(3 Jun 1873 - 25 Dec 1961)
Science Quotes by Otto Loewi (2 quotes)
A drug is a substance which, if injected into a rabbit, produces a paper.
— Otto Loewi
The night before Easter Sunday of that year (1920) I awoke, turned on the light, and jotted down a few notes on a tiny slip of thin paper. Then I fell asleep again. It occurred to me at six oclock in the morning that during the night I had written down something most important, but I was unable to decipher the scrawl. The next night, at three oclock, the idea returned. It was the design of an experiment to determine whether the hypothesis of chemical transmission that I had uttered seventeen years ago was correct. I got up immediately, went to the laboratory, and performed a simple experiment on a frog heart according to the nocturnal design. I have to describe this experiment briefly since its results became the foundation of the theory of chemical transmission of the nervous impulse. The hearts of two frogs were isolated, the first with its nerves, the second without. Both hearts were attached to Straub cannulas filled with a little Ringer solution. The vagus nerve of the first heart was stimulated for a few minutes. Then the Ringer solution that had been in the first heart during the stimulation of the vagus was transferred to the second heart. It slowed and its beats diminished just as if its vagus had been stimulated. Similarly, when the accelerator nerve was stimulated and the Ringer from this period transferred, the second heart speeded up and its beats increased. These results unequivocally proved that the nerves do not influence the heart directly but liberate from their terminals specific chemical substances which, in their turn, cause the well-known modifications of the function of the heart characteristic of the stimulation of its nerves.
— Otto Loewi
Quotes by others about Otto Loewi (1)
Hitherto the conception of chemical transmission at nerve endings and neuronal synapses, originating in Loewis discovery, and with the extension that the work of my colleagues has been able to give to it, can claim one practical result, in the specific, though alas only short, alleviation of the condition of myasthenia gravis, by eserine and its synthetic analogues.
- 3 Jun - short biography, births, deaths and events on date of Loewi's birth.