“Advance, ye mates! Cross your lances full before me. Well done! Let me touch the axis.” So saying, with extended arm, he grasped the three level, radiating lances at their crossed centre; while so doing, suddenly and nervously twitched them; meanwhile, glancing intently from Starbuck to Stubb; from Stubb to Flask. It seemed as though, by some nameless, interior volition, he would fain have shocked into them the same fiery emotion accumulated within the Leyden jar of his own magnetic life. The three mates quailed before his strong, sustained, and mystic aspect. Stubb and Flask looked sideways from him; the honest eye of Starbuck fell downright.
“In vain!&rsdquo; cried Ahab; “but, maybe, ’tis well. For did ye three but once take the full-forced shock, then mine own electric thing, that had perhaps expired from out me. Perchance, too, it would have dropped ye dead.…”
[Commentary by Henry Schlesinger: Electricity—mysterious and powerful as it seemed at the time—served as a perfect metaphor for Captain Ahab’s primal obsession and madness, which he transmits through the crew as if through an electrical circuit in Moby-Dick.]

[Alchemists] enrich the ears of men with vain words, but empty their Pockets of their Money. Whence it appears to be no Art, but a Composition of Trifles, and inventions of mad brains.

[I have] a strong conviction that controversial reply and rejoinder is but a vain occupation.

Frustra fit per plura, quod fieri potest per pauciora.
It is vain to do with more what can be done with less.

Natura nihil agit frustra.
Nature does nothing in vain.

Natura nihil agit frustra [Nature does nothing in vain] is the only indisputible axiom in philosophy. There are no grotesques in nature; not any thing framed to fill up empty cantons, and unncecessary spaces.

That the Sun will not rise Tomorrow is no less intelligible a Proposition and implies no more contradiction than the Affirmation that it will rise. We should in vain, therefore, attempt to demonstrate its falsehood.

A primâ facie argument in favour of the efficacy of prayer is therefore to be drawn from the very general use of it. The greater part of mankind, during all the historic ages, have been accustomed to pray for temporal advantages. How vain, it may be urged, must be the reasoning that ventures to oppose this mighty consensus of belief! Not so. The argument of universality either proves too much, or else it is suicidal.

A great part of its [higher arithmetic] theories derives an additional charm from the peculiarity that important propositions, with the impress of simplicity on them, are often easily discovered by induction, and yet are of so profound a character that we cannot find the demonstrations till after many vain attempts; and even then, when we do succeed, it is often by some tedious and artificial process, while the simple methods may long remain concealed.

About the use of language: it is impossible to sharpen a pencil with a blunt axe. It is equally vain to try to do it with ten blunt axes instead.

Academies have been instituted to guard the avenues of their languages, to retain fugitives, and repulse intruders; but their vigilance and activity have hitherto been vain; sounds are too volatile and subtile for legal restraints; to enchain syllables, and to lash the wind, are equally the undertakings of pride, unwilling to measure its desires by its strength.

After seeking in vain for the construction of a perpetual motion machine, the relations were investigated which must subsist between the forces of nature if such a machine is to be impossible; and this inverted question led to the discovery of the law of the conservation of energy, which, again, explained the impossibility of perpetual motion in the sense originally intended.

After the birth of printing books became widespread. Hence everyone throughout Europe devoted himself to the study of literature... Every year, especially since 1563, the number of writings published in every field is greater than all those produced in the past thousand years. Through them there has today been created a new theology and a new jurisprudence; the Paracelsians have created medicine anew and the Copernicans have created astronomy anew. I really believe that at last the world is alive, indeed seething, and that the stimuli of these remarkable conjunctions did not act in vain.

After what has been premised, I think we may lay down the following Conclusions. First, It is plain Philosophers amuse themselves in vain, when they inquire for any natural efficient Cause, distinct from a Mind or Spirit. Secondly, Considering the whole Creation is the Workmanship of a wise and good Agent, it should seem to become Philosophers, to employ their Thoughts (contrary to what some hold) about the final Causes of Things: And I must confess, I see no reason, why pointing out the various Ends, to which natural Things are adapted and for which they were originally with unspeakable Wisdom contrived, should not be thought one good way of accounting for them, and altogether worthy a Philosopher.

