[Concerning] phosphorescent bodies, and in particular to uranium salts whose phosphorescence has a very brief duration. With the double sulfate of uranium and potassium ... I was able to perform the following experiment: One wraps a Lumière photographic plate with a bromide emulsion in two sheets of very thick black paper, such that the plate does not become clouded upon being exposed to the sun for a day. One places on the sheet of paper, on the outside, a slab of the phosphorescent substance, and one exposes the whole to the sun for several hours. When one then develops the photographic plate, one recognizes that the silhouette of the phosphorescent substance appears in black on the negative. If one places between the phosphorescent substance and the paper a piece of money or a metal screen pierced with a cut-out design, one sees the image of these objects appear on the negative. One can repeat the same experiments placing a thin pane of glass between the phosphorescent substance and the paper, which excludes the possibility of chemical action due to vapors which might emanate from the substance when heated by the sun's rays. One must conclude from these experiments that the phosphorescent substance in question emits rays which pass through the opaque paper and reduces silver salts.
[Although the sun is irrelevant, and he misinterprets the role of phosphorescence, he has discovered the effect of radioactivity.]

[Concerning] the usual contempt with which an orthodox analytic group treats all outsiders and strangers ... I urge you to think of the young psychoanalysts as your colleagues, collaborators and partners and not as spies, traitors and wayward children. You can never develop a science that way, only an orthodox church.

[Culture] denotes an historically transmitted pattern of meanings embodied in symbols, a system of inherited conceptions expressed in symbolic forms, by means of which men communicate, perpetuate, and develop their knowledge about and attitudes toward life.

[T]he explosive development of our intellect, … I personally think was at least partly triggered by the fact we developed this way of talking with words. … We can bring people from different disciplines together to discuss a problem. That’s because of words. We now have developed a moral code with our words. And we know perfectly well what we should and shouldn’t do.

Between the frontiers of the three super-states Eurasia, Oceania, and Eastasia, and not permanently in possession of any of them, there lies a rough quadrilateral with its corners at Tangier, Brazzaville, Darwin, and Hongkong. These territories contain a bottomless reserve of cheap labour. Whichever power controls equatorial Africa, or the Middle East or Southern India or the Indonesian Archipelago, disposes also of the bodies of hundreds of millions of ill-paid and hardworking coolies, expended by their conquerors like so much coal or oil in the race to turn out more armaments, to capture more territory, to control more labour, to turn out more armaments, to capture more territory, to control…
Thus George Orwell—in his only reference to the less-developed world.
I wish I could disagree with him. Orwell may have erred in not anticipating the withering of direct colonial controls within the “quadrilateral” he speaks about; he may not quite have gauged the vehemence of urges to political self-assertion. Nor, dare I hope, was he right in the sombre picture of conscious and heartless exploitation he has painted. But he did not err in predicting persisting poverty and hunger and overcrowding in 1984 among the less privileged nations.
I would like to live to regret my words but twenty years from now, I am positive, the less-developed world will be as hungry, as relatively undeveloped, and as desperately poor, as today.

Reply when questioned on the safety of the polio vaccine he developed: It is safe, and you can’t get safer than safe.

~~[Unverified]~~ [Louis Pasteur’s] … theory of germs is a ridiculous fiction. How do you think that these germs in the air can be numerous enough to develop into all these organic infusions? If that were true, they would be numerous enough to form a thick fog, as dense as iron.

1839—The fermentation satire
THE MYSTERY OF ALCOHOLIC FERMENTATION RESOLVED
(Preliminary Report by Letter) Schwindler
I am about to develop a new theory of wine fermentation … Depending on the weight, these seeds carry fermentation to completion somewhat less than as in the beginning, which is understandable … I shall develop a new theory of wine fermentation [showing] what simple means Nature employs in creating the most amazing phenomena. I owe it to the use of an excellent microscope designed by Pistorius.
When brewer’s yeast is mixed with water the microscope reveals that the yeast dissolves into endless small balls, which are scarcely 1/800th of a line in diameter … If these small balls are placed in sugar water, it can be seen that they consist of the eggs of animals. As they expand, they burst, and from them develop small creatures that multiply with unbelievable rapidity in a most unheard of way. The form of these animals differs from all of the 600 types described up until now. They possess the shape of a Beinsdorff still (without the cooling apparatus). The head of the tube is a sort of proboscis, the inside of which is filled with fine bristles 1/2000th of a line long. Teeth and eyes are not discernible; however, a stomach, intestinal canal, anus (a rose red dot), and organs for secretion of urine are plainly discernible. From the moment they are released from the egg one can see these animals swallow the sugar from the solution and pass it to the stomach. It is digested immediately, a process recognized easily by the resultant evacuation of excrements. In a word, these infusors eat sugar, evacuate ethyl alcohol from the intestinal canal, and carbon dioxide from the urinary organs. The bladder, in the filled state, has the form of a champagne bottle; when empty, it is a small button … As soon as the animals find no more sugar present, they eat each other up, which occurs through a peculiar manipulation; everything is digested down to the eggs which pass unchanged through the intestinal canal. Finally, one again fermentable yeast, namely the seed of the animals, which remain over.

A general course in mathematics should be required of all officers for its practical value, but no less for its educational value in training the mind to logical forms of thought, in developing the sense of absolute truthfulness, together with a confidence in the accomplishment of definite results by definite means.

