[Choosing to become a geophysicist was] entirely accidental and was due to the difficulty of getting a job during the depression. There happened to be one available in Cambridge at the time when I needed it.

[On mediocrity] What we have today is a retreat into low-level goodness. Men are all working hard building barbecues, being devoted to their wives and spending time with their children. Many of us feel, “We never had it so good!” After three wars and a depression, we’re impressed by the rising curve. All we want is it not to blow up.

A lazy part of us is like a tumbleweed. It doesn’t move on its own. Sometimes it takes a lot of Depression to get tumbleweeds moving.

At first I became depressed. I seemed to be getting worse pretty rapidly. There didn’t seem any point in working on my Ph.D. because I didn’t know I would live long enough to finish it.

Concern should drive us into action, not into a depression.

Consider the plight of a scientist of my age. I graduated from the University of California at Berkeley in 1940. In the 41 years since then the amount of biological information has increased 16 fold; during these 4 decades my capacity to absorb new information has declined at an accelerating rate and now is at least 50% less than when I was a graduate student. If one defines ignorance as the ratio of what is available to be known to what is known, there seems no alternative to the conclusion that my ignorance is at least 25 times as extensive as it was when I got my bachelor’s degree. Although I am sure that my unfortunate condition comes as no surprise to my students and younger colleagues, I personally find it somewhat depressing. My depression is tempered, however, by the fact that all biologists, young or old, developing or senescing, face the same melancholy situation because of an interlocking set of circumstances.

Depression is merely anger without enthusiasm.

Depression is rage spread thin.

Farm animals feel pleasure and sadness, excitement and resentment, depression, fear, and pain. They are far more aware and intelligent than we ever imagined … They are individuals in their own right.

Hormones, vitamines, stimulants and depressives are oils upon the creaky machinery of life. Principal item, however, is the machinery.

I hadn’t been aware that there were doors closed to me until I started knocking on them. I went to an all-girls school. There were 75 chemistry majors in that class, but most were going to teach it … When I got out and they didn't want women in the laboratory, it was a shock … It was the Depression and nobody was getting jobs. But I had taken that to mean nobody was getting jobs … [when I heard] “You're qualified. But we’ve never had a woman in the laboratory before, and we think you’d be a distracting influence.”

I was depressed at that time. I was in analysis. I was suicidal as a matter of fact and would have killed myself, but I was in analysis with a strict Freudian, and, if you kill yourself, they make you pay for the sessions you miss.

If Melancholy increases so far, that from the great motion of the Liquid of the Brain the Patient be thrown into a wild Fury, it is call’d Madness.… The greatest Remedy for it is to throw the Patient unwarily into the Sea, and to keep him under Water as long as he can possibly bear without being quite stifled.

If thou examinest a man having a break in the column of his nose, his nose being disfigured, and a [depression] being in it, while the swelling that is on it protrudes, [and] he had discharged blood from both his nostrils, thou shouldst say concerning him: “One having a break in the column of his nose. An ailment which I will treat. “Thou shouldst cleanse [it] for him [with] two plugs of linen. Thou shouldst place two [other] plugs of linen saturated with grease in the inside of his two nostrils. Thou shouldst put [him] at his mooring stakes until the swelling is drawn out. Thou shouldst apply for him stiff rolls of linen by which his nose is held fast. Thou shouldst treat him afterward [with] lint, every day until he recovers.

If we admit our depression openly and freely, those around us get from it an experience of freedom rather than the depression itself.

Iron and coal dominated everywhere, from grey to black: the black boots, the black stove-pipe hat, the black coach or carriage, the black iron frame of the hearth, the black cooking pots and pans and stoves. Was it a mourning? Was it protective coloration? Was it mere depression of the senses? No matter what the original color of the paleotechnic milieu might be it was soon reduced by reason of the soot and cinders that accompanied its activities, to its characteristic tones, grey, dirty-brown, black.

Our Generation has had no Great war, no Great Depression. Our war is spiritual. Our depression is our lives.

