“Time’s noblest offspring is the last.” This line of Bishop Berkeley’s expresses the real cause of the belief in progress in the animal creation.

All the events which occur upon the earth result from Law: even those actions which are entirely dependent on the caprices of the memory, or the impulse of the passions, are shown by statistics to be, when taken in the gross, entirely independent of the human will. As a single atom, man is an enigma; as a whole, he is a mathematical problem. As an individual, he is a free agent; as a species, the offspring of necessity.

Altering a gene in the gene line to produce improved offspring is likely to be very difficult because of the danger of unwanted side effects. It would also raise obvious ethical problems.

Despite the high long-term probability of extinction, every organism alive today, including every person reading this paper, is a link in an unbroken chain of parent-offspring relationships that extends back unbroken to the beginning of life on earth. Every living organism is a part of an enormously long success story—each of its direct ancestors has been sufficiently well adapted to its physical and biological environments to allow it to mature and reproduce successfully. Viewed thus, adaptation is not a trivial facet of natural history, but a biological attribute so central as to be inseparable from life itself.

Doubt is the offspring of knowledge: the savage never doubts at all.

Experiments on ornamental plants undertaken in previous years had proven that, as a rule, hybrids do not represent the form exactly intermediate between the parental strains. Although the intermediate form of some of the more striking traits, such as those relating to shape and size of leaves, pubescence of individual parts, and so forth, is indeed nearly always seen, in other cases one of the two parental traits is so preponderant that it is difficult or quite impossible, to detect the other in the hybrid. The same is true for Pisum hybrids. Each of the seven hybrid traits either resembles so closely one of the two parental traits that the other escapes detection, or is so similar to it that no certain distinction can be made. This is of great importance to the definition and classification of the forms in which the offspring of hybrids appear. In the following discussion those traits that pass into hybrid association entirely or almost entirely unchanged, thus themselves representing the traits of the hybrid, are termed dominating and those that become latent in the association, recessive. The word 'recessive' was chosen because the traits so designated recede or disappear entirely in the hybrids, but reappear unchanged in their progeny, as will be demonstrated later.

Fertilization of mammalian eggs is followed by successive cell divisions and progressive differentiation, first into the early embryo and subsequently into all of the cell types that make up the adult animal. Transfer of a single nucleus at a specific stage of development, to an enucleated unfertilized egg, provided an opportunity to investigate whether cellular differentiation to that stage involved irreversible genetic modification. The first offspring to develop from a differentiated cell were born after nuclear transfer from an embryo-derived cell line that had been induced to became quiescent. Using the same procedure, we now report the birth of live lambs from three new cell populations established from adult mammary gland, fetus and embryo. The fact that a lamb was derived from an adult cell confirms that differentiation of that cell did not involve the irreversible modification of genetic material required far development to term. The birth of lambs from differentiated fetal and adult cells also reinforces previous speculation that by inducing donor cells to became quiescent it will be possible to obtain normal development from a wide variety of differentiated cells.
[Co-author of paper announcing the cloned sheep, ‘Dolly’.]

Huts they made then, and fire, and skins for clothing,
And a woman yielded to one man in wedlock...
... Common, to see the offspring they had made; The human race began to mellow then. Because of fire their shivering forms no longer
Could bear the cold beneath the covering sky.

I can't tell you if genius is hereditary, because heaven has granted me no offspring.

It is better for all the world, if instead of waiting to execute degenerate offspring for crime, or to let them starve for their imbecility, society can prevent those who are manifestly unfit for continuing their kind. The principle that sustains compulsory vaccinations is broad enough to cover cutting Fallopian tubes. Three generations of imbeciles are enough.

It is still believed, apparently, that there is some thing mysteriously laudable about achieving viable offspring. I have searched the sacred and profane scriptures, for many years, but have yet to find any ground for this notion. To have a child is no more creditable than to have rheumatism–and no more discreditable. Ethically, it is absolutely meaningless. And practically, it is mainly a matter of chance.

It is the structure of the universe that has taught this knowledge to man. That structure is an ever existing exhibition of every principle upon which every part of mathematical science is founded. The offspring of this science is mechanics; for mechanics are no other than the principles of science appplied practically.

Life through many long periods has been manifested in a countless host of varying structures, all circumscribed by one general plan, each appointed to a definite place, and limited to an appointed duration. On the whole the earth has been thus more and more covered by the associated life of plants and animals, filling all habitable space with beings capable of enjoying their own existence or ministering to the enjoyment of others; till finally, after long preparation, a being was created capable of the wonderful power of measuring and weighing all the world of matter and space which surrounds him, of treasuring up the past history of all the forms of life, and considering his own relation to the whole. When he surveys this vast and co-ordinated system, and inquires into its history and origin, can he be at a loss to decide whether it be a work of Divine thought and wisdom, or the fortunate offspring of a few atoms of matter, warmed by the anima mundi, a spark of electricity, or an accidental ray of sunshine?

