[Professor Pauling] confesses that he had harboured the feeling that sooner or later he would be the one to get the DNA structure; and although he was pleased with the double-helix, he ‘rather wished the idea had been his’.

Becoming serious is a grievous fault in hobbyists. It is an axiom that no hobby should either seek or need rational justification. To wish to do it is reason enough. To find reasons why it is useful or beneficial converts it at once from an avocation into an industry–lowers it at once to the ignominious category of an 'exercise' undertaken for health, power, or profit. Lifting dumbbells is not a hobby. It is a confession of subservience, not an assertion of liberty.

Beware of the problem of testing too many hypotheses; the more you torture the data, the more likely they are to confess, but confessions obtained under duress may not be admissible in the court of scientific opinion.

Few will deny that even in the first scientific instruction in mathematics the most rigorous method is to be given preference over all others. Especially will every teacher prefer a consistent proof to one which is based on fallacies or proceeds in a vicious circle, indeed it will be morally impossible for the teacher to present a proof of the latter kind consciously and thus in a sense deceive his pupils. Notwithstanding these objectionable so-called proofs, so far as the foundation and the development of the system is concerned, predominate in our textbooks to the present time. Perhaps it will be answered, that rigorous proof is found too difficult for the pupil’s power of comprehension. Should this be anywhere the case,—which would only indicate some defect in the plan or treatment of the whole,—the only remedy would be to merely state the theorem in a historic way, and forego a proof with the frank confession that no proof has been found which could be comprehended by the pupil; a remedy which is ever doubtful and should only be applied in the case of extreme necessity. But this remedy is to be preferred to a proof which is no proof, and is therefore either wholly unintelligible to the pupil, or deceives him with an appearance of knowledge which opens the door to all superficiality and lack of scientific method.

I … began my career as a wireless amateur. After 43 years in radio, I do not mind confessing that I am still an amateur. Despite many great achievements in the science of radio and electronics, what we know today is far less than what we have still to learn.

If we betake ourselves to the statistical method, we do so confessing that we are unable to follow the details of each individual case, and expecting that the effects of widespread causes, though very different in each individual, will produce an average result on the whole nation, from a study of which we may estimate the character and propensities of an imaginary being called the Mean Man.

Nothing holds me ... I will indulge in my sacred fury; I will triumph over mankind by the honest confession that I have stolen the golden vases of the Egyptians to build up a tabernacle for my God, far away from the confines of Egypt. If you forgive me, I rejoice ; if you are angry, I can bear it. The die is cast; the book is written, to be read either now or by posterity, I care not which. It may well wait a century for a reader, as God has waited six thousand years for an observer.

Thus science strips off, one after the other, the more or less gross materialisations by which we endeavour to form an objective image of the soul, till men of science, speculating, in their non-scientific intervals, like other men on what science may possibly lead to, have prophesied that we shall soon have to confess that the soul is nothing else than a function of certain complex material systems.

To prove to an indignant questioner on the spur of the moment that the work I do was useful seemed a thankless task and I gave it up. I turned to him with a smile and finished, “To tell you the truth we don’t do it because it is useful but because it’s amusing.” The answer was thought of and given in a moment: it came from deep down in my soul, and the results were as admirable from my point of view as unexpected. My audience was clearly on my side. Prolonged and hearty applause greeted my confession. My questioner retired shaking his head over my wickedness and the newspapers next day, with obvious approval, came out with headlines “Scientist Does It Because It’s Amusing!” And if that is not the best reason why a scientist should do his work, I want to know what is. Would it be any good to ask a mother what practical use her baby is? That, as I say, was the first evening I ever spent in the United States and from that moment I felt at home. I realised that all talk about science purely for its practical and wealth-producing results is as idle in this country as in England. Practical results will follow right enough. No real knowledge is sterile. The most useless investigation may prove to have the most startling practical importance: Wireless telegraphy might not yet have come if Clerk Maxwell had been drawn away from his obviously “useless” equations to do something of more practical importance. Large branches of chemistry would have remained obscure had Willard Gibbs not spent his time at mathematical calculations which only about two men of his generation could understand. With this faith in the ultimate usefulness of all real knowledge a man may proceed to devote himself to a study of first causes without apology, and without hope of immediate return.