Science knows no politics. Are we in this frenzy of [the Depression] economy, brought about by those who control the wealth of this country, seeking to put a barrier on science and research for the paltry sum of $39,113 out of an appropriation of $100,000,000?

Society is becoming increasingly aware of the power of science to bring weal or woe to mankind. But now when it is seen that the same science that brings prosperity and comfort may lead to depression and discomfort, men are beginning to look with mixed feelings at this monster which society may exalt or persecute, but cannot view with indifference. Perhaps my topic today should have read “Ought Scientists to be Burnt at the Stake?” I shall not attempt to decide this question, but only to present in a cursory way some of the pros and cons … But if scientists are to be destroyed, let them not alone by the victims; every creative thought must be extirpated. A philosopher’s epigram may kindle a world war. So scientist, inventor, artist, poet and every sort of troublous enthusiast must together be brought before the bar of the new inquisition

Suppose a number of equal waves of water to move upon the surface of a stagnant lake, with a certain constant velocity, and to enter a narrow channel leading out of the lake. Suppose then another similar cause to have excited another equal series of waves, which arrive at the same time, with the first. Neither series of waves will destroy the other, but their effects will be combined: if they enter the channel in such a manner that the elevations of one series coincide with those of the other, they must together produce a series of greater joint elevations; but if the elevations of one series are so situated as to correspond to the depressions of the other, they must exactly fill up those depressions. And the surface of the water must remain smooth; at least I can discover no alternative, either from theory or from experiment.

The achievements of the Beagle did not just depend on FitzRoy’s skill as a hydrographer, nor on Darwin’s skill as a natural scientist, but on the thoroughly effective fashion in which everyone on board pulled together. Of course Darwin and FitzRoy had their quarrels, but all things considered, they were remarkably infrequent. To have shared such cramped quarters for nearly five years with a man often suffering from serious depression, prostrate part of the time with sea sickness, with so little friction, Darwin must have been one of the best-natured people ever! This is, indeed, apparent in his letters. And anyone who has participated in a scientific expedition will agree that when he wrote from Valparaiso in July 1834 that ‘The Captain keeps all smooth by rowing everyone in turn, which of course he has as much right to do as a gamekeeper to shoot partridges on the first of September’, he was putting a finger on an important ingredient in the Beagle’s success.

The idea that the bumps or depressions on a man's head indicate the presence or absence of certain moral characteristics in his mental equipment is one of the absurdities developed from studies in this field that has long since been discarded by science. The ideas of the phrenologist Gall, however ridiculous they may now seem in the light of a century's progress, were nevertheless destined to become metamorphosed into the modern principles of cerebral localization.

The land! That is where our roots are. There is the basis of our physical life. The farther we get away from the land, the greater our insecurity. From the land comes everything that supports life, everything we use for the service of physical life. The land has not collapsed or shrunk in either extent or productivity. It is there waiting to honor all the labor we are willing to invest in it, and able to tide us across any dislocation of economic conditions.

The sooner patients can be removed from the depressing influence of general hospital life the more rapid their convalescence.

The vacuum-apparatus requires that its manipulators constantly handle considerable amounts of mercury. Mercury is a strong poison, particularly dangerous because of its liquid form and noticeable volatility even at room temperature. Its poisonous character has been rather lost sight of during the present generation. My co-workers and myself found from personal experience-confirmed on many sides when published—that protracted stay in an atmosphere charged with only 1/100 of the amount of mercury required for its saturation, sufficed to induce chronic mercury poisoning. This first reveals itself as an affection of the nerves, causing headaches, numbness, mental lassitude, depression, and loss of memory; such are very disturbing to one engaged in intellectual occupations.

Why did I decide to undertake my doctorate research in the exotic field of boron hydrides? As it happened, my girl friend, Sarah Baylen, soon to become my wife, presented me with a graduation gift, Alfred Stock's book, The Hydrides of Boron and Silicon. I read this book and became interested in the subject. How did it happen that she selected this particular book? This was the time of the Depression. None of us had much money. It appears she selected as her gift the most economical chemistry book ($2.06) available in the University of Chicago bookstore. Such are the developments that can shape a career.