Internal Quotes (22 quotes)
[Defining Life] An internal principle of action.
A complete theory of evolution must acknowledge a balance between ‘external’ forces of environment imposing selection for local adaptation and ‘internal’ forces representing constraints of inheritance and development. Vavilov placed too much emphasis on internal constraints and downgraded the power of selection. But Western Darwinians have erred equally in practically ignoring (while acknowledging in theory) the limits placed on selection by structure and development–what Vavilov and the older biologists would have called ‘laws of form.’
Alike in the external and the internal worlds, the man of science sees himself in the midst of perpetual changes of which he can discover neither the beginning nor the end.
Among people I have met, the few whom I would term “great” all share a kind of unquestioned, fierce dedication; an utter lack of doubt about the value of their activities (or at least an internal impulse that drives through any such angst); and above all, a capacity to work (or at least to be mentally alert for unexpected insights) at every available moment of every day of their lives.
From this fountain (the free will of God) it is those laws, which we call the laws of nature, have flowed, in which there appear many traces of the most wise contrivance, but not the least shadow of necessity. These therefore we must not seek from uncertain conjectures, but learn them from observations and experimental. He who is presumptuous enough to think that he can find the true principles of physics and the laws of natural things by the force alone of his own mind, and the internal light of his reason, must either suppose the world exists by necessity, and by the same necessity follows the law proposed; or if the order of Nature was established by the will of God, the [man] himself, a miserable reptile, can tell what was fittest to be done.
I think that the event which, more than anything else, led me to the search for ways of making more powerful radio telescopes, was the recognition, in 1952, that the intense source in the constellation of Cygnus was a distant galaxy—1000 million light years away. This discovery showed that some galaxies were capable of producing radio emission about a million times more intense than that from our own Galaxy or the Andromeda nebula, and the mechanisms responsible were quite unknown. ... [T]he possibilities were so exciting even in 1952 that my colleagues and I set about the task of designing instruments capable of extending the observations to weaker and weaker sources, and of exploring their internal structure.
Life is inseparable from water. For all terrestrial animals, including birds, the inescapable need for maintaining an adequate state of hydration in a hostile, desiccating environment is a central persistent constraint which exerts a sustained selective pressure on every aspect of the life cycle. It has been said, with some justification, that the struggle for existence is a struggle for free energy for doing physiological work. It can be said with equal justification for terrestrial organisms that the struggle for existence is a struggle to maintain an aqueous internal environment in which energy transformations for doing work can take place.
Life is the continuous adjustment of internal relations to external relations.
Life is the twofold internal movement of composition and decomposition at once general and continuous.
Mathematics may be likened to a large rock whose interior composition we wish to examine. The older mathematicians appear as persevering stone cutters slowly attempting to demolish the rock from the outside with hammer and chisel. The later mathematicians resemble expert miners who seek vulnerable veins, drill into these strategic places, and then blast the rock apart with well placed internal charges.
Men today who have had an irreproachable training in the art are seen to abstain from the use of the hand as from the plague, and for this very reason, lest they should be slandered by the masters of the profession as barbers… . For it is indeed above all things the wide prevalence of this hateful error that prevents us even in our age from taking up the healing art as a whole, makes us confine ourselves merely to the treatment of internal complaints, and, if I may utter the blunt truth once for all, causes us, to the great detriment of mankind, to study to be healers only in a very limited degree.
My internal and external life depend so much on the work of others that I must make an extreme effort to give as much as I receive.
No matter how we twist and turn we shall always come back to the cell. The eternal merit of Schwann does not lie in his cell theory that has occupied the foreground for so long, and perhaps will soon be given up, but in his description of the development of the various tissues, and in his demonstration that this development (hence all physiological activity) is in the end traceable back to the cell. Now if pathology is nothing but physiology with obstacles, and diseased life nothing but healthy life interfered with by all manner of external and internal influences then pathology too must be referred back to the cell.
Science is the construction of parsimonious, internally consistent models that can reliably predict future observations.
So, then, the Tincture of the Philosophers is a universal medicine, and consumes all diseases, by whatsoever name they are called, just like an invisible fire. The dose is very small, but its effect is most powerful. By means thereof I have cured the leprosy, venereal disease, dropsy, the falling sickness, colic, scab, and similar afflictions; also lupus, cancer, noli-metangere, fistulas, and the whole race of internal diseases, more surely than one could believe.