All possible truth is practical. To ask whether our conception of chair or table corresponds to the real chair or table apart from the uses to which they may be put, is as utterly meaningless and vain as to inquire whether a musical tone is red or yellow. No other conceivable relation than this between ideas and things can exist. The unknowable is what I cannot react upon. The active part of our nature is not only an essential part of cognition itself, but it always has a voice in determining what shall be believed and what rejected.

And for rejecting such a Medium, we have the Authority of those the oldest and most celebrated Philosophers of Greece and Phoenicia, who made a Vacuum, and Atoms, and the Gravity of Atoms, the first Principles of their Philosophy; tacitly attributing Gravity to some other Cause than dense Matter. Later Philosophers banish the Consideration of such a Cause out of natural Philosophy, feigning Hypotheses for explaining all things mechanically, and referring other Causes to Metaphysicks: Whereas the main Business of natural Philosophy is to argue from Phaenomena without feigning Hypotheses, and to deduce Causes from Effects, till we come to the very first Cause, which certainly is not mechanical; and not only to unfold the Mechanism of the World, but chiefly to resolve these and such like Questions. What is there in places almost empty of Matter, and whence is it that the Sun and Planets gravitate towards one another, without dense Matter between them? Whence is it that Nature doth nothing in vain; and whence arises all that Order and Beauty which we see in the World? ... does it not appear from phaenomena that there is a Being incorporeal, living, intelligent, omnipresent, who in infinite space, as it were in his Sensory, sees the things themselves intimately, and thoroughly perceives them, and comprehends them wholly by their immediate presence to himself.

And I believe there are many Species in Nature, which were never yet taken notice of by Man, and consequently of no use to him, which yet we are not to think were created in vain; but it’s likely … to partake of the overflowing Goodness of the Creator, and enjoy their own Beings. But though in this sense it be not true, that all things were made for Man; yet thus far it is, that all the Creatures in the World may be some way or other useful to us, at least to exercise our Wits and Understandings, in considering and contemplating of them, and so afford us Subject of Admiring and Glorifying their and our Maker. Seeing them, we do believe and assert that all things were in some sense made for us, we are thereby obliged to make use of them for those purposes for which they serve us, else we frustrate this End of their Creation.

And, notwithstanding a few exceptions, we do undoubtedly find that the most truly eminent men have had not only their affections, but also their intellect, greatly influenced by women. I will go even farther; and I will venture to say that those who have not undergone that influence betray a something incomplete and mutilated. We detect, even in their genius, a certain frigidity of tone; and we look in vain for that burning fire, that gushing and spontaneous nature with which our ideas of genius are indissolubly associated. Therefore, it is, that those who are most anxious that the boundaries of knowledge should be enlarged, ought to be most eager that the influence of women should be increased, in order that every resource of the human mind may be at once and quickly brought into play.

As historians, we refuse to allow ourselves these vain speculations which turn on possibilities that, in order to be reduced to actuality, suppose an overturning of the Universe, in which our globe, like a speck of abandoned matter, escapes our vision and is no longer an object worthy of our regard. In order to fix our vision, it is necessary to take it such as it is, to observe well all parts of it, and by indications infer from the present to the past.

Attention makes the genius; all learning, fancy, and science depend on it. Newton traced back his discoveries to its unwearied employment. It builds bridges, opens new worlds, and heals diseases; without it Taste is useless, and the beauties of literature are unobserved; as the rarest flowers bloom in vain, if the eye be not fixed upon the bed.

But for the persistence of a student of this university in urging upon me his desire to study with me the modern algebra I should never have been led into this investigation; and the new facts and principles which I have discovered in regard to it (important facts, I believe), would, so far as I am concerned, have remained still hidden in the womb of time. In vain I represented to this inquisitive student that he would do better to take up some other subject lying less off the beaten track of study, such as the higher parts of the calculus or elliptic functions, or the theory of substitutions, or I wot not what besides. He stuck with perfect respectfulness, but with invincible pertinacity, to his point. He would have the new algebra (Heaven knows where he had heard about it, for it is almost unknown in this continent), that or nothing. I was obliged to yield, and what was the consequence? In trying to throw light upon an obscure explanation in our text-book, my brain took fire, I plunged with re-quickened zeal into a subject which I had for years abandoned, and found food for thoughts which have engaged my attention for a considerable time past, and will probably occupy all my powers of contemplation advantageously for several months to come.

