… the embryological record, as it is usually presented to us, is both imperfect and misleading. It may be compared to an ancient manuscript, with many of the sheets lost, others displaced, and with spurious passages interpolated by a later hand. … Like the scholar with his manuscript, the embryologist has by a process of careful and critical examination to determine where the gaps are present, to detect the later insertions, and to place in order what has been misplaced.

...while science gives us implements to use, science alone does not determine for what ends they will be employed. Radio is an amazing invention. Yet now that it is here, one suspects that Hitler never could have consolidated his totalitarian control over Germany without its use. One never can tell what hands will reach out to lay hold on scientific gifts, or to what employment they will be put. Ever the old barbarian emerges, destructively using the new civilization.

[Haunted by the statistic that the best predictor of SAT scores is family income:] Where you were born, into what family you are born, what their resources are, are to a large extent are going to determine the quality of education you receive, beginning in preschool and moving all the way up through college.
And what this is going to create in America is a different kind of aristocracy that's going to be self-perpetuating, unless we find ways to break that juggernaut.
... I think what that really reflects is the fact that resources, and not wealth necessarily, but just good middle-class resources, can buy quality of experience for children.

[In mathematics] we behold the conscious logical activity of the human mind in its purest and most perfect form. Here we learn to realize the laborious nature of the process, the great care with which it must proceed, the accuracy which is necessary to determine the exact extent of the general propositions arrived at, the difficulty of forming and comprehending abstract concepts; but here we learn also to place confidence in the certainty, scope and fruitfulness of such intellectual activity.

[Mathematics] has for its object the indirect measurement of magnitudes, and it proposes to determine magnitudes by each other, according to the precise relations which exist between them.

[Someone] remarked to me once: Physicians should not say, I have cured this man, but, This man didn’t die in my care. In physics too one might say, For such and such a phenomenon I have determined causes whose absurdity cannot finally be proved, instead of saying, I have explained it.

[T]he phenomena of animal life correspond to one another, whether we compare their rank as determined by structural complication with the phases of their growth, or with their succession in past geological ages; whether we compare this succession with their relative growth, or all these different relations with each other and with the geographical distribution of animals upon the earth. The same series everywhere!

[To identify ancient sites] The primary requirement is a human skeleton or artifacts that are clearly the work of humans. Next, this evidence must lie in situ within undisturbed geological deposits. The artifacts should be directly associated with stratigraphy. Finally, the minimum age of the site must be determined by a direct link with fossils of known age or with material that has been reliably dated.

“Pieces” almost always appear 'as parts' in whole processes. ... To sever a “'part” from the organized whole in which it occurs—whether it itself be a subsidiary whole or an “element”—is a very real process usually involving alterations in that “part”. Modifications of a part frequently involve changes elsewhere in the whole itself. Nor is the nature of these alterations arbitrary, for they too are determined by whole-conditions.

Question: Explain how to determine the time of vibration of a given tuning-fork, and state what apparatus you would require for the purpose.
Answer: For this determination I should require an accurate watch beating seconds, and a sensitive ear. I mount the fork on a suitable stand, and then, as the second hand of my watch passes the figure 60 on the dial, I draw the bow neatly across one of its prongs. I wait. I listen intently. The throbbing air particles are receiving the pulsations; the beating prongs are giving up their original force; and slowly yet surely the sound dies away. Still I can hear it, but faintly and with close attention; and now only by pressing the bones of my head against its prongs. Finally the last trace disappears. I look at the time and leave the room, having determined the time of vibration of the common “pitch” fork. This process deteriorates the fork considerably, hence a different operation must be performed on a fork which is only lent.

Une même expression, dont les géomètres avaient considéré les propriétés abstraites, … représente'aussi le mouvement de la lumière dans l’atmosphère, quelle détermine les lois de la diffusion de la chaleur dans la matière solide, et quelle entre dans toutes les questions principales de la théorie des probabilités.
The same expression whose abstract properties geometers had considered … represents as well the motion of light in the atmosphere, as it determines the laws of diffusion of heat in solid matter, and enters into all the chief problems of the theory of probability.

A principle of induction would be a statement with the help of which we could put inductive inferences into a logically acceptable form. In the eyes of the upholders of inductive logic, a principle of induction is of supreme importance for scientific method: “... this principle”, says Reichenbach, “determines the truth of scientific theories. To eliminate it from science would mean nothing less than to deprive science of the power to decide the truth or falsity of its theories. Without it, clearly, science would no longer have the right to distinguish its theories from the fanciful and arbitrary creations of the poet’s mind.” Now this principle of induction cannot be a purely logical truth like a tautology or an analytic statement. Indeed, if there were such a thing as a purely logical principle of induction, there would be no problem of induction; for in this case, all inductive inferences would have to be regarded as purely logical or tautological transformations, just like inferences in inductive logic. Thus the principle of induction must be a synthetic statement; that is, a statement whose negation is not self-contradictory but logically possible. So the question arises why such a principle should be accepted at all, and how we can justify its acceptance on rational grounds.

A railroad may have to be carried over a gorge or arroya. Obviously it does not need an Engineer to point out that this may be done by filling the chasm with earth, but only a Bridge Engineer is competent to determine whether it is cheaper to do this or to bridge it, and to design the bridge which will safely and most cheaply serve.

A touchstone to determine the actual worth of an “intellectual”—find out how he feels about astrology.

