...great difficulties are felt at first and these cannot be overcome except by starting from experiments .. and then be conceiving certain hypotheses ... But even so, very much hard work remains to be done and one needs not only great perspicacity but often a degree of good fortune.

[About any invention] (1) everything that’s already in the world when you’re born is just normal; (2) anything that gets invented between then and before you turn thirty is incredibly exciting and creative and with any luck you can make a career out of it; (3) anything that gets invented after you’re thirty is against the natural order of things and the beginning of the end of civilisation as we know it until it’s been around for about ten years when it gradually turns out to be alright really.

[To one of his students he saw in a school dramatic production:] I’ve always been proud that Course X leaves little time for outside activities. You have proved me wrong so far and I’m glad you have. But don’t push your luck too far!

Dilbert: Maybe I’m unlucky in love because I’m so knowledgeable about science that I intimidate people. Their intimidation becomes low self-esteem, then they reject me to protect their egos.
Dogbert: Occam’s Razor.
Dilbert: What is “Occam's Razor”?
Dogbert: A guy named Occam had a rule about the world. Basically he said that when there are multiple explanations for something the simplest explanation is usually correct. The simplest explanation for your poor love life is that you’re immensely unattractive.
Dilbert: Maybe Occam had another rule that specifically exempted this situation, but his house burned down with all his notes. Then he forgot.
Dogbert: Occam’s Razor.
Dilbert: I’m an idiot.
Dogbert: I don’t think we can rule it out at this point.

~~[Misattributed - NOT by Jefferson]~~ I am a great believer in Luck. The harder I work, the more of it I seem to have.

A good deal of my research in physics has consisted in not setting out to solve some particular problem, but simply examining mathematical quantities of a kind that physicists use and trying to fit them together in an interesting way, regardless of any application that the work may have. It is simply a search for pretty mathematics. It may turn out later to have an application. Then one has good luck. At age 78.

A lucky physician is better than a learned one.

A visitor to Niels Bohr's country cottage, noticing a horseshoe hanging on the wall, teasing the eminent scientist about this ancient superstition. “Can it be true that you, of all people, believe it will bring you luck?'
'Of course not,' replied Bohr, 'but I understand it brings you luck whether you believe it or not.'”

All successful men have agreed to one thing,—they were causationists. They believed that things went not by luck, but by law; that there was not a weak or a cracked link in the chain that joins the first and last of things.

All the inventions that the world contains,
Were not by reason first found out, nor brains;
But pass for theirs who had the luck to light
Upon them by mistake or oversight.

And Lady Luck remains tantalizingly in the shadows, pulling some of evolution's strings—but nobody knows how many.

Anyone of common mental and physical health can practice scientific research. … Anyone can try by patient experiment what happens if this or that substance be mixed in this or that proportion with some other under this or that condition. Anyone can vary the experiment in any number of ways. He that hits in this fashion on something novel and of use will have fame. … The fame will be the product of luck and industry. It will not be the product of special talent.

Everything in nature goes by law, and not by luck.

Foreshadowings of the principles and even of the language of [the infinitesimal] calculus can be found in the writings of Napier, Kepler, Cavalieri, Pascal, Fermat, Wallis, and Barrow. It was Newton's good luck to come at a time when everything was ripe for the discovery, and his ability enabled him to construct almost at once a complete calculus.

Further, the same Arguments which explode the Notion of Luck, may, on the other side, be useful in some Cases to establish a due comparison between Chance and Design: We may imagine Chance and Design to be, as it were, in Competition with each other, for the production of some sorts of Events, and many calculate what Probability there is, that those Events should be rather be owing to the one than to the other.

Good luck is science not yet classified; just as the supernatural is the natural not yet understood.

I am a great believer in Luck. The harder I work, the more of it I seem to have.

I am only a physicist with nothing material to show for my labours. I have never even seen the ionosphere, although I have worked on the subject for thirty years. That does show how lucky people can be. If there had been no ionosphere I would not have been standing here this morning.

I don’t know what your Company is feeling as of today about the work of Dr. Alice Hamilton on benzol [benzene] poisoning. I know that back in the old days some of your boys used to think that she was a plain nuisance and just picking on you for luck. But I have a hunch that as you have learned more about the subject, men like your good self have grown to realize the debt that society owes her for her crusade. I am pretty sure that she has saved the lives of a great many girls in can-making plants and I would hate to think that you didn’t agree with me.

I find I’m luckier when I work harder.

I have been able to solve a few problems of mathematical physics on which the greatest mathematicians since Euler have struggled in vain … But the pride I might have held in my conclusions was perceptibly lessened by the fact that I knew that the solution of these problems had almost always come to me as the gradual generalization of favorable examples, by a series of fortunate conjectures, after many errors. I am fain to compare myself with a wanderer on the mountains who, not knowing the path, climbs slowly and painfully upwards and often has to retrace his steps because he can go no further—then, whether by taking thought or from luck, discovers a new track that leads him on a little till at length when he reaches the summit he finds to his shame that there is a royal road by which he might have ascended, had he only the wits to find the right approach to it. In my works, I naturally said nothing about my mistake to the reader, but only described the made track by which he may now reach the same heights without difficulty.

I have been trying to point out that in our lives chance may have an astonishing influence and, if I may offer advice to the young laboratory worker, it would be this—never neglect an extraordinary appearance or happening. It may be—usually is, in fact—a false alarm that leads to nothing, but may on the other hand be the clue provided by fate to lead you to some important advance.

