“She can't do sums a bit!” the Queens said together, with great emphasis.
“Can you do sums?” Alice said, turning suddenly on the White Queen, for she didn't like being found fault with so much.
The Queen gasped and shut her eyes. “I can do Addition, if you give me time-but I can do Subtraction, under any circumstances!”

“That’s another thing we’ve learned from your Nation,” said Mein Herr, “map-making. But we’ve carried it much further than you. What do you consider the largest map that would be really useful?”
“About six inches to the mile.”
“Only six inches!” exclaimed Mein Herr. “We very soon got to six yards to the mile. Then we tried a hundred yards to the mile. And then came the grandest idea of all! We actually made a map of the country, on the scale of a mile to the mile!”
“Have you used it much?” I enquired.
“It has never been spread out, yet,” said Mein Herr: “the farmers objected: they said it would cover the whole country, and shut out the sunlight! So we now use the country itself, as its own map, and I assure you it does nearly as well.”

[1665-04-30] ...Great fear of the sicknesses here in the City, it being said that two or three houses are already shut up. God preserve us all.

[1665-06-11] I out of doors a little to show forsooth my new suit, and back again; and in going, saw poor Dr Burnets door shut. But he hath, I hear, gained goodwill among his neighbours; for he discovered it himself first, and caused himself to be shut up of his own accord - which was very handsome.

[1665-08-16] ...Hence to the Exchange, which I have not been a great while. But Lord, how sad a sight it is to see the streets empty of people, and very few upon the Change - jealous of every door that one sees shut up, lest it should be the plague - and about us, two shops in three, if not more, generally shut up. ... It was dark before I could get home; and so land at church-yard stairs, where to my great trouble I met a dead Corps, of the plague, in the narrow ally, just bringing down a little pair of stairs - but I thank God I was not much disturbed at it. However, I shall beware of being late abroad again.

[1665-09-14] ...my finding that although the Bill [total of dead] in general is abated, yet the City within the walls is encreasd and likely to continue so (and is close to our house there) - my meeting dead corps's of the plague, carried to be buried close to me at noonday through the City in Fanchurch-street - to see a person sick of the sores carried close by me by Grace-church in a hackney-coach - my finding the Angell tavern at the lower end of Tower-hill shut up; and more then that, the alehouse at the Tower-stairs; and more then that, that the person was then dying of the plague when I was last there, a little while ago at night, to write a short letter there, and I overheard the mistress of the house sadly saying to her husband somebody was very ill, but did not think it was of the plague - to hear that poor Payne my waterman hath buried a child and is dying himself - to hear that a labourer I sent but the other day to Dagenhams to know how they did there is dead of the plague and that one of my own watermen, that carried me daily, fell sick as soon as he had landed me on Friday morning last, when I had been all night upon the water ... is now dead of the plague - to hear ... that Mr Sidny Mountagu is sick of a desperate fever at my Lady Carteret's at Scott's hall - to hear that Mr. Lewes hath another daughter sick - and lastly, that both my servants, W Hewers and Tom Edwards, have lost their fathers, both in St. Sepulcher's parish, of the plague this week - doth put me into great apprehensions of melancholy, and with good reason. But I put off the thoughts of sadness as much as I can, and the rather to keep my wife in good heart and family also.

[Describing the effects of over-indulgence in wine:]
But most too passive, when the blood runs low
Too weakly indolent to strive with pain,
And bravely by resisting conquer fate,
Try Circe's arts; and in the tempting bowl
Of poisoned nectar sweet oblivion swill.
Struck by the powerful charm, the gloom dissolves
In empty air; Elysium opens round,
A pleasing frenzy buoys the lightened soul,
And sanguine hopes dispel your fleeting care;
And what was difficult, and what was dire,
Yields to your prowess and superior stars:
The happiest you of all that e'er were mad,
Or are, or shall be, could this folly last.
But soon your heaven is gone: a heavier gloom
Shuts o'er your head; and, as the thundering stream,
Swollen o'er its banks with sudden mountain rain,
Sinks from its tumult to a silent brook,
So, when the frantic raptures in your breast
Subside, you languish into mortal man;
You sleep, and waking find yourself undone,
For, prodigal of life, in one rash night
You lavished more than might support three days.
A heavy morning comes; your cares return
With tenfold rage. An anxious stomach well
May be endured; so may the throbbing head;
But such a dim delirium, such a dream,
Involves you; such a dastardly despair
Unmans your soul, as maddening Pentheus felt,
When, baited round Citheron's cruel sides,
He saw two suns, and double Thebes ascend.