A very small cause which escapes our notice determines a considerable effect that we cannot fail to see, and then we say that the effect is due to chance. If we knew exactly the laws of nature and the situation of the universe at the initial moment, we could predict exactly the situation of that same universe at a succeeding moment.

Ability is what you’re capable of doing. Motivation determines what you do. Attitude determines how well you do it.

Activity bears fruit in habit, and the kind of activity determines the quality of the habit.

Admit for a moment, as a hypothesis, that the Creator had before his mind a projection of the whole life-history of the globe, commencing with any point which the geologist may imagine to have been a fit commencing point, and ending with some unimaginable acme in the indefinitely distant future. He determines to call this idea into actual existence, not at the supposed commencing point, but at some stage or other of its course. It is clear, then, that at the selected stage it appears, exactly as it would have appeared at that moment of its history, if all the preceding eras of its history had been real.

All the different classes of beings which taken together make up the universe are, in the ideas of God who knows distinctly their essential gradations, only so many ordinates of a single curve so closely united that it would be impossible to place others between any two of them, since that would imply disorder and imperfection. Thus men are linked with the animals, these with the plants and these with the fossils which in turn merge with those bodies which our senses and our imagination represent to us as absolutely inanimate. And, since the law of continuity requires that when the essential attributes of one being approximate those of another all the properties of the one must likewise gradually approximate those of the other, it is necessary that all the orders of natural beings form but a single chain, in which the various classes, like so many rings, are so closely linked one to another that it is impossible for the senses or the imagination to determine precisely the point at which one ends and the next begins?all the species which, so to say, lie near the borderlands being equivocal, at endowed with characters which might equally well be assigned to either of the neighboring species. Thus there is nothing monstrous in the existence zoophytes, or plant-animals, as Budaeus calls them; on the contrary, it is wholly in keeping with the order of nature that they should exist. And so great is the force of the principle of continuity, to my thinking, that not only should I not be surprised to hear that such beings had been discovered?creatures which in some of their properties, such as nutrition or reproduction, might pass equally well for animals or for plants, and which thus overturn the current laws based upon the supposition of a perfect and absolute separation of the different orders of coexistent beings which fill the universe;?not only, I say, should I not be surprised to hear that they had been discovered, but, in fact, I am convinced that there must be such creatures, and that natural history will perhaps some day become acquainted with them, when it has further studied that infinity of living things whose small size conceals them for ordinary observation and which are hidden in the bowels of the earth and the depth of the sea.

Although gravity is by far the weakest force of nature, its insidious and cumulative action serves to determine the ultimate fate not only of individual astronomical objects but of the entire cosmos. The same remorseless attraction that crushes a star operates on a much grander scale on the universe as a whole.

An idealist believes the short run doesn’t count. A cynic believes the long run doesn’t matter. A realist believes that what is done or left undone in the short run determines the long run.

Any conception which is definitely and completely determined by means of a finite number of specifications, say by assigning a finite number of elements, is a mathematical conception. Mathematics has for its function to develop the consequences involved in the definition of a group of mathematical conceptions. Interdependence and mutual logical consistency among the members of the group are postulated, otherwise the group would either have to be treated as several distinct groups, or would lie beyond the sphere of mathematics.

Any experiment may be regarded as forming an individual of a 'population' of experiments which might be performed under the same conditions. A series of experiments is a sample drawn from this population.
Now any series of experiments is only of value in so far as it enables us to form a judgment as to the statistical constants of the population to which the experiments belong. In a great number of cases the question finally turns on the value of a mean, either directly, or as the mean difference between the two qualities.
If the number of experiments be very large, we may have precise information as to the value of the mean, but if our sample be small, we have two sources of uncertainty:— (I) owing to the 'error of random sampling' the mean of our series of experiments deviates more or less widely from the mean of the population, and (2) the sample is not sufficiently large to determine what is the law of distribution of individuals.

Applied science, purposeful and determined, and pure science, playful and freely curious, continuously support and stimulate each other. The great nation of the future will be the one which protects the freedom of pure science as much as it encourages applied science.

Both social and biosocial factors are necessary to interpret crosscultural studies, with the general proviso that one’s research interest determines which elements, in what combinations, are significant for the provision of understanding.

But here I stop–short of any deterministic speculation that attributes specific behaviors to the possession of specific altruist or opportunist genes. Our genetic makeup permits a wide range of behaviors–from Ebenezer Scrooge before to Ebenezer Scrooge after. I do not believe that the miser hoards through opportunist genes or that the philanthropist gives because nature endowed him with more than the normal complement of altruist genes. Upbringing, culture, class, status, and all the intangibles that we call ‘free will,’ determine how we restrict our behaviors from the wide spectrum–extreme altruism to extreme selfishness–that our genes permit.

But how is one to determine what is pleasing to God? ... Whatever is unpleasant to man is pleasant to God. The test is the natural instinct of man. If there arises within one’s dark recesses a hot desire to do this or that, then it is the paramount duty of a Christian to avoid doing this or that. And if, on the contrary, one cherishes an abhorrence of the business, then one must tackle it forthwith, all the time shouting ‘Hallelujah!’ A simple enough religion, surely–simple, satisfying and idiotic.

By what process of reasoning should the State of Texas be more concerned in the conviction of the guilty than in the acquittal of the innocent? [Urging the use of scopolamine “truth serum” to determine innocence.]

Controlled research … endeavors to pick out of the web of nature’s activities some single strand and trace it towards its origin and its terminus and determine its relation to other strands.

