… (T)he same cause, such as electricity, can simultaneously affect all sensory organs, since they are all sensitive to it; and yet, every sensory nerve reacts to it differently; one nerve perceives it as light, another hears its sound, another one smells it; another tastes the electricity, and another one feels it as pain and shock. One nerve perceives a luminous picture through mechanical irritation, another one hears it as buzzing, another one senses it as pain… He who feels compelled to consider the consequences of these facts cannot but realize that the specific sensibility of nerves for certain impressions is not enough, since all nerves are sensitive to the same cause but react to the same cause in different ways… (S)ensation is not the conduction of a quality or state of external bodies to consciousness, but the conduction of a quality or state of our nerves to consciousness, excited by an external cause.
Law of Specific Nerve Energies.

...He cannot conclude however, without observing, that from the contemplation of so great a variety of extraneous fossils discovered in the cliffs which were evidently the produce of very different climates, he thinks himself rationally induced to believe that nothing short of an universal deluge could be a cause adequate to this effect.

...they have never affirm'd any thing, concerning the Cause, till the Trial was past: whereas, to do it before, is a most venomous thing in the making of Sciences; for whoever has fix'd on his Cause, before he experimented; can hardly avoid fitting his Experiment to his Observations, to his own Cause, which he had before imagin'd; rather than the Cause to the Truth of the Experiment itself.
Referring to experiments of the Aristotelian mode, whereby a preconceived truth would be illustrated merely to convince people of the validity of the original thought.

...those experiments be not only esteemed which have an immediate and present use, but those principally which are of most universal consequence for invention of other experiments, and those which give more light to the invention of causes; for the invention of the mariner's needle, which giveth the direction, is of no less benefit for navigation than the invention of the sails, which give the motion.

’Tis evident, that as common Air when reduc’d to half Its wonted extent, obtained near about twice as forcible a Spring as it had before; so this thus- comprest Air being further thrust into half this narrow room, obtained thereby a Spring about as strong again as that It last had, and consequently four times as strong as that of the common Air. And there is no cause to doubt, that If we had been here furnisht with a greater quantity of Quicksilver and a very long Tube, we might by a further compression of the included Air have made It counter-balance “the pressure” of a far taller and heavier Cylinder of Mercury. For no man perhaps yet knows how near to an infinite compression the Air may be capable of, If the compressing force be competently increast.

“Time’s noblest offspring is the last.” This line of Bishop Berkeley’s expresses the real cause of the belief in progress in the animal creation.

[A certain class of explanations in science are] analgesics that dull the ache of incomprehension without removing the cause.

[An engineer's] invention causes things to come into existence from ideas, makes world conform to thought; whereas science, by deriving ideas from observation, makes thought conform to existence.

[Bobby Clark:] What causes the water in a watermelon?
[Paul McCullough:] They plant the seeds in the spring.

[Having already asserted his opposition to communism in every respect by signing the regents' oath, his answer to a question why a non-Communist professor should refuse to take a non-Communist oath as a condition of University employment was that to do so would imply it was] up to an accused person to clear himself. ... That sort of thing is going on in Washington today and is a cause of alarm to thoughtful citizens. It is the method used in totalitarian countries. It sounds un-American to people who don’t like to be pushed around. If someone says I ought to do a certain thing the burden should be on him to show I why I should, not on me to show why I should not.

[It] is the little causes, long continued, which are considered as bringing about the greatest changes of the earth.

[My Book] will endeavour to establish the principle[s] of reasoning in ... [geology]; and all my geology will come in as illustration of my views of those principles, and as evidence strengthening the system necessarily arising out of the admission of such principles, which... are neither more nor less than that no causes whatever have from the earliest time to which we can look back, to the present, ever acted, but those now acting; and that they never acted with different degrees of energy from that which they now exert.

[Someone] remarked to me once: Physicians should not say, I have cured this man, but, This man didn’t die in my care. In physics too one might say, For such and such a phenomenon I have determined causes whose absurdity cannot finally be proved, instead of saying, I have explained it.

[The Book of Genesis is] [p]rofoundly interesting and indeed pathetic to me are those attempts of the opening mind of man to appease its hunger for a Cause. But the Book of Genesis has no voice in scientific questions. It is a poem, not a scientific treatise. In the former aspect it is for ever beautiful; in the latter it has been, and it will continue to be, purely obstructive and hurtful.'

[The parasite that causes malaria] edges through the cells of the stomach wall of the mosquito and forms a cyst which grows and eventually bursts to release hundreds of “sporozoites” into the body cavity of the mosquito … As far as we can tell, the parasite does not harm the mosquito … It has always seemed to me, though, that these growing cysts … must at least give the mosquito something corresponding to a stomach-ache.

[The principle, in building a sewer system, was] ...of diverting the cause of the mischief to a locality where it can do no mischief.

[We need not think] that there is any Contradiction, when Philosophy teaches that to be done by Nature; which Religion, and the Sacred Scriptures, teach us to be done by God: no more, than to say, That the balance of a Watch is moved by the next Wheel, is to deny that Wheel, and the rest, to be moved by the Spring; and that both the Spring, and all the other Parts, are caused to move together by the Maker of them. So God may be truly the Cause of This Effect, although a Thousand other Causes should be supposed to intervene: For all Nature is as one Great Engine, made by, and held in His Hand.

The Mighty Task is Done

At last the mighty task is done;
Resplendent in the western sun
The Bridge looms mountain high;
Its titan piers grip ocean floor,
Its great steel arms link shore with shore,
Its towers pierce the sky.

On its broad decks in rightful pride,
The world in swift parade shall ride,
Throughout all time to be;
Beneath, fleet ships from every port,
Vast landlocked bay, historic fort,
And dwarfing all the sea.

To north, the Redwood Empires gates;
To south, a happy playground waits,
In Rapturous appeal;
Here nature, free since time began,
Yields to the restless moods of man,
Accepts his bonds of steel.