But since the brain, as well as the cerebellum, is composed of many parts, variously figured, it is possible, that nature, which never works in vain, has destined those parts to various uses, so that the various faculties of the mind seem to require different portions of the cerebrum and cerebellum for their production.

Charles Darwin [is my personal favorite Fellow of the Royal Society]. I suppose as a physical scientist I ought to have chosen Newton. He would have won hands down in an IQ test, but if you ask who was the most attractive personality then Darwin is the one you'd wish to meet. Newton was solitary and reclusive, even vain and vindictive in his later years when he was president of the society.

Everything material which is the subject of knowledge has number, order, or position; and these are her first outlines for a sketch of the universe. If our feeble hands cannot follow out the details, still her part has been drawn with an unerring pen, and her work cannot be gainsaid. So wide is the range of mathematical sciences, so indefinitely may it extend beyond our actual powers of manipulation that at some moments we are inclined to fall down with even more than reverence before her majestic presence. But so strictly limited are her promises and powers, about so much that we might wish to know does she offer no information whatever, that at other moments we are fain to call her results but a vain thing, and to reject them as a stone where we had asked for bread. If one aspect of the subject encourages our hopes, so does the other tend to chasten our desires, and he is perhaps the wisest, and in the long run the happiest, among his fellows, who has learned not only this science, but also the larger lesson which it directly teaches, namely, to temper our aspirations to that which is possible, to moderate our desires to that which is attainable, to restrict our hopes to that of which accomplishment, if not immediately practicable, is at least distinctly within the range of conception.

First of all a natural talent is required; for when Nature opposes, everything else is in vain; but when Nature leads the way to what is most excellent, instruction in the art takes place...

Formerly one sought the feeling of the grandeur of man by pointing to his divine origin: this has now become a forbidden way, for at its portal stands the ape, together with other gruesome beasts, grinning knowingly as if to say: no further in this direction! One therefore now tries the opposite direction: the way mankind is going shall serve as proof of his grandeur and kinship with God. Alas this, too, is vain! At the end of this way stands the funeral urn of the last man and gravedigger (with the inscription “nihil humani a me alienum puto”). However high mankind may have evolved—and perhaps at the end it will stand even lower than at the beginning!— it cannot pass over into a higher order, as little as the ant and the earwig can at the end of its “earthly course” rise up to kinship with God and eternal life. The becoming drags the has-been along behind it: why should an exception to this eternal spectacle be made on behalf of some little star or for any little species upon it! Away with such sentimentalities!

Geologists have not been slow to admit that they were in error in assuming that they had an eternity of past time for the evolution of the earth’s history. They have frankly acknowledged the validity of the physical arguments which go to place more or less definite limits to the antiquity of the earth. They were, on the whole, disposed to acquiesce in the allowance of 100 millions of years granted to them by Lord Kelvin, for the transaction of the whole of the long cycles of geological history. But the physicists have been insatiable and inexorable. As remorseless as Lear’s daughters, they have cut down their grant of years by successive slices, until some of them have brought the number to something less than ten millions. In vain have the geologists protested that there must somewhere be a flaw in a line of argument which tends to results so entirely at variance with the strong evidence for a higher antiquity, furnished not only by the geological record, but by the existing races of plants and animals. They have insisted that this evidence is not mere theory or imagination, but is drawn from a multitude of facts which become hopelessly unintelligible unless sufficient time is admitted for the evolution of geological history. They have not been able to disapprove the arguments of the physicists, but they have contended that the physicists have simply ignored the geological arguments as of no account in the discussion.

Geometric writings are not rare in which one would seek in vain for an idea at all novel, for a result which sooner or later might be of service, for anything in fact which might be destined to survive in the science; and one finds instead treatises on trivial problems or investigations on special forms which have absolutely no use, no importance, which have their origin not in the science itself but in the caprice of the author; or one finds applications of known methods which have already been made thousands of times; or generalizations from known results which are so easily made that the knowledge of the latter suffices to give at once the former. Now such work is not merely useless; it is actually harmful because it produces a real incumbrance in the science and an embarrassment for the more serious investigators; and because often it crowds out certain lines of thought which might well have deserved to be studied.

