[Alfred Russell] Wallace's sales agent, back in London, heard mutterings from some naturalists that young Mr. Wallace ought to quit theorizing and stick to gathering facts. Besides expressing their condescension toward him in particular, that criticism also reflected a common attitude that fact-gathering, not theory, was the proper business of all naturalists.

[The screw machine] was on the principle of the guage or sliding lathe now in every workshop throughout the world; the perfection of which consists in that most faithful agent gravity, making the joint, and that almighty perfect number three, which is in harmony itself. I was young when I learned that principle. I had never seen my grandmother putting a chip under a three-legged milking-stool; but she always had to put a chip under a four-legged table, to keep it steady. I cut screws of all dimensions by this machine, and did them perfectly. (1846)

After what has been premised, I think we may lay down the following Conclusions. First, It is plain Philosophers amuse themselves in vain, when they inquire for any natural efficient Cause, distinct from a Mind or Spirit. Secondly, Considering the whole Creation is the Workmanship of a wise and good Agent, it should seem to become Philosophers, to employ their Thoughts (contrary to what some hold) about the final Causes of Things: And I must confess, I see no reason, why pointing out the various Ends, to which natural Things are adapted and for which they were originally with unspeakable Wisdom contrived, should not be thought one good way of accounting for them, and altogether worthy a Philosopher.

All material Things seem to have been composed of the hard and solid Particles … variously associated with the first Creation by the Counsel of an intelligent Agent. For it became him who created them to set them in order: and if he did so, it is unphilosophical to seek for any other Origin of the World, or to pretend that it might arise out of a Chaos by the mere Laws of Nature.

All power, all subordination rests on the executioner: he is the horror and the bond of human association. Remove this incomprehensible agent from the world, and the very moment order gives way to chaos, thrones topple, and society disappears

All the events which occur upon the earth result from Law: even those actions which are entirely dependent on the caprices of the memory, or the impulse of the passions, are shown by statistics to be, when taken in the gross, entirely independent of the human will. As a single atom, man is an enigma; as a whole, he is a mathematical problem. As an individual, he is a free agent; as a species, the offspring of necessity.

Although I have several agents who know the Niam-Niam country, I did not dare to make anything of their unreliable statements before I could orient myself. These Nubians are unpredictable to a high degree, they have a very poor memory for names and practically no human idea of the points of the compass; the agents of the merchants of Khartoum who are entrusted with such great journeys are to the last man absolute liars, braggarts and habitual fibbers.

Apart from the hostile influence of man, the organic and the inorganic world are … bound together by such mutual relations and adaptations as secure, if not the absolute permanence and equilibrium of both … at least a very slow and gradual succession of changes in those conditions. But man is everywhere a disturbing agent. Wherever he plants his foot, the harmonies of nature are turned to discords.

But the fact is that when wine is taken in moderation, it gives rise to a large amount of breath, whose character is balanced, and whose luminosity is strong and brilliant. Hence wine disposes greatly to gladness, and the person is subject to quite trivial exciting agents. The breath now takes up the impression of agents belonging to the present time more easily than it does those which relate to the future; it responds to agents conducive to delight rather than those conducive to a sense of beauty.

But the World being once fram’d, and the course of Nature establish’d, the Naturalist, (except in some few cases, where God, or Incorporeal Agents interpose), has recourse to the first Cause but for its general and ordinary Support and Influence, whereby it preserves Matter and Motion from Annihilation or Desition; and in explicating particular phenomena, considers onely the Size, Shape, Motion, (or want of it) Texture, and the resulting Qualities and Attributes of the small particles of Matter.

Electricity is but yet a new agent for the arts and manufactures, and, doubtless, generations unborn will regard with interest this century, in which it has been first applied to the wants of mankind.

Every body continues in its state of rest or uniform motion in a straight line, except in so far as it doesn’t. … The suggestion that the body really wanted to go straight but some mysterious agent made it go crooked is picturesque but unscientific.

