[My] numberless observations... made on the Strata... [have] made me confident of their uniformity throughout this Country & [have] led me to conclude that the same regularity... will be found to extend to every part of the Globe for Nature has done nothing by piecemeal. [T]here is no inconsistency in her productions. [T]he Horse never becomes an Ass nor the Crab an Apple by any intermixture or artificial combination whatever[. N]or will the Oak ever degenerate into an Ash or an Ash into an Elm. [H]owever varied by Soil or Climate the species will still be distinct on this ground. [T]hen I argue that what is found here may be found elsewhere[.] When proper allowances are made for such irregularities as often occur and the proper situation and natural agreement is well understood I am satisfied there will be no more difficulty in ascertaining the true quality of the Strata and the place of its possition [sic] than there is now in finding the true Class and Character of Plants by the Linean [sic] System.

[Oppenheimer is] tense, dedicated, deeper than deep, somewhat haunted, uncertain, calm, confident, and full, full, full of knowledge, not only of particles and things but of men and motives, and of the basic humanity that may be the only savior we have in this strange world he and his colleagues have discovered.

But for us, it’s different. Look again at that dot. That’s here. That’s home. That’s us. On it everyone you love, everyone you know, everyone you ever heard of, every human being who ever was, lived out their lives. The aggregate of our joy and suffering, thousands of confident religions, ideologies, and economic doctrines, every hunter and forager, every hero and coward, every creator and destroyer of civilization, every king and peasant, every young couple in love, every mother and father, hopeful child, inventor and explorer, every teacher of morals, every corrupt politician, every “superstar,” every “supreme leader,” every saint and sinner in the history of our species lived there - on a mote of dust suspended in a sunbeam.

Error held as truth has much the effect of truth. In politics and religion this fact upsets many confident predictions.

Every well established truth is an addition to the sum of human power, and though it may not find an immediate application to the economy of every day life, we may safely commit it to the stream of time, in the confident anticipation that the world will not fail to realize its beneficial results.

Four college students taking a class together, had done so well through the semester, and each had an “A”. They were so confident, the weekend before finals, they went out partying with friends. Consequently, on Monday, they overslept and missed the final. They explained to the professor that they had gone to a remote mountain cabin for the weekend to study, but, unfortunately, they had a flat tire on the way back, didn’t have a spare, and couldn’t get help for a long time. As a result, they missed the final. The professor kindly agreed they could make up the final the following day. When they arrived the next morning, he placed them each in separate rooms, handed each one a test booklet, and told them to begin. The the first problem was simple, worth 5 points. Turning the page they found the next question, written: “(For 95 points): Which tire?”

I am willing to believe that my unobtainable sixty seconds within a sponge or a flatworm might not reveal any mental acuity that I would care to ca ll consciousness. But I am also confident ... that vultures and sloths, as close evolutionary relatives with the same basic set of organs, lie on our side of any meaningful (and necessarily fuzzy) border–and that we are therefore not mistaken when we look them in the eye and see a glimmer of emotional and conceptual affinity.

I feel more confident and more satisfied when I reflect that I have two professions and not one. Medicine is my lawful wife and literature is my mistress. When I get tired of one I spend the night with the other. Though it's disorderly it's not so dull, and besides, neither really loses anything, through my infidelity.

I undertake my scientific research with the confident assumption that the earth follows the laws of nature which God established at creation. … My studies are performed with the confidence that God will not capriciously confound scientific results by “slipping in” a miracle.

I would not be confident in everything I say about the argument: but one thing I would fight for to the end, both in word and in deed if I were able—that if we believe we should try to find out what is not known, we should be better and braver and less idle than if we believed that what we do not know is impossible to find out and that we need not even try.

If our so-called facts are changing shadows, they are shadows cast by the light of constant truth. So too in religion we are repelled by that confident theological doctrine… but we need not turn aside from the measure of light that comes into our experience showing us a Way through the unseen world.

In fact a favourite problem of [Tyndall] is—Given the molecular forces in a mutton chop, deduce Hamlet or Faust therefrom. He is confident that the Physics of the Future will solve this easily.