Discoveries are always accidental; and the great use of science is by investigating the nature of the effects produced by any process or contrivance, and of the causes by which they are brought about, to explain the operation and determine the precise value of every new invention. This fixes as it were the latitude and longitude of each discovery, and enables us to place it in that part of the map of human knowledge which it ought to occupy. It likewise enables us to use it in taking bearings and distances, and in shaping our course when we go in search of new discoveries.

During my span of life science has become a matter of public concern and the l'art pour l'art standpoint of my youth is now obsolete. Science has become an integral and most important part of our civilization, and scientific work means contributing to its development. Science in our technical age has social, economic, and political functions, and however remote one's own work is from technical application it is a link in the chain of actions and decisions which determine the fate of the human race. I realized this aspect of science in its full impact only after Hiroshima.

Equations are Expressions of Arithmetical Computation, and properly have no place in Geometry, except as far as Quantities truly Geometrical (that is, Lines, Surfaces, Solids, and Proportions) may be said to be some equal to others. Multiplications, Divisions, and such sort of Computations, are newly received into Geometry, and that unwarily, and contrary to the first Design of this Science. For whosoever considers the Construction of a Problem by a right Line and a Circle, found out by the first Geometricians, will easily perceive that Geometry was invented that we might expeditiously avoid, by drawing Lines, the Tediousness of Computation. Therefore these two Sciences ought not to be confounded. The Ancients did so industriously distinguish them from one another, that they never introduced Arithmetical Terms into Geometry. And the Moderns, by confounding both, have lost the Simplicity in which all the Elegance of Geometry consists. Wherefore that is Arithmetically more simple which is determined by the more simple Equation, but that is Geometrically more simple which is determined by the more simple drawing of Lines; and in Geometry, that ought to be reckoned best which is geometrically most simple.

Even though the realms of religion and science in themselves are clearly marked off from each other, nevertheless there exist between the two strong reciprocal relationships and dependencies. Though religion may be that which determines the goal, it has, nevertheless, learned from science, in the broadest sense, what means will contribute to the attainment of the goals it has set up. But science can only be created by those who are thoroughly imbued with the aspiration toward truth and understanding. This source of feeling, however, springs from the sphere of religion. To this there also belongs the faith in the possibility that the regulations valid for the world of existence are rational, that is, comprehensible to reason. I cannot conceive of a genuine scientist without that profound faith. The situation may be expressed by an image: science without religion is lame, religion without science is blind.

Every species of plant and animal is determined by a pool of germ plasm that has been most carefully selected over a period of hundreds of millions of years. We can understand now why it is that mutations in these carefully selected organisms almost invariably are detrimental.The situation can be suggested by a statement by Dr. J.B.S. Haldane: “My clock is not keeping perfect time. It is conceivable that it will run better if I shoot a bullet through it; but it is much more probable that it will stop altogether.” Professor George Beadle, in this connection, has asked: “What is the chance that a typographical error would improve Hamlet?”

Everything is determined … by forces over which we have no control. It is determined for the insect as well as the star. Human beings, vegetables, or cosmic dust—we all dance to a mysterious tune, intoned in the distance by an invisible piper.

Experimental investigation, to borrow a phrase employed by Kepler respecting the testing of hypotheses, is “a very great thief of time.” Sometimes it costs many days to determine a fact that can be stated in a line.

Fear, rage and pain, and the pangs of hunger are all primitive experiences which human beings share with the lower animals. These experiences are properly classed as among the most powerful that determine the action of men and beasts

Finding the world would not accommodate to his theory, he wisely determined to accommodate the theory to the world.

For Linnaeus, Homo sapiens was both special and not special ... Special and not special have come to mean nonbiological and biological, or nurture and nature. These later polarizations are nonsensical. Humans are animals and everything we do lies within our biological potential ... the statement that humans are animals does not imply that our specific patterns of behavior and social arrangements are in any way directly determined by our genes. Potentiality and determination are different concepts.

Fractals are patterns which occur on many levels. This concept can be applied to any musical parameter. I make melodic fractals, where the pitches of a theme I dream up are used to determine a melodic shape on several levels, in space and time. I make rhythmic fractals, where a set of durations associated with a motive get stretched and compressed and maybe layered on top of each other. I make loudness fractals, where the characteristic loudness of a sound, its envelope shape, is found on several time scales. I even make fractals with the form of a piece, its instrumentation, density, range, and so on. Here I’ve separated the parameters of music, but in a real piece, all of these things are combined, so you might call it a fractal of fractals.

Gauss was not the son of a mathematician; Handel’s father was a surgeon, of whose musical powers nothing is known; Titian was the son and also the nephew of a lawyer, while he and his brother, Francesco Vecellio, were the first painters in a family which produced a succession of seven other artists with diminishing talents. These facts do not, however, prove that the condition of the nerve-tracts and centres of the brain, which determine the specific talent, appeared for the first time in these men: the appropriate condition surely existed previously in their parents, although it did not achieve expression. They prove, as it seems to me, that a high degree of endowment in a special direction, which we call talent, cannot have arisen from the experience of previous generations, that is, by the exercise of the brain in the same specific direction.

Given a situation, a system with a Leerstelle [a gap], whether a given completion (Lueckenfuellung) does justice to the structure, is the “right” one, is often determined by the structure of the system, the situation. There are requirements, structurally determined; there are possible in pure cases unambiguous decisions as to which completion does justice to the situation, which does not, which violates the requirements and the situation.