No collateral science had profited so much by palæontology as that which teaches the structure and mode of formation of the earth’s crust, with the relative position, time, and order of formation of its constituent stratified and unstratified parts. Geology has left her old hand-maiden mineralogy to rest almost wholly on the broad shoulders of her young and vigorous offspring, the science of organic remains.

Of all the offspring of Time, Error is the most ancient, and is so old and familiar an acquaintance, that Truth, when discovered, comes upon most of us like an intruder, and meets the intruder’s welcome.

Owing to the imperfection of language the offspring is termed a new animal, but it is in truth a branch or elongation of the parent; since a part of the embryon-animal is, or was, a part of the parent; and therefore in strict language it cannot be said to be entirely new at the time of its production; and therefore it may retain some of the habits of the parent-system. (1794)

Owing to this struggle for life, any variation, however slight and from whatever cause proceeding, if it be in any degree profitable to an individual of any species, in its infinitely complex relationship to other organic beings and to external nature, will tend to the preservation of that individual, and will generally be inherited by its offspring.

Quantitative work shows clearly that natural selection is a reality, and that, among other things, it selects Mendelian genes, which are known to be distributed at random through wild populations, and to follow the laws of chance in their distribution to offspring. In other words, they are an agency producing variation of the kind which Darwin postulated as the raw material on which selection acts.

Segregation is the offspring of an illicit intercourse between injustice and immorality.

So long as the mother, Ignorance, lives, it is not safe for Science, the offspring, to divulge the hidden causes of things.

That alone is worthy to be called Natural History, which investigates and records the condition of living things, of things in a state of nature; if animals, of living animals:— which tells of their 'sayings and doings,' their varied notes and utterances, songs and cries; their actions, in ease and under the pressure of circumstances; their affections and passions, towards their young, towards each other, towards other animals, towards man: their various arts and devices, to protect their progeny, to procure food, to escape from their enemies, to defend themselves from attacks; their ingenious resources for concealment; their stratagems to overcome their victims; their modes of bringing forth, of feeding, and of training, their offspring; the relations of their structure to their wants and habits; the countries in which they dwell; their connexion with the intimate world around them, mountain or plain, forest or field, barren heath or bushy dell, open savanna or wild hidden glen, river, lake, or sea:— this would be indeed zoology, i.e. the science of living creatures.

The framing of hypotheses is, for the enquirer after truth, not the end, but the beginning of his work. Each of his systems is invented, not that he may admire it and follow it into all its consistent consequences, but that he may make it the occasion of a course of active experiment and observation. And if the results of this process contradict his fundamental assumptions, however ingenious, however symmetrical, however elegant his system may be, he rejects it without hesitation. He allows no natural yearning for the offspring of his own mind to draw him aside from the higher duty of loyalty to his sovereign, Truth, to her he not only gives his affections and his wishes, but strenuous labour and scrupulous minuteness of attention.

The moment one has offered an original explanation for a phenomenon which seems satisfactory, that moment affection for his intellectual child springs into existence, and as the explanation grows into a definite theory his parental affections cluster about his offspring and it grows more and more dear to him. ... There springs up also unwittingly a pressing of the theory to make it fit the facts and a pressing of the facts to make them fit the theory... To avoid this grave danger, the method of multiple working hypotheses is urged. It differs from the simple working hypothesis in that it distributes the effort and divides the affections... In developing the multiple hypotheses, the effort is to bring up into view every rational exploration of the phenomenon in hand and to develop every tenable hypothesis relative to its nature, cause or origin, and to give to all of these as impartially as possible a working form and a due place in the investigation. The investigator thus becomes the parent of a family of hypotheses; and by his parental relations to all is morally forbidden to fasten his affections unduly upon anyone. ... Each hypothesis suggests its own criteria, its own method of proof, its own method of developing the truth, and if a group of hypotheses encompass the subject on all sides, the total outcome of means and of methods is full and rich.