Every physical fact, every expression of nature, every feature of the earth, the work of any and all of those agents which make the face of the world what it is, and as we see it, is interesting and instructive. Until we get hold of a group of physical facts, we do not know what practical bearings they may have, though right-minded men know that they contain many precious jewels, which science, or the expert hand of philosophy will not fail top bring out, polished, and bright, and beautifully adapted to man's purposes.

Every scientist is an agent of cultural change. He may not be a champion of change; he may even resist it, as scholars of the past resisted the new truths of historical geology, biological evolution, unitary chemistry, and non-Euclidean geometry. But to the extent that he is a true professional, the scientist is inescapably an agent of change. His tools are the instruments of change—skepticism, the challenge to establish authority, criticism, rationality, and individuality.

For if there is any truth in the dynamical theory of gases the different molecules in a gas at uniform temperature are moving with very different velocities. Put such a gas into a vessel with two compartments [A and B] and make a small hole in the wall about the right size to let one molecule through. Provide a lid or stopper for this hole and appoint a doorkeeper, very intelligent and exceedingly quick, with microscopic eyes but still an essentially finite being.
Whenever he sees a molecule of great velocity coming against the door from A into B he is to let it through, but if the molecule happens to be going slow he is to keep the door shut. He is also to let slow molecules pass from B to A but not fast ones ... In this way the temperature of B may be raised and that of A lowered without any expenditure of work, but only by the intelligent action of a mere guiding agent (like a pointsman on a railway with perfectly acting switches who should send the express along one line and the goods along another).
I do not see why even intelligence might not be dispensed with and the thing be made self-acting.
Moral The 2nd law of Thermodynamics has the same degree of truth as the statement that if you throw a tumblerful of water into the sea you cannot get the same tumblerful of water out again.

From that night on, the electron—up to that time largely the plaything of the scientist—had clearly entered the field as a potent agent in the supplying of man's commercial and industrial needs… The electronic amplifier tube now underlies the whole art of communications, and this in turn is at least in part what has made possible its application to a dozen other arts. It was a great day for both science and industry when they became wedded through the development of the electronic amplifier tube.

Habit is thus the enormous fly-wheel of society, its most precious conservative agent. It alone is what keeps us all within the bounds of ordinance, and saves the children of fortune from the envious uprisings of the poor. It alone prevents the hardest and most repulsive walks of life from being deserted by those brought up to tread therein.

I heard … xenon was a good anesthesia. … I thought, “How can xenon, which doesn’t form any chemical compounds, serve as a general anesthetic? … I lay awake at night for a few minutes before going to sleep, and during the next couple of weeks each night I would think, “…how do anesthetic agents work?" Then I forgot to do it after a while, but I’d trained my unconscious mind to keep this question alive and to call [it] to my consciousness whenever a new idea turned up…. So seven years went by. [One day I] put my feet up on the desk and started reading my mail, and here was a letter from George Jeffrey … an x-ray crystallographer, on his determination of the structure of a hydrate crystal. Immediately I sat up, took my feet off the desk, and said, “I understand anesthesia!” … I spent a year [and] determined the structure of chloroform hydrate, and then I wrote my paper published in June of 1961.

I shall conclude, for the time being, by saying that until Philosophers make observations (especially of mountains) that are longer, more attentive, orderly, and interconnected, and while they fail to recognize the two great agents, fire and water, in their distinct affects, they will not be able to understand the causes of the great natural variety in the disposition, structure, and other matter that can be observed in the terrestrial globe in a manner that truly corresponds to the facts and to the phenomena of Nature.

If the 'Principle of Relativity' in an extreme sense establishes itself, it seems as if even Time would become discontinuous and be supplied in atoms, as money is doled out in pence or centimes instead of continuously;—in which case our customary existence will turn out to be no more really continuous than the events on a kinematograph screen;—while that great agent of continuity, the Ether of Space, will be relegated to the museum of historical curiosities.