Launched midst a thousand hopes and fears,
Damned by a thousand hostile sneers,
Yet Neer its course was stayed,
But ask of those who met the foe
Who stood alone when faith was low,
Ask them the price they paid.

Ask of the steel, each strut and wire,
Ask of the searching, purging fire,
That marked their natal hour;
Ask of the mind, the hand, the heart,
Ask of each single, stalwart part,
What gave it force and power.

An Honored cause and nobly fought
And that which they so bravely wrought,
Now glorifies their deed,
No selfish urge shall stain its life,
Nor envy, greed, intrigue, nor strife,
Nor false, ignoble creed.

High overhead its lights shall gleam,
Far, far below lifes restless stream,
Unceasingly shall flow;
For this was spun its lithe fine form,
To fear not war, nor time, nor storm,
For Fate had meant it so.

Die Phylogenese ist die mechanische Ursache cler Ontogenese.
Phylogenesis is the mechanical cause of ontogenesis.

Dieu, c'est le voile mystérieux sous lequel nous cachons notre ignorance de la cause première.
God is the mysterious veil under which we hide our ignorance of the cause.

Dilbert: Evolution must be true because it is a logical conclusion of the scientific method.
Dogbert: But science is based on the irrational belief that because we cannot perceive reality all at once, things called “time” and “cause and effect” exist.
Dilbert: That’s what I was taught and that’s what I believe.
Dogbert: Sounds cultish.

Enlightenment is man’s emergence from his self-incurred immaturity. Immaturity is the inability to use one's own understanding without the guidance of another. This immaturity is self-incurred if its cause is not lack of understanding, but lack of resolution and courage to use it without the guidance of another. The motto of enlightenment is therefore: Sapere aude! Have courage to use your own understanding!

Error of confounding cause and effect.—There is no more dangerous error than confounding consequence with cause: I call it the intrinsic depravity of reason. … I take an example: everybody knows the book of the celebrated Comaro, in which he recommends his spare diet as a recipe for a long and happy life,—for a virtuous life also. Few books have been read so much… I believe hardly any book … has caused so much harm, has shortened so many lives, as this well-meant curiosity. The source of this mischief is in confounding consequence with cause. The candid Italian saw in his diet the cause of his long life, while the prerequisite to long life, the extraordinary slowness of the metabolic process, small consumption, was the cause of his spare diet. He was not at liberty to eat little or much; his frugality—was not of “free will;” he became sick when he ate more.

Felix, qui potuit rerum cognoscere causas.
Blessed is he who has been able to win knowledge of the causes of things.

He who doth with the greatest exactness imaginable, weigh every individual thing that shall or hath hapned to his Patient, and may be known from the Observations of his own, or of others, and who afterwards compareth all these with one another, and puts them in an opposite view to such Things as happen in a healthy State; and lastly, from all this with the nicest and severest bridle upon his reasoning faculty riseth to the knowledge of the very first Cause of the Disease, and of the Remedies fit to remove them; He, and only He deserveth the Name of a true Physician.

I believe in logic, the sequence of cause and effect, and in science its only begotten son our law, which was conceived by the ancient Greeks, thrived under Isaac Newton, suffered under Albert Einstein…
That fragment of a 'creed for materialism' which a friend in college had once shown him rose through Donald's confused mind.

L’analyse mathématique … dans l’étude de tous les phénomènes; elle les interprète par le même langage, comme pour attester l’unité et la simplicité du plan de l’univers, et rendre encore plus manifeste cet ordre immuable qui préside à toutes les causes naturelles.
Mathematical analysis … in the study of all phenomena, interprets them by the same language, as if to attest the unity and simplicity of the plan of the universe, and to make still more evident that unchangeable order which presides over all natural causes.

Lehre von den Ursachen der organischen Gestaltungen.
Developmental mechanics... is the doctrine of the causes of organic forms.

Les causes primordiales ne nous sont point connues; mais elles sont assujetties à des lois simples et constantes, que l’on peut découvrir par l’observation, et dont l’étude est l’objet de la philosophie naturelle.
Primary causes are unknown to us; but are subject to simple and constant laws, which may be discovered by observation, the study of them being the object of natural philosophy.

Nunc naturalem causam quaerimus et assiduam, non raram fortuitam.
Now we are looking for a natural and constant cause, not a rare and accidental one.

Ratbert (as lab rat, to scientist): Doc, we have to talk. Every day you feed me over a hundred pounds of macaroni and cheese. At first I thought you were just being a good host. But lately I’ve been thinking it could be something far more sinister.
Scientist (thinking): Macaroni and cheese causes paranoia.

The Word Reason in the English Language has different Significances: sometimes it is taken for true, and clear Principles: Sometimes for clear, and fair deductions from those Principles: and sometimes for Cause, and particularly the final Cause: but the Consideration I shall have of it here, is in a Signification different from all these; and that is, as it stands for a Faculty of Man, That Faculty, whereby Man is supposed to be distinguished from Beasts; and wherein it is evident he much surpasses them.

1. Universal CHEMISTRY is the Art of resolving mixt, compound, or aggregate Bodies into their Principles; and of composing such Bodies from those Principles. 2. It has for its Subject all the mix’d, compound, and aggregate Bodies that are and resolvable and combinable and Resolution and Combination, or Destruction and Generation, for its Object. 3. Its Means in general, are either remote or immediate; that is, either Instruments or the Operations themselves. 4. Its End is either philosophical and theoretical; or medicinal, mechanical, œconomical, and practical. 5. Its efficient Cause is the Chemist.

A celebrated author and divine has written to me that “he has gradually learnt to see that it is just as noble a conception of the Deity to believe that He created a few original forms capable of self-development into other and needful forms, as to believe that He required a fresh act of creation to supply the voids caused by the action of His laws.”