Even fairly good students, when they have obtained the solution of the problem and written down neatly the argument, shut their books and look for something else. Doing so, they miss an important and instructive phase of the work. ... A good teacher should understand and impress on his students the view that no problem whatever is completely exhausted.

For if there is any truth in the dynamical theory of gases the different molecules in a gas at uniform temperature are moving with very different velocities. Put such a gas into a vessel with two compartments [A and B] and make a small hole in the wall about the right size to let one molecule through. Provide a lid or stopper for this hole and appoint a doorkeeper, very intelligent and exceedingly quick, with microscopic eyes but still an essentially finite being.
Whenever he sees a molecule of great velocity coming against the door from A into B he is to let it through, but if the molecule happens to be going slow he is to keep the door shut. He is also to let slow molecules pass from B to A but not fast ones ... In this way the temperature of B may be raised and that of A lowered without any expenditure of work, but only by the intelligent action of a mere guiding agent (like a pointsman on a railway with perfectly acting switches who should send the express along one line and the goods along another).
I do not see why even intelligence might not be dispensed with and the thing be made self-acting.
Moral The 2nd law of Thermodynamics has the same degree of truth as the statement that if you throw a tumblerful of water into the sea you cannot get the same tumblerful of water out again.

Genetics has enticed a great many explorers during the past two decades. They have labored with fruit-flies and guinea-pigs, with sweet peas and corn, with thousands of animals and plants in fact, and they have made heredity no longer a mystery but an exact science to be ranked close behind physics and chemistry in definiteness of conception. One is inclined to believe, however, that the unique magnetic attraction of genetics lies in the vision of potential good which it holds for mankind rather than a circumscribed interest in the hereditary mechanisms of the lowly species used as laboratory material. If man had been found to be sharply demarcated from the rest of the occupants of the world, so that his heritage of physical form, of physiological function, and of mental attributes came about in a superior manner setting him apart as lord of creation, interest in the genetics of the humbler organisms—if one admits the truth—would have flagged severely. Biologists would have turned their attention largely to the ways of human heredity, in spite of the fact that the difficulties encountered would have rendered progress slow and uncertain. Since this was not the case, since the laws ruling the inheritance of the denizens of the garden and the inmates of the stable were found to be applicable to prince and potentate as well, one could shut himself up in his laboratory and labor to his heart's content, feeling certain that any truth which it fell to his lot to discover had a real human interest, after all.

Go into a room where the shutters are always shut (in a sick-room or a bed-room there should never be shutters shut), and though the room be uninhabited—though the air has never been polluted by the breathing of human beings, you will observe a close, musty smell of corrupt air—of air unpurified by the effect of the sun's rays.

Good work is no done by “humble” men. It is one of the first duties of a professor, for example, in any subject, to exaggerate a little both the importance of his subject and his own importance in it. A man who is always asking “Is what I do worth while?” and “Am I the right person to do it?” will always be ineffective himself and a discouragement to others. He must shut his eyes a little and think a little more of his subject and himself than they deserve. This is not too difficult: it is harder not to make his subject and himself ridiculous by shutting his eyes too tightly.

I cannot shut my eyes to the fact that the production of wealth is not the work of any one man, and the acquisition of great fortunes is not possible without the co-operation of multitudes of men.

I think we all have a little voice inside us that will guide us. It may be God, I don’t know. But I think that if we shut out all the noise and clutter from our lives and listen to that voice, it will tell us the right thing to do.

If A is a success in life, I should say the formula is A = X + Y + Z, X being work and Y being play. … … [Z] is keeping your mouth shut.

If I were forced to sum up in one sentence what the Copenhagen interpretation says to me, it would be “Shut up and calculate!”

If you take a plunge into the sea, you unconsciously close your pores against the cold. If you go out on a cold day, you consciously put on an overcoat. Science can give you reason why you should not make & put on an overcoat without knowing it just as you shut your pores.

In these strenuous times, we are likely to become morbid and look constantly on the dark side of life, and spend entirely too much time considering and brooding over what we can't do, rather than what we can do, and instead of growing morose and despondent over opportunities either real or imaginary that are shut from us, let us rejoice at the many unexplored fields in which there is unlimited fame and fortune to the successful explorer and upon which there is no color line; simply the survival of the fittest.

It suddenly struck me that that tiny pea, pretty and blue, was the Earth. I put up my thumb and shut one eye, and my thumb blotted out the planet Earth. I didn’t feel like a giant. I felt very, very small.