THE OATH. I swear by Apollo [the healing God], the physician and Aesclepius [son of Apollo], and Health [Hygeia], and All-heal [Panacea], and all the gods and goddesses, that, according to my ability and judgment, I will keep this Oath and this stipulation—to reckon him who taught me this Art equally dear to me as my parents, to share my substance with him, and relieve his necessities if required; to look upon his offspring in the same footing as my own brothers, and to teach them this art, if they shall wish to learn it, without fee or stipulation; and that by precept, lecture, and every other mode of instruction, I will impart a knowledge of the Art to my own sons, and those of my teachers, and to disciples bound by a stipulation and oath according to the law of medicine, but to none others. I will follow that system of regimen which, according to my ability and judgment, I consider for the benefit of my patients, and abstain from whatever is deleterious and mischievous. I will give no deadly medicine to any one if asked, nor suggest any such counsel; and in like manner I will not give to a woman a pessary to produce abortion. With purity and with holiness I will pass my life and practice my Art. I will not cut persons laboring under the stone, but will leave this to be done by men who are practitioners of this work. Into whatever houses I enter, I will go into them for the benefit of the sick, and will abstain from every voluntary act of mischief and corruption; and, further, from the seduction of females or males, of freemen and slaves. Whatever, in connection with my professional practice or not, in connection with it, I see or hear, in the life of men, which ought not to be spoken of abroad, I will not divulge, as reckoning that all such should be kept secret. While I continue to keep this Oath unviolated, may it be granted to me to enjoy life and the practice of the art, respected by all men, in all times! But should I trespass and violate this Oath, may the reverse be my lot!

The precise equivalence of the chromosomes contributed by the two sexes is a physical correlative of the fact that the two sexes play, on the whole, equal parts in hereditary transmission, and it seems to show that the chromosomal substance, the chromatin, is to be regarded as the physical basis of inheritance. Now, chromatin is known to be closely similar to, if not identical with, a substance known as nuclein (C₂₉H₄₉N₉O₂₂, according to Miescher), which analysis shows to be a tolerably definite chemical compased of nucleic acid (a complex organic acid rich in phosphorus) and albumin. And thus we reach the remarkable conclusion that inheritance may, perhaps, be effected by the physical transmission of a particular chemical compound from parent to offspring.

The responsibility which rests upon man is proportional to the ability which he possesses and the opportunity which he faces. Perhaps that responsibility is no greater for him than was that of Notharctus or Eohippus or a trilobite, each in his own day, but because of man’s unique abilities it is the greatest responsibility that has ever rested upon any of the earth’s offspring.

Then if the first argument remains secure (for nobody will produce a neater one, than the length of the periodic time is a measure of the size of the spheres), the order of the orbits follows this sequence, beginning from the highest: The first and highest of all is the sphere of the fixed stars, which contains itself and all things, and is therefore motionless. It is the location of the universe, to which the motion and position of all the remaining stars is referred. For though some consider that it also changes in some respect, we shall assign another cause for its appearing to do so in our deduction of the Earth’s motion. There follows Saturn, the first of the wandering stars, which completes its circuit in thirty years. After it comes Jupiter which moves in a twelve-year long revolution. Next is Mars, which goes round biennially. An annual revolution holds the fourth place, in which as we have said is contained the Earth along with the lunar sphere which is like an epicycle. In fifth place Venus returns every nine months. Lastly, Mercury holds the sixth place, making a circuit in the space of eighty days. In the middle of all is the seat of the Sun. For who in this most beautiful of temples would put this lamp in any other or better place than the one from which it can illuminate everything at the same time? Aptly indeed is he named by some the lantern of the universe, by others the mind, by others the ruler. Trismegistus called him the visible God, Sophocles' Electra, the watcher over all things. Thus indeed the Sun as if seated on a royal throne governs his household of Stars as they circle around him. Earth also is by no means cheated of the Moon’s attendance, but as Aristotle says in his book On Animals the Moon has the closest affinity with the Earth. Meanwhile the Earth conceives from the Sun, and is made pregnant with annual offspring. We find, then, in this arrangement the marvellous symmetry of the universe, and a sure linking together in harmony of the motion and size of the spheres, such as could be perceived in no other way. For here one may understand, by attentive observation, why Jupiter appears to have a larger progression and retrogression than Saturn, and smaller than Mars, and again why Venus has larger ones than Mercury; why such a doubling back appears more frequently in Saturn than in Jupiter, and still more rarely in Mars and Venus than in Mercury; and furthermore why Saturn, Jupiter and Mars are nearer to the Earth when in opposition than in the region of their occultation by the Sun and re-appearance. Indeed Mars in particular at the time when it is visible throughout the night seems to equal Jupiter in size, though marked out by its reddish colour; yet it is scarcely distinguishable among stars of the second magnitude, though recognized by those who track it with careful attention. All these phenomena proceed from the same course, which lies in the motion of the Earth. But the fact that none of these phenomena appears in the fixed stars shows their immense elevation, which makes even the circle of their annual motion, or apparent motion, vanish from our eyes.