A creative force that either creates itself or arises from nothing, and which is a causa sui (its own cause), exactly resembles Baron Munchhausen, who drew himself out of the bog by taking hold of his own hair.

A drop from the nose of Fleming, who had a cold, fell onto an agar plate where large yellow colonies of a contaminant had grown, and lysosyme was discovered. He made this important discovery because when he saw that the colonies of the contaminant were fading, his mind went straight to the right cause of the phenomenon he was observing—that the drop from his nose contained a lytic substance. And also immediately, he thought that this substance might be present in many secretions and tissues of the body. And he found this was so—the substance was in tears, saliva, leucocytes, skin, fingernails, mother's milk—thus very widely distributed in amounts and also in plants.

A fact is like a sack which won’t stand up if it’s empty. In order that it may stand up, one has to put into it the reason and sentiment which caused it to exist.

A Frenchman who arrives in London, will find Philosophy, like every Thing else, very much chang’d there. He had left the World a plenum, and he now finds it a vacuum. At Paris the Universe is seen, compos’d of Vortices of subtile Matter; but nothing like it is seen in London. In France, ‘tis the Pressure of the Moon that causes the Tides; but in England ‘tis the Sea that gravitates towards the Moon; so what when you think that the Moon should make it flood with us, those Gentlemen fancy it should be Ebb, which, very unluckily, cannot be prov’d. For to be able to do this, ‘tis necessary the Moon and the Tides should have been enquir’d into, at the very instant of the Creation.

A great surgeon performs operations for stone by a single method; later he makes a statistical summary of deaths and recoveries, and he concludes from these statistics that the mortality law for this operation is two out of five. Well, I say that this ratio means literally nothing scientifically and gives us no certainty in performing the next operation; for we do not know whether the next case will be among the recoveries or the deaths. What really should be done, instead of gathering facts empirically, is to study them more accurately, each in its special determinism. We must study cases of death with great care and try to discover in them the cause of mortal accidents so as to master the cause and avoid the accidents.

A mind exclusively bent upon the idea of utility necessarily narrows the range of the imagination. For it is the imagination which pictures to the inner eye of the investigator the indefinitely extending sphere of the possible,—that region of hypothesis and explanation, of underlying cause and controlling law. The area of suggestion and experiment is thus pushed beyond the actual field of vision.

A mind which has once imbibed a taste for scientific enquiry, and has learnt the habit of applying its principles readily to the cases which occur, has within itself an inexhaustable source of pure and exciting contemplations:— One would think that Shakespeare had such a mind in view when he describes a contemplative man as finding
    “Tongues in trees—books in running brooks—
    Sermons in stones—and good in everything.”
Accustomed to trace the operations of general causes and the exemplification of general laws, in circumstances where the uninformed and uninquiring eye, perceives neither novelty nor beauty, he walks in the midst of wonders; every object which falls in his way elucidates some principle, affords some instruction and impresses him with a sense of harmony and order. Nor is it a mere passive pleasure which is thus communicated. A thousand questions are continually arising in his mind, a thousand objects of enquiry presenting themselves, which keep his faculties in constant exercise, and his thoughts perpetually on the wing, so that lassitude is excluded from his life, and that craving after artificial excitement and dissipation of the mind, which leads so many into frivolous, unworthy, and destructive pursuits, is altogether eradicated from his bosom.

A science cannot be played with. If an hypothesis is advanced that obviously brings into direct sequence of cause and effect all the phenomena of human history, we must accept it, and if we accept it, we must teach it.

A science cannot be played with. If an hypothesis is advanced that obviously brings into direct sequence of cause and effect all the phenomena of human history, we must accept it, and if we accept it, we must teach it.

A single and distinct luminous body causes stronger relief in the objects than a diffused light; as may be seen by comparing one side of a landscape illuminated by the sun, and one overshadowed by clouds, and illuminated only by the diffused light of the atmosphere.

A thorough advocate in a just cause, a penetrating mathematician facing the starry heavens, both alike bear the semblance of divinity

A very small cause which escapes our notice determines a considerable effect that we cannot fail to see, and then we say that the effect is due to chance. If we knew exactly the laws of nature and the situation of the universe at the initial moment, we could predict exactly the situation of that same universe at a succeeding moment.

About eight days ago I discovered that sulfur in burning, far from losing weight, on the contrary, gains it; it is the same with phosphorus; this increase of weight arises from a prodigious quantity of air that is fixed during combustion and combines with the vapors. This discovery, which I have established by experiments, that I regard as decisive, has led me to think that what is observed in the combustion of sulfur and phosphorus may well take place in the case of all substances that gain in weight by combustion and calcination; and I am persuaded that the increase in weight of metallic calxes is due to the same cause... This discovery seems to me one of the most interesting that has been made since Stahl and since it is difficult not to disclose something inadvertently in conversation with friends that could lead to the truth I have thought it necessary to make the present deposit to the Secretary of the Academy to await the time I make my experiments public.

Adrenalin does not excite sympathetic ganglia when applied to them directly, as does nicotine. Its effective action is localised at the periphery. The existence upon plain muscle of a peripheral nervous network, that degenerates only after section of both the constrictor and inhibitory nerves entering it, and not after section of either alone, has been described. I find that even after such complete denervation, whether of three days' or ten months' duration, the plain muscle of the dilatator pupillae will respond to adrenalin, and that with greater rapidity and longer persistence than does the iris whose nervous relations are uninjured. Therefore it cannot be that adrenalin excites any structure derived from, and dependent for its persistence on, the peripheral neurone. But since adrenalin does not evoke any reaction from muscle that has at no time of its life been innervated by the sympathetic, the point at which the stimulus of the chemical excitant is received, and transformed into what may cause the change of tension of the muscle fibre, is perhaps a mechanism developed out of the muscle cell in response to its union with the synapsing sympathetic fibre, the function of which is to receive and transform the nervous impulse. Adrenalin might then be the chemical stimulant liberated on each occasion when the impulse arrives at the periphery.

