A designer must always think about the unfortunate production engineer who will have to manufacture what you have designed; try to understand his problems.

A mouse can fall down a mine shaft a third of a mile deep without injury. A rat falling the same distance would break his bones; a man would simply splash ... Elephants have their legs thickened to an extent that seems disproportionate to us, but this is necessary if their unwieldly bulk is to be moved at all ... A 60-ft. man would weigh 1000 times as much as a normal man, but his thigh bone would have its area increased by only 100 times ... Consequently such an unfortunate monster would break his legs the moment he tried to move.
Expressing, in picturesque terms, the strength of an organism relative to its bulk.

A physician is an unfortunate gentleman who is every day required to perform a miracle; namely to reconcile health with intemperance.

A week or so after I learned that I was to receive the Miller Award, our president, Marty Morton, phoned and asked me if I would utter a few words of scientific wisdom as a part of the ceremony. Unfortunately for me, and perhaps for you, I agreed to do so. In retrospect I fear that my response was a serious error, because I do not feel wise. I do not know whether to attribute my response to foolhardiness, to conceit, to an inordinate susceptibility to flattery, to stupidity, or to some combination of these unfortunate attributes all of which I have been told are recognizable in my personality. Personally, I tend to favor stupidity, because that is a condition over which I have little control.

Consider the plight of a scientist of my age. I graduated from the University of California at Berkeley in 1940. In the 41 years since then the amount of biological information has increased 16 fold; during these 4 decades my capacity to absorb new information has declined at an accelerating rate and now is at least 50% less than when I was a graduate student. If one defines ignorance as the ratio of what is available to be known to what is known, there seems no alternative to the conclusion that my ignorance is at least 25 times as extensive as it was when I got my bachelor’s degree. Although I am sure that my unfortunate condition comes as no surprise to my students and younger colleagues, I personally find it somewhat depressing. My depression is tempered, however, by the fact that all biologists, young or old, developing or senescing, face the same melancholy situation because of an interlocking set of circumstances.

Fifty years ago Geology was in its infancy; there were but few who cultivated it as a Science ... If an unfortunate lover of nature was seen hammering in a stone quarry, he was generally supposed to be slightly demented.

I think the name atomic theory was an unfortunate one. We talk fluently about atoms as the smallest particles that exist, and chemists regard them as indivisible … To my mind the infinitely small is as incomprehensible as the infinitely great. … we cannot comprehend it, we cannot take it in. And so with the atom. Therefore I think that it would have been better to have taken a different word—say minim—which would have been a safer term than atom.

If in Germany the goddess Justitia had not the unfortunate habit of depositing the ministerial portfolios only in the cradles of her own progeny, who knows how many a German mathematician might not also have made an excellent minister.

In long intervals I have expressed an opinion on public issues whenever they appeared to be so bad and unfortunate that silence would have made me feel guilty of complicity.

In my experience most mathematicians are intellectually lazy and especially dislike reading experimental papers. He (René Thom) seemed to have very strong biological intuitions but unfortunately of negative sign.

It [analysis] lacks at this point such plan and unity that it is really amazing that it can be studied by so many people. The worst is that it has not at all been treated with rigor. There are only a few propositions in higher analysis that have been demonstrated with complete rigor. Everywhere one finds the unfortunate manner of reasoning from the particular to the general, and it is very unusual that with such a method one finds, in spite of everything, only a few of what many be called paradoxes. It is really very interesting to seek the reason.
In my opinion that arises from the fact that the functions with which analysis has until now been occupied can, for the most part, be expressed by means of powers. As soon as others appear, something that, it is true, does not often happen, this no longer works and from false conclusions there flow a mass of incorrect propositions.

It is an unfortunate fact that we can secure peace only by preparing for war.

It is said that the composing of the Lilavati was occasioned by the following circumstance. Lilavati was the name of the author’s daughter, concerning whom it appeared, from the qualities of the ascendant at her birth, that she was destined to pass her life unmarried, and to remain without children. The father ascertained a lucky hour for contracting her in marriage, that she might be firmly connected and have children. It is said that when that hour approached, he brought his daughter and his intended son near him. He left the hour cup on the vessel of water and kept in attendance a time-knowing astrologer, in order that when the cup should subside in the water, those two precious jewels should be united. But, as the intended arrangement was not according to destiny, it happened that the girl, from a curiosity natural to children, looked into the cup, to observe the water coming in at the hole, when by chance a pearl separated from her bridal dress, fell into the cup, and, rolling down to the hole, stopped the influx of water. So the astrologer waited in expectation of the promised hour. When the operation of the cup had thus been delayed beyond all moderate time, the father was in consternation, and examining, he found that a small pearl had stopped the course of the water, and that the long-expected hour was passed. In short, the father, thus disappointed, said to his unfortunate daughter, I will write a book of your name, which shall remain to the latest times—for a good name is a second life, and the ground-work of eternal existence.

Mathematics will not be properly esteemed in wider circles until more than the a b c of it is taught in the schools, and until the unfortunate impression is gotten rid of that mathematics serves no other purpose in instruction than the formal training of the mind. The aim of mathematics is its content, its form is a secondary consideration and need not necessarily be that historic form which is due to the circumstance that mathematics took permanent shape under the influence of Greek logic.

One precept for the scientist-to-be is already obvious. Do not place yourself in an environment where your advisor is already suffering from scientific obsolescence. If one is so unfortunate as to receive his training under a person who is either technically or intellectually obsolescent, one finds himself to be a loser before he starts. It is difficult to move into a position of leadership if one’s launching platform is a scientific generation whose time is already past.

The ruthless destruction of their forests by the Chinese is one of the reasons why famine and plague today hold this nation in their sinister grasp. Denudation, wherever practiced, leaves naked soil; floods and erosion follow, and when the soil is gone men must also go—and the process does not take long. The great plains of Eastern China were centuries ago transformed from forest into agricultural land. The mountain plateau of Central China have also within a few hundred years been utterly devastated of tree growth, and no attempt made at either natural or artificial reforestation. As a result, the water rushes off the naked slopes in veritable floods, gullying away the mountain sides, causing rivers to run muddy with yellow soil, and carrying enormous masses of fertile earth to the sea. Water courses have also changed; rivers become uncontrollable, and the water level of the country is lowered perceptibly. In consequence, the unfortunate people see their crops wither and die for lack of water when it is most needed.

The surgeon is a man of action. By temperament and by training he prefers to serve the sick by operating on them, and he inwardly commiserates with a patient so unfortunate as to have a disease not suited to surgical treatment. Young surgeons, busy mastering the technicalities of the art, are particularly alert to seize every legitimate opportunity to practice technical maneuvers, the more complicated the better.

What is the meaning of human life, or of organic life altogether? To answer this question at all implies a religion. Is there any sense then, you ask, in putting it? I answer, the man who regards his own life and that of his fellow creatures as meaningless is not merely unfortunate but almost disqualified for life.

Your remarks upon chemical notation with the variety of systems which have arisen, &c., &c., had almost stirred me up to regret publicly that such hindrances to the progress of science should exist. I cannot help thinking it a most unfortunate thing that men who as experimentalists & philosophers are the most fitted to advance the general cause of science & knowledge should by promulgation of their own theoretical views under the form of nomenclature, notation, or scale, actually retard its progress.