[In] the realm of science, … what we have achieved will be obsolete in ten, twenty or fifty years. That is the fate, indeed, that is the very meaning of scientific work. … Every scientific “fulfillment” raises new “questions” and cries out to be surpassed and rendered obsolete. Everyone who wishes to serve science has to resign himself to this.

A great swindle of our time is the assumption that science has made religion obsolete. All science has damaged is the story of Adam and Eve and the story of Jonah and the Whale. Everything else holds up pretty well, particularly lessons about fairness and gentleness. People who find those lessons irrelevant in the twentieth century are simply using science as an excuse for greed and harshness. Science has nothing to do with it, friends.

Does human spaceflight simply have a life of its own, without a realistic objective that is remotely commensurate with its costs? Or, indeed, is human spaceflight now obsolete?

During my span of life science has become a matter of public concern and the l'art pour l'art standpoint of my youth is now obsolete. Science has become an integral and most important part of our civilization, and scientific work means contributing to its development. Science in our technical age has social, economic, and political functions, and however remote one's own work is from technical application it is a link in the chain of actions and decisions which determine the fate of the human race. I realized this aspect of science in its full impact only after Hiroshima.

Every living language, like the perspiring bodies of living creatures, is in perpetual motion and alteration; some words go off, and become obsolete; others are taken in, and by degrees grow into common use; or the same word is inverted to a new sense and notion, which in tract of time makes as observable a change in the air and features of a language as age makes in the lines and mien of a face.

I call upon the scientific community in our country, those who gave us nuclear weapons, to turn their great talents now to the cause of mankind and world peace, to give us the means of rendering those nuclear weapons impotent and obsolete.
About his proposed Strategic Defense Initiative, later to be known as 'Star Wars.')

If a project is truly innovative, you cannot possibly know its exact cost and exact schedule at the beginning. And if you do know the exact cost and the exact schedule, chances are that the technology is obsolete.

If it works, it’s obsolete.

It is popular to believe that the age of the individual and, above all, of the free individual, is past in science. There are many administrators of science and a large component of the general population who believe that mass attacks can do anything, and even that ideas are obsolete. Behind this drive to the mass attack there are a number of strong psychological motives. Neither the public or the big administrator has too good an understanding of the inner continuity of science, but they both have seen its world-shaking consequences, and they are afraid of it. Both of them wish to decerebrate the scientist, even as the Byzantine State emasculated its civil servants. Moreover, the great administrator who is not sure of his own intellectual level can aggrandize himself only by cutting his scientific employees down to size.

Mapping the human genome has been compared with putting a man on the moon, but I believe it is more than that. This is the outstanding achievement not only of our lifetime, but in terms of human history. A few months ago I compared the project to the invention of the wheel. On reflection, it is more than that. I can well imagine technology making the wheel obsolete. But this code is the essence of mankind, and as long as humans exists, this code is going to be important and will be used.

Science keeps religion from sinking into the valley of crippling irrationalism and paralyzing obscurantism. Religion prevents science from falling into the marsh of obsolete materialism and moral nihilism.

Standard mathematics has recently been rendered obsolete by the discovery that for years we have been writing the numeral five backward. This has led to reevaluation of counting as a method of getting from one to ten. Students are taught advanced concepts of Boolean algebra, and formerly unsolvable equations are dealt with by threats of reprisals.

The frequent allegation that the selective processes in the human species are no longer 'natural' is due to persistence of the obsolete nineteenth-century concept of 'natural' selection. The error of this view is made clear when we ask its proponents such questions as, why should the 'surviving fittest' be able to withstand cold and inclement weather without the benefit of fire and clothing? Is it not ludicrous to expect selection to make us good at defending ourselves against wild beasts when wild beasts are getting to be so rare that it is a privilege to see one outside of a zoo? Is it necessary to eliminate everyone who has poor teeth when our dentists stand ready to provide us with artificial ones? Is it a great virtue to be able to endure pain when anaesthetics are available?
[Co-author with American statistician Gordon Allen]

These creators, makers of the new, can never become obsolete, for in the arts there is no correct answer. The story of discoverers could be told in simple chronological order, since the latest science replaces what went before. But the arts are another story—a story of infinite addition. We must find order in the random flexings of the imagination.

Well-established theories collapse under the weight of new facts and observations which cannot be explained, and then accumulate to the point where the once useful theory is clearly obsolete.
[Using Thomas S. Kuhn's theories to frame his argument about the relationship beween science and technology: as new facts continue to accumulate, a new, more accurate paradigm must replace the old one.]