Happy the men who made the first essay,
And to celestial regions found the way!
No earthly vices clogg’d their purer souls,
That they could soar so high as touch the poles:
Sublime their thoughts and from pollution clear,
Bacchus and Venus held no revels there;
From vain ambition free; no love of war
Possess’d their minds, nor wranglings at the bar;
No glaring grandeur captivates their eyes,
For such see greater glory in the skies:
Thus these to heaven attain.

He who seeks for methods without having a definite problem in mind seeks for the most part in vain.

Hypochondriacs squander large sums of time in search of nostrums by which they vainly hope they may get more time to squander.

I am now convinced that we have recently become possessed of experimental evidence of the discrete or grained nature of matter, which the atomic hypothesis sought in vain for hundreds and thousands of years. The isolation and counting of gaseous ions, on the one hand, which have crowned with success the long and brilliant researches of J.J. Thomson, and, on the other, agreement of the Brownian movement with the requirements of the kinetic hypothesis, established by many investigators and most conclusively by J. Perrin, justify the most cautious scientist in now speaking of the experimental proof of the atomic nature of matter, The atomic hypothesis is thus raised to the position of a scientifically well-founded theory, and can claim a place in a text-book intended for use as an introduction to the present state of our knowledge of General Chemistry.

I have been able to solve a few problems of mathematical physics on which the greatest mathematicians since Euler have struggled in vain … But the pride I might have held in my conclusions was perceptibly lessened by the fact that I knew that the solution of these problems had almost always come to me as the gradual generalization of favorable examples, by a series of fortunate conjectures, after many errors. I am fain to compare myself with a wanderer on the mountains who, not knowing the path, climbs slowly and painfully upwards and often has to retrace his steps because he can go no further—then, whether by taking thought or from luck, discovers a new track that leads him on a little till at length when he reaches the summit he finds to his shame that there is a royal road by which he might have ascended, had he only the wits to find the right approach to it. In my works, I naturally said nothing about my mistake to the reader, but only described the made track by which he may now reach the same heights without difficulty.

I think we may picture those domains where understanding exists, whether in physics, chemistry, biology, psychology, economics or any other discipline as cultivated valleys in a formidably mountainous country. We may recognise in principle that we all inhabit the same world but in practice we do well to cultivate our own valleys, with an occasional assault on the more accessible foothills, rather than to build roads in a vain attempt at colonisation.

I uphold my own rights, and therefore I also recognize the rights of others. This is the principle I act upon in life, in politics and in science. We owe it to ourselves to defend our rights, for it is the only guarantee for our individual development, and for our influence upon the community at large. Such a defence is no act of vain ambition, and it involves no renunciation of purely scientific aims. For, if we would serve science, we must extend her limits, not only as far as our own knowledge is concerned, but in the estimation of others.

If [in a rain forest] the traveler notices a particular species and wishes to find more like it, he must often turn his eyes in vain in every direction. Trees of varied forms, dimensions, and colors are around him, but he rarely sees any of them repeated. Time after time he goes towards a tree which looks like the one he seeks, but a closer examination proves it to be distinct.

If the [Vestiges] be true, the labours of sober induction are in vain; religion is a lie; human law is a mass of folly, and a base injustice; morality is moonshine; our labours for the black people of Africa were works of madmen; and man and woman are only better beasts!

In going on with these Experiments, how many pretty systems do we build, which we soon find ourselves oblig’d to destroy! If there is no other Use discover’d of Electricity, this, however, is something considerable, that it may help to make a vain Man humble.

In the final, the positive, state, the mind has given over the vain search after absolute notions, the origin and destination of the universe, and the causes of phenomena, and applies itself to the study of their laws—that is, their invariable relations of succession and resemblance. Reasoning and observation, duly combined, are the means of this knowledge. What is now understood when we speak of an explanation of facts is simply the establishment of a connection between single phenomena and some general facts.