A casual glance at crystals may lead to the idea that they were pure sports of nature, but this is simply an elegant way of declaring one’s ignorance. With a thoughtful examination of them, we discover laws of arrangement. With the help of these, calculation portrays and links up the observed results. How variable and at the same time how precise and regular are these laws! How simple they are ordinarily, without losing anything of their significance! The theory which has served to develop these laws is based entirely on a fact, whose existence has hitherto been vaguely discerned rather than demonstrated. This fact is that in all minerals which belong to the same species, these little solids, which are the crystal elements and which I call their integrant molecules, have an invariable form, in which the faces lie in the direction of the natural fracture surfaces corresponding to the mechanical division of the crystals. Their angles and dimensions are derived from calculations combined with observation.

A closer look at the course followed by developing theory reveals for a start that it is by no means as continuous as one might expect, but full of breaks and at least apparently not along the shortest logical path. Certain methods often afforded the most handsome results only the other day, and many might well have thought that the development of science to infinity would consist in no more than their constant application. Instead, on the contrary, they suddenly reveal themselves as exhausted and the attempt is made to find other quite disparate methods. In that event there may develop a struggle between the followers of the old methods and those of the newer ones. The former's point of view will be termed by their opponents as out-dated and outworn, while its holders in turn belittle the innovators as corrupters of true classical science.

A great department of thought must have its own inner life, however transcendent may be the importance of its relations to the outside. No department of science, least of all one requiring so high a degree of mental concentration as Mathematics, can be developed entirely, or even mainly, with a view to applications outside its own range. The increased complexity and specialisation of all branches of knowledge makes it true in the present, however it may have been in former times, that important advances in such a department as Mathematics can be expected only from men who are interested in the subject for its own sake, and who, whilst keeping an open mind for suggestions from outside, allow their thought to range freely in those lines of advance which are indicated by the present state of their subject, untrammelled by any preoccupation as to applications to other departments of science. Even with a view to applications, if Mathematics is to be adequately equipped for the purpose of coping with the intricate problems which will be presented to it in the future by Physics, Chemistry and other branches of physical science, many of these problems probably of a character which we cannot at present forecast, it is essential that Mathematics should be allowed to develop freely on its own lines.

A large part of mathematics which becomes useful developed with absolutely no desire to be useful, and in a situation where nobody could possibly know in what area it would become useful; and there were no general indications that it ever would be so.

A multidisciplinary study group ... estimated that it would be 1980 before developments in artificial intelligence make it possible for machines alone to do much thinking or problem solving of military significance. That would leave, say, five years to develop man-computer symbiosis and 15 years to use it. The 15 may be 10 or 500, but those years should be intellectually the most creative and exciting in the history of mankind.

A natural science is one whose propositions on limited domains of nature can have only a correspondingly limited validity; and that science is not a philosophy developing a world-view of nature as a whole or about the essence of things.

A new species develops if a population which has become geographically isolated from its parental species acquires during this period of isolation characters which promote or guarantee reproductive isolation when the external barriers break down.

A research laboratory jealous of its reputation has to develop less formal, more intimate ways of forming a corporate judgment of the work its people do. The best laboratories in university departments are well known for their searching, mutual questioning.

A schism has taken place among the chemists. A particular set of them in France have undertaken to remodel all the terms of the science, and to give every substance a new name, the composition, and especially the termination of which, shall define the relation in which it stands to other substances of the same family, But the science seems too much in its infancy as yet, for this reformation; because in fact, the reformation of this year must be reformed again the next year, and so on, changing the names of substances as often as new experiments develop properties in them undiscovered before. The new nomenclature has, accordingly, been already proved to need numerous and important reformations. ... It is espoused by the minority here, and by the very few, indeed, of the foreign chemists. It is particularly rejected in England.

A vast technology has been developed to prevent, reduce, or terminate exhausting labor and physical damage. It is now dedicated to the production of the most trivial conveniences and comfort.

Adam is fading out. It is on account of Darwin and that crowd. I can see that he is not going to last much longer. There's a plenty of signs. He is getting belittled to a germ—a little bit of a speck that you can't see without a microscope powerful enough to raise a gnat to the size of a church. They take that speck and breed from it: first a flea; then a fly, then a bug, then cross these and get a fish, then a raft of fishes, all kinds, then cross the whole lot and get a reptile, then work up the reptiles till you've got a supply of lizards and spiders and toads and alligators and Congressmen and so on, then cross the entire lot again and get a plant of amphibiums, which are half-breeds and do business both wet and dry, such as turtles and frogs and ornithorhyncuses and so on, and cross-up again and get a mongrel bird, sired by a snake and dam'd by a bat, resulting in a pterodactyl, then they develop him, and water his stock till they've got the air filled with a million things that wear feathers, then they cross-up all the accumulated animal life to date and fetch out a mammal, and start-in diluting again till there's cows and tigers and rats and elephants and monkeys and everything you want down to the Missing Link, and out of him and a mermaid they propagate Man, and there you are! Everything ship-shape and finished-up, and nothing to do but lay low and wait and see if it was worth the time and expense.

Adrenalin does not excite sympathetic ganglia when applied to them directly, as does nicotine. Its effective action is localised at the periphery. The existence upon plain muscle of a peripheral nervous network, that degenerates only after section of both the constrictor and inhibitory nerves entering it, and not after section of either alone, has been described. I find that even after such complete denervation, whether of three days' or ten months' duration, the plain muscle of the dilatator pupillae will respond to adrenalin, and that with greater rapidity and longer persistence than does the iris whose nervous relations are uninjured. Therefore it cannot be that adrenalin excites any structure derived from, and dependent for its persistence on, the peripheral neurone. But since adrenalin does not evoke any reaction from muscle that has at no time of its life been innervated by the sympathetic, the point at which the stimulus of the chemical excitant is received, and transformed into what may cause the change of tension of the muscle fibre, is perhaps a mechanism developed out of the muscle cell in response to its union with the synapsing sympathetic fibre, the function of which is to receive and transform the nervous impulse. Adrenalin might then be the chemical stimulant liberated on each occasion when the impulse arrives at the periphery.