If we assume that there is only one enzyme present to act as an oxidizing agent, we must assume for it as many different degrees of activity as are required to explain the occurrence of the various colors known to mendelize (three in mice, yellow, brown, and black). If we assume that a different enzyme or group of enzymes is responsible for the production of each pigment we must suppose that in mice at least three such enzymes or groups of enzymes exist. To determine which of these conditions occurs in mice is not a problem for the biologist, but for the chemist. The biologist must confine his attention to determining the number of distinct agencies at work in pigment formation irrespective of their chemical nature. These agencies, because of their physiological behavior, the biologist chooses to call 'factors,' and attempts to learn what he can about their functions in the evolution of color varieties.

In all cases when a particular agent or cause is to be studied, experiments should be arranged in such a way as to lead if possible to results depending on it alone ; or, if this cannot be done, they should be arranged so as to increase the effects due to the cause to be studied till these so far exceed the unavoidable concomitants, that the latter may be considered as only disturbing, not essentially modifying the effects of the principal agent.

In all speculations on the origin, or agents that have produced the changes on this globe, it is probable that we ought to keep within the boundaries of the probable effects resulting from the regular operations of the great laws of nature which our experience and observation have brought within the sphere of our knowledge. When we overleap those limits, and suppose a total change in nature's laws, we embark on the sea of uncertainty, where one conjecture is perhaps as probable as another; for none of them can have any support, or derive any authority from the practical facts wherewith our experience has brought us acquainted.

In the conception of a machine or the product of a machine there is a point where one may leave off for parsimonious reasons, without having reached aesthetic perfection; at this point perhaps every mechanical factor is accounted for, and the sense of incompleteness is due to the failure to recognize the claims of the human agent. Aesthetics carries with it the implications of alternatives between a number of mechanical solutions of equal validity; and unless this awareness is present at every stage of the process … it is not likely to come out with any success in the final stage of design.

Is it possible that a promiscuous Jumble of Printing Letters should often fall into a Method and Order, which should stamp on Paper a coherent Discourse; or that a blind fortuitous Concourse of Atoms, not guided by an Understanding Agent, should frequently constitute the Bodies of any Species of Animals.

It has been long considered possible to explain the more ancient revolutions on... [the Earth's] surface by means of these still existing causes; in the same manner as it is found easy to explain past events in political history, by an acquaintance with the passions and intrigues of the present day. But we shall presently see that unfortunately this is not the case in physical history:—the thread of operation is here broken, the march of nature is changed, and none of the agents that she now employs were sufficient for the production of her ancient works.

It has been shown to be possible, by deliberately planned and chemotherapeutic approach, to discover curative agents which act specifically and aetiologically against diseases due to protozoal infections, and especially against the spirilloses, and amongst these against syphilis in the first place. Further evidence for the specificity of the action of dihydroxydiaminoarsenobenzene [Salvarsan ‘606’] is the disappearance of the Wasserman reaction, which reaction must … be regarded as indicative of a reaction of the organism to the constituents of the spirochaetes.

It is contrary to the usual order of things, that events so harmonious as those of the system of the world, should depend on such diversified agents as are supposed to exist in our artificial arrangements; and there is reason to anticipate a great reduction in the number of undecompounded bodies, and to expect that the analogies of nature will be found conformable to the refined operations of art. The more the phenomena of the universe are studied, the more distinct their connection appears, and the more simple their causes, the more magnificent their design, and the more wonderful the wisdom and power of their Author.

It is inconceivable, that inanimate brute matter should, without the mediation of something else, which is not material, operate upon and affect other matter without mutual contact … That gravity should be innate, inherent, and essential to matter, so that one body may act upon another at a distance, through a vacuum, without the mediation of anything else, by and through which their action and force may be conveyed from one to another, is to me so great an absurdity, that I believe no man who has in philosophical matters a competent faculty of thinking, can ever fall into it. Gravity must be caused by an agent, acting constantly according to certain laws; but whether this agent be material or immaterial, I have left to the consideration of my readers.

It is probable that all heavy matter possesses—latent and bound up with the structure of the atom—a similar quantity of energy to that possessed by radium. If it could be tapped and controlled, what an agent it would be in shaping the world's destiny! The man who puts his hand on the lever by which a parsimonious nature regulates so jealously the output of this store of energy would possess a weapon by which he could destroy the Earth if he chose.
A prescient remark on atomic energy after the discovery of radioactivity, but decades before the harnessing of nuclear fission in an atomic bomb became a reality.