In this great celestial creation, the catastrophy of a world, such as ours, or even the total dissolution of a system of worlds, may possibly be no more to the great Author of Nature, than the most common accident in life with us, and in all probability such final and general Doomsdays may be as frequent there, as even Birthdays or mortality with us upon the earth. This idea has something so cheerful in it, that I know I can never look upon the stars without wondering why the whole world does not become astronomers; and that men endowed with sense and reason should neglect a science they are naturally so much interested in, and so capable of enlarging their understanding, as next to a demonstration must convince them of their immortality, and reconcile them to all those little difficulties incident to human nature, without the least anxiety. All this the vast apparent provision in the starry mansions seem to promise: What ought we then not to do, to preserve our natural birthright to it and to merit such inheritance, which alas we think created all to gratify alone a race of vain-glorious gigantic beings, while they are confined to this world, chained like so many atoms to a grain of sand.

Let me not seem to have lived in vain.

Man is an eating animal, a drinking animal, and a sleeping animal, and one placed in a material world, which alone furnishes all the human animal can desire. He is gifted besides with knowing faculties, practically to explore and to apply the resources of this world to his use. These are realities. All else is nothing; conscience and sentiment are mere figments of the imagination. Man has but five gates of knowledge, the five senses; he can know nothing but through them; all else is a vain fancy, and as for the being of a God, the existence of a soul, or a world to come, who can know anything about them? Depend upon it, my dear madam, these are only the bugbears by which men of sense govern fools.

Mathematicians have tried in vain to this day to discover some order in the sequence of prime numbers, and we have reason to believe that it is a mystery into which the human mind will never penetrate.

Men always fool themselves when they give up experience for systems born of the imagination. Man is the work of nature, he exists in nature, he is subject to its laws, he can not break free, he can not leave even in thought; it is in vain that his spirit wants to soar beyond the bounds of the visible world, he is always forced to return.

Mock on, mock on, Voltaire, Rousseau!
Mock on, mock on: 'Tis all in vain!
You throw the sand against the wind,
And the wind blows it back again.
And every sand becomes a gem
Reflected in the beams divine;
Blown back they blind the mocking eye,
But still in Israel's paths they shine.
The atoms of Democritus
And Newton's particles of light
Are sands upon the Red Sea shore,
Where Israel's tents do shine so bright.

Nature does nothing in vain when less will serve; for Nature is pleased with simplicity and affects not the pomp of superfluous causes.

No place affords a more striking conviction of the vanity of human hopes than a publick library; for who can see the wall crouded on every side by mighty volumes, the works of laborious meditation, and accurate inquiry, now scarcely known but by the catalogue, and preserved only to encrease the pomp of learning, without considering how many hours have been wasted in vain endeavours, how often imagination has anticipated the praises of futurity, how many statues have risen to the eye of vanity, how many ideal converts have elevated zeal, how often wit has exulted in the eternal infamy of his antagonists, and dogmatism has delighted in the gradual advances of his authority, the immutability of his decrees, and the perpetuity of his power.
Non unquam dedit
Documenta fors majora, quam fragili loco
Starent superbi.
Seneca, Troades, II, 4-6
Insulting chance ne'er call'd with louder voice,
On swelling mortals to be proud no more.
Of the innumerable authors whose performances are thus treasured up in magnificent obscurity, most are forgotten, because they never deserved to be remembered, and owed the honours which they have once obtained, not to judgment or to genius, to labour or to art, but to the prejudice of faction, the stratagem of intrigue, or the servility of adulation.
Nothing is more common than to find men whose works are now totally neglected, mentioned with praises by their contemporaries, as the oracles of their age, and the legislators of science. Curiosity is naturally excited, their volumes after long enquiry are found, but seldom reward the labour of the search. Every period of time has produced these bubbles of artificial fame, which are kept up a while by the breath of fashion and then break at once and are annihilated. The learned often bewail the loss of ancient writers whose characters have survived their works; but perhaps if we could now retrieve them we should find them only the Granvilles, Montagus, Stepneys, and Sheffields of their time, and wonder by what infatuation or caprice they could be raised to notice.
It cannot, however, be denied, that many have sunk into oblivion, whom it were unjust to number with this despicable class. Various kinds of literary fame seem destined to various measures of duration. Some spread into exuberance with a very speedy growth, but soon wither and decay; some rise more slowly, but last long. Parnassus has its flowers of transient fragrance as well as its oaks of towering height, and its laurels of eternal verdure.