All animals whatsoever, whether they fly or swim or walk upon dry land, whether they bring forth their young alive or in the egg, develop in the same way.

All children are curious and I wonder by what process this trait becomes developed in some and suppressed in others. I suspect again that schools and colleges help in the suppression insofar as they meet curiosity by giving the answers, rather than by some method that leads from narrower questions to broader questions. It is hard to satisfy the curiosity of a child, and even harder to satisfy the curiosity of a scientist, and methods that meet curiosity with satisfaction are thus not apt to foster the development of the child into the scientist. I don't advocate turning all children into professional scientists, although I think there would be advantages if all adults retained something of the questioning attitude, if their curiosity were less easily satisfied by dogma, of whatever variety.

Although the cooking of food presents some unsolved problems, the quick warming of cooked food and the thawing of frozen food both open up some attractive uses. ... There is no important reason why the the housewife of the future should not purchase completely frozen meals at the grocery store just as she buys quick frozen vegetables. With a quick heating, high-frequency unit in her kitchen, food preparation from a pre-cooked, frozen meal becomes a simple matter.
[Predicting home kitchen appliances could be developed from the radionic tube employed to jam enemy radar in World War II.]

America has always been greatest when we dared to be great. We can reach for greatness again. We can follow our dreams to distant stars, living and working in space for peaceful, economic, and scientific gain. Tonight, I am directing NASA to develop a permanently manned space station and to do it within a decade.

An evolution is a series of events that in itself as series is purely physical, — a set of necessary occurrences in the world of space and time. An egg develops into a chick; … a planet condenses from the fluid state, and develops the life that for millions of years makes it so wondrous a place. Look upon all these things descriptively, and you shall see nothing but matter moving instant after instant, each instant containing in its full description the necessity of passing over into the next. … But look at the whole appreciatively, historically, synthetically, as a musician listens to a symphony, as a spectator watches a drama. Now you shall seem to have seen, in phenomenal form, a story.

And now, as a germination of planetary dimensions, comes the thinking layer which over its full extent develops and intertwines its fibres, not to confuse and neutralise them but to reinforce them in the living unity of a single tissue.

And yet in a funny way our lack of success led to our breakthrough; because, since we could not get a cell line off the shelf doing what we wanted, we were forced to construct it. And the original experiment ... developed into a method for the production of hybridomas ... [which] was of more importance than our original purpose.

Any conception which is definitely and completely determined by means of a finite number of specifications, say by assigning a finite number of elements, is a mathematical conception. Mathematics has for its function to develop the consequences involved in the definition of a group of mathematical conceptions. Interdependence and mutual logical consistency among the members of the group are postulated, otherwise the group would either have to be treated as several distinct groups, or would lie beyond the sphere of mathematics.

Any demanding high technology tends to develop influential and dedicated constituencies of those who link its commercial success with both the public welfare and their own. Such sincerely held beliefs, peer pressures, and the harsh demands that the work i

Apprehension by the senses supplies, directly or indirectly, the material of all human knowledge; or, at least, the stimulus necessary to develop every inborn faculty of the mind.

As the human fetus develops, its changing form seems to retrace the whole of human evolution from the time we were cosmic dust to the time we were single-celled organisms in the primordial sea to the time we were four-legged, land-dwelling reptiles and beyond, to our current status as large­brained, bipedal mammals. Thus, humans seem to be the sum total of experience since the beginning of the cosmos.

As to how far in advance of the first flight the man should know he’s going. I’m not in agreement with the argument that says word should be delayed until the last possible moment to save the pilot from developing a bad case of the jitters. If we don’t have the confidence to keep from getting clutched at that time, we have no business going at all. If I’m the guy going, I’ll be glad to get the dope as soon as possible. As for keeping this a big secret from us and having us all suited up and then saying to one man “you go” and stuffing him in and putting the lid on that thing and away he goes, well, we’re all big boys now.

At the present time it is of course quite customary for physicists to trespass on chemical ground, for mathematicians to do excellent work in physics, and for physicists to develop new mathematical procedures. … Trespassing is one of the most successful techniques in science.

Because intelligence is our own most distinctive feature, we may incline to ascribe superior intelligence to the basic primate plan, or to the basic plan of the mammals in general, but this point requires some careful consideration. There is no question at all that most mammals of today are more intelligent than most reptiles of today. I am not going to try to define intelligence or to argue with those who deny thought or consciousness to any animal except man. It seems both common and scientific sense to admit that ability to learn, modification of action according to the situation, and other observable elements of behavior in animals reflect their degrees of intelligence and permit us, if only roughly, to compare these degrees. In spite of all difficulties and all the qualifications with which the expert (quite properly) hedges his conclusions, it also seems sensible to conclude that by and large an animal is likely to be more intelligent if it has a larger brain at a given body size and especially if its brain shows greater development of those areas and structures best developed in our own brains. After all, we know we are intelligent, even though we wish we were more so.