It seeming impossible in any other manner to properly restrict the use of this powerful agent [calomel, a mercury compound, mercurous chloride], it is directed that it be struck from the supply table, and that no further requisitions for this medicine be approved by Medical Directors. ... modern pathology has proved the impropriety of the use of mercury in very many of those diseases in which it was formerly unfailingly administered. ... No doubt can exist that more harm has resulted from the misuse [of this agent], in the treatment of disease, than benefit from their proper administration.
W.A. Hammond, Surgeon General, Washington D.C., 4 May 1863

Knowledge always desires increase; it is like fire which must first be kindled by some external agent, but which will afterward propagate itself.

Man is a free moral agent and can be magnanimous and deal disinterestedly, humanity is a definite goal, social justice is desirable and possible, individual lives may be gloriously diversified, uniquely individualized, and yet socially useful; or, these are mere phrases, snares to catch gulls, soothing syrup for our troubled souls.

Man is not the creature of circumstances, circumstances are the creatures of man. We are free agents, and man is more powerful than matter.

Metals are the great agents by which we can examine the recesses of nature; and their uses are so multiplied, that they have become of the greatest importance in every occupation of life. They are the instruments of all our improvements, of civilization itself, and are even subservient to the progress of the human mind towards perfection. They differ so much from each other, that nature seems to have had in view all the necessities of man, in order that she might suit every possible purpose his ingenuity can invent or his wants require.

Natural powers, principally those of steam and falling water, are subsidized and taken into human employment Spinning-machines, power-looms, and all the mechanical devices, acting, among other operatives, in the factories and work-shops, are but so many laborers. They are usually denominated labor-saving machines, but it would be more just to call them labor-doing machines. They are made to be active agents; to have motion, and to produce effect; and though without intelligence, they are guided by laws of science, which are exact and perfect, and they produce results, therefore, in general, more accurate than the human hand is capable of producing.

Natural science is founded on minute critical views of the general order of events taking place upon our globe, corrected, enlarged, or exalted by experiments, in which the agents concerned are placed under new circumstances, and their diversified properties separately examined. The body of natural science, then, consists of facts; is analogy,—the relation of resemblance of facts by which its different parts are connected, arranged, and employed, either for popular use, or for new speculative improvements.

No comfort should be drawn from the spurious belief that because extinction is a natural process, man is merely another Darwinian agent.

No subject of philosophical inquiry within the limits of human investigation is more calculated to excite admiration and to awaken curiosity than fire; and there is certainly none more extensively useful to mankind. It is owing, no doubt, to our being acquainted with it from our infancy, that we are not more struck with its appearance, and more sensible of the benefits we derive from it. Almost every comfort and convenience which man by his ingenuity procures for himself is obtained by its assistance; and he is not more distinguished from the brute creation by the use of speech, than by his power over that wonderful agent.

No! What we need are not prohibitory marriage laws, but a reformed society, an educated public opinion which will teach individual duty in these matters. And it is to the women of the future that I look for the needed reformation. Educate and train women so that they are rendered independent of marriage as a means of gaining a home and a living, and you will bring about natural selection in marriage, which will operate most beneficially upon humanity. When all women are placed in a position that they are independent of marriage, I am inclined to think that large numbers will elect to remain unmarried—in some cases, for life, in others, until they encounter the man of their ideal. I want to see women the selective agents in marriage; as things are, they have practically little choice. The only basis for marriage should be a disinterested love. I believe that the unfit will be gradually eliminated from the race, and human progress secured, by giving to the pure instincts of women the selective power in marriage. You can never have that so long as women are driven to marry for a livelihood.

