[Molecular biology] is concerned particularly with the forms of biological molecules and with the evolution, exploitation and ramification of these forms in the ascent to higher and higher levels of organisation. Molecular biology is predominantly three-dimensional and structural—which does not mean, however, that it is merely a refinement of morphology. It must at the same time inquire into genesis and function.

All scientists must focus closely on limited targets. Whether or not one’s findings on a limited subject will have wide applicability depends to some extent on chance, but biologists of superior ability repeatedly focus on questions the answers to which either have wide ramifications or lead to new areas of investigation. One procedure that can be effective is to attempt both reduction and synthesis; that is, direct a question at a phenomenon on one integrative level, identify its mechanism at a simpler level, then extrapolate its consequences to a more complex level of integration.

As buds give rise by growth to fresh buds, and these, if vigorous, branch out and overtop on all sides many a feebler branch, so by generation I believe it has been with the great Tree of Life, which fills with its dead and broken branches the crust of the earth, and covers the surface with its ever branching and beautiful ramifications.

Should a scientist consider possible ramifications of his research and their effects on society,…? Answer: I think it is impossible for anybody, scientist or not, to foresee the ramifications. We might say that that is a definition of basic science. Vide Einstein’s discovery of 1905 of the equivalence of mass and energy and the development of atomic weaponry. … CONSIDER RAMIFICATIONS? IMPOSSIBLE.

The fact that this chain of life existed [at volcanic vents on the seafloor] in the black cold of the deep sea and was utterly independent of sunlight—previously thought to be the font of all Earth’s life—has startling ramifications. If life could flourish there, nurtured by a complex chemical process based on geothermal heat, then life could exist under similar conditions on planets far removed from the nurturing light of our parent star, the Sun.

The Humorless Person: I have a friend who has about as much sense of humor as the wooden Indian of commerce. Some time ago he made a trip through the Mammoth Cave of Kentucky. … He did his sight-seeing very thoroughly. He didn’t miss a single ramification in that great crack in the face of Mother Nature. … I asked him what he thought of the Mammoth Cave. “Well,” said he, “taking it as a hole, it is all right.”

The theory of ramification is one of pure colligation, for it takes no account of magnitude or position; geometrical lines are used, but these have no more real bearing on the matter than those employed in genealogical tables have in explaining the laws of procreation.

To my knowledge there are no written accounts of Fermi’s contributions to the [first atomic bomb] testing problems, nor would it be easy to reconstruct them in detail. This, however, was one of those occasions in which Fermi’s dominion over all physics, one of his most startling characteristics, came into its own. The problems involved in the Trinity test ranged from hydrodynamics to nuclear physics, from optics to thermodynamics, from geophysics to nuclear chemistry. Often they were closely interrelated, and to solve one’it was necessary to understand all the others. Even though the purpose was grim and terrifying, it was one of the greatest physics experiments of all time. Fermi completely immersed himself in the task. At the time of the test he was one of the very few persons (or perhaps the only one) who understood all the technical ramifications.