[A significant invention] must be startling, unexpected. It must come to a world that is not prepared for it.

By destroying the biological character of phenomena, the use of averages in physiology and medicine usually gives only apparent accuracy to the results. From our point of view, we may distinguish between several kinds of averages: physical averages, chemical averages and physiological and pathological averages. If, for instance, we observe the number of pulsations and the degree of blood pressure by means of the oscillations of a manometer throughout one day, and if we take the average of all our figures to get the true or average blood pressure and to learn the true or average number of pulsations, we shall simply have wrong numbers. In fact, the pulse decreases in number and intensity when we are fasting and increases during digestion or under different influences of movement and rest; all the biological characteristics of the phenomenon disappear in the average. Chemical averages are also often used. If we collect a man's urine during twenty-four hours and mix all this urine to analyze the average, we get an analysis of a urine which simply does not exist; for urine, when fasting, is different from urine during digestion. A startling instance of this kind was invented by a physiologist who took urine from a railroad station urinal where people of all nations passed, and who believed he could thus present an analysis of average European urine! Aside from physical and chemical, there are physiological averages, or what we might call average descriptions of phenomena, which are even more false. Let me assume that a physician collects a great many individual observations of a disease and that he makes an average description of symptoms observed in the individual cases; he will thus have a description that will never be matched in nature. So in physiology, we must never make average descriptions of experiments, because the true relations of phenomena disappear in the average; when dealing with complex and variable experiments, we must study their various circumstances, and then present our most perfect experiment as a type, which, however, still stands for true facts. In the cases just considered, averages must therefore be rejected, because they confuse, while aiming to unify, and distort while aiming to simplify. Averages are applicable only to reducing very slightly varying numerical data about clearly defined and absolutely simple cases.

CREATION OF LIFE.
The Startling Discovery of Prof. Loeb.
Lower Animals Produced by Chemical Means.
Process May Apply to the Human Species.
Immaculate Conception is Explained.
Wonderful Experiments Conducted at Woods Hole.

I have not trodden through a conventional university course, but I am striking out a new path for myself. I have made a special investigation of divergent series in general and the results I get are termed by the local mathematicians as “startling.”

I may conclude this chapter by quoting a saying of Professor Agassiz, that whenever a new and startling fact is brought to light in science, people first say, 'it is not true,' then that 'it is contrary to religion,' and lastly, 'that everybody knew it before.'

I was sitting in a chair in the patent office at Bern when all of a sudden a thought occurred to me: “If a person falls freely he will not feel his own weight.” I was startled. This simple thought made a deep impression on me. It impelled me toward a theory of gravitation.

One summer day, while I was walking along the country road on the farm where I was born, a section of the stone wall opposite me, and not more than three or four yards distant, suddenly fell down. Amid the general stillness and immobility about me the effect was quite startling. ... It was the sudden summing up of half a century or more of atomic changes in the material of the wall. A grain or two of sand yielded to the pressure of long years, and gravity did the rest.

Science usually advances by a succession of small steps, through a fog in which even the most keen-sighted explorer can seldom see more than a few paces ahead. Occasionally the fog lifts, an eminence is gained, and a wider stretch of territory can be surveyed—sometimes with startling results. A whole science may then seem to undergo a kaleidoscopic rearrangement, fragments of knowledge sometimes being found to fit together in a hitherto unsuspected manner. Sometimes the shock of readjustment may spread to other sciences; sometimes it may divert the whole current of human thought.

Such startling announcements as these should be deprecated as being unworthy of science and mischievous to its true progress.

The fact that this chain of life existed [at volcanic vents on the seafloor] in the black cold of the deep sea and was utterly independent of sunlight—previously thought to be the font of all Earth’s life—has startling ramifications. If life could flourish there, nurtured by a complex chemical process based on geothermal heat, then life could exist under similar conditions on planets far removed from the nurturing light of our parent star, the Sun.

The most startling result of Faraday’s Law is perhaps this. If we accept the hypothesis that the elementary substances are composed of atoms, we cannot avoid concluding that electricity also, positive as well as negative, is divided into definite elementary portions, which behave like atoms of electricity.

The science and technology which have advanced man safely into space have brought about startling medical advances for man on earth. Out of space research have come new knowledge, techniques and instruments which have enabled some bedridden invalids to walk, the totally deaf to hear, the voiceless to talk, and, in the foreseeable future, may even make it possible for the blind to “see.”

To live is so startling it leaves little time for other occupations.

To my knowledge there are no written accounts of Fermi’s contributions to the [first atomic bomb] testing problems, nor would it be easy to reconstruct them in detail. This, however, was one of those occasions in which Fermi’s dominion over all physics, one of his most startling characteristics, came into its own. The problems involved in the Trinity test ranged from hydrodynamics to nuclear physics, from optics to thermodynamics, from geophysics to nuclear chemistry. Often they were closely interrelated, and to solve one’it was necessary to understand all the others. Even though the purpose was grim and terrifying, it was one of the greatest physics experiments of all time. Fermi completely immersed himself in the task. At the time of the test he was one of the very few persons (or perhaps the only one) who understood all the technical ramifications.

To prove to an indignant questioner on the spur of the moment that the work I do was useful seemed a thankless task and I gave it up. I turned to him with a smile and finished, “To tell you the truth we don’t do it because it is useful but because it’s amusing.” The answer was thought of and given in a moment: it came from deep down in my soul, and the results were as admirable from my point of view as unexpected. My audience was clearly on my side. Prolonged and hearty applause greeted my confession. My questioner retired shaking his head over my wickedness and the newspapers next day, with obvious approval, came out with headlines “Scientist Does It Because It’s Amusing!” And if that is not the best reason why a scientist should do his work, I want to know what is. Would it be any good to ask a mother what practical use her baby is? That, as I say, was the first evening I ever spent in the United States and from that moment I felt at home. I realised that all talk about science purely for its practical and wealth-producing results is as idle in this country as in England. Practical results will follow right enough. No real knowledge is sterile. The most useless investigation may prove to have the most startling practical importance: Wireless telegraphy might not yet have come if Clerk Maxwell had been drawn away from his obviously “useless” equations to do something of more practical importance. Large branches of chemistry would have remained obscure had Willard Gibbs not spent his time at mathematical calculations which only about two men of his generation could understand. With this faith in the ultimate usefulness of all real knowledge a man may proceed to devote himself to a study of first causes without apology, and without hope of immediate return.