Biological disciplines tend to guide research into certain channels. One consequence is that disciplines are apt to become parochial, or at least to develop blind spots, for example, to treat some questions as “interesting” and to dismiss others as “uninteresting.” As a consequence, readily accessible but unworked areas of genuine biological interest often lie in plain sight but untouched within one discipline while being heavily worked in another. For example, historically insect physiologists have paid relatively little attention to the behavioral and physiological control of body temperature and its energetic and ecological consequences, whereas many students of the comparative physiology of terrestrial vertebrates have been virtually fixated on that topic. For the past 10 years, several of my students and I have exploited this situation by taking the standard questions and techniques from comparative vertebrate physiology and applying them to insects. It is surprising that this pattern of innovation is not more deliberately employed.

Biological diversity is unique in its importance to both developed and developing countries.

Books and libraries and the will to use them are among the most important tools our nation has to diffuse knowledge and to develop our powers of creative wisdom.

But we must take other steps, such as increasing conservation, developing an ethanol industry, and increasing CAFE standards if we are to make our country safer by cutting our reliance on foreign oil.

Cayley was singularly learned in the work of other men, and catholic in his range of knowledge. Yet he did not read a memoir completely through: his custom was to read only so much as would enable him to grasp the meaning of the symbols and understand its scope. The main result would then become to him a subject of investigation: he would establish it (or test it) by algebraic analysis and, not infrequently, develop it so to obtain other results. This faculty of grasping and testing rapidly the work of others, together with his great knowledge, made him an invaluable referee; his services in this capacity were used through a long series of years by a number of societies to which he was almost in the position of standing mathematical advisor.

Character cannot be developed in ease and quiet. Only through experience of trial and suffering can the soul be strengthened, ambition inspired, and success achieved.

Chemical engineering is the profession in which a knowledge of mathematics, chemistry and other natural sciences gained by study, experience and practice is applied with judgment to develop economic ways of using materials and energy for the benefit of mankind.

Chemistry is like a majestic skyscraper. The concrete secure foundation of chemistry consists of countless experimentally observed facts. The theories, principles and laws developed from these observations are like an elevator which runs from the bottom to the top of the edifice.

Complex organisms cannot be construed as the sum of their genes, nor do genes alone build particular items of anatomy or behavior by them selves. Most genes influence several aspects of anatomy and behavior–as they operate through complex interactions with other genes and their products, and with environmental factors both within and outside the developing organism. We fall into a deep error, not just a harmful oversimplification, when we speak of genes ‘for’ particular items of anatomy or behavior.

Consciously and systematically Klein sought to enthrall me with the problems of mathematical physics, and to win me over to his conception of these problems as developed it in lecture courses in previous years. I have always regarded Klein as my real teacher only in things mathematical, but also in mathematical physics and in my conception of mechanics.

Conservation means development as much as it does protection. I recognize the right and duty of this generation to develop and use the natural resources of our land; but I do not recognize the right to waste them, or to rob, by wasteful use, the generations that come after us.

Consider a cow. A cow doesn’t have the problem-solving skill of a chimpanzee, which has discovered how to get termites out of the ground by putting a stick into a hole. Evolution has developed the brain’s ability to solve puzzles, and at the same time has produced in our brain a pleasure of solving problems.

Consider the plight of a scientist of my age. I graduated from the University of California at Berkeley in 1940. In the 41 years since then the amount of biological information has increased 16 fold; during these 4 decades my capacity to absorb new information has declined at an accelerating rate and now is at least 50% less than when I was a graduate student. If one defines ignorance as the ratio of what is available to be known to what is known, there seems no alternative to the conclusion that my ignorance is at least 25 times as extensive as it was when I got my bachelor’s degree. Although I am sure that my unfortunate condition comes as no surprise to my students and younger colleagues, I personally find it somewhat depressing. My depression is tempered, however, by the fact that all biologists, young or old, developing or senescing, face the same melancholy situation because of an interlocking set of circumstances.

Do you realize we’ve got 250 million years of coal? But coal has got environmental hazards to it, but there’s—I’m convinced, and I know that we—technology can be developed so we can have zero-emissions coal-fired electricity plants.

Does it not seem as if Algebra had attained to the dignity of a fine art, in which the workman has a free hand to develop his conceptions, as in a musical theme or a subject for a painting? It has reached a point where every properly developed algebraical composition, like a skillful landscape, is expected to suggest the notion of an infinite distance lying beyond the limits of the canvas.

Dust consisting of fine fibers of asbestos, which are insoluble and virtually indestructible, may become a public health problem in the near future. At a recent international conference on the biological effects of asbestos sponsored by the New York Academy of Sciences, participants pointed out on the one hand that workers exposed to asbestos dust are prone in later life to develop lung cancer, and on the other hand that the use of this family of fibrous silicate compounds has expanded enormously during the past few decades. A laboratory curiosity 100 years ago, asbestos today is a major component of building materials.

E.W. Goodpasture showed that the virus of fowl pox could be grown in the tissues of the developing chick embryo. Nearly all the later practical advances in the control of virus diseases in man and animals sprang from this single discovery.

Ecology has not yet explicitly developed the kind of cohesive, simplifying generalizations exemplified by, say, the laws of physics. Nevertheless there are a number of generalizations that are already evident in what we now know about the ecosphere and that can be organized into a kind of informal set of laws of ecology.

Education enlarges the child’s survey of the world in which he lives. Education stimulates and develops a child’s individuality. Education should harmonize the individual will and the institutional will.