O Timothy, keep that which is committed to thy trust, avoiding profane and vain babblings, and oppositions of science falsely so called; Which some professing have erred concerning faith. Grace be with thee. Amen.

Of what use are the great number of petrifactions, of different species, shape and form which are dug up by naturalists? Perhaps the collection of such specimens is sheer vanity and inquisitiveness. I do not presume to say; but we find in our mountains the rarest animals, shells, mussels, and corals embalmed in stone, as it were, living specimens of which are now being sought in vain throughout Europe. These stones alone whisper in the midst of general silence.

Our most distinguished “man of science” was the then veteran John Dalton. He was rarely absent from his seat in a warm corner of the room during the meetings of the Literary and Philosophical Society. Though a sober-minded Quaker, he was not devoid of some sense of fun; and there was a tradition amongst us, not only that he had once been a poet, but that, although a bachelor, two manuscript copies were still extant of his verses on the subject of matrimonial felicity; and it is my belief there was foundation for the tradition. The old man was sensitive on the subject of his age. Dining one day ... he was placed between two ladies ... [who] resolved to extract from him some admission on the tender point, but in vain. Though never other than courteous, Dalton foiled all their feminine arts and retained his secret. ... Dalton's quaint and diminutive figure was a strongly individualized one.

Perfect as the wing of a bird may be, it will never enable the bird to fly if unsupported by the air. Facts are the air of science. Without them a man of science can never rise. Without them your theories are vain surmises. But while you are studying, observing, experimenting, do not remain content with the surface of things. Do not become a mere recorder of facts, but try to penetrate the mystery of their origin. Seek obstinately for the laws that govern them.

Philosophy [the universe] is written in that great book which ever lies before our eyes ... We cannot understand it if we do not first learn the language and grasp the symbols in which it is written. The book is written in the mathematical language ... without whose help it is humanly impossible to comprehend a single word of it, and without which one wanders in vain through a dark labyrinth.

Religious feeling is as much a verity as any other part of human consciousness; and against it, on its subjective side, the waves of science beat in vain.

Science gains from it [the pendulum] more than one can expect. With its huge dimensions, the apparatus presents qualities that one would try in vain to communicate by constructing it on a small [scale], no matter how carefully. Already the regularity of its motion promises the most conclusive results. One collects numbers that, compared with the predictions of theory, permit one to appreciate how far the true pendulum approximates or differs from the abstract system called 'the simple pendulum'.

Science progresses by a series of combinations in which chance plays not the least role. Its life is rough and resembles that of minerals which grow by juxtaposition [accretion]. This applies not only to science such as it emerges [results] from the work of a series of scientists, but also to the particular research of each one of them. In vain would analysts dissimulate: (however abstract it may be, analysis is no more our power than that of others); they do not deduce, they combine, they compare: (it must be sought out, sounded out, solicited.) When they arrive at the truth it is by cannoning from one side to another that they come across it.

Science too proceeds by lantern-flashes; it explores nature’s inexhaustible mosaic piece by piece. Too often the wick lacks oil; the glass panes of the lantern may not be clean. No matter: his work is not in vain who first recognizes and shows to others one speck of the vast unknown.

Science! Curse thee, thou vain toy…!

See with what force yon river’s crystal stream
Resists the weight of many a massy beam.
To sink the wood the more we vainly toil,
The higher it rebounds, with swift recoil.
Yet that the beam would of itself ascend
No man will rashly venture to contend.
Thus too the flame has weight, though highly rare,
Nor mounts but when compelled by heavier air.

So is not mathematical analysis then not just a vain game of the mind? To the physicist it can only give a convenient language; but isn’t that a mediocre service, which after all we could have done without; and, it is not even to be feared that this artificial language be a veil, interposed between reality and the physicist’s eye? Far from that, without this language most of the intimate analogies of things would forever have remained unknown to us; and we would never have had knowledge of the internal harmony of the world, which is, as we shall see, the only true objective reality.

The advance of science is not comparable to the changes of a city, where old edifices are pitilessly torn down to give place to new, but to the continuous evolution of zoologic types which develop ceaselessly and end by becoming unrecognisable to the common sight, but where an expert eye finds always traces of the prior work of the centuries past. One must not think then that the old-fashioned theories have been sterile and vain.