He [Lord Bacon] appears to have been utterly ignorant of the discoveries which had just been made by Kepler’s calculations … he does not say a word about Napier’s Logarithms, which had been published only nine years before and reprinted more than once in the interval. He complained that no considerable advance had been made in Geometry beyond Euclid, without taking any notice of what had been done by Archimedes and Apollonius. He saw the importance of determining accurately the specific gravities of different substances, and himself attempted to form a table of them by a rude process of his own, without knowing of the more scientific though still imperfect methods previously employed by Archimedes, Ghetaldus and Porta. He speaks of the εὕρηκα of Archimedes in a manner which implies that he did not clearly appreciate either the problem to be solved or the principles upon which the solution depended. In reviewing the progress of Mechanics, he makes no mention either of Archimedes, or Stevinus, Galileo, Guldinus, or Ghetaldus. He makes no allusion to the theory of Equilibrium. He observes that a ball of one pound weight will fall nearly as fast through the air as a ball of two, without alluding to the theory of acceleration of falling bodies, which had been made known by Galileo more than thirty years before. He proposed an inquiry with regard to the lever,—namely, whether in a balance with arms of different length but equal weight the distance from the fulcrum has any effect upon the inclination—though the theory of the lever was as well understood in his own time as it is now. … He speaks of the poles of the earth as fixed, in a manner which seems to imply that he was not acquainted with the precession of the equinoxes; and in another place, of the north pole being above and the south pole below, as a reason why in our hemisphere the north winds predominate over the south.

Hence, a generative grammar must be a system of rules that can iterate to generate an indefinitely large number of structures. This system of rules can be analyzed into the three major components of a generative grammar: the syntactic, phonological, and semantic components... the syntactic component of a grammar must specify, for each sentence, a deep structure that determines its semantic interpretation and a surface structure that determines its phonetic interpretation. The first of these is interpreted by the semantic component; the second, by the phonological component.

I am particularly concerned to determine the probability of causes and results, as exhibited in events that occur in large numbers, and to investigate the laws according to which that probability approaches a limit in proportion to the repetition of events. That investigation deserves the attention of mathematicians because of the analysis required. It is primarily there that the approximation of formulas that are functions of large numbers has its most important applications. The investigation will benefit observers in identifying the mean to be chosen among the results of their observations and the probability of the errors still to be apprehended. Lastly, the investigation is one that deserves the attention of philosophers in showing how in the final analysis there is a regularity underlying the very things that seem to us to pertain entirely to chance, and in unveiling the hidden but constant causes on which that regularity depends. It is on the regularity of the main outcomes of events taken in large numbers that various institutions depend, such as annuities, tontines, and insurance policies. Questions about those subjects, as well as about inoculation with vaccine and decisions of electoral assemblies, present no further difficulty in the light of my theory. I limit myself here to resolving the most general of them, but the importance of these concerns in civil life, the moral considerations that complicate them, and the voluminous data that they presuppose require a separate work.

I cannot but be astonished that Sarsi should persist in trying to prove by means of witnesses something that I may see for myself at any time by means of experiment. Witnesses are examined in doutbful matters which are past and transient, not in those which are actual and present. A judge must seek by means of witnesses to determine whether Peter injured John last night, but not whether John was injured, since the judge can see that for himself.

I concluded that I might take as a general rule the principle that all things which we very clearly and obviously conceive are true: only observing, however, that there is some difficulty in rightly determining the objects which we distinctly conceive.

I do not personally want to believe that we already know the equations that determine the evolution and fate of the universe; it would make life too dull for me as a scientist. … I hope, and believe, that the Space Telescope might make the Big Bang cosmology appear incorrect to future generations, perhaps somewhat analogous to the way that Galileo’s telescope showed that the earth-centered, Ptolemaic system was inadequate.

I imagined in the beginning, that a few experiments would determine the problem; but experience soon convinced me, that a very great number indeed were necessary before such an art could be brought to any tolerable degree of perfection.
Upon pursuing the ''

I know a good many men of great learning—that is, men born with an extraordinary eagerness and capacity to acquire knowledge. One and all, they tell me that they can't recall learning anything of any value in school. All that schoolmasters managed to accomplish with them was to test and determine the amount of knowledge that they had already acquired independently—and not infrequently the determination was made clumsily and inaccurately.

I like people. I like animals, too—whales and quail, dinosaurs and dodos. But I like human beings especially, and I am unhappy that the pool of human germ plasm, which determines the nature of the human race, is deteriorating.
[Stating his alarm for the effect of radioactive fallout on human heredity. The article containing the quote was published three days after he was awarded the 1962 Nobel Peace Prize.]

I should like to compare this rearrangement which the proteins undergo in the animal or vegetable organism to the making up of a railroad train. In their passage through the body parts of the whole may be left behind, and here and there new parts added on. In order to understand fully the change we must remember that the proteins are composed of Bausteine united in very different ways. Some of them contain Bausteine of many kinds. The multiplicity of the proteins is determined by many causes, first through the differences in the nature of the constituent Bausteine; and secondly, through differences in the arrangement of them. The number of Bausteine which may take part in the formation of the proteins is about as large as the number of letters in the alphabet. When we consider that through the combination of letters an infinitely large number of thoughts may be expressed, we can understand how vast a number of the properties of the organism may be recorded in the small space which is occupied by the protein molecules. It enables us to understand how it is possible for the proteins of the sex-cells to contain, to a certain extent, a complete description of the species and even of the individual. We may also comprehend how great and important the task is to determine the structure of the proteins, and why the biochemist has devoted himself with so much industry to their analysis.