Edward [Teller] isn’t the cloistered kind of scientist. He gets his ideas in conversation and develops them by trying them out on people. We were coming back from Europe on the Ile de France and I was standing in the ship’s nightclub when he came up and said, 'Freddie, I think I have an idea.’ It was something he’d just thought of about magnetohydrodynamics. I was a bachelor then and I’d located several good-looking girls on the ship, but I knew what I had to do, so I disappeared and started working on the calculations. I’d get something finished and start prowling on the deck again when Edward would turn up out of the night and we’d walk the deck together while he talked and I was the brick wall he was bouncing these things off of. By the end of the trip we had a paper. He’d had the ideas, and I’d done some solving of equations. But he insisted that we sign in alphabetical order, which put my name first.

Engineering is the profession in which a knowledge of the mathematical and natural sciences gained by study, experience, and practice is applied with judgment to develop ways to utilize, economically, the materials and forces of nature for the benefit of mankind.

Engineers apply the theories and principles of science and mathematics to research and develop economical solutions to practical technical problems. Their work is the link between scientific discoveries and commercial applications. Engineers design products, the machinery to build those products, the factories in which those products are made, and the systems that ensure the quality of the product and efficiency of the workforce and manufacturing process. They design, plan, and supervise the construction of buildings, highways, and transit systems. They develop and implement improved ways to extract, process, and use raw materials, such as petroleum and natural gas. They develop new materials that both improve the performance of products, and make implementing advances in technology possible. They harness the power of the sun, the earth, atoms, and electricity for use in supplying the Nation’s power needs, and create millions of products using power. Their knowledge is applied to improving many things, including the quality of health care, the safety of food products, and the efficient operation of financial systems.

Engineers at General Motors have developed a revolutionary new engine whose only function is to lubricate itself.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Every science begins by accumulating observations, and presently generalizes these empirically; but only when it reaches the stage at which its empirical generalizations are included in a rational generalization does it become developed science.

Evolution is the conviction that organisms developed their current forms by an extended history of continual transformation, and that ties of genealogy bind all living things into one nexus. Panselectionism is a denial of history, for perfection covers the tracks of time. A perfect wing may have evolved to its current state, but it may have been created just as we find it. We simply cannot tell if perfection be our only evidence. As Darwin himself understood so well, the primary proofs of evolution are oddities and imperfections that must record pathways of historical descent–the panda’s thumb and the flamingo’s smile of my book titles (chosen to illustrate this paramount principle of history).

Experimental physicists … walk a narrow path with pitfalls on either side. If we spend all our time developing equipment, we risk the appellation of “plumber,” and if we merely use the tools developed by others, we risk the censure of our peers for being parasitic.

Faced with the widespread destruction of the environment, people everywhere are coming to understand that we cannot continue to use the goods of the earth as we have in the past … [A] new ecological awareness is beginning to emerge which rather than being downplayed, ought to be encouraged to develop into concrete programs and initiatives. (8 Dec 1989)

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

First Law
In every animal which has not passed the limit of its development, a more frequent and continuous use of any organ gradually strengthens, develops and enlarges that organ, and gives it a power proportional to the length of time it has been so used; while the permanent disuse of any organ imperceptibly weakens and deteriorates it, and progressively diminishes its functional capacity, until it finally disappears.

Fish does not now—nor can it ever—feed the world. … Many developed, wealthy nations … dine on seafood more for taste than for necessity. … not one would on average incur any protein deficiency even if fish were completely removed from its dinner tables.

Five per cent vision is better than no vision at all. Five per cent hearing is better than no hearing at all. Five per cent flight efficiency is better than no flight at all. It is thoroughly believable that every organ or apparatus that we actually see is the product of a smooth trajectory through animal space, a trajectory in which every intermediate stage assisted survival and reproduction.
[Rebutting the Creationist assertion that fully developed organs could not have arisen 'by chance.']

For the better part of my last semester at Garden City High, I constructed a physical pendulum and used it to make a “precision” measurement of gravity. The years of experience building things taught me skills that were directly applicable to the construction of the pendulum. Twenty-five years later, I was to develop a refined version of this measurement using laser-cooled atoms in an atomic fountain interferometer.
[Outcome of high school physics teacher, Thomas Miner, encouraging Chu's ambitious laboratory project.]

Good methods can teach us to develop and use to better purpose the faculties with which nature has endowed us, while poor methods may prevent us from turning them to good account. Thus the genius of inventiveness, so precious in the sciences, may be diminished or even smothered by a poor method, while a good method may increase and develop it.

Gynaecologists are very smooth indeed. Because they have to listen to woeful and sordid symptoms they develop an expression of refinement and sympathy.

He should avail himself of their resources in such ways as to advance the expression of the spirit in the life of mankind. He should use them so as to afford to every human being the greatest possible opportunity for developing and expressing his distinctively human capacity as an instrument of the spirit, as a centre of sensitive and intelligent awareness of the objective universe, as a centre of love of all lovely things, and of creative action for the spirit.

How have people come to be taken in by The Phenomenon of Man? Just as compulsory primary education created a market catered for by cheap dailies and weeklies, so the spread of secondary and latterly of tertiary education has created a large population of people, often with well-developed literary and scholarly tastes who have been educated far beyond their capacity to undertake analytical thought … [The Phenomenon of Man] is written in an all but totally unintelligible style, and this is construed as prima-facie evidence of profundity.

Human nature is not a machine to be built after a model, and set to do exactly the work prescribed for it, but a tree, which requires to grow and develop itself on all sides, according to the tendency of the inward forces which make it a living thing.

I am very unhappy to conclude that the hydrogen bomb should be developed and built.

I came here to help make America more competitive and prosperous by developing an energy policy that increases conservation, promotes cleaner technologies, encourages development of renewables and enhances domestic production of gas and oil.