Leo Szilard’s Ten Commandments:
1. Recognize the connections of things and the laws of conduct of men, so that you may know what you are doing.
2. Let your acts be directed towards a worthy goal, but do not ask if they will reach it; they are to be models and examples, not means to an end.
3. Speak to all men as you do to yourself, with no concern for the effect you make, so that you do not shut them out from your world; lest in isolation the meaning of life slips out of sight and you lose the belief in the perfection of the creation.
4. Do not destroy what you cannot create.
5. Touch no dish, except that you are hungry.
6. Do not covet what you cannot have.
7. Do not lie without need.
8. Honor children. Listen reverently to their words and speak to them with infinite love.
9. Do your work for six years; but in the seventh, go into solitude or among strangers, so that the memory of your friends does not hinder you from being what you have become.
10. Lead your life with a gentle hand and be ready to leave whenever you are called.

Mr. Darwin in the Zoological Gardens. Frank Darwin told me his father was once standing near the hippopotamus cage when a little boy and girl, aged four and five, came up. The hippopotamus shut his eyes for a minute. “That bird’s dead,” said the little girl; “come along.”

No true geologist holds by the development hypothesis;—it has been resigned to sciolists and smatterers;—and there is but one other alternative. They began to be, through the miracle of creation. From the evidence furnished by these rocks we are shut down either to belief in miracle, or to something else infinitely harder of reception, and as thoroughly unsupported by testimony as it is contrary to experience. Hume is at length answered by the severe truths of the stony science.

Once I dipt into the future far as human eye could see,
And I saw the Chief Forecaster, dead as any one can be-
Dead and damned and shut in Hades as a liar from his birth,
With a record of unreason seldom paralleled on earth.
While I looked he reared him solemnly, that incandescent youth,
From the coals that he’s preferred to the advantages of truth.
He cast his eyes about him and above him; then he wrote
On a slab of thin asbestos what I venture here to quote-
For I read it in the rose-light of the everlasting glow:
Cloudy; variable winds, with local showers; cooler; snow.

Only dream I ever have... is it the surface of the Sun? Every time I shut my eyes... it’s always the same.

People do more talking than listening: under the law of gravity, it takes more energy to shut one's mouth than to open it.

Shut your eyes to the medical columns of the newspapers, and you will save yourself many forebodings and symptoms.

Since 1849 I have studied incessantly, under all its aspects, a question which was already in my mind [since 1832. I confess that my scheme is still a mere dream, and I do not shut my eyes to the fact that so long as I alone believe it to be possible, it is virtually impossible. ... The scheme in question is the cutting of a canal through the Isthmus of Suez. This has been thought of from the earliest historical times, and for that very reason is looked upon as impracticable. Geographical dictionaries inform us indeed that the project would have been executed long ago but for insurmountable obstacles. [On his inspiration for the Suez Canal.]

The attempted synthesis of paleontology and genetics, an essential part of the present study, may be particularly surprising and possibly hazardous. Not long ago, paleontologists felt that a geneticist was a person who shut himself in a room, pulled down the shades, watched small flies disporting themselves in milk bottles, and thought that he was studying nature. A pursuit so removed from the realities of life, they said, had no significance for the true biologist. On the other hand, the geneticists said that paleontology had no further contributions to make to biology, that its only point had been the completed demonstration of the truth of evolution, and that it was a subject too purely descriptive to merit the name 'science'. The paleontologist, they believed, is like a man who undertakes to study the principles of the internal combustion engine by standing on a street corner and watching the motor cars whiz by.

The cases of action at a distance are becoming, in a physical point of view, daily more and more important. Sound, light, electricity, magnetism, gravitation, present them as a series.
The nature of sound and its dependence on a medium we think we understand, pretty well. The nature of light as dependent on a medium is now very largely accepted. The presence of a medium in the phenomena of electricity and magnetism becomes more and more probable daily. We employ ourselves, and I think rightly, in endeavouring to elucidate the physical exercise of these forces, or their sets of antecedents and consequents, and surely no one can find fault with the labours which eminent men have entered upon in respect of light, or into which they may enter as regards electricity and magnetism. Then what is there about gravitation that should exclude it from consideration also? Newton did not shut out the physical view, but had evidently thought deeply of it; and if he thought of it, why should not we, in these advanced days, do so too?

The object of opening the mind, as of opening the mouth, is to shut it again on something solid.

The silence of a shut park does not sound like the country silence; it is tense and confined.

The traditional method of confronting the student not with the problem but with the finished solution means depriving him of all excitement, to shut off the creative impulse, to reduce the adventure of mankind to a dusty heap of theorems.