If we assume that there is only one enzyme present to act as an oxidizing agent, we must assume for it as many different degrees of activity as are required to explain the occurrence of the various colors known to mendelize (three in mice, yellow, brown, and black). If we assume that a different enzyme or group of enzymes is responsible for the production of each pigment we must suppose that in mice at least three such enzymes or groups of enzymes exist. To determine which of these conditions occurs in mice is not a problem for the biologist, but for the chemist. The biologist must confine his attention to determining the number of distinct agencies at work in pigment formation irrespective of their chemical nature. These agencies, because of their physiological behavior, the biologist chooses to call 'factors,' and attempts to learn what he can about their functions in the evolution of color varieties.

If we view mathematical speculations with reference to their use, it appears that they should be divided into two classes. To the first belong those which furnish some marked advantage either to common life or to some art, and the value of such is usually determined by the magnitude of this advantage. The other class embraces those speculations which, though offering no direct advantage, are nevertheless valuable in that they extend the boundaries of analysis and increase our resources and skill. Now since many investigations, from which great advantage may be expected, must be abandoned solely because of the imperfection of analysis, no small value should be assigned to those speculations which promise to enlarge the field of anaylsis.

In a sense [for the Copenhagen Interpretation], the observer picks what happens. One of the unsolved questions is whether the observer’s mind or will somehow determines the choice, or whether it is simply a case of sticking in a thumb and pulling out a plum at random.

In all likelihood, it is the local conditions of society, which determine the form of the disease, and we can so far think of it as a fairly general result, that the simplest form is the more common, the more paltry and unbalanced the food, and the worse the dwellings are.

In the application of inductive logic to a given knowledge situation, the total evidence available must be used as a basis for determining the degree of confirmation.

In the case of chemical investigations known as decompositions or analyses, it is first important to determine exactly what ingredients you are dealing with, or chemically speaking, what substances are contained in a given mixture or composite. For this purpose we use reagents, i.e., substances that possess certain properties and characteristics, which we well know from references or personal experience, such that the changes which they bring about or undergo, so to say the language that they speak thereby inform the researcher that this or that specific substance is present in the mixture in question.

In the following pages I offer nothing more than simple facts, plain arguments, and common sense; and have no other preliminaries to settle with the reader, than that he will divest himself of prejudice and repossession, and suffer his reason and feelings to determine for themselves; and that he will put on, or rather that he will not put off, the true character of man, and generously enlarge his view beyond the present day.

In the patient who succumbed, the cause of death was evidently something which was not found in the patient who recovered; this something we must determine, and then we can act on the phenomena or recognize and foresee them accurately. But not by statistics shall we succeed in this; never have statistics taught anything, and never can they teach anything about the nature of the phenomenon.

In this respect mathematics fails to reproduce with complete fidelity the obvious fact that experience is not composed of static bits, but is a string of activity, or the fact that the use of language is an activity, and the total meanings of terms are determined by the matrix in which they are embedded.

It is in this mutual dependence of the functions and the aid which they reciprocally lend one another that are founded the laws which determine the relations of their organs and which possess a necessity equal to that of metaphysical or mathematical laws, since it is evident that the seemly harmony between organs which interact is a necessary condition of existence of the creature to which they belong and that if one of these functions were modified in a manner incompatible with the modifications of the others the creature could no longer continue to exist.

It is natural for man to relate the units of distance by which he travels to the dimensions of the globe that he inhabits. Thus, in moving about the earth, he may know by the simple denomination of distance its proportion to the whole circuit of the earth. This has the further advantage of making nautical and celestial measurements correspond. The navigator often needs to determine, one from the other, the distance he has traversed from the celestial arc lying between the zeniths at his point of departure and at his destination. It is important, therefore, that one of these magnitudes should be the expression of the other, with no difference except in the units. But to that end, the fundamental linear unit must be an aliquot part of the terrestrial meridian. ... Thus, the choice of the metre was reduced to that of the unity of angles.

It is not always the magnitude of the differences observed between species that must determine specific distinctions, but the constant preservation of those differences in reproduction.

It is not the amount of oxygen that determines flammability, but its proportion in the mixture with nitrogen. About 40 per cent of the nitrogen on Earth is now buried in the crust; perhaps in the Cretaceous that nitrogen had not yet been buried and existed in the air and so kept the proportion of oxygen safer for trees [from greatly intensified forest fires].

It is now necessary to indicate more definitely the reason why mathematics not only carries conviction in itself, but also transmits conviction to the objects to which it is applied. The reason is found, first of all, in the perfect precision with which the elementary mathematical concepts are determined; in this respect each science must look to its own salvation .... But this is not all. As soon as human thought attempts long chains of conclusions, or difficult matters generally, there arises not only the danger of error but also the suspicion of error, because since all details cannot be surveyed with clearness at the same instant one must in the end be satisfied with a belief that nothing has been overlooked from the beginning. Every one knows how much this is the case even in arithmetic, the most elementary use of mathematics. No one would imagine that the higher parts of mathematics fare better in this respect; on the contrary, in more complicated conclusions the uncertainty and suspicion of hidden errors increases in rapid progression. How does mathematics manage to rid itself of this inconvenience which attaches to it in the highest degree? By making proofs more rigorous? By giving new rules according to which the old rules shall be applied? Not in the least. A very great uncertainty continues to attach to the result of each single computation. But there are checks. In the realm of mathematics each point may be reached by a hundred different ways; and if each of a hundred ways leads to the same point, one may be sure that the right point has been reached. A calculation without a check is as good as none. Just so it is with every isolated proof in any speculative science whatever; the proof may be ever so ingenious, and ever so perfectly true and correct, it will still fail to convince permanently. He will therefore be much deceived, who, in metaphysics, or in psychology which depends on metaphysics, hopes to see his greatest care in the precise determination of the concepts and in the logical conclusions rewarded by conviction, much less by success in transmitting conviction to others. Not only must the conclusions support each other, without coercion or suspicion of subreption, but in all matters originating in experience, or judging concerning experience, the results of speculation must be verified by experience, not only superficially, but in countless special cases.