I conceived and developed a new geometry of nature and implemented its use in a number of diverse fields. It describes many of the irregular and fragmented patterns around us, and leads to full-fledged theories, by identifying a family of shapes I call fractals.

I consider the differences between man and animals in propensities, feelings, and intellectual faculties, to be the result of the same cause as that which we assign for the variations in other functions, viz. difference of organization; and that the superiority of man in rational endowments is not greater than the more exquisite, complicated, and perfectly developed structure of his brain, and particularly of his ample cerebral hemispheres, to which the rest of the animal kingdom offers no parallel, nor even any near approximation, is sufficient to account for.

I decided to study science and, on arrival at Cambridge, became extremely excited and interested in biochemistry when I first heard about it…. It seemed to me that here was a way to really understand living matter and to develop a more scientific basis to many medical problems.

I don’t think we’ll go there [Mars] until we go back to the Moon and develop a technology base for living and working and transporting ourselves through space.

I feel like a white granular mass of amorphous crystals—my formula appears to be isomeric with Spasmotoxin. My aurochloride precipitates into beautiful prismatic needles. My Platinochloride develops octohedron crystals,—with fine blue florescence. My physiological action is not indifferent. One millionth of a grain injected under the skin of a frog produced instantaneous death accompanied by an orange blossom odor. The heart stopped in systole. A base—L₃H₉NG₄—offers analogous reaction to phosmotinigstic acid.

I hardly look upon this as an operational mission. My job has just been to develop something which will break down a dam wall. I look upon this raid as my last great experiment to see if it can be done on the actual thing.

I have a sense of humor; but over the years that sense has developed one blind spot. I can no longer laugh at ignorance or stupidity. Those are our chief enemies, and it is dangerous to make fun of them.

I have always considered my work a joint effort. I was fortunate to have worked on great ideas and with very intelligent people. I may have developed a few equations no one had thought of before but that was nothing unusual—everybody did that.

I learned a lot of different things from different schools. MIT is a very good place…. It has developed for itself a spirit, so that every member of the whole place thinks that it’s the most wonderful place in the world—it’s the center, somehow, of scientific and technological development in the United States, if not the world … and while you don’t get a good sense of proportion there, you do get an excellent sense of being with it and in it, and having motivation and desire to keep on…

I presume that few who have paid any attention to the history of the Mathematical Analysis, will doubt that it has been developed in a certain order, or that that order has been, to a great extent, necessary—being determined, either by steps of logical deduction, or by the successive introduction of new ideas and conceptions, when the time for their evolution had arrived. And these are the causes that operate in perfect harmony. Each new scientific conception gives occasion to new applications of deductive reasoning; but those applications may be only possible through the methods and the processes which belong to an earlier stage.

I sometimes ask myself how it came about that I was the one to develop the theory of relativity. The reason, I think, is that a normal adult never stops to think about the problem of space and time. These are things which he has thought of as a child. But my intellectual development was retarded, as a result of which I began to wonder about space and time only when I had already grown up.

I think it is the general rule that the originator of a new idea is not the most suitable person to develop it, because his fears of something going wrong are really too strong…
At age 69.

I think we are living in a new time. I think that the ways of working when there was not the current widespread questioning of what science does are no longer applicable. Besides, there is a difference between the sort of research you do when you’re developing something for the first time and the sort of thing you have to do to make sure it continues to work—and the two different sorts of research are done best by different sorts of people. And, just as with basic science, one needs confirmatory experiments. One can’t just have one group saying “yes they’re safe, yes they’re safe, take our word for it, we made them and we know they’re safe”. Someone else, quite independent, needs to take a look, do the confirmatory experiment. Duplication in this case can do nothing but good.

I used to say the evening that I developed the first x-ray photograph I took of insulin in 1935 was the most exciting moment of my life. But the Saturday afternoon in late July 1969, when we realized that the insulin electron density map was interpretable, runs that moment very close.

I will insist particularly upon the following fact, which seems to me quite important and beyond the phenomena which one could expect to observe: The same [double sulfate of uranium and potassium] crystalline crusts, arranged the same way [as reported to the French academy on 24 Feb 1896] with respect to the photographic plates, in the same conditions and through the same screens, but sheltered from the excitation of incident rays and kept in darkness, still produce the same photographic images … [when kept from 26 Feb 1896] in the darkness of a bureau drawer. … I developed the photographic plates on the 1st of March, expecting to find the images very weak. Instead the silhouettes appeared with great intensity.
It is important to observe that it appears this phenomenon must not be attributed to the luminous radiation emitted by phosphorescence … One hypothesis which presents itself to the mind naturally enough would be to suppose that these rays, whose effects have a great similarity to the effects produced by the rays studied by M. Lenard and M. Röntgen, are invisible rays …
[Having eliminated phosphorescence as a cause, he has further revealed the effect of the as yet unknown radioactivity.]

If I had my life to live over again I would not devote it to develop new industrial processes: I would try to add my humble efforts to use Science to the betterment of the human race.
I despair of the helter-skelter methods of our vaulted homo sapiens, misguided by his ignorance and his politicians. If we continue our ways, there is every possibility that the human race may follow the road of former living races of animals whose fossils proclaim that they were not fit to continue. Religion, laws and morals is not enough. We need more. Science can help us.

If necessity is the mother of invention, scientifically developed production is the mother of scientific research.

If we denote excitation as an end-effect by the sign plus (+), and inhibition as end-effect by the sign minus (–), such a reflex as the scratch-reflex can be termed a reflex of double-sign, for it develops excitatory end-effect and then inhibitory end-effect even during the duration of the exciting stimulus.