After what has been premised, I think we may lay down the following Conclusions. First, It is plain Philosophers amuse themselves in vain, when they inquire for any natural efficient Cause, distinct from a Mind or Spirit. Secondly, Considering the whole Creation is the Workmanship of a wise and good Agent, it should seem to become Philosophers, to employ their Thoughts (contrary to what some hold) about the final Causes of Things: And I must confess, I see no reason, why pointing out the various Ends, to which natural Things are adapted and for which they were originally with unspeakable Wisdom contrived, should not be thought one good way of accounting for them, and altogether worthy a Philosopher.

Again there is another great and powerful cause why the sciences have made but little progress; which is this. It is not possible to run a course aright when the goal itself has not been rightly placed.

Agreeing that plants and animals were produced by Omnipotent fiat does not exclude the idea of natural order and what we call secondary causes. The record of the fiat—“Let the earth bring forth grass, the herb yielding seed,” etc., “and it was so;” “let the earth bring forth the living creature after his kind” — seems even to imply them.

Alcmaeon maintains that the bond of health is the 'equal balance' of the powers, moist and dry, cold and hot, bitter and sweet, and the rest, while the 'supremacy' of one of them is the cause of disease; for the supremacy of either is destructive. Illness comes aboutdirectly through excess of heat or cold, indirectly through surfeit or deficiency of nourishment; and its centre is either the blood or the marrow or the brain. It sometimes arises in these centres from external causes, moisture of some sort or environment or exhaustion or hardship or similar causes. Health on the other hand is the proportionate admixture of the qualities.

All science is concerned with the relationship of cause and effect. Each scientific discovery increases man’s ability to predict the consequences of his actions and thus his ability to control future events.

All successful men have agreed to one thing,—they were causationists. They believed that things went not by luck, but by law; that there was not a weak or a cracked link in the chain that joins the first and last of things.

All the experiments which have been hitherto carried out, and those that are still being daily performed, concur in proving that between different bodies, whether principles or compounds, there is an agreement, relation, affinity or attraction (if you will have it so), which disposes certain bodies to unite with one another, while with others they are unable to contract any union: it is this effect, whatever be its cause, which will help us to give a reason for all the phenomena furnished by chemistry, and to tie them together.

All the unhappiness of men arises from one single fact, that they cannot stay quietly in their own chamber.

All things appear and disappear because of the concurrence of causes and conditions. Nothing ever exists entirely alone; everything is in relationship to everything else.

All things are hidden, obscure and debatable if the cause of the phenomena is unknown, but everything is clear if its cause be known.

Although to penetrate into the intimate mysteries of nature and thence to learn the true causes of phenomena is not allowed to us, nevertheless it can happen that a certain fictive hypothesis may suffice for explaining many phenomena.

An infinity of these tiny animals defoliate our plants, our trees, our fruits... they attack our houses, our fabrics, our furniture, our clothing, our furs ... He who in studying all the different species of insects that are injurious to us, would seek means of preventing them from harming us, would seek to cause them to perish, proposes for his goal important tasks indeed.

And for rejecting such a Medium, we have the Authority of those the oldest and most celebrated Philosophers of Greece and Phoenicia, who made a Vacuum, and Atoms, and the Gravity of Atoms, the first Principles of their Philosophy; tacitly attributing Gravity to some other Cause than dense Matter. Later Philosophers banish the Consideration of such a Cause out of natural Philosophy, feigning Hypotheses for explaining all things mechanically, and referring other Causes to Metaphysicks: Whereas the main Business of natural Philosophy is to argue from Phaenomena without feigning Hypotheses, and to deduce Causes from Effects, till we come to the very first Cause, which certainly is not mechanical; and not only to unfold the Mechanism of the World, but chiefly to resolve these and such like Questions. What is there in places almost empty of Matter, and whence is it that the Sun and Planets gravitate towards one another, without dense Matter between them? Whence is it that Nature doth nothing in vain; and whence arises all that Order and Beauty which we see in the World? ... does it not appear from phaenomena that there is a Being incorporeal, living, intelligent, omnipresent, who in infinite space, as it were in his Sensory, sees the things themselves intimately, and thoroughly perceives them, and comprehends them wholly by their immediate presence to himself.

And it shall come to pass in that day, saith the Lord God, that I will cause the sun to go down at noon, and I will darken the earth in the clear day.

And so I conclude that blood lives and is nourished of itself and in no way depends on any other part of the body as being prior to it or more excellent... So that from this we may perceive the causes not only of life in general... but also of longer or shorter life, of sleeping and waking, of skill, of strength and so forth.

And there are absolutely no judgments (or rules) in Mechanics which do not also pertain to Physics, of which Mechanics is a part or type: and it is as natural for a clock, composed of wheels of a certain kind, to indicate the hours, as for a tree, grown from a certain kind of seed, to produce the corresponding fruit. Accordingly, just as when those who are accustomed to considering automata know the use of some machine and see some of its parts, they easily conjecture from this how the other parts which they do not see are made: so, from the perceptible effects and parts of natural bodies, I have attempted to investigate the nature of their causes and of their imperceptible parts.

Anton Chekhov wrote that ‘one must not put a loaded rifle on stage if no one is thinking of firing it.’ Good drama requires spare and purposive action, sensible linking of potential causes with realized effects. Life is much messier; nothing happens most of the time. Millions of Americans (many hotheaded) own rifles (many loaded), but the great majority, thank God, do not go off most of the time. We spend most of real life waiting for Godot, not charging once more unto the breach.

As a physicist who devoted his entire life to sober science, to the study of matter, I am sure that I am free from the suspicion of being considered a zealot. And so, according to my research of the atom, I say this: There is no matter in itself. All matter arises and exists only through a force that vibrates the atomic particles and holds them together to form the tiniest solar system of the universe. However, since there is no intelligent force or eternal power in the entire universe—mankind has not been able to invent the much-anticipated perpetuum mobile—we must accept a conscious intelligent mind behind this force. This spirit is the cause of all matter.