Now, all causes of natural effects must be expressed by means of lines, angles and figures, for otherwise it is impossible to grasp their explanation. This is evident as follows. A natural agent multiplies its power from itself to the recipient, whether it acts on sense or on matter. This power is sometimes called species, sometimes a likeness, and it is the same thing whatever it may be called; and the agent sends the same power into sense and into matter, or into its own contrary, as heat sends the same thing into the sense of touch and into a cold body. For it does not act, by deliberation and choice, and therefore it acts in a single manner whatever it encounters, whether sense or something insensitive, whether something animate or inanimate. But the effects are diversified by the diversity of the recipient, for when this power is received by the senses, it produces an effect that is somehow spiritual and noble; on the other hand, when it is received by matter, it produces a material effect. Thus the sun produces different effects in different recipients by the same power, for it cakes mud and melts ice.

Now, it may be stretching an analogy to compare epidemics of cholera—caused by a known agent—with that epidemic of violent crime which is destroying our cities. It is unlikely that our social problems can be traced to a single, clearly defined cause in the sense that a bacterial disease is ‘caused’ by a microbe. But, I daresay, social science is about as advanced in the late twentieth century as bacteriological science was in the mid nineteenth century. Our forerunners knew something about cholera; they sensed that its spread was associated with misdirected sewage, filth, and the influx of alien poor into crowded, urban tenements. And we know something about street crime; nowhere has it been reported that a member of the New York Stock Exchange has robbed ... at the point of a gun. Indeed, I am naively confident that an enlightened social scientist of the next century will be able to point out that we had available to us at least some of the clues to the cause of urban crime.

Politicians, real-estate agents, used-car salesmen, and advertising copy-writers are expected to stretch facts in self-serving directions, but scientists who falsify their results are regarded by their peers as committing an inexcusable crime. Yet the sad fact is that the history of science swarms with cases of outright fakery and instances of scientists who unconsciously distorted their work by seeing it through lenses of passionately held beliefs.

Politicians, real-estate agents, used-car salesmen, and advertising copy-writers are expected to stretch facts in self-serving directions, but scientists who falsify their results are regarded by their peers as committing an inexcusable crime. Yet the sad fact is that the history of science swarms with cases of outright fakery and instances of scientists who unconsciously distorted their work by seeing it through lenses of passionately held beliefs.

Reason and free inquiry are the only effectual agents against error.

Science has thus, most unexpectedly, placed in our hands a new power of great but unknown energy. It does not wake the winds from their caverns; nor give wings to water by the urgency of heat; nor drive to exhaustion the muscular power of animals; nor operate by complicated mechanism; nor summon any other form of gravitating force, but, by the simplest means—the mere contact of metallic surfaces of small extent, with feeble chemical agents, a power everywhere diffused through nature, but generally concealed from our senses, is mysteriously evolved, and by circulation in insulated wires, it is still more mysteriously augmented, a thousand and a thousand fold, until it breaks forth with incredible energy.

Science never saw a ghost, nor does it look for any, but it sees everywhere the traces, and it is itself the agent, of a Universal Intelligence.

So then Gravity may put ye Planets into Motion, but without ye divine Power it could never put them into such a Circulating Motion as they have about ye Sun; & therefore, for this, as well as other Reasons, I am compelled to ascribe ye Frame of this Systeme to an intelligent agent.

The active agent is readily filterable and the name “penicillin” has been given to filtrates of broth cultures of the mould. … It is suggested that it may be an efficient antiseptic for application to, or injection into, areas infected with penicillin-sensitive microbes.

The cerebrum I consider as the grand organ by which the mind is united to the body. Into it all the nerves from the external organs of the senses enter; and from it all the nerves which are agents of the will pass out.

The discovery of an interaction among the four hemes made it obvious that they must be touching, but in science what is obvious is not necessarily true. When the structure of hemoglobin was finally solved, the hemes were found to lie in isolated pockets on the surface of the subunits. Without contact between them how could one of them sense whether the others had combined with oxygen? And how could as heterogeneous a collection of chemical agents as protons, chloride ions, carbon dioxide, and diphosphoglycerate influence the oxygen equilibrium curve in a similar way? It did not seem plausible that any of them could bind directly to the hemes or that all of them could bind at any other common site, although there again it turned out we were wrong. To add to the mystery, none of these agents affected the oxygen equilibrium of myoglobin or of isolated subunits of hemoglobin. We now know that all the cooperative effects disappear if the hemoglobin molecule is merely split in half, but this vital clue was missed. Like Agatha Christie, Nature kept it to the last to make the story more exciting. There are two ways out of an impasse in science: to experiment or to think. By temperament, perhaps, I experimented, whereas Jacques Monod thought.