The alchemists of past centuries tried hard to make the elixir of life: ... Those efforts were in vain; it is not in our power to obtain the experiences and the views of the future by prolonging our lives forward in this direction. However, it is well possible in a certain sense to prolong our lives backwards by acquiring the experiences of those who existed before us and by learning to know their views as well as if we were their contemporaries. The means for doing this is also an elixir of life.

The barrenness of doubt had to make itself felt before it could be supplanted by knowledge. It was not until Hume, by carrying scepticism to its uttermost extent, had shown its unsatisfactory character and vain results, that the germs of scientific method, implanted by Bacon and Descartes, could develop and bear fruit in the positive philosophy of Comte.

The difficulty really is psychological and exists in the perpetual torment that results from your saying to yourself, “But how can it be like that?” which is a reflection of uncontrolled but utterly vain desire to see it in terms of something familiar. … If you will simply admit that maybe [Nature] does behave like this, you will find her a delightful, entrancing thing. Do not keep saying to yourself, if you can possible avoid it, "But how can it be like that?" because you will get 'down the drain', into a blind alley from which nobody has escaped. Nobody knows how it can be like that.
[About wave-particle duality.]

The great truths with which it [mathematics] deals, are clothed with austere grandeur, far above all purposes of immediate convenience or profit. It is in them that our limited understandings approach nearest to the conception of that absolute and infinite, towards which in most other things they aspire in vain. In the pure mathematics we contemplate absolute truths, which existed in the divine mind before the morning stars sang together, and which will continue to exist there, when the last of their radiant host shall have fallen from heaven. They existed not merely in metaphysical possibility, but in the actual contemplation of the supreme reason. The pen of inspiration, ranging all nature and life for imagery to set forth the Creator’s power and wisdom, finds them best symbolized in the skill of the surveyor. "He meted out heaven as with a span;" and an ancient sage, neither falsely nor irreverently, ventured to say, that “God is a geometer”.

The human understanding is unquiet; it cannot stop or rest, and still presses onward, but in vain. Therefore it is that we cannot conceive of any end or limit to the world, but always as of necessity it occurs to us that there is something beyond... But he is no less an unskilled and shallow philosopher who seeks causes of that which is most general, than he who in things subordinate and subaltern omits to do so

The Primal Plant is going be the strangest creature in the world, which Nature herself must envy me. With this model and the key to it, it will be possible to go on for ever inventing plants and know that their existence is logical; that is to say, if they do not actually exist, they could, for they are not the shadowy phantoms of a vain imagination, but possess an inner necessity and truth. The same law will be applicable to all other living organisms.

The pursuits of the greatest trifles may sometimes have a very good effect. The search after the philosopher’s stone has preserved chemistry; and the following astrology so much in former ages has been the cause of astronomy’s being so much advanced in ours. Sir Isaac Newton himself has owned that he began with studying judicial astrology, and that it was his pursuits of that idle and vain study which led him into the beauties and love of astronomy.

The question, What is cholera? is left unsolved. Concerning this, the fundamental point, all is darkness and confusion, vague theory, and a vain speculation. Is it a fungus, an insect, a miasm, an electrical disturbance, a deficiency of ozone, a morbid offscouring from the intestinal canal? We know nothing; we are at sea, in a whirlpool of conjecture.

The whole strenuous intellectual work of an industrious research worker would appear, after all, in vain and hopeless, if he were not occasionally through some striking facts to find that he had, at the end of all his criss-cross journeys, at last accomplished at least one step which was conclusively nearer the truth.

Their vain presumption of knowing all can take beginning solely from their never having known anything; for if one has but once experienced the perfect knowledge of one thing, and truly tasted what it is to know, he shall perceive that of infinite other conclusions he understands not so much as one.

This single Stick, which you now behold ingloriously lying in that neglected Corner, I once knew in a flourishing State in a Forest: It was full of Sap, full of Leaves, and full of Boughs: But now, in vain does the busy Art of Man pretend to vie with Nature, by tying that withered Bundle of Twigs to its sapless Trunk: It is at best but the Reverse of what it was; a Tree turned upside down, the Branches on the Earth, and the Root in the Air.