As for me ... I would much rather be a perfected ape than a degraded Adam. Yes, if it is shown to me that my humble ancestors were quadrupedal animals, arboreal herbivores, brothers or cousins of those who were also the ancestors of monkeys and apes, far from blushing in shame for my species because of its genealogy and parentage, I will be proud of all that evolution has accomplished, of the continuous improvement which takes us up to the highest order, of the successive triumphs that have made us superior to all of the other species ... the splendid work of progress.
I will conclude in saying: the fixity of species is almost impossible, it contradicts the mode of succession and of the distribution of species in the sequence of extant and extinct creatures. It is therefore extremely likely that species are variable and are subject to evolution. But the causes, the mechanisms of this evolution are still unknown.

As for the causes of magnetic movements, referred to in the schools of philosophers to the four elements and to prime qualities, these we leave for roaches and moths to prey upon.

As I stood behind the coffin of my little son the other day, with my mind bent on anything but disputation, the officiating minister read, as part of his duty, the words, 'If the dead rise not again, let us eat and drink, for to-morrow we die.' I cannot tell you how inexpressibly they shocked me. Paul had neither wife nor child, or he must have known that his alternative involved a blasphemy against all that well best and noblest in human nature. I could have laughed with scorn. What! Because I am face to face with irreparable loss, because I have given back to the source from whence it came, the cause of a great happiness, still retaining through all my life the blessings which have sprung and will spring from that cause, I am to renounce my manhood, and, howling, grovel in bestiality? Why, the very apes know better, and if you shoot their young, the poor brutes grieve their grief out and do not immediately seek distraction in a gorge.

As soon as the circumstances of an experiment are well known, we stop gathering statistics. … The effect will occur always without exception, because the cause of the phenomena is accurately defined. Only when a phenomenon includes conditions as yet undefined,Only when a phenomenon includes conditions as yet undefined, can we compile statistics. … we must learn therefore that we compile statistics only when we cannot possibly help it; for in my opinion, statistics can never yield scientific truth.

As the ostensible effect of the heat … consists not in warming the surrounding bodies but in rendering the ice fluid, so, in the case of boiling, the heat absorbed does not warm surrounding bodies but converts the water into vapor. In both cases, considered as the cause of warmth, we do not perceive its presence: it is concealed, or latent, and I gave it the name of “latent heat.”

Astronomy teaches the correct use of the sun and the planets. These may be put on a frame of little sticks and turned round. This causes the tides. Those at the ends of the sticks are enormously far away. From time to time a diligent searching of the sticks reveals new planets. The orbit of the planet is the distance the stick goes round in going round. Astronomy is intensely interesting; it should be done at night, in a high tower at Spitzbergen. This is to avoid the astronomy being interrupted. A really good astronomer can tell when a comet is coming too near him by the warning buzz of the revolving sticks.

Astronomy, as the science of cyclical motions, has nothing in common with Geology. But look at Astronomy where she has an analogy with Geology; consider our knowledge of the heavens as a palaetiological science;—as the study of a past condition, from which the present is derived by causes acting in time. Is there no evidence of a beginning, or of a progress?

At the end of the book [Zoonomia] he sums up his [Erasmus Darwin] views in the following sentences: “The world has been evolved, not created: it has arisen little by little from a small beginning, and has increased through the activity of the elemental forces embodied in itself, and so has rather grown than come into being at an almighty word.” “What a sublime idea of the infinite might of the great Architect, the Cause of all causes, the Father of all fathers, the Ens Entium! For if we would compare the Infinite, it would surely require a greater Infinite to cause the causes of effects than to produce the effects themselves.”
[This is a restatement, not a verbatim quote of the original words of Erasmus Darwin, who attributed the idea he summarized to David Hume.]

At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.

At the moment I am occupied by an investigation with Kirchoff which does not allow us to sleep. Kirchoff has made a totally unexpected discovery, inasmuch as he has found out the cause for the dark lines in the solar spectrum and can produce these lines artificially intensified both in the solar spectrum and in the continuous spectrum of a flame, their position being identical with that of Fraunhofer’s lines. Hence the path is opened for the determination of the chemical composition of the Sun and the fixed stars.

Ax: 100 Every thing doth naturally persevere in yt state in wch it is unlesse it bee interrupted by some externall cause, hence… [a] body once moved will always keepe ye same celerity, quantity & determination of its motion.

Biology can be divided into the study of proximate causes, the study of the physiological sciences (broadly conceived), and into the study of ultimate (evolutionary) causes, the subject of natural history.

Blood mixture and the result drop in the racial level is the sole cause of the dying out of old cultures; for men do not perish as a result of lost wars, but by the loss of that force of resistance which is continued only in pure blood. All who are not of good race in this world are chaff.

Büchsel in his reminiscences from the life of a country parson relates that he sought his recreation in Lacroix’s Differential Calculus and thus found intellectual refreshment for his calling. Instances like this make manifest the great advantage which occupation with mathematics affords to one who lives remote from the city and is compelled to forego the pleasures of art. The entrancing charm of mathematics, which captivates every one who devotes himself to it, and which is comparable to the fine frenzy under whose ban the poet completes his work, has ever been incomprehensible to the spectator and has often caused the enthusiastic mathematician to be held in derision. A classic illustration is the example of Archimedes….

But come, hear my words, for truly learning causes the mind to grow. For as I said before in declaring the ends of my words … at one time there grew to be the one alone out of many, and at another time it separated so that there were many out of the one; fire and water and earth and boundless height of air, and baneful Strife apart from these, balancing each of them, and Love among them, their equal in length and breadth.