The facts of nature are what they are, but we can only view them through the spectacles of our mind. Our mind works largely by metaphor and comparison, not always (or often) by relentless logic. When we are caught in conceptual traps, the best exit is often a change in metaphor–not because the new guideline will be truer to nature (for neither the old nor the new metaphor lies ‘out there’ in the woods), but because we need a shift to more fruitful perspectives, and metaphor is often the best agent of conceptual transition.

The great companies did not know that the line between hunger and anger is a thin line. And money that might have gone to wages went for gas, for guns, for agents and spies, for blacklists, for drilling. On the highways the people moved like ants and searched for work, for food. And the anger began to ferment.

The history of a species, or any natural phenomenon that requires unbroken continuity in a world of trouble, works like a batting streak. All are games of a gambler playing with a limited stake against a house with infinite resources. The gambler must eventually go bust. His aim can only be to stick around as long as possible, to have some fun while he’s at it, and, if he happens to be a moral agent as well, to worry about staying the course with honor.

The inducing substance, on the basis of its chemical and physical properties, appears to be a highly polymerized and viscous form of sodium desoxyribonucleate. On the other hand, the Type m capsular substance, the synthesis of which is evoked by this transforming agent, consists chiefly of a non-nitrogenous polysaccharide constituted of glucose-glucuronic acid units linked in glycosidic union. The presence of the newly formed capsule containing this type-specific polysaccharide confers on the transformed cells all the distinguishing characteristics of Pneumococcus Type III. Thus, it is evident that the inducing substance and the substance produced in turn are chemically distinct and biologically specific in their action and that both are requisite in determining the type of specificity of the cell of which they form a part. The experimental data presented in this paper strongly suggest that nucleic acids, at least those of the desoxyribose type, possess different specificities as evidenced by the selective action of the transforming principle.

The initiation of the fermentation process does not require so complicated an apparatus as is represented by the living cell. The agent responsible for the fermenting action of the press juice is rather to be regarded as a dissolved substance, doubtless a protein; this will be denoted zymase.

The injurious agent in cigarettes comes principally from the burning paper wrapper. The substance thereby formed is called “acrolein.” It has a violent action on the nerve centers, producing degeneration of the cells of the brain, which is quite rapid among boys. Unlike most narcotics, this degeneration is permanent and uncontrollable. I employ no person who smokes cigarettes.
[From the Laboratory of Thomas A. Edison, Orange, N.J., April 26, 1914.]

The instinct of brutes and insects can be the effect of nothing else than the wisdom and skill of a powerful ever-living agent.

The laboratory work was the province of Dr Searle, an explosive, bearded Nemesis who struck terror into my heart. If one made a blunder one was sent to ‘stand in the corner’ like a naughty child. He had no patience with the women students. He said they disturbed the magnetic equipment, and more than once I heard him shout ‘Go and take off your corsets!’ for most girls wore these garments then, and steel was beginning to replace whalebone as a stiffening agent. For all his eccentricities, he gave us excellent training in all types of precise measurement and in the correct handling of data.

The more innocuous the name of a weapon, the more hideous its impact. (Some of the most horrific weapons of the Vietnam era were named “Bambi”, “Infant”, “Daisycutter”, “Grasshopper”, and “Agent Orange.” Nor is the trend new: from the past we have “Mustard Gas”, “Angel Chasers” (two cannonballs linked with a chain for added destruction) and “The Peacemaker” to name but a few.)