If we wish to imitate the physical sciences, we must not imitate them in their contemporary, most developed form; we must imitate them in their historical youth, when their state of development was comparable to our own at the present time. Otherwise we should behave like boys who try to copy the imposing manners of full-grown men without understanding their raison d’être, also without seeing that in development one cannot jump over intermediate and preliminary phases.

In 1975, ... [speaking with Shiing Shen Chern], I told him I had finally learned ... the beauty of fiber-bundle theory and the profound Chern-Weil theorem. I said I found it amazing that gauge fields are exactly connections on fiber bundles, which the mathematicians developed without reference to the physical world. I added, “this is both thrilling and puzzling, since you mathematicians dreamed up these concepts out of nowhere.” He immediately protested: “No, no. These concepts were not dreamed up. They were natural and real.”

In a great number of the cosmogonic myths the world is said to have developed from a great water, which was the prime matter. In many cases, as for instance in an Indian myth, this prime matter is indicated as a solution, out of which the solid earth crystallized out.

In an age of egoism, it is so difficult to persuade man that of all studies, the most important is that of himself. This is because egoism, like all passions, is blind. The attention of the egoist is directed to the immediate needs of which his senses give notice, and cannot be raised to those reflective needs that reason discloses to us; his aim is satisfaction, not perfection. He considers only his individual self; his species is nothing to him. Perhaps he fears that in penetrating the mysteries of his being he will ensure his own abasement, blush at his discoveries, and meet his conscience. True philosophy, always at one with moral science, tells a different tale. The source of useful illumination, we are told, is that of lasting content, is in ourselves. Our insight depends above all on the state of our faculties; but how can we bring our faculties to perfection if we do not know their nature and their laws! The elements of happiness are the moral sentiments; but how can we develop these sentiments without considering the principle of our affections, and the means of directing them? We become better by studying ourselves; the man who thoroughly knows himself is the wise man. Such reflection on the nature of his being brings a man to a better awareness of all the bonds that unite us to our fellows, to the re-discovery at the inner root of his existence of that identity of common life actuating us all, to feeling the full force of that fine maxim of the ancients: 'I am a man, and nothing human is alien to me.'

In early times, when the knowledge of nature was small, little attempt was made to divide science into parts, and men of science did not specialize. Aristotle was a master of all science known in his day, and wrote indifferently treatises on physics or animals. As increasing knowledge made it impossible for any one man to grasp all scientific subjects, lines of division were drawn for convenience of study and of teaching. Besides the broad distinction into physical and biological science, minute subdivisions arose, and, at a certain stage of development, much attention was, given to methods of classification, and much emphasis laid on the results, which were thought to have a significance beyond that of the mere convenience of mankind.
But we have reached the stage when the different streams of knowledge, followed by the different sciences, are coalescing, and the artificial barriers raised by calling those sciences by different names are breaking down. Geology uses the methods and data of physics, chemistry and biology; no one can say whether the science of radioactivity is to be classed as chemistry or physics, or whether sociology is properly grouped with biology or economics. Indeed, it is often just where this coalescence of two subjects occurs, when some connecting channel between them is opened suddenly, that the most striking advances in knowledge take place. The accumulated experience of one department of science, and the special methods which have been developed to deal with its problems, become suddenly available in the domain of another department, and many questions insoluble before may find answers in the new light cast upon them. Such considerations show us that science is in reality one, though we may agree to look on it now from one side and now from another as we approach it from the standpoint of physics, physiology or psychology.

In my first publication I might have claimed that I had come to the conclusion, as a result of serious study of the literature and deep thought, that valuable antibacterial substances were made by moulds and that I set out to investigate the problem. That would have been untrue and I preferred to tell the truth that penicillin started as a chance observation. My only merit is that I did not neglect the observation and that I pursued the subject as a bacteriologist. My publication in 1929 was the starting-point of the work of others who developed penicillin especially in the chemical field.

In outer space you develop an instant global consciousness, a people orientation, an intense dissatisfaction with the state of the world, and a compulsion to do something about it. From out there on the moon, international politics look so petty. You want to grab a politician by the scruff of the neck and drag him a quarter of a million miles out and say, “Look at that, you son of a bitch.”

In physics we deal with states of affairs much simpler than those of psychology and yet we again and again learn that our task is not to investigate the essence of things—we do not at all know what this would mean&mash;but to develop those concepts that allow us to speak with each other about the events of nature in a fruitful manner.

In recent times, modern science has developed to give mankind, for the first time in the history of the human race, a way of securing a more abundant life which does not simply consist in taking away from someone else.

In science it is a service of the highest merit to seek out those fragmentary truths attained by the ancients, and to develop them further.

In the benzene nucleus we have been given a soil out of which we can see with surprise the already-known realm of organic chemistry multiply, not once or twice but three, four, five or six times just like an equivalent number of trees. What an amount of work had suddenly become necessary, and how quickly were busy hands found to carry it out! First the eye moves up the six stems opening out from the tremendous benzene trunk. But already the branches of the neighbouring stems have become intertwined, and a canopy of leaves has developed which becomes more spacious as the giant soars upwards into the air. The top of the tree rises into the clouds where the eye cannot yet follow it. And to what an extent is this wonderful benzene tree thronged with blossoms! Everywhere in the sea of leaves one can spy the slender hydroxyl bud: hardly rarer is the forked blossom [Gabelblüte] which we call the amine group, the most frequent is the beautiful cross-shaped blossom we call the methyl group. And inside this embellishment of blossoms, what a richness of fruit, some of them shining in a wonderful blaze of color, others giving off an overwhelming fragrance.