The man who is thoroughly convinced of the universal operation of the law of causation cannot for a moment entertain the idea of a being who interferes in the course of events–provided, of course, that he takes the hypothesis of causality really seriously. He has no use for the religion of fear and equally little for social or moral religion. A God who rewards and punishes is inconceivable to him for the simple reason that a man’s actions are determined by necessity, external and internal, so that in God’s eyes he cannot be responsible, any more than an inanimate object is responsible for the motions it undergoes. Science has therefore been charged with undermining morality, but the charge is unjust. A man’s ethical behavior should be based effectually on sympathy, education, and social tie s and needs; no religious basis is necessary. Man would indeed be in a poor way if he had to be restrained by fear of punishment and hopes of reward after death.
The responsibility for maintaining the composition of the blood in respect to other constituents devolves largely upon the kidneys. It is no exaggeration to say that the composition of the blood is determined not by what the mouth ingests but by what the kidneys keep; they are the master chemists of our internal environment, which, so to speak, they synthesize in reverse. When, among other duties, they excrete the ashes of our body fires, or remove from the blood the infinite variety of foreign substances which are constantly being absorbed from our indiscriminate gastrointestinal tracts, these excretory operations are incidental to the major task of keeping our internal environment in an ideal, balanced state. Our glands, our muscles, our bones, our tendons, even our brains, are called upon to do only one kind of physiological work, while our kidneys are called upon to perform an innumerable variety of operations. Bones can break, muscles can atrophy, glands can loaf, even the brain can go to sleep, without immediately endangering our survival, but when the kidneys fail to manufacture the proper kind of blood neither bone, muscle, gland nor brain can carry on.
The work of the inventor consists of conceptualizing, combining, and ordering what is possible according to the laws of nature. This inner working out which precedes the external has a twofold characteristic: the participation of the subconscious in the inventing subject; and that encounter with an external power which demands and obtains complete subjugation, so that the way to the solution is experienced as the fitting of one's own imagination to this power.
There are those who say that the human kidney was created to keep the blood pure, or more precisely, to keep our internal environment in an ideal balanced state. This I must deny. I grant that the human kidney is a marvelous organ, but I cannot grant that it was purposefully designed to excrete urine or to regulate the composition of the blood or to subserve the physiological welfare of Homo sapiens in any sense. Rather I contend that the human kidney manufactures the kind of urine that it does, and it maintains the blood in the composition which that fluid has, because this kidney has a certain functional architecture; and it owes that architecture not to design or foresight or to any plan, but to the fact that the earth is an unstable sphere with a fragile crust, to the geologic revolutions that for six hundred million years have raised and lowered continents and seas, to the predacious enemies, and heat and cold, and storms and droughts; to the unending succession of vicissitudes that have driven the mutant vertebrates from sea into fresh water, into desiccated swamps, out upon the dry land, from one habitation to another, perpetually in search of the free and independent life, perpetually failing, for one reason or another, to find it.
There is no gene ‘for’ such unambiguous bits of morphology as your left kneecap or your fingernail ... Hundreds of genes contribute to the building of most body parts and their action is channeled through a kaleidoscopic series of environmental influences: embryonic and postnatal, internal and external. Parts are not translated genes, and selection doesn’t even work directly on parts.
Whatever things are not derived from objects themselves, whether by the external senses or by the sensation of internal thoughts, are to be taken as hypotheses…. Those things which follow from the phenomena neither by demonstration nor by the argument of induction, I hold as hypotheses.
… just as the astronomer, the physicist, the geologist, or other student of objective science looks about in the world of sense, so, not metaphorically speaking but literally, the mind of the mathematician goes forth in the universe of logic in quest of the things that are there; exploring the heights and depths for facts—ideas, classes, relationships, implications, and the rest; observing the minute and elusive with the powerful microscope of his Infinitesimal Analysis; observing the elusive and vast with the limitless telescope of his Calculus of the Infinite; making guesses regarding the order and internal harmony of the data observed and collocated; testing the hypotheses, not merely by the complete induction peculiar to mathematics, but, like his colleagues of the outer world, resorting also to experimental tests and incomplete induction; frequently finding it necessary, in view of unforeseen disclosures, to abandon one hopeful hypothesis or to transform it by retrenchment or by enlargement:—thus, in his own domain, matching, point for point, the processes, methods and experience familiar to the devotee of natural science.