The native hospital in Tunis was the focal point of my research. Often, when going to the hospital, I had to step over the bodies of typhus patients who were awaiting admission to the hospital and had fallen exhausted at the door. We had observed a certain phenomenon at the hospital, of which no one recognized the significance, and which drew my attention. In those days typhus patients were accommodated in the open medical wards. Before reaching the door of the wards they spread contagion. They transmitted the disease to the families that sheltered them, and doctors visiting them were also infected. The administrative staff admitting the patients, the personnel responsible for taking their clothes and linen, and the laundry staff were also contaminated. In spite of this, once admitted to the general ward the typhus patient did not contaminate any of the other patients, the nurses or the doctors. I took this observation as my guide. I asked myself what happened between the entrance to the hospital and the wards. This is what happened: the typhus patient was stripped of his clothes and linen, shaved and washed. The contagious agent was therefore something attached to his skin and clothing, something which soap and water could remove. It could only be the louse. It was the louse.

The nervous system is the most complex and delicate instrument on our planet, by means of which relations, connections are established between the numerous parts of the organism, as well as between the organism, as a highly complex system, and the innumerable, external influences. If the closing and opening of electric current is now regarded as an ordinary technical device, why should there be any objection to the idea that the same principle acts in this wonderful instrument? On this basis the constant connection between the external agent and the response of the organism, which it evokes, can be rightly called an unconditioned reflex, and the temporary connection—a conditioned reflex.

The only distinct meaning of the word “natural” is stated, fixed, or settled; since what is natural as much requires and presupposes an intelligent agent to render it so, i.e. to effect it continually or at stated times, as what is supernatural or miraculous does to effect it for once.

The possibility that the infective agent may not contain nucleic acid and consist only of a peptide or peptide-polysaccharide complex which has replication properties within susceptible cells is intriguing. If peptides, short-chain proteins, or peptide/fatty-acid/ polysaccharide complexes activate nucleic-acid template activity in the host genes to produce identical infective particles, this would invalidate the accepted dogma of present-day molecular biology in which D.N.A. and R.N.A. templates control all biological activity.

The study of the serum of immunized animals forms a new chapter in the history of the struggle between the animal and infective agents, under which heading practical results of the highest importance are already inscribed. Any explanation of the phenomena is, however, still far from complete.

There is no drink like pure water, provided one realizes that it is alcohol that is the purifying agent.

There is, it appears, a conspiracy of scientists afoot. Their purpose is to break down religion, propagate immorality, and so reduce mankind to the level of brutes. They are the sworn and sinister agents of Beelzebub, who yearns to conquer the world, and has his eye especially upon Tennessee.
[Report on the Scopes Monkey Trial.]

To demonstrate experimentally that a microscopic organism actually is the cause of a disease and the agent of contagion, I know no other way, in the present state of Science, than to subject the microbe (the new and happy term introduced by M. Sédillot) to the method of cultivation out of the body.

Very few people, including authors willing to commit to paper, ever really read primary sources–certainly not in necessary depth and contemplation, and often not at all ... When writers close themselves off to the documents of scholarship, and then rely only on seeing or asking, they become conduits and sieves rather than thinkers. When, on the other hand, you study the great works of predecessors engaged in the same struggle, you enter a dialogue with human history and the rich variety of our own intellectual traditions. You insert yourself, and your own organizing powers, into this history–and you become an active agent, not merely a ‘reporter.’

What it is important to realize is that automation ... is an attempt to exercise control, not only of the mechanical process itself, but of the human being who once directed it: turning him from an active to a passive agent, and finally eliminating him all together.

When I received the Nobel Prize, the only big lump sum of money I have ever seen, I had to do something with it. The easiest way to drop this hot potato was to invest it, to buy shares. I knew that World War II was coming and I was afraid that if I had shares which rise in case of war, I would wish for war. So I asked my agent to buy shares which go down in the event of war. This he did. I lost my money and saved my soul.

With a few honorable exceptions the press of the United States is at the beck and call of the patent medicines. Not only do the newspapers modify news possibly affecting these interests, but they sometimes become their agents.

With the sole guidance of our practical knowledge of those physical agents which we see actually used in the continuous workings of nature, and of our knowledge of the respective effects induced by the same workings, we can with reasonable basis surmise what the forces were which acted even in the remotest times.