if the surface of the moon were covered with diamonds, it would hardly be worthwhile bringing them back.

The hybridoma technology was a by-product of basic research. Its success in practical applications is to a large extent the result of unexpected and unpredictable properties of the method. It thus represents another clear-cut example of the enormous practical impact of an investment in research which might not have been considered commercially worthwhile, or of immediate medical relevance. It resulted from esoteric speculations, for curiosity’s sake, only motivated by a desire to understand nature.

The more experiences and experiments accumulate in the exploration of nature, the more precarious the theories become. But it is not always good to discard them immediately on this account. For every hypothesis which once was sound was useful for thinking of previous phenomena in the proper interrelations and for keeping them in context. We ought to set down contradictory experiences separately, until enough have accumulated to make building a new structure worthwhile.

Unfortunately what is little recognized is that the most worthwhile scientific books are those in which the author clearly indicates what he does not know; for an author most hurts his readers by concealing difficulties.