There cannot always be fresh fields of conquest by the knife; there must be portions of the human frame that will ever remain sacred from its intrusions, at least in the surgeon's hands. That we have already, if not quite, reached these final limits, there can be little question. The abdomen, the chest, and the brain will be forever shut from the intrusion of the wise and humane surgeon.

These parsons are so in the habit of dealing with the abstractions of doctrines as if there was no difficulty about them whatever, so confident, from the practice of having the talk all to themselves for an hour at least every week with no one to gainsay a syllable they utter, be it ever so loose or bad, that they gallop over the course when their field is Botany or Geology as if we were in the pews and they in the pulpit ... There is a story somewhere of an Englishman, Frenchman, and German being each called on to describe a camel. The Englishman immediately embarked for Egypt, the Frenchman went to the Jardin des Plantes, and the German shut himself up in his study and thought it out!

Time is awake when all things sleep.
Time stands straight when all things fall.
Time shuts in all and will not be shut.
Is, was, and shall be are Time’s children.
O Reason! be witness! be stable!

To appreciate a work of art we need bring with us nothing from life, no knowledge of its ideas and affairs, no familiarity with its emotions. Art transports us from the world of man’s activity to a world of æsthetic exaltation. For a moment we are shut off from human interests; our anticipations and memories are arrested; we are lifted above the stream of life. The pure mathematician rapt in his studies knows a state of mind which I take to be similar, if not identical. He feels an emotion for his speculations which arises from no perceived relation between them and the lives of men, but springs, inhuman or super-human, from the heart of an abstract science. I wonder, sometimes, whether the appreciators of art and of mathematical solutions are not even more closely allied.

To isolate mathematics from the practical demands of the sciences is to invite the sterility of a cow shut away from the bulls.

To pick a hole–say in the 2nd law of Ω^cs, that if two things are in contact the hotter cannot take heat from the colder without external agency.
Now let A & B be two vessels divided by a diaphragm and let them contain elastic molecules in a state of agitation which strike each other and the sides. Let the number of particles be equal in A & B but let those in A have equal velocities, if oblique collisions occur between them their velocities will become unequal & I have shown that there will be velocities of all magnitudes in A and the same in B only the sum of the squares of the velocities is greater in A than in B.
When a molecule is reflected from the fixed diaphragm CD no work is lost or gained.
If the molecule instead of being reflected were allowed to go through a hole in CD no work would be lost or gained, only its energy would be transferred from the one vessel to the other.
Now conceive a finite being who knows the paths and velocities of all the molecules by simple inspection but who can do no work, except to open and close a hole in the diaphragm, by means of a slide without mass.
Let him first observe the molecules in A and when lie sees one coming the square of whose velocity is less than the mean sq. vel. of the molecules in B let him open a hole & let it go into B. Next let him watch for a molecule in B the square of whose velocity is greater than the mean sq. vel. in A and when it comes to the hole let him draw and slide & let it go into A, keeping the slide shut for all other molecules.
Then the number of molecules in A & B are the same as at first but the energy in A is increased and that in B diminished that is the hot system has got hotter and the cold colder & yet no work has been done, only the intelligence of a very observant and neat fingered being has been employed. Or in short if heat is the motion of finite portions of matter and if we can apply tools to such portions of matter so as to deal with them separately then we can take advantage of the different motion of different portions to restore a uniformly hot system to unequal temperatures or to motions of large masses. Only we can't, not being clever enough.

What politicians do not understand is that [Ian] Wilmut discovered not so much a technical trick as a new law of nature. We now know that an adult mammalian cell can fire up all the dormant genetic instructions that shut down as it divides and specializes and ages, and thus can become a source of new life. You can outlaw technique; you cannot repeal biology.
Writing after Wilmut's successful cloning of the sheep, Dolly, that research on the cloning of human beings cannot be suppressed.

When I was in college studying science, I found the experience fundamentally unsatisfying. I was continually oppressed by the feeling that my only role was to “shut up and learn.” I felt there was nothing I could say to my instructors that they would find interesting. … As I sat in the science lecture hall, I was utterly silent. That’s not a good state to be in when you are 19 years old.

When you get up here in space and you go into the weightlessness environment, your body is not sure what really just happened to it. So your stomach, intestines, and that stuff kind of shuts down for a few hours to figure out what is going on and during that timeframe your body is not doing much with your food. After your body figures out that it can handle the new environment, everything cranks back up and your food, stomach and intestines and all start working like normal.