But it is just this characteristic of simplicity in the laws of nature hitherto discovered which it would be fallacious to generalize, for it is obvious that simplicity has been a part cause of their discovery, and can, therefore, give no ground for the supposition that other undiscovered laws are equally simple.

But no other theory can explain so much. Continental drift is without a cause or a physical theory. It has never been applied to any but the last part of geological time.

But shall gravity be therefore called an occult cause, and thrown out of philosophy, because the cause of gravity is occult and not yet discovered? Those who affirm this, should be careful not to fall into an absurdity that may overturn the foundations of all philosophy. For causes usually proceed in a continued chain from those that are more compounded to those that are more simple; when we are arrived at the most simple cause we can go no farther ... These most simple causes will you then call occult and reject them? Then you must reject those that immediately depend on them.

But the World being once fram’d, and the course of Nature establish’d, the Naturalist, (except in some few cases, where God, or Incorporeal Agents interpose), has recourse to the first Cause but for its general and ordinary Support and Influence, whereby it preserves Matter and Motion from Annihilation or Desition; and in explicating particular phenomena, considers onely the Size, Shape, Motion, (or want of it) Texture, and the resulting Qualities and Attributes of the small particles of Matter.

But when science, passing beyond its own limits, assumes to take the place of theology, and sets up its own conception of the order of Nature as a sufficient account of its cause, it is invading a province of thought to which it has no claim, and not unreasonably provokes the hostility of its best friends.

By firm immutable immortal laws Impress’d on Nature by the GREAT FIRST CAUSE,
Say, MUSE! how rose from elemental strife
Organic forms, and kindled into life;
How Love and Sympathy with potent charm
Warm the cold heart, the lifted hand disarm;
Allure with pleasures, and alarm with pains,
And bind Society in golden chains.

Can quantum mechanics represent the fact that an electron finds itself approximately in a given place and that it moves approximately with a given velocity, and can we make these approximations so close that they do not cause experimental difficulties?

Can the cause be reached from knowledge of the effect with the same certainty as the effect can be shown to follow from its cause? Is it possible for one effect to have many causes? If one determinate cause cannot be reached from the effect, since there is no effect which has not some cause, it follows that an effect, when it has one cause, may have another, and so that there may be several causes of it.

Cleveland, even now I can remember
Cause the Cuyahoga River
Goes smokin’ through my dreams
Burn on, big river, burn on
Burn on, big river, burn on
Now the Lord can make you tumble
And the Lord can make you turn
And the Lord can make you overflow
But the Lord can’t make you burn.

Common sense needs to be renamed
Cause nowadays it’s rare.

Conscientious and careful physicians allocate causes of disease to natural laws, while the ablest scientists go back to medicine for their first principles.

Considering it as thus established, that heat is not a substance, but a dynamical form of mechanical effect, we perceive that there must be an equivalence between mechanical work and heat, as between cause and effect.

Copernicus, the most learned man whom we are able to name other than Atlas and Ptolemy, even though he taught in a most learned manner the demonstrations and causes of motion based on observation, nevertheless fled from the job of constructing tables, so that if anyone computes from his tables, the computation is not even in agreement with his observations on which the foundation of the work rests. Therefore first I have compared the observations of Copernicus with those of Ptolemy and others as to which are the most accurate, but besides the bare observations, I have taken from Copernicus nothing other than traces of demonstrations. As for the tables of mean motion, and of prosthaphaereses and all the rest, I have constructed these anew, following absolutely no other reasoning than that which I have judged to be of maximum harmony.

Development of Western science is based on two great achievements: the invention of the formal logical system (in Euclidean geometry) by the Greek philosophers, and the discovery of the possibility to find out causal relationships by systematic experiment (during the Renaissance). In my opinion, one has not to be astonished that the Chinese sages have not made these steps. The astonishing thing is that these discoveries were made at all.

Discoveries are always accidental; and the great use of science is by investigating the nature of the effects produced by any process or contrivance, and of the causes by which they are brought about, to explain the operation and determine the precise value of every new invention. This fixes as it were the latitude and longitude of each discovery, and enables us to place it in that part of the map of human knowledge which it ought to occupy. It likewise enables us to use it in taking bearings and distances, and in shaping our course when we go in search of new discoveries.

Disease is largely a removable evil. It continues to afflict humanity, not only because of incomplete knowledge of its causes and lack of individual and public hygiene, but also because it is extensively fostered by harsh economic and industrial conditions and by wretched housing in congested communities. ... The reduction of the death rate is the principal statistical expression and index of human social progress. It means the saving and lengthening of lives of thousands of citizens, the extension of the vigorous working period well into old age, and the prevention of inefficiency, misery, and suffering. These advances can be made by organized social effort. Public health is purchasable. (1911)

Dissections daily convince us of our ignorance of disease, and cause us to blush at our prescriptions. What mischief have we done under the belief of false facts and false theories! We have assisted in multiplying diseases; we have done more; we have increased their mortality. ... I am pursuing Truth, and am indifferent whither I am led, if she is my only leader.

Doctor Thomas …
Said, “Cancer’s a funny thing.
Nobody knows what the cause is,
Though some pretend they do;
It’s like some hidden assassin
Waiting to strike at you.
Childless women get it.
And men when they retire;
It’s as if there had to be some outlet
For their foiled creative fire.”

Earthquakes may be brought about because wind is caught up in the earth, so the earth is dislocated in small masses and is continually shaken, and that causes it to sway.

Education has, thus, become the chief problem of the world, its one holy cause. The nations that see this will survive, and those that fail to do so will slowly perish. There must be re-education of the will and of the heart as well as of the intellect, and the ideals of service must supplant those of selfishness and greed. ... Never so much as now is education the one and chief hope of the world.

EFFECT, n. The second of two phenomena which always occur together in the same order. The first, called a Cause, is said to generate the other—which is no more sensible than it would be for one who has never seen a dog except in pursuit of a rabbit to declare the rabbit the cause of the dog.

