Commitment to the Space Shuttle program is the right step for America to take, in moving out from our present beach-head in the sky to achieve a real working presence in space—because the Space Shuttle will give us routine access to space by sharply reducing costs in dollars and preparation time.

For a successful technology, reality must take precedence over public relations, for nature cannot be fooled.

I have decided today that the United States should proceed at once with the development of an entirely new type of space transportation system designed to help transform the space frontier of the 1970s into familiar territory, easily accessible for human endeavor in the 1980s and ’90s. This system will center on a space vehicle that can shuttle repeatedly from Earth to orbit and back. It will revolutionize transportation into near space, by routinizing it. It will take the astronomical costs out of astronautics. In short, it will go a long way toward delivering the rich benefits of practical space utilization and the valuable spin-offs from space efforts into the daily lives of Americans and all people.

The Columbia is lost; there are no survivors. … In an age when space flight has come to seem almost routine, it is easy to overlook the dangers of travel by rocket, and the difficulties of navigating the fierce outer atmosphere of the Earth. These astronauts knew the dangers, and they faced them willingly, knowing they had a high and noble purpose in life. Because of their courage and daring idealism, we will miss them all the more. … The cause in which they died will continue. Mankind is led into the darkness beyond our world by the inspiration of discovery and the longing to understand. Our journey into space will go on.

The crew of the shuttle Columbia did not return safely to Earth; yet we can pray that all are safely home.

The follow-on space shuttle program has fallen far short of the Apollo program in its appeal to human aspirations. The launching of the Hubble Space Telescope and the subsequent repair and servicing missions by skilled crews are highlights of the shuttle’s service to science. … Otherwise, the shuttle’s contribution to science has been modest, and its contribution to utilitarian applications of space technology has been insignificant.

The game of status seeking, organized around committees, is played in roughly the same fashion in Africa and in America and in the Soviet Union. Perhaps the aptitude for this game is a part of our genetic inheritance, like the aptitude for speech and for music. The game has had profound consequences for science. In science, as in the quest for a village water supply, big projects bring enhanced status; small projects do not. In the competition for status, big projects usually win, whether or not they are scientifically justified. As the committees of academic professionals compete for power and influence, big science becomes more and more preponderant over small science. The large and fashionable squeezes out the small and unfashionable. The space shuttle squeezes out the modest and scientifically more useful expendable launcher. The Great Observatory squeezes out the Explorer. The centralized adduction system squeezes out the village well. Fortunately, the American academic system is pluralistic and chaotic enough that first-rate small science can still be done in spite of the committees. In odd corners, in out-of the-way universities, and in obscure industrial laboratories, our Fulanis are still at work.

The totality of life, known as the biosphere to scientists and creation to theologians, is a membrane of organisms wrapped around Earth so thin it cannot be seen edgewise from a space shuttle, yet so internally complex that most species composing it remain undiscovered. The membrane is seamless. From Everest's peak to the floor of the Mariana Trench, creatures of one kind or another inhabit virtually every square inch of the planetary surface.

There’s no question in my mind that the capability of [the space shuttle] to put 65,000 pounds in low earth orbit—to put payloads up there cheaper than we’ve been able to do it before, not having to throw away the booster—will absolutely revolutionize the way we do business here on earth in ways that we just can’t imagine. It will help develop science and technology. With the space shuttle—when we get it operational—we’ll be able to do in 5 or 10 years what it would take us 20 to 30 years to do otherwise in science and technology development.

This [disaster] is a day we have managed to avoid for a quarter of a century. We’ve talked about it before and speculated about it, and it finally has occurred. We hoped we could push this day back forever.

To use a Southern euphemism, our space program has been snake-bit.
Comment on the failed launch of an unmanned rocket, only a short time after the explosion of Space Shuttle Challenger.

You know something I could really do without? The Space Shuttle. … It’s irresponsible. The last thing we should be doing is sending our grotesquely distorted DNA out into space.