It is terrifying to think how much research is needed to determine the truth of even the most unimportant fact.

It is the care we bestow on apparently trifling, unattractive detail and very troublesome minutiae which determines the result.

It seems to me that the view toward which we are tending is that the specificity in gene action is always a chemical specificity, probably the production of enzymes which guide metabolic processes along particular channels. A given array of genes thus determines the production of a particular kind of protoplasm with particular properties—such, for example, as that of responding to surface forces by the formation of a special sort of semipermeable membrane, and that of responding to trivial asymmetries in the play of external stimuli by polarization, with consequent orderly quantitative gradients in all physiologic processes. Different genes may now be called into play at different points in this simple pattern, either through the local formation of their specific substrates for action, or by activation of a mutational nature. In either case the pattern becomes more complex and qualitatively differentiated. Successive interactions of differentiated regions and the calling into play of additional genes may lead to any degree of complexity of pattern in the organism as a largely self-contained system. The array of genes, assembled in the course of evolution, must of course be one which determines a highly self­regulatory system of reactions. On this view the genes are highly specific chemically, and thus called into play only under very specific conditions; but their morphological effects, if any, rest on quantitative influences of immediate or remote products on growth gradients, which are resultants of all that has gone on before in the organism.

Just as it will never be successfully challenged that the French language, progressively developing and growing more perfect day by day, has the better claim to serve as a developed court and world language, so no one will venture to estimate lightly the debt which the world owes to mathematicians, in that they treat in their own language matters of the utmost importance, and govern, determine and decide whatever is subject, using the word in the highest sense, to number and measurement.

Just as the spectroscope opened up a new astronomy by enabling the astronomer to determine some of the constituents of which distant stars are composed, so the seismograph, recording the unfelt motion of distant earthquakes, enables us to see into the earth and determine its nature with as great a certainty, up to a certain point, as if we could drive a tunnel through it and take samples of the matter passed through.

Just as, in civil History, one consults title-deeds, one studies coins, one deciphers ancient inscriptions, in order to determine the epochs of human revolutions and to fix the dates of moral [i.e. human] events; so, in Natural History, one must excavate the archives of the world, recover ancient monuments from the depths of the earth, collect their remains, and assemble in one body of proofs all the evidence of physical changes that enable us to reach back to the different ages of Nature. This, then, is the order of the times indicated by facts and monuments: these are six epochs in the succession of the first ages of Nature; six spaces of duration, the limits of which although indeterminate are not less real; for these epochs are not like those of civil History ... that we can count and measure exactly; nevertheless we can compare them with each other and estimate their relative duration.

Let me suggest to you a simple test one can apply to scientific activities to determine whether or not they can constitute the practice of physics. Is what you are doing beautiful? Many beautiful things are created without the use of physical knowledge, but I know of no really worthwhile physics that isn’t beautiful. Indeed, one of the most distressing symptoms of scientific illiteracy is the impression so often given to school children that science is a mechanistic activity subject to algorithmic description.

Let us now discuss the extent of the mathematical quality in Nature. According to the mechanistic scheme of physics or to its relativistic modification, one needs for the complete description of the universe not merely a complete system of equations of motion, but also a complete set of initial conditions, and it is only to the former of these that mathematical theories apply. The latter are considered to be not amenable to theoretical treatment and to be determinable only from observation.

Life is not determined by consciousness, but consciousness by life.

Man, in his quest for knowledge and progress, is determined and cannot be deterred. The exploration of space will go ahead, whether we join in or not, and it is one of the great adventures of all time, and no nation which expects to be the leader of other nations can expect to stay behind in this race for space.

Mathematics pursues its own course unrestrained, not indeed with an unbridled licence which submits to no laws, but rather with the freedom which is determined by its own nature and in conformity with its own being.

Moreover, I am now well-informed about that part of the country to be traversed, as I can acquire the most exact information from the Nubian leaders, who are truly well-versed in regional knowledge, and thus supported in my route I could determine positions with the greatest certainty. I could not do this before, as one only learns how to interpret the statements of the Nubians by undertaking such a journey.

Mutations merely furnish random raw material for evolution, and rarely, if ever determine the course of the process.

My Rainforests Project … has three main elements. Firstly, to determine how much funding the rainforest countries need to re-orientate their economies so that the trees are worth more alive than dead.

Nature in her unfathomable designs had mixed us of clay and flame, of brain and mind, that the two things hang indubitably together and determine each other’s being but how or why, no mortal may ever know.