Thou to whom the sick and dying
Ever came, nor came in vain,
With thy healing hands replying
To their wearied cry of pain.

To teach vain Wits that Science little known,
T' admire Superior Sense, and doubt their own!

To this I may add another form of temptation, manifold in its dangers … There exists in the soul … a cupidity which does not take delight in the carnal pleasure but in perceptions acquired through the flesh. It is a vain inquisitiveness dignified with the title of knowledge and science. As this is rooted in the appetite for knowing, and as among the senses the eyes play a leading role in acquiring knowledge, the divine word calls it “the lust of the eyes” (I John, 2: 16) … To satisfy this diseased craving … people study the operations of nature, which lie beyond our grasp when there is no advantage in knowing and the investigators simply desire knowledge for its own sake. This motive is again at work if, using a perverted science for the same end, people try to achieve things by magical arts.

To what purpose should People become fond of the Mathematicks and Natural Philosophy? … People very readily call Useless what they do not understand. It is a sort of Revenge… One would think at first that if the Mathematicks were to be confin’d to what is useful in them, they ought only to be improv'd in those things which have an immediate and sensible Affinity with Arts, and the rest ought to be neglected as a Vain Theory. But this would be a very wrong Notion. As for Instance, the Art of Navigation hath a necessary Connection with Astronomy, and Astronomy can never be too much improv'd for the Benefit of Navigation. Astronomy cannot be without Optics by reason of Perspective Glasses: and both, as all parts of the Mathematicks are grounded upon Geometry … .

Voluntary attention is … a habit, an imitation of natural attention, which … serves, at the same time, as its point of departure and point of support. … Attention … creates nothing; and if the brain be sterile, if the associations are poor, it will act its part in vain.

We are not to suppose, that there is any violent exertion of power, such as is required in order to produce a great event in little time; in nature, we find no deficiency in respect of time, nor any limitation with regard to power. But time is not made to flow in vain; nor does there ever appear the exertion of superfluous power, or the manifestation of design, not calculated in wisdom to effect some general end.

We are so presumptuous that we would wish to be known by all the world, even by people who shall come after, when we shall be no more; and we are so vain that the esteem of five or six neighbours delights and contents us.

We have the satisfaction to find, that in nature there is wisdom, system and consistency. For having, in the natural history of this earth, seen a succession of worlds, we may from this conclude that, there is a system in nature; in like manner as, from seeing revolutions of the planets, it is concluded, that there is a system by which they are intended to continue those revolutions. But if the succession of worlds is established in the system of nature, it is vain to look for anything higher in the origin of the earth. The result, therefore, of our present enquiry is, that we find no vestige of a beginning,-no prospect of an end.

We know the truth not only through our reason but also through our heart. It is through the latter that we know first principles, and reason, which has nothing to do with it, tries in vain to refute them.

We speak of it [astrology] as an extinct science; yet let but an eclipse of the sun happen, or a comet visit the evening sky, and in a moment we all believe in astrology. In vain do you tell the gazers on such spectacles that a solar eclipse is only the moon acting for the time as a candle-extinguisher to the sun, and give them bits of smoked glass to look through, and draw diagrams on the blackboard to explain it all. They listen composedly, and seem convinced, but in their secret hearts they are saying—“What though you can see it through a glass darkly, and draw it on a blackboard, does that show that it has no moral significance? You can draw a gallows or a guillotine, or write the Ten Commandments on a blackboard, but does that deprive them of meaning?” And so with the comet. No man will believe that the splendid stranger is hurrying through the sky solely on a momentous errand of his own. No! he is plainly signalling, with that flashing sword of his, something of importance to men,—something at all events that, if we could make it out, would be found of huge concern to us.

What parts of the interior or the atmosphere give rise to the various phenomena, or indeed, if these regions have any parts at all, are questions which we ask of the stars in vain.

Whence is it that nature does nothing in vain; and whence arises all that order and beauty which we see in the world?

Who thinks all Science, as all Virtue, vain;
Who counts Geometry and numbers Toys…

Whoever, in the pursuit of science, seeks after immediate practical utility, may generally rest assured that he will seek in vain.

You should know how many incompetent men I had to compete with - in vain!