I never found it easy. People say I was lucky twice but I resent that. We stuck with [cimetidine] for four years with no progress until we eventually succeeded. It was not luck, it was bloody hard work.
[Rejecting that drug discovery was easier in the past.]

I tell [medical students] that they are the luckiest persons on earth to be in medical school, and to forget all this worry about H.M.O.’s and keep your eye on helping the patient. It’s the best time ever to be a doctor because you can heal and treat conditions that were untreatable even a couple of years ago.

If my efforts have led to greater success than usual, this is due, I believe, to the fact that during my wanderings in the field of medicine, I have strayed onto paths where the gold was still lying by the wayside. It takes a little luck to be able to distinguish gold from dross, but that is all.

If there is such a thing as luck, then I must be the most unlucky fellow in the world. I’ve never once made a lucky strike in all my life. When I get after something that I need, I start finding everything in the world that I don’t need—one damn thing after another. I find ninety-nine things that I don’t need, and then comes number one hundred, and that—at the very last—turns out to be just what I had been looking for.

It is grindingly, creakingly, crashingly obvious that, if Darwinism were really a theory of chance, it couldn’t work. You don't need to be a mathematician or physicist to calculate that an eye or a haemoglobin molecule would take from here to infinity to self-assemble by sheer higgledy-piggledy luck. Far from being a difficulty peculiar to Darwinism, the astronomic improbability of eyes and knees, enzymes and elbow joints and all the other living wonders is precisely the problem that any theory of life must solve, and that Darwinism uniquely does solve. It solves it by breaking the improbability up into small, manageable parts, smearing out the luck needed, going round the back of Mount Improbable and crawling up the gentle slopes, inch by million-year inch. Only God would essay the mad task of leaping up the precipice in a single bound.

It was a stroke of luck. The only credit you can claim is not ignoring your stroke of luck.

Medicine in its present state is, it seems to me, by now completely discovered, insofar as it teaches in each instance the particular details and the correct measures. For anyone who has an understanding of medicine in this way depends very little upon good luck, but is able to do good with or without luck. For the whole of medicine has been established, and the excellent principles discovered in it clearly have very little need of good luck.

Not from the stars do I my judgement pluck,
And yet methinks I have astronomy.
But not to tell of good or evil luck,
Of plagues, of dearths, or season's quality;
Nor can I fortune to brief minutes tell,
Pointing to each his thunder, rain, and wind,
Or say with princes if it shall go well …

One sometimes finds what one is not looking for.

Organization is simply the means by which the acts of ordinary men can be made to add up to extraordinary results. To this idea of progress that does not wait on some lucky break, some chance discovery, or some rare stroke of genius, but instead is achieved through systematic, cumulative effort, the engineer has contributed brilliantly.

Science predicts that many different kinds of universe will be spontaneously created out of nothing. It is a matter of chance which we are in.
[Answer to question: You've said there is no reason to invoke God to light the blue touchpaper. Is our existence all down to luck?]

Scientific research was much like prospecting: you went out and you hunted, armed with your maps and instruments, but in the ened your preparations did not matter, or even your intuition. You needed your luck, and whatever benefits accrued to the diligent, through sheer, grinding hard work.

Statistically the probability of any one of us being here is so small that you would think the mere fact of existence would keep us all in a contented dazzlement of surprise. We are alive against the stupendous odds of genetics, infinitely outnumbered by all the alternates who might, except for luck, be in our places.

Success in research needs four Gs: Glück, Geduld, Geschick und Geld. Luck, patience, skill and money.

The dice of God are always loaded.
[A fragment from a lost play of Sophocles, “Ever the dice of Zeus fall well.”]

The first rule of discovery is to have brains and good luck. The second rule of discovery is to sit tight and wait till you get a bright idea.

The unlucky doctor treats the head of a disease; the lucky doctor its tail.

The world of science and the world of literature have much in common. Each is an international club, helping to tie mankind together across barriers of nationality, race, and language. I have been doubly lucky, being accepted as a member of both.

To be a scholar of mathematics you must be born with talent, insight, concentration, taste, luck, drive and the ability to visualize and guess.

True, no one can absolutely control the direction of his life; but each person can certainly influence it. The armchair explorers who complain that they never got their “one lucky shot” were never really infected by the incurable drive to explore. Those who have the bug—go.

We should admit in theory what is already very largely a case in practice, that the main currency of scientific information is the secondary sources in the forms of abstracts, reports, tables, &c., and that the primary sources are only for detailed reference by very few people. It is possible that the fate of most scientific papers will be not to be read by anyone who uses them, but with luck they will furnish an item, a number, some facts or data to such reports which may, but usually will not, lead to the original paper being consulted. This is very sad but it is the inevitable consequence of the growth of science. The number of papers that can be consulted is absolutely limited, no more time can be spent in looking up papers, by and large, than in the past. As the number of papers increase the chance of any one paper being looked at is correspondingly diminished. This of course is only an average, some papers may be looked at by thousands of people and may become a regular and fixed part of science but most will perish unseen.

What helps luck is a habit of watching for opportunities, of having a patient but restless mind, of sacrificing one’s ease or vanity, or uniting a love of detail to foresight, and of passing through hard times bravely [and cheerfully].