Nature proceeds little by little from things lifeless to animal life in such a way that it is impossible to determine the exact line of demarcation, nor on which side thereof an intermediate form should lie. Thus, next after lifeless things comes the plant, and of plants one will differ from another as to its amount of apparent vitality; and, in a word, the whole genus of plants, whilst it is devoid of life as compared with an animal, is endowed with life as compared with other corporeal entities. Indeed, as we just remarked, there is observed in plants a continuous scale of ascent towards the animal. So, in the sea, there are certain objects concerning which one would be at a loss to determine whether they be animal or vegetable. For instance, certain of these objects are fairly rooted, and in several cases perish if detached.

No part of the world can be truly understood without a knowledge of its garment of vegetation, for this determines not only the nature of the animal inhabitants but also the occupations of the majority of human beings.

One always finds among men who are reputed to be reasonable some evidence of this tendency to inquire into the reason of things; of this desire to know not simply how things are, but why they are one way rather than another; and, consequently, of this awareness of a relation which is not gained through the senses, this notion of an abstract bond by virtue of which one thing is subordinated to another which determines and explains it.

Our papers have been making a great deal of American “know-how” ever since we had the misfortune to discover the atomic bomb. There is one quality more important than know-how” and we cannot accuse the United States of any undue amount of it. This is “know-what,” by which we determine not only how to accomplish our purposes, but what our purposes are to be.

Philosophy stands in need of a science which shall determine the possibility, principles, and extent of human knowledge à priori.

Physicists speak of the particle representation or the wave representation. Bohr's principle of complementarity asserts that there exist complementary properties of the same object of knowledge, one of which if known will exclude knowledge of the other. We may therefore describe an object like an electron in ways which are mutually exclusive—e.g., as wave or particle—without logical contradiction provided we also realize that the experimental arrangements that determine these descriptions are similarly mutually exclusive. Which experiment—and hence which description one chooses—is purely a matter of human choice.

Plants, generally speaking, meet the impact of the terrestrial environment head on, although of course they in turn modify the physical environment by adventitious group activity. The individual plant cannot select its habitat; its location is largely determined by the vagaries of the dispersal of seeds or spores and is thus profoundly affected by chance. Because of their mobility and their capacity for acceptance or rejection terrestrial animals, in contrast, can and do actively seek out and utilize the facets of the environment that allow their physiological capacities to function adequately. This means that an animal by its behavior can fit the environment to its physiology by selecting situations in which its physiological capacities can cope with physical conditions. If one accepts this idea, it follows that there is no such thing as The Environment, for there exist as many different terrestrial environments as there are species of animals.

Public health is purchasable. Within a few natural and important limitations any community can determine its own health.

Quantum mechanics and relativity, taken together, are extraordinarily restrictive, and they therefore provide us with a great logical machine. We can explore with our minds any number of possible universes consisting of all kinds of mythical particles and interactions, but all except a very few can be rejected on a priori grounds because they are not simultaneously consistent with special relativity and quantum mechanics. Hopefully in the end we will find that only one theory is consistent with both and that theory will determine the nature of our particular universe.

Research may start from definite problems whose importance it recognizes and whose solution is sought more or less directly by all forces. But equally legitimate is the other method of research which only selects the field of its activity and, contrary to the first method, freely reconnoitres in the search for problems which are capable of solution. Different individuals will hold different views as to the relative value of these two methods. If the first method leads to greater penetration it is also easily exposed to the danger of unproductivity. To the second method we owe the acquisition of large and new fields, in which the details of many things remain to be determined and explored by the first method.

Salt water when it turns into vapour becomes sweet, and the vapour does not form salt water when it condenses again. This I know by experiment. The same thing is true in every case of the kind: wine and all fluids that evaporate and condense back into a liquid state become water. They all are water modified by a certain admixture, the nature of which determines their flavour.
[Aristotle describing his distillation experiment.]

Science cannot determine origin, and so cannot determine destiny. As it presents only a sectional view of creation, it gives only a sectional view of everything in creation.

Science through its physical technological consequences is now determining the relations which human beings, severally and in groups, sustain to one another. If it is incapable of developing moral techniques which will also determine those relations, the split in modern culture goes so deep that not only democracy but all civilized values are doomed.

Scientists still do not appear to understand sufficiently that all earth sciences must contribute evidence toward unveiling the state of our planet in earlier times, and that the truth of the matter can only be reached by combing all this evidence. ... It is only by combing the information furnished by all the earth sciences that we can hope to determine 'truth' here, that is to say, to find the picture that sets out all the known facts in the best arrangement and that therefore has the highest degree of probability. Further, we have to be prepared always for the possibility that each new discovery, no matter what science furnishes it, may modify the conclusions we draw.

Study of the patients’ diets was begun in 1915 in an attempt to determine if some sort of dietary deficiency could be found. The similarity of certain symptoms and signs of pernicious anemia to those in pellagra, sprue, and beriberi was appreciated.

Suppose you were given a watch, a tube to sight with and a string, and then asked to determine the distance to the nearest star. Or you were asked the chemical composition, pressure or temperature of the Sun. A hundred or more years ago, these questions seemed impossible. Now astronomers are answering them all the time, and they believe their answers. Why? Because there are many parallel ways and tests, and they all give the same answers.

The … publicity is always the same; only the blanks need to be filled in: “It was announced today by scientists at [Harvard, Vanderbilt, Stanford] Medical School that a gene responsible for [some, many, a common form of] [schizophrenia, Alzheimer’s, arterio-sclerosis, prostate cancer] has been located and its DNA sequence determined. This exciting research, say scientists, is the first step in what may eventually turn out to be a possible cure for this disease.”