In the progressive growth of astronomy, physics or mechanical science was developed, and when this had been, to a certain degree, successfully cultivated, it gave birth to the science of chemistry.

In the twenties the late Dr. Glenn Frank, an eminent social scientist, developed a new statement of the scientific code, which has been referred to as the “Five Fingers of the Scientific Method.” It may be outlined as follows: find the facts; filter the facts; focus the facts; face the facts; follow the facts. The facts or truths are found by experimentation; the motivation is material. The facts are filtered by research into the literature; the motivation is material. The facts are focused by the publication of results; again the motivation is material. Thus the first three-fifths of the scientific method have a material motivation. It is about time scientists acknowledge that there is more to the scientific convention than the material aspect. Returning to the fourth and fifth fingers of Dr. Frank's conception of the scientific method, the facts should be faced by the proper interpretation of them for society. In other words, a scientist must assume social responsibility for his discoveries, which means that he must have a moral motivation. Finally, in the fifth definition of the scientific method, the facts are to be followed by their proper application to everyday life in society, which means moral motivation through responsibility to society.

In working out an invention, the most important quality is persistence. Nearly every man who develops an idea works it up to the point where it looks impossible, and then he gets discouraged. That’s not the place to become discouraged, that's the place to get interested.

Influenced by him, and probably even more so by my brother Theodore a year older than me, I soon became interested in biology and developed a respect for the importance of science and the scientific method.

Intelligence is important in psychology for two reasons. First, it is one of the most scientifically developed corners of the subject, giving the student as complete a view as is possible anywhere of the way scientific method can be applied to psychological problems. Secondly, it is of immense practical importance, educationally, socially, and in regard to physiology and genetics.

Inventions are best developed on your own. When you work for other people or borrow money from them, maintaining freedom of intellect is difficult.

Is man a peculiar organism? Does he originate in a wholly different way from a dog, bird, frog, or fish? and does he thereby justify those who assert that he has no place in nature, and no real relationship with the lower world of animal life? Or does he develop from a similar embryo, and undergo the same slow and gradual progressive modifications? The answer is not for an instant doubtful, and has not been doubtful for the last thirty years. The mode of man’s origin and the earlier stages of his development are undoubtedly identical with those of the animals standing directly below him in the scale; without the slightest doubt, he stands in this respect nearer the ape than the ape does to the dog. (1863)

It has been asserted … that the power of observation is not developed by mathematical studies; while the truth is, that; from the most elementary mathematical notion that arises in the mind of a child to the farthest verge to which mathematical investigation has been pushed and applied, this power is in constant exercise. By observation, as here used, can only be meant the fixing of the attention upon objects (physical or mental) so as to note distinctive peculiarities—to recognize resemblances, differences, and other relations. Now the first mental act of the child recognizing the distinction between one and more than one, between one and two, two and three, etc., is exactly this. So, again, the first geometrical notions are as pure an exercise of this power as can be given. To know a straight line, to distinguish it from a curve; to recognize a triangle and distinguish the several forms—what are these, and all perception of form, but a series of observations? Nor is it alone in securing these fundamental conceptions of number and form that observation plays so important a part. The very genius of the common geometry as a method of reasoning—a system of investigation—is, that it is but a series of observations. The figure being before the eye in actual representation, or before the mind in conception, is so closely scrutinized, that all its distinctive features are perceived; auxiliary lines are drawn (the imagination leading in this), and a new series of inspections is made; and thus, by means of direct, simple observations, the investigation proceeds. So characteristic of common geometry is this method of investigation, that Comte, perhaps the ablest of all writers upon the philosophy of mathematics, is disposed to class geometry, as to its method, with the natural sciences, being based upon observation. Moreover, when we consider applied mathematics, we need only to notice that the exercise of this faculty is so essential, that the basis of all such reasoning, the very material with which we build, have received the name observations. Thus we might proceed to consider the whole range of the human faculties, and find for the most of them ample scope for exercise in mathematical studies. Certainly, the memory will not be found to be neglected. The very first steps in number—counting, the multiplication table, etc., make heavy demands on this power; while the higher branches require the memorizing of formulas which are simply appalling to the uninitiated. So the imagination, the creative faculty of the mind, has constant exercise in all original mathematical investigations, from the solution of the simplest problems to the discovery of the most recondite principle; for it is not by sure, consecutive steps, as many suppose, that we advance from the known to the unknown. The imagination, not the logical faculty, leads in this advance. In fact, practical observation is often in advance of logical exposition. Thus, in the discovery of truth, the imagination habitually presents hypotheses, and observation supplies facts, which it may require ages for the tardy reason to connect logically with the known. Of this truth, mathematics, as well as all other sciences, affords abundant illustrations. So remarkably true is this, that today it is seriously questioned by the majority of thinkers, whether the sublimest branch of mathematics,—the infinitesimal calculus—has anything more than an empirical foundation, mathematicians themselves not being agreed as to its logical basis. That the imagination, and not the logical faculty, leads in all original investigation, no one who has ever succeeded in producing an original demonstration of one of the simpler propositions of geometry, can have any doubt. Nor are induction, analogy, the scrutinization of premises or the search for them, or the balancing of probabilities, spheres of mental operations foreign to mathematics. No one, indeed, can claim preeminence for mathematical studies in all these departments of intellectual culture, but it may, perhaps, be claimed that scarcely any department of science affords discipline to so great a number of faculties, and that none presents so complete a gradation in the exercise of these faculties, from the first principles of the science to the farthest extent of its applications, as mathematics.