ELECTRICITY, n. The power that causes all natural phenomena not known to be caused by something else. It is the same thing as lightning, and its famous attempt to strike Dr. Franklin is one of the most picturesque incidents in that great and good man's career. The memory of Dr. Franklin is justly held in great reverence, particularly in France, where a waxen effigy of him was recently on exhibition, bearing the following touching account of his life and services to science:
Monsieur Franqulin, inventor of electricity. This illustrious savant, after having made several voyages around the world, died on the Sandwich Islands and was devoured by savages, of whom not a single fragment was ever recovered.
Electricity seems destined to play a most important part in the arts and industries. The question of its economical application to some purposes is still unsettled, but experiment has already proved that it will propel a street car better than a gas jet and give more light than a horse.

Emission of lava … during geological time … would produce more contraction than any reasonable amount of cooling of the Earth. It has been shown that contraction could lead to fracturing of a kind which might show many of the principal features observed in existing and past mountains. A vast amount remains to be done, but no other theory can explain so much. Continental drift is without a cause or a physical theory. It has never been applied to any but the last part of geological time.

Eratosthenes declares that it is no longer necessary to inquire as to the cause of the overflow of the Nile, since we know definitely that men have come to the sources of the Nile and have observed the rains there.

Even environmentalists seem more concerned about the loss of a year or so of life expectation through cancer than they are about the degradation of the natural world by deforestation or greenhouse gases—something that could cause the death of our grandchildren.

Even more difficult to explain, than the breaking-up of a single mass into fragments, and the drifting apart of these blocks to form the foundations of the present-day continents, is the explanation of the original production of the single mass, or PANGAEA, by the concentration of the former holosphere of granitic sial into a hemisphere of compressed and crushed gneisses and schists. Creep and the effects of compression, due to shrinking or other causes, have been appealed to but this is hardly a satisfactory explanation. The earth could no more shrug itself out of its outer rock-shell unaided, than an animal could shrug itself out of its hide, or a man wriggle out of his skin, or even out of his closely buttoned coat, without assistance either of his own hands or those of others.

Every chemical substance, every plant, every animal in its growth, teaches the unity of the cause, the variety of appearance.

Every complete set of chromosomes contains the full code; so there are, as a rule, two copies of the latter in the fertilized egg cell, which forms the earliest stage of the future individual. In calling the structure of the chromosome fibres a code-script we mean that the all-penetrating mind, once conceived by Laplace, to which every causal connection lay immediately open, could tell from their structure whether the egg would develop, under suitable conditions, into a black cock or into a speckled hen, into a fly or a maize plant, a rhododendron, a beetle, a mouse or a woman. To which we may add, that the appearances of the egg cells are very often remarkably similar; and even when they are not, as in the case of the comparatively gigantic eggs of birds and reptiles, the difference is not so much in the relevant structures as in the nutritive material which in these cases is added for obvious reasons.
But the term code-script is, of course, too narrow. The chromosome structures are at the same time instrumental in bringing about the development they foreshadow. They are law-code and executive power?or, to use another simile, they are architect's plan and builder’s craft-in one.

Every form of life can be produced by physical forces in one of two ways: either by coming into being out of formless matter, or by the modification of an already existing form by a continued process of shaping. In the latter case the cause of this modification may lie either in the influence of a dissimilar male generative matter upon the female germ, or in the influence of other powers which operate only after procreation.

Every occurrence in Nature is preceded by other occurrences which are its causes, and succeeded by others which are its effects. The human mind is not satisfied with observing and studying any natural occurrence alone, but takes pleasure in connecting every natural fact with what has gone before it, and with what is to come after it.

Every phenomenon, however trifling it be, has a cause, and a mind infinitely powerful, and infinitely well-informed concerning the laws of nature could have foreseen it from the beginning of the ages. If a being with such a mind existed, we could play no game of chance with him; we should always lose.

Every rule has its limits, and every concept its ambiguities. Most of all is this true in the science of life, where nothing quite corresponds to our ideas; similar ends are reached by varied means, and no causes are simple.

Everyone admits that the male is the primary efficient cause in generation, as being that in whom the species or form resides, and they further assert that his genitures emitted in coitus causes the egg both to exist and to be fertile. But how the semen of the cock produces the chick from the egg, neither the philosophers nor the physicians of yesterday or today have satisfactorily explained, or solved the problem formulated by Aristotle.

Everything around us is filled with mystery and magic. I find this no cause for despair, no reason to turn for solace to esoteric formulae or chariots of gods. On the contrary, our inability to find easy answers fills me with a fierce pride in our ambivalent biology … with a constant sense of wonder and delight that we should be part of anything so profound.

Exper. I. I made a small hole in a window-shutter, and covered it with a piece of thick paper, which I perforated with a fine needle. For greater convenience of observation I placed a small looking-glass without the window-shutter, in such a position as to reflect the sun's light, in a direction nearly horizontal, upon the opposite wall, and to cause the cone of diverging light to pass over a table on which were several little screens of card-paper. I brought into the sunbeam a slip of card, about one-thirtieth of an inch in breadth, and observed its shadow, either on the wall or on other cards held at different distances. Besides the fringes of colour on each side of the shadow, the shadow itself was divided by similar parallel fringes, of smaller dimensions, differing in number, according to the distance at which the shadow was observed, but leaving the middle of the shadow always white. Now these fringes were the joint effects of the portions of light passing on each side of the slip of card and inflected, or rather diffracted, into the shadow. For, a little screen being placed a few inches from the card, so as to receive either edge of the shadow on its margin, all the fringes which had before been observed in the shadow on the wall, immediately disappeared, although the light inflected on the other side was allowed to retain its course, and although this light must have undergone any modification that the proximity of the other edge of the slip of card might have been capable of occasioning... Nor was it for want of a sufficient intensity of light that one of the two portions was incapable of producing the fringes alone; for when they were both uninterrupted, the lines appeared, even if the intensity was reduced to one-tenth or one-twentieth.