The application of botanical and zoological evidence to determine the relative age of rocks—this chronometry of the earth's surface which was already present to the lofty mind of Hooke—indicates one of the most glorious epochs of modern geognosy, which has finally, on the Continent at least, been emancipated from the way of Semitic doctrines. Palaeontological investigations have imparted a vivifying breath of grace and diversity to the science of the solid structure of the earth.

The assumptions of population thinking are diametrically opposed to those of the typologist. The populationist stresses the uniqueness of everything in the organic world. What is true for the human species,–that no two individuals are alike, is equally true for all other species of animals and plants ... All organisms and organic phenomena are composed of unique features and can be described collectively only in statistical terms. Individuals, or any kind of organic entities, form populations of which we can determine the arithmetic mean and the statistics of variation. Averages are merely statistical abstractions, only the individuals of which the populations are composed have reality. The ultimate conclusions of the population thinker and of the typologist are precisely the opposite. For the typologist, the type (eidos) is real and the variation. an illusion, while for the populationist the type (average) is an abstraction and only the variation is real. No two ways of looking at nature could be more different.

The axioms of geometry are—according to my way of thinking—not arbitrary, but sensible. statements, which are, in general, induced by space perception and are determined as to their precise content by expediency.

The basic thesis of gestalt theory might be formulated thus: there are contexts in which what is happening in the whole cannot be deduced from the characteristics of the separate pieces, but conversely; what happens to a part of the whole is, in clearcut cases, determined by the laws of the inner structure of its whole.

The best and safest way of philosophising seems to be, first to enquire diligently into the properties of things, and to establish those properties by experiences [experiments] and then to proceed slowly to hypotheses for the explanation of them. For hypotheses should be employed only in explaining the properties of things, but not assumed in determining them; unless so far as they may furnish experiments.

The chemists who uphold dualism are far from being agreed among themselves; nevertheless, all of them in maintaining their opinion, rely upon the phenomena of chemical reactions. For a long time the uncertainty of this method has been pointed out: it has been shown repeatedly, that the atoms put into movement during a reaction take at that time a new arrangement, and that it is impossible to deduce the old arrangement from the new one. It is as if, in the middle of a game of chess, after the disarrangement of all the pieces, one of the players should wish, from the inspection of the new place occupied by each piece, to determine that which it originally occupied.

The conditions that direct the order of the whole of the living world around us, are marked by their persistence in improving the birthright of successive generations. They determine, at much cost of individual comfort, that each plant and animal shall, on the general average, be endowed at its birth with more suitable natural faculties than those of its representative in the preceding generation.

The dexterous management of terms and being able to fend and prove with them, I know has and does pass in the world for a great part of learning; but it is learning distinct from knowledge, for knowledge consists only in perceiving the habitudes and relations of ideas one to another, which is done without words; the intervention of sounds helps nothing to it. And hence we see that there is least use of distinction where there is most knowledge: I mean in mathematics, where men have determined ideas with known names to them; and so, there being no room for equivocations, there is no need of distinctions.

The diversity of life is extraordinary. There is said to be a million or so different kinds of living animals, and hundreds of thousands of kinds of plants. But we don’t need to think of the world at large. It is amazing enough to stop and look at a forest or at a meadow—at the grass and trees and caterpillars and hawks and deer. How did all these different kinds of things come about; what forces governed their evolution; what forces maintain their numbers and determine their survival or extinction; what are their relations to each other and to the physical environment in which they live? These are the problems of natural history.

The experiment serves two purposes, often independent one from the other: it allows the observation of new facts, hitherto either unsuspected, or not yet well defined; and it determines whether a working hypothesis fits the world of observable facts.

The first principle of architectural beauty is that the essential lines of a construction be determined by a perfect appropriateness to its use.

The fundamental activity of medical science is to determine the ultimate causation of disease.

The hypotheses which we accept ought to explain phenomena which we have observed. But they ought to do more than this; our hypotheses ought to foretell phenomena which have not yet been observed; ... because if the rule prevails, it includes all cases; and will determine them all, if we can only calculate its real consequences. Hence it will predict the results of new combinations, as well as explain the appearances which have occurred in old ones. And that it does this with certainty and correctness, is one mode in which the hypothesis is to be verified as right and useful.

The idea of making a fault a subject of study and not an object to be merely determined has been the most important step in the course of my methods of observation. If I have obtained some new results it is to this that I owe it.

The ingenuity and effective logic that enabled chemists to determine complex molecular structures from the number of isomers, the reactivity of the molecule and of its fragments, the freezing point, the empirical formula, the molecular weight, etc., is one of the outstanding triumphs of the human mind.

The man or corporation who has not determined at the outset to do good to others while doing good to himself will fail in the end.

The man who is thoroughly convinced of the universal operation of the law of causation cannot for a moment entertain the idea of a being who interferes in the course of events–provided, of course, that he takes the hypothesis of causality really seriously. He has no use for the religion of fear and equally little for social or moral religion. A God who rewards and punishes is inconceivable to him for the simple reason that a man’s actions are determined by necessity, external and internal, so that in God’s eyes he cannot be responsible, any more than an inanimate object is responsible for the motions it undergoes. Science has therefore been charged with undermining morality, but the charge is unjust. A man’s ethical behavior should be based effectually on sympathy, education, and social ties and needs; no religious basis is necessary. Man would indeed be in a poor way if he had to be restrained by fear of punishment and hopes of reward after death.