In the modern world, science and society often interact in a perverse way. We live in a technological society, and technology causes political problems. The politicians and the public expect science to provide answers to the problems. Scientific experts are paid and encouraged to provide answers. The public does not have much use for a scientist who says, “Sorry, but we don’t know.” The public prefers to listen to scientists who give confident answers to questions and make confident predictions of what will happen as a result of human activities. So it happens that the experts who talk publicly about politically contentious questions tend to speak more clearly than they think. They make confident predictions about the future, and end up believing their own predictions. Their predictions become dogmas which they do not question. The public is led to believe that the fashionable scientific dogmas are true, and it may sometimes happen that they are wrong. That is why heretics who question the dogmas are needed.

My dear child, be not afraid of the pains and be not afraid, be as tough and confident as you can and let not your courage flag and your hope fail. I assure you, with God’s help it will go better than you think! Just hang on tight with both hands so you tremble not. It will soon pass. You will see that Our Dear Lord will soon help you. How quickly a pain passes! Who should let his courage flag so quickly, for God’s help is at hand.

No one believes an hypothesis except its originator but everyone believes an experiment except the experimenter. Most people are ready to believe something based on experiment but the experimenter knows the many little things that could have gone wrong in the experiment. For this reason the discoverer of a new fact seldom feels quite so confident of it as others do. On the other hand other people are usually critical of an hypothesis, whereas the originator identifies himself with it and is liable to become devoted to it.

Nothing can be more fatal to progress than a too confident reliance upon mathematical symbols; for the student is only too apt to take the easier course, and consider the formula and not the fact as the physical reality.

Nothing is so firmly believed as what we least know; nor any people so confident as those who entertain us with fabulous stories, such as your alchemists, judicial astrologers, fortune-tellers, and physicians.

Now, it may be stretching an analogy to compare epidemics of cholera—caused by a known agent—with that epidemic of violent crime which is destroying our cities. It is unlikely that our social problems can be traced to a single, clearly defined cause in the sense that a bacterial disease is ‘caused’ by a microbe. But, I daresay, social science is about as advanced in the late twentieth century as bacteriological science was in the mid nineteenth century. Our forerunners knew something about cholera; they sensed that its spread was associated with misdirected sewage, filth, and the influx of alien poor into crowded, urban tenements. And we know something about street crime; nowhere has it been reported that a member of the New York Stock Exchange has robbed ... at the point of a gun. Indeed, I am naively confident that an enlightened social scientist of the next century will be able to point out that we had available to us at least some of the clues to the cause of urban crime.

Scientists are the easiest to fool. ... They think in straight, predictable, directable, and therefore misdirectable, lines. The only world they know is the one where everything has a logical explanation and things are what they appear to be. Children and conjurors—they terrify me. Scientists are no problem; against them I feel quite confident.

The only solid piece of scientific truth about which I feel totally confident is that we are profoundly ignorant about nature. ... It is this sudden confrontation with the depth and scope of ignorance that represents the most significant contribution of twentieth-century science to the human intellect.

There's a tendency these days to use science as a religion, and to see geneticists as the high priests of that religion. But, the irony is that, as geneticists know more, they get less and less confident.

These parsons are so in the habit of dealing with the abstractions of doctrines as if there was no difficulty about them whatever, so confident, from the practice of having the talk all to themselves for an hour at least every week with no one to gainsay a syllable they utter, be it ever so loose or bad, that they gallop over the course when their field is Botany or Geology as if we were in the pews and they in the pulpit ... There is a story somewhere of an Englishman, Frenchman, and German being each called on to describe a camel. The Englishman immediately embarked for Egypt, the Frenchman went to the Jardin des Plantes, and the German shut himself up in his study and thought it out!

Time was when all the parts of the subject were dissevered, when algebra, geometry, and arithmetic either lived apart or kept up cold relations of acquaintance confined to occasional calls upon one another; but that is now at an end; they are drawn together and are constantly becoming more and more intimately related and connected by a thousand fresh ties, and we may confidently look forward to a time when they shall form but one body with one soul.

When the mathematician says that such and such a proposition is true of one thing, it may be interesting, and it is surely safe. But when he tries to extend his proposition to everything, though it is much more interesting, it is also much more dangerous. In the transition from one to all, from the specific to the general, mathematics has made its greatest progress, and suffered its most serious setbacks, of which the logical paradoxes constitute the most important part. For, if mathematics is to advance securely and confidently, it must first set its affairs in order at home.

When we think how narrow and devious this path of nature is, how dimly we can trace it, for all our lamps of science, and how from the darkness which girds it round great and terrible possibilities loom ever shadowly upwards, it is a bold and a confident man who will put a limit to the strange by-oaths into which the human spirit may wander.