Extremely hazardous is the desire to explain everything, and to supply whatever appears a gap in history—for in this propensity lies the first cause and germ of all those violent and arbitrary hypotheses which perplex and pervert the science of history far more than the open avowal of our ignorance, or the uncertainty of our knowledge: hypotheses which give an oblique direction, or an exaggerated and false extension, to a view of the subject originally not incorrect.

Far from becoming discouraged, the philosopher should applaud nature, even when she appears miserly of herself or overly mysterious, and should feel pleased that as he lifts one part of her veil, she allows him to glimpse an immense number of other objects, all worthy of investigation. For what we already know should allow us to judge of what we will be able to know; the human mind has no frontiers, it extends proportionately as the universe displays itself; man, then, can and must attempt all, and he needs only time in order to know all. By multiplying his observations, he could even see and foresee all phenomena, all of nature's occurrences, with as much truth and certainty as if he were deducing them directly from causes. And what more excusable or even more noble enthusiasm could there be than that of believing man capable of recognizing all the powers, and discovering through his investigations all the secrets, of nature!

First causes are outside the realm of science.

First, by what means it is that a Plant, or any Part of it, comes to Grow, a Seed to put forth a Root and Trunk... How the Aliment by which a Plant is fed, is duly prepared in its several Parts ... How not only their Sizes, but also their Shapes are so exceedingly various ... Then to inquire, What should be the reason of their various Motions; that the Root should descend; that its descent should sometimes be perpendicular, sometimes more level: That the Trunk doth ascend, and that the ascent thereof, as to the space of Time wherein it is made, is of different measures... Further, what may be the Causes as of the Seasons of their Growth; so of the Periods of their Lives; some being Annual, others Biennial, others Perennial ... what manner the Seed is prepared, formed and fitted for Propagation.

For it is the duty of an astronomer to compose the history of the celestial motions or hypotheses about them. Since he cannot in any certain way attain to the true causes, he will adopt whatever suppositions enable the motions to be computed correctly from the principles of geometry for the future as well as for the past.

For man being the minister and interpreter of nature, acts and understands so far as he has observed of the order, the works and mind of nature, and can proceed no further; for no power is able to loose or break the chain of causes, nor is nature to be conquered but by submission: whence those twin intentions, human knowledge and human power, are really coincident; and the greatest hindrance to works is the ignorance of causes.

For nature by the same cause, provided it remain in the same condition, always produces the same effect, so that either coming-to-be or passing-away will always result.

For want of a nail the shoe was lost; for want of a shoe the horse was lost; and for want of a horse, the rider was lost, being overtaken and slain by the enemy; all for the want of a horse-shoe nail.

From the physician, as emphatically the student of Nature, is expected not only an inquiry into cause, but an investigation of the whole empire of Nature and a determination of the applicability of every species of knowledge to the improvement of his art.

From thus meditating on the great similarity of the structure of the warm-blooded animals, and at the same time of the great changes they undergo both before and after their nativity; and by considering in how minute a portion of time many of the changes of animals above described have been produced; would it be too bold to imagine that, in the great length of time since the earth began to exist, perhaps millions of ages before the commencement of the history of mankind would it be too bold to imagine that all warm-blooded animals have arisen from one living filament, which THE GREAT FIRST CAUSE endued with animality, with the power of acquiring new parts, attended with new propensities, directed by irritations, sensations, volitions and associations, and thus possessing the faculty of continuing to improve by its own inherent activity, and of delivering down these improvements by generation to its posterity, world without end!

Geology is the science which investigates the successive changes that have taken place in the organic and inorganic kingdoms of nature; it enquires into the causes of these changes, and the influence which they have exerted in modifying the surface and external structure of our planet.

George Stephenson, with a sagacity of mind in advance of the science of his day, answered, when asked what was the ultimate cause of motion of his locomotive engine, ‘that it went by the bottled-up rays of the sun.’

Giordano Bruno was the martyr; though the cause for which he suffered was not that of science, but that of free imaginative speculation. His death in the year 1600 ushered in the first century of modern science in the strict sense of the term.

Happy is he who has been able to learn the causes of things.

He who wishes to explain Generation must take for his theme the organic body and its constituent parts, and philosophize about them; he must show how these parts originated, and how they came to be in that relation in which they stand to each other. But he who learns to know a thing not only from its phenomena, but also its reasons and causes; and who, therefore, not by the phenomena merely, but by these also, is compelled to say: “The thing must be so, and it cannot be otherwise; it is necessarily of such a character; it must have such qualities; it is impossible for it to possess others”—understands the thing not only historically but truly philosophically, and he has a philosophic knowledge of it. Our own Theory of Generation is to be such a philosphic comprehension of an organic body, a very different one from one merely historical. (1764)

He, who for an ordinary cause, resigns the fate of his patient to mercury, is a vile enemy to the sick; and, if he is tolerably popular, will, in one successful season, have paved the way for the business of life, for he has enough to do, ever afterward, to stop the mercurial breach of the constitutions of his dilapidated patients. He has thrown himself in fearful proximity to death, and has now to fight him at arm's length as long as the patient maintains a miserable existence.

Hence when a person is in great pain, the cause of which he cannot remove, he sets his teeth firmly together, or bites some substance between them with great vehemence, as another mode of violent exertion to produce a temporary relief. Thus we have the proverb where no help can be has in pain, 'to grin and abide;' and the tortures of hell are said to be attended with 'gnashing of teeth.'Describing a suggestion of the origin of the grin in the present form of a proverb, 'to grin and bear it.'

Herrmann Pidoux and Armand Trousseau stated 'Disease exists within us, because of us, and through us', Pasteur did not entirely disagree, 'This is true for certain diseases', he wrote cautiously, only to add immediately: 'I